Browse by UCL people
Group by: Type | Date
Number of items: 50.
Article
(2016)
Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study.
The Lancet Infectious Diseases
, 16
(5)
pp. 565-575.
10.1016/S1473-3099(15)00536-8.
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Ahmed, N;
Flavell, S;
Ferns, B;
Frampton, D;
Edwards, SG;
Miller, RF;
Grant, P;
... Gupta, RK; + view all
(2019)
Development of the R263K Mutation to Dolutegravir in an HIV-1 Subtype D Virus Harboring 3 Class-Drug Resistance.
Open Forum Infectious Diseases
, 6
(1)
, Article ofy329. 10.1093/ofid/ofy329.
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Chimukangara, B;
Lessells, RJ;
Rhee, SY;
Giandhari, J;
Kharsany, ABM;
Naidoo, K;
Lewis, L;
... de Oliveira, T; + view all
(2019)
Trends in Pretreatment HIV-1 Drug Resistance in Antiretroviral Therapy-naive Adults in South Africa, 2000–2016: A Pooled Sequence Analysis.
EClinicalMedicine
, 9
pp. 26-34.
10.1016/j.eclinm.2019.03.006.
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Collier, DA;
De Marco, A;
Ferreira, IATM;
Meng, B;
Datir, RP;
Walls, AC;
Kemp, SA;
... Gupta, RK; + view all
(2021)
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies.
Nature
, 593
pp. 136-141.
10.1038/s41586-021-03412-7.
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Collier, DA;
Ferreira, IATM;
Kotagiri, P;
Datir, R;
Lim, E;
Touizer, E;
Meng, B;
... Gupta, RK; + view all
(2021)
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2.
Nature
, 596
pp. 417-422.
10.1038/s41586-021-03739-1.
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Collier, D;
Iwuji, C;
Derache, A;
de Oliveira, T;
Okesola, N;
Calmy, A;
Dabis, F;
... Gupta, RK; + view all
(2017)
Virological Outcomes of Second-line Protease Inhibitor-Based Treatment for Human Immunodeficiency Virus Type 1 in a High-Prevalence Rural South African Setting: A Competing-Risks Prospective Cohort Analysis.
CLINICAL INFECTIOUS DISEASES
, 64
(8)
pp. 1006-1016.
10.1093/cid/cix015.
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Collier, DA;
Assennato, SM;
Warne, B;
Sithole, N;
Sharrocks, K;
Ritchie, A;
Ravji, P;
... CITIID-NIHR COVID BioResource Collaboration; + view all
(2020)
Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study.
Cell Reports Medicine
, 1
(5)
, Article 100062. 10.1016/j.xcrm.2020.100062.
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Collier, DA;
Haddow, L;
Brijkumar, J;
Moosa, M-YS;
Benjamin, L;
Gupta, RK;
(2018)
HIV Cerebrospinal Fluid Escape and Neurocognitive Pathology in the Era of Combined Antiretroviral Therapy: What Lies Beneath the Tip of the Iceberg in Sub-Saharan Africa.
Brain Sciences
, 8
(10)
, Article 190. 10.3390/brainsci8100190.
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Collier, DA;
Monit, C;
Gupta, RK;
(2019)
The Impact of HIV-1 Drug Escape on the Global Treatment Landscape.
Cell Host & Microbe
, 26
(1)
pp. 48-60.
10.1016/j.chom.2019.06.010.
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Datir, R;
Kemp, S;
El Bouzidi, K;
Mlchocova, P;
Goldstein, R;
Breuer, J;
Towers, GJ;
... Gupta, RK; + view all
(2020)
In Vivo Emergence of a Novel Protease Inhibitor Resistance Signature in HIV-1 Matrix.
mBio
, 11
(6)
10.1128/mBio.02036-20.
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El Bouzidi, K;
Collier, D;
Nastouli, E;
Copas, AJ;
Miller, RF;
Gupta, RK;
(2016)
Virological efficacy of PI monotherapy for HIV-1 in clinical practice.
Journal of Antimicrobial Chemotherapy
, 71
(11)
pp. 3228-3234.
10.1093/jac/dkw265.
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El Bouzidi, K;
Datir, R;
Dakum, P;
Ndembi, N;
Gupta, RK;
(2019)
Baseline PI susceptibility by HIV-1 Gag-protease phenotyping and subsequent virological suppression with PI-based second-line ART in Nigeria.
Journal of Antimicrobial Chemotherapy
pp. 1402-1407.
10.1093/jac/dkz005.
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El Bouzidi, K;
Kemp, SA;
Datir, RP;
Murtala-Ibrahim, F;
Aliyu, A;
Kwaghe, V;
Frampton, D;
... Gupta, RK; + view all
(2020)
High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment.
Journal of Antimicrobial Chemotherapy
10.1093/jac/dkaa033.
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Fox-Lewis, A;
Coltart, G;
Rice, S;
Sen, R;
Gourtsoyannis, Y;
Hyare, H;
Gupta, RK;
(2016)
Extensive subclinical sinusitis leading to Moraxella osloensis meningitis.
IDCases
, 6
pp. 39-42.
10.1016/j.idcr.2016.08.007.
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Goodall, RL;
Dunn, DT;
Nkurunziza, P;
Mugarura, L;
Pattery, T;
Munderi, P;
Kityo, C;
... DART Virology Group; + view all
(2017)
Rapid accumulation of HIV-1 thymidine analogue mutations and phenotypic impact following prolonged viral failure on zidovudine-based first-line ART in sub-Saharan Africa.
Journal of Antimicrobial Chemotherapy
, 72
(5)
pp. 1450-1455.
10.1093/jac/dkw583.
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Gregson, J;
Kaleebu, P;
Marconi, VC;
van Vuuren, C;
Ndembi, N;
Hamers, RL;
Kanki, P;
... Gupta, RK; + view all
(2017)
Occult HIV-1 drug resistance to thymidine analogues following failure of first-line tenofovir combined with a cytosine analogue and nevirapine or efavirenz in sub Saharan Africa: a retrospective multi-centre cohort study.
The Lancet Infectious Diseases
, 17
(3)
pp. 296-304.
10.1016/S1473-3099(16)30469-8.
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Gregson, J;
Rhee, SY;
Datir, R;
Pillay, D;
Perno, CF;
Derache, A;
Shafer, RS;
(2019)
HIV-1 viral load is elevated in individuals with reverse transcriptase mutation M184V/I during virological failure of first line antiretroviral therapy and is associated with compensatory mutation L74I.
Journal of Infectious Diseases
10.1093/infdis/jiz631.
(In press).
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Gupta, RK;
Abdul-Jawad, S;
McCoy, LE;
Mok, HP;
Peppa, D;
Salgado, M;
Martinez-Picado, J;
... Olavarria, E; + view all
(2019)
HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation.
Nature
, 568
pp. 244-249.
10.1038/s41586-019-1027-4.
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Gupta, RK;
Goodall, RL;
Ranopa, M;
Kityo, C;
Munderi, P;
Lyagoba, F;
Mugarura, L;
... DART Virology Group and Trial Team; + view all
(2014)
High Rate of HIV Re-suppression After Viral Failure on First Line Antiretroviral Therapy in the Absence of Switch to Second Line.
Clin Infect Dis
, 58
(7)
pp. 1023-1026.
10.1093/cid/cit933.
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Gupta, RK;
Gregson, J;
Parkin, N;
Haile-Selassie, H;
Tanuri, A;
Andrade Forero, L;
Kaleebu, P;
... Bertagnolio, S; + view all
(2018)
HIV-1 drug resistance before initiation or re-initiation of first-line antiretroviral therapy in low-income and middle-income countries: a systematic review and meta-regression analysis.
The Lancet Infectious Diseases
, 18
(3)
pp. 346-355.
10.1016/S1473-3099(17)30702-8.
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Gupta, RK;
Hue, S;
Schaller, T;
Verschoor, E;
Pillay, D;
Towers, GJ;
(2009)
Mutation of a Single Residue Renders Human Tetherin Resistant to HIV-1 Vpu-Mediated Depletion.
PLoS Pathogens
, 5
(5)
, Article e1000443. 10.1371/journal.ppat.1000443.
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Gupta, RK;
Marks, M;
Edwards, SG;
Smith, K;
Fletcher, K;
Lee, SM;
Ramsay, A;
... Miller, RF; + view all
(2014)
A declining CD4 count and diagnosis of HIV-associated hodgkin Lymphoma: Do prior clinical symptoms and laboratory abnormalities aid diagnosis?
PLoS One
, 9
(2)
, Article e87442. 10.1371/journal.pone.0087442.
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Gupta, RK;
Peppa, D;
Hill, AL;
Gálvez, C;
Salgado, M;
Pace, M;
McCoy, LE;
... Olavarria, E; + view all
(2020)
Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report.
The Lancet HIV
, 7
(5)
e340-e347.
10.1016/S2352-3018(20)30069-2.
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Gupta-Wright, A;
Fielding, K;
van Oosterhout, JJ;
Alufandika, M;
Grint, DJ;
Chimbayo, E;
Heaney, J;
... Gupta, RK; + view all
(2020)
Virological failure, HIV-1 drug resistance, and early mortality in adults admitted to hospital in Malawi: an observational cohort study.
Lancet HIV
, 7
(9)
e620-e628.
10.1016/S2352-3018(20)30172-7.
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Kemp, SA;
Collier, DA;
Datir, RP;
Ferreira, IATM;
Gayed, S;
Jahun, A;
Hosmillo, M;
... Gupta, RK; + view all
(2021)
SARS-CoV-2 evolution during treatment of chronic infection.
Nature
, 592
pp. 277-282.
10.1038/s41586-021-03291-y.
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Kugathasan, R;
Collier, DA;
Haddow, LJ;
El Bouzidi, K;
Edwards, SG;
Cartledge, JD;
Miller, RF;
(2017)
Diffuse White Matter Signal Abnormalities on Magnetic Resonance Imaging Are Associated With Human Immunodeficiency Virus Type 1 Viral Escape in the Central Nervous System Among Patients With Neurological Symptoms.
CLINICAL INFECTIOUS DISEASES
, 64
(8)
pp. 1059-1065.
10.1093/cid/cix035.
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Lustig, G;
Cele, S;
Karim, F;
Derache, A;
Ngoepe, A;
Khan, K;
Gosnell, BI;
... Sigal, A; + view all
(2021)
T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy.
PLOS Pathogens
, 17
(9)
, Article e1009871. 10.1371/journal.ppat.1009871.
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Mlcochova, P;
Kemp, SA;
Dhar, MS;
Papa, G;
Meng, B;
Ferreira, IATM;
Datir, R;
... Gupta, RK; + view all
(2021)
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion.
Nature
, 599
pp. 114-119.
10.1038/s41586-021-03944-y.
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Mlcochova, P;
Apolonia, L;
Kluge, SF;
Sridharan, A;
Kirchhoff, F;
Malim, MH;
Sauter, D;
(2015)
Immune evasion activities of accessory proteins Vpu, Nef and Vif are conserved in acute and chronic HIV-1 infection.
Virology
, 482
pp. 72-78.
10.1016/j.virol.2015.03.015.
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Mlcochova, P;
Caswell, SJ;
Taylor, IA;
Towers, GJ;
Gupta, RK;
(2017)
DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages.
The Embo Journal
10.15252/embj.201796880.
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Mlcochova, P;
Collier, D;
Ritchie, A;
Assennato, SM;
Hosmillo, M;
Goel, N;
Meng, B;
... Cambridge Institute of Therapeutic Immunology and Infectious Dis, .; + view all
(2020)
Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant.
Cell Reports Medicine
, 1
(6)
, Article 100099. 10.1016/j.xcrm.2020.100099.
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Mlcochova, P;
Sutherland, KA;
Watters, SA;
Bertoli, C;
de Bruin, RAM;
Rehwinkel, J;
Neil, SJ;
... Gupta, RK; + view all
(2017)
A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.
The EMBO Journal
, 36
(5)
pp. 604-616.
10.15252/embj.201696025.
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Mlcochova, P;
Watters, SA;
Towers, GJ;
Noursadeghi, M;
Gupta, RK;
(2014)
Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages.
Retrovirology
, 11
(1)
, Article 25. 10.1186/1742-4690-11-25.
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Mlcochova, P;
Winstone, H;
Zuliani-Alvarez, L;
Gupta, RK;
(2020)
TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages.
Cell Reports
, 30
(12)
3972-3980.e5.
10.1016/j.celrep.2020.03.008.
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Paredes, R;
Tzou, PL;
Van Zyl, G;
Barrow, G;
Camacho, R;
Carmona, S;
Grant, PM;
... Shafer, RW; + view all
(2017)
Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation.
PLoS ONE
, 12
(7)
, Article e0181357.. 10.1371/journal.pone.0181357.
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Phillips, AN;
Bansi-Matharu, L;
Venter, F;
Havlir, D;
Pozniak, A;
Kuritzkes, DR;
Wensing, A;
... Bertagnolio, S; + view all
(2020)
Updated assessment of risks and benefits of dolutegravir versus efavirenz in new antiretroviral treatment initiators in sub-Saharan Africa: modelling to inform treatment guidelines.
Lancet HIV
10.1016/S2352-3018(19)30400-X.
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Phillips, AN;
Venter, F;
Havlir, D;
Pozniak, A;
Kuritzkes, D;
Wensing, A;
Lundgren, JD;
... Calmy, A; + view all
(2019)
Risks and benefits of dolutegravir-based antiretroviral drug regimens in sub-Saharan Africa: a modelling study.
The Lancet HIV
, 6
(2)
e116-e127.
10.1016/S2352-3018(18)30317-5.
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Power, RA;
Davaniah, S;
Derache, A;
Wilkinson, E;
Tanser, F;
Gupta, RK;
Pillay, D;
(2016)
Genome-Wide Association Study of HIV Whole Genome Sequences Validated using Drug Resistance.
PLOS ONE
, 11
(9)
10.1371/journal.pone.0163746.
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Rhee, SY;
Varghese, V;
Holmes, SP;
Van Zyl, GU;
Steegen, K;
Boyd, MA;
Cooper, DA;
... Shafer, RW; + view all
(2017)
Mutational Correlates of Virological Failure in Individuals Receiving a WHO-Recommended Tenofovir-Containing First-Line Regimen: An International Collaboration.
EBioMedicine
, 18
pp. 225-235.
10.1016/j.ebiom.2017.03.024.
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Smith, NMG;
Mlcochova, P;
Watters, SA;
Aasa-Chapman, MMI;
Rabin, N;
Moore, S;
Edwards, SG;
... Gupta, RK; + view all
(2015)
Proof of principle for immune control of 1 global HIV1 reactivation in vivo.
Clinical Infectious Diseases
10.1093/cid/civ219.
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Sungnak, W;
Huang, N;
Bécavin, C;
Berg, M;
Queen, R;
Litvinukova, M;
Talavera-López, C;
... HCA Lung Biological Network; + view all
(2020)
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
Nature Medicine
, 26
pp. 681-687.
10.1038/s41591-020-0868-6.
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Sutherland, KA;
Collier, DA;
Claiborne, DT;
Prince, JL;
Deymier, MJ;
Goldstein, RA;
Hunter, E;
(2016)
Wide variation in susceptibility of transmitted/founder HIV-1 subtype C Isolates to protease inhibitors and association with in vitro replication efficiency.
Scientific Reports
, 6
(38153)
10.1038/srep38153.
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Sutherland, KA;
Ghosn, J;
Gregson, J;
Mbisa, JL;
Chaix, ML;
Cohen Codar, I;
Delfraissy, JF;
... Gupta, RK; + view all
(2015)
HIV-1 subtype influences susceptibility and response to monotherapy with the protease inhibitor lopinavir/ritonavir.
Journal of Antimicrobial Chemotherapy
, 70
(1)
pp. 243-248.
10.1093/jac/dku365.
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Sutherland, KA;
Goodall, RL;
McCormick, A;
Kapaata, A;
Lyagoba, F;
Kaleebu, P;
Thiltgen, G;
... DART Trial Team; + view all
(2015)
Gag-Protease Sequence Evolution Following Protease Inhibitor Monotherapy Treatment Failure in HIV-1 Viruses Circulating in East Africa.
AIDS Research and Human Retroviruses
, 31
(10)
pp. 1032-1037.
10.1089/aid.2015.0138.
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Sutherland, KA;
Mbisa, JL;
Ghosn, J;
Chaix, ML;
Cohen-Codar, I;
Hue, S;
Delfraissy, JF;
... Gupta, RK; + view all
(2014)
Phenotypic characterization of virological failure following lopinavir/ritonavir monotherapy using full-length gag-protease genes.
Journal of Antimicrobial Chemotherapy
, 69
(12)
pp. 3340-3348.
10.1093/jac/dku296.
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Sutherland, KA;
Parry, CM;
McCormick, A;
Kapaata, A;
Lyagoba, F;
Kaleebu, P;
Gilks, CF;
... DART Virology Group, .; + view all
(2015)
Evidence for Reduced Drug Susceptibility without Emergence of Major Protease Mutations following Protease Inhibitor Monotherapy Failure in the SARA Trial.
PLoS One
, 10
(9)
, Article e0137834. 10.1371/journal.pone.0137834.
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Tunbak, H;
Enriquez-Gasca, R;
Tie, CHC;
Gould, PA;
Mlcochova, P;
Gupta, RK;
Fernandes, L;
... Rowe, HM; + view all
(2020)
The HUSH complex is a gatekeeper of type I interferon through epigenetic regulation of LINE-1s.
Nature Communications
, 11
, Article 5387. 10.1038/s41467-020-19170-5.
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Watters, SA;
Mlcochova, P;
Maldarelli, F;
Goonetilleke, N;
Pillay, D;
Gupta, RK;
(2016)
Sequential CCR5-Tropic HIV-1 Reactivation from Distinct Cellular Reservoirs following Perturbation of Elite Control.
PLOS ONE
, 11
(7)
, Article e0158854. 10.1371/journal.pone.0158854.
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Thesis
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Gupta, R.K.;
(2011)
HIV-1 drug resistance and investigation of Tetherin-Vpu as a potential therapeutic target.
Doctoral thesis , UCL (University College London).
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Watters, SA;
(2016)
Dynamics of HIV-1 viral populations in individuals undergoing chemotherapy.
Doctoral thesis , UCL (University College London).
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