Irving, E;
Tagalakis, AD;
Maeshima, R;
Hart, SL;
Eaton, S;
Lehtonen, A;
Stoker, AW;
(2020)
The liposomal delivery of hydrophobic oxidovanadium complexes imparts highly effective cytotoxicity and differentiating capacity in neuroblastoma tumour cells.
Scientific Reports
, 10
(1)
, Article 16660. 10.1038/s41598-020-73539-6.
Preview |
Text
Irving_et_al-2020-Scientific_Reports.pdf - Published Version Download (2MB) | Preview |
Abstract
Oxidovanadium complexes with organic ligands are well known to have cytotoxic or diferentiating capabilities against a range of cancer cell types. Their limited use in clinical testing though has resulted largely from uncertainties about the long-term toxicities of such complexes, due in part to the speciation to vanadate ions in the circulation. We hypothesised that more highly stable complexes, delivered using liposomes, may provide improved opportunities for oxidovanadium applications against cancer. In this study we sourced specifcally hydrophobic forms of oxidovanadium complexes with the explicit aim of demonstrating liposomal encapsulation, bioavailability in cultured neuroblastoma cells, and efective cytotoxic or diferentiating activity. Our data show that four ethanol-solubilised complexes with amine bisphenol, aminoalcohol bisphenol or salan ligands are equally or more efective than a previously used complex bis(maltolato)oxovanadium(V) in neuroblastoma cell lines. Moreover, we show that one of these complexes can be stably incorporated into cationic liposomes where it retains very good bioavailability, apparently low speciation and enhanced efcacy compared to ethanol delivery. This study provides the frst proof-of-concept that stable, hydrophobic oxidovanadium complexes retain excellent cellular activity when delivered efectively to cancer cells with nanotechnology. This ofers the improved prospect of applying oxidovanadium-based drugs in vivo with increased stability and reduced of-target toxicity.
| Type: | Article |
|---|---|
| Title: | The liposomal delivery of hydrophobic oxidovanadium complexes imparts highly effective cytotoxicity and differentiating capacity in neuroblastoma tumour cells |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41598-020-73539-6 |
| Publisher version: | http://dx.doi.org/10.1038/s41598-020-73539-6 |
| Language: | English |
| Additional information: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Biochemistry, Cancer, Cancer therapy, Cell biology, Drug delivery, Paediatric cancer |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Genetics and Genomic Medicine Dept UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10111854 |
Archive Staff Only
 |
View Item |
