%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Roger Paredes, Philip L. Tzou, Gert van Zyl, Geoff Barrow, Ricardo Camacho, Sergio Carmona, Philip M. Grant, Ravindra K. Gupta, Raph L. Hamers, P. Richard Harrigan, Michael R. Jordan, Rami Kantor, David A. Katzenstein, Daniel R. Kuritzkes, Frank Maldarelli, Dan Otelea, Carole L. Wallis, Jonathan M. Schapiro, Robert W. Shafer
Collaborative update of a rule-based expert system for HIV-1 genotypic resistance test interpretation
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 13 0 R/Contents 14 0 R/TrimBox[0 0 612 792]>>
endobj
13 0 obj
[15 0 R 16 0 R 17 0 R 18 0 R]
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.ref001)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.ref002)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.ref003)>>
endobj
18 0 obj
<>/Border[0 0 0]/A 19 0 R>>
endobj
19 0 obj
<>
endobj
14 0 obj
[20 0 R 21 0 R 22 0 R 23 0 R 24 0 R]
endobj
20 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 466.1144 m
199.9998 466.1144 l
199.9998 466.6144 l
575.9997 466.6144 l
f*
0.83 0.64 0.02 0 k
258.0661 250.9228 m
262.8283 250.9228 l
h
f*
267.3071 250.9228 m
272.0126 250.9228 l
h
f*
507.685 224.9008 m
512.4472 224.9008 l
h
f*
0 g
1 j
1 J
9.5 0 0 9.5 200.0125 707.7543 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(efavirenz,)Tj
4.5055 0 Td
(etravirine,)Tj
4.5534 0 Td
(nevirapine)Tj
4.5533 0 Td
(,)Tj
0.4953 0 Td
(and)Tj
1.8679 0 Td
(rilpivirine;)Tj
4.3743 0 Td
(the)Tj
1.5933 0 Td
(PIs)Tj
1.659 0 Td
(atazanavir/r,)Tj
5.6633 0 Td
(darunavir/r,)Tj
5.2158 0 Td
(and)Tj
1.8678 0 Td
(lopina-)Tj
-36.3489 -1.474 Td
(vir/r)Tj
1.8619 0 Td
(\(with)Tj
2.2975 0 Td
(/r)Tj
1.48 0 Td
(indicating)Tj
4.3743 0 Td
(pharmacological)Tj
7.3999 0 Td
(boosting)Tj
3.9446 0 Td
(with)Tj
1.9693 0 Td
(ritonavir)Tj
3.7238 0 Td
(or)Tj
1.0921 0 Td
(cobicistat\);)Tj
4.9412 0 Td
(and)Tj
1.856 0 Td
(the)Tj
1.5933 0 Td
(INSTIs)Tj
-36.5339 -1.474 Td
(dolutegravir,)Tj
5.6513 0 Td
(elvitegravir,)Tj
5.2695 0 Td
(and)Tj
1.8619 0 Td
(raltegravir.)Tj
4.8875 0 Td
(There)Tj
2.8048 0 Td
(was)Tj
1.9812 0 Td
(a)Tj
0.7699 0 Td
(range)Tj
2.7451 0 Td
(of)Tj
1.0443 0 Td
(opinion)Tj
3.3956 0 Td
(as)Tj
1.2652 0 Td
(to)Tj
1.0443 0 Td
(whether)Tj
3.7417 0 Td
(the)Tj
-36.4623 -1.474 Td
(NRTIs)Tj
3.0375 0 Td
(stavudine)Tj
4.4459 0 Td
(and)Tj
1.8679 0 Td
(didanosine)Tj
4.9889 0 Td
(and)Tj
1.8619 0 Td
(the)Tj
1.5994 0 Td
(PIs)Tj
1.653 0 Td
(nelfinavir,)Tj
4.4399 0 Td
(indinavir/r,)Tj
4.7742 0 Td
(saquinavir/r,)Tj
5.5976 0 Td
(fosampre-)Tj
-34.2662 -1.474 Td
(navir/r,)Tj
3.2404 0 Td
(and)Tj
1.8679 0 Td
(tipranavir/r)Tj
4.8875 0 Td
(should)Tj
3.1211 0 Td
(be)Tj
1.3188 0 Td
(included.)Tj
4.1654 0 Td
(The)Tj
1.9336 0 Td
(expert)Tj
2.9659 0 Td
(panel)Tj
2.6317 0 Td
(members)Tj
4.3504 0 Td
(provided)Tj
4.0103 0 Td
(highly)Tj
2.7869 0 Td
(con-)Tj
-37.2799 -1.474 Td
(cordant)Tj
3.5149 0 Td
(DRM)Tj
2.4825 0 Td
(pattern-ARV)Tj
5.6753 0 Td
(interpretations)Tj
6.4749 0 Td
(with)Tj
1.9813 0 Td
(only)Tj
2.029 0 Td
(6%)Tj
1.647 0 Td
(of)Tj
1.0503 0 Td
(NRTI,)Tj
2.8168 0 Td
(6%)Tj
1.647 0 Td
(of)Tj
1.0503 0 Td
(NNRTI,)Tj
3.5329 0 Td
(5%)Tj
1.6471 0 Td
(of)Tj
1.0503 0 Td
(PI,)Tj
-36.5996 -1.474 Td
(and)Tj
1.8619 0 Td
(3%)Tj
1.653 0 Td
(of)Tj
1.0503 0 Td
(INSTI)Tj
2.763 0 Td
(individual)Tj
4.3206 0 Td
(expert)Tj
2.9659 0 Td
(interpretations)Tj
6.4809 0 Td
(differing)Tj
3.7298 0 Td
(from)Tj
2.208 0 Td
(the)Tj
1.5934 0 Td
(expert)Tj
2.9719 0 Td
(panel)Tj
2.6258 0 Td
(median)Tj
3.4612 0 Td
(by)Tj
-37.6857 -1.474 Td
(more)Tj
2.4765 0 Td
(than)Tj
2.1424 0 Td
(one)Tj
1.8679 0 Td
(resistance)Tj
4.7264 0 Td
(level.)Tj
2.5183 0 Td
(The)Tj
1.9335 0 Td
(expert)Tj
2.966 0 Td
(panel)Tj
2.6317 0 Td
(median)Tj
3.4612 0 Td
(differed)Tj
3.515 0 Td
(from)Tj
2.2021 0 Td
(the)Tj
1.5993 0 Td
(HIVDB)Tj
3.2524 0 Td
(7.0)Tj
1.5933 0 Td
(GRT-)Tj
-36.886 -1.474 Td
(IS)Tj
1.1577 0 Td
(for)Tj
1.3785 0 Td
(20)Tj
1.3189 0 Td
(\(12.5%\))Tj
3.682 0 Td
(of)Tj
1.0503 0 Td
(the)Tj
1.5934 0 Td
(160)Tj
1.8619 0 Td
(DRM)Tj
2.4825 0 Td
(pattern-ARV)Tj
5.6753 0 Td
(combinations)Tj
6.0392 0 Td
(including)Tj
4.1058 0 Td
(12)Tj
1.3188 0 Td
(NRTI,)Tj
2.8168 0 Td
(two)Tj
1.7604 0 Td
(NNRTI,)Tj
-36.2415 -1.474 Td
(and)Tj
1.8619 0 Td
(six)Tj
1.4322 0 Td
(INSTI)Tj
2.763 0 Td
(pattern-ARV)Tj
5.6753 0 Td
(combinations.)Tj
6.3197 0 Td
(Eighteen)Tj
4.1177 0 Td
(of)Tj
1.0443 0 Td
(these)Tj
2.6437 0 Td
(differences)Tj
5.0546 0 Td
(were)Tj
2.3632 0 Td
(updated)Tj
3.7895 0 Td
(in)Tj
-37.0651 -1.4741 Td
(HIVDB)Tj
3.2523 0 Td
(8.1)Tj
1.5994 0 Td
(GRT-IS)Tj
3.5925 0 Td
(to)Tj
1.0443 0 Td
(reflect)Tj
2.9182 0 Td
(the)Tj
1.5934 0 Td
(expert)Tj
2.9719 0 Td
(panel)Tj
2.6257 0 Td
(median.)Tj
3.7417 0 Td
(Additionally,)Tj
5.538 0 Td
(HIVDB)Tj
3.2524 0 Td
(users)Tj
2.6437 0 Td
(are)Tj
1.6471 0 Td
(now)Tj
-36.4206 -1.474 Td
(provided)Tj
4.0042 0 Td
(with)Tj
1.9753 0 Td
(the)Tj
1.5934 0 Td
(option)Tj
2.9122 0 Td
(to)Tj
1.0444 0 Td
(exclude)Tj
3.6223 0 Td
(those)Tj
2.6377 0 Td
(ARVs)Tj
2.7631 0 Td
(not)Tj
1.5933 0 Td
(considered)Tj
5.0487 0 Td
(to)Tj
1.0443 0 Td
(be)Tj
1.3188 0 Td
(universally)Tj
4.8816 0 Td
(required.)Tj
ET
Q
q
1 j
1 J
0 w
11.4998 0 0 11.4998 200.0125 524.6362 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Conclusions)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 507.6283 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(The)Tj
1.9275 0 Td
(HIVDB)Tj
3.2583 0 Td
(GRT-IS)Tj
3.5926 0 Td
(was)Tj
1.9812 0 Td
(updated)Tj
3.7895 0 Td
(through)Tj
3.5687 0 Td
(a)Tj
0.7698 0 Td
(collaborative)Tj
5.7588 0 Td
(process)Tj
3.688 0 Td
(to)Tj
1.0443 0 Td
(reflect)Tj
2.9122 0 Td
(changes)Tj
3.9566 0 Td
(in)Tj
0.9847 0 Td
(HIV)Tj
-37.2322 -1.474 Td
(drug)Tj
2.196 0 Td
(resistance)Tj
4.7264 0 Td
(knowledge,)Tj
5.2158 0 Td
(treatment)Tj
4.4041 0 Td
(guidelines,)Tj
4.9352 0 Td
(and)Tj
1.8619 0 Td
(expert)Tj
2.9719 0 Td
(opinion.)Tj
3.6702 0 Td
(Such)Tj
2.4765 0 Td
(a)Tj
0.7699 0 Td
(process)Tj
-33.2279 -1.474 Td
(broadens)Tj
4.3384 0 Td
(consensus)Tj
4.9472 0 Td
(among)Tj
3.2464 0 Td
(experts)Tj
3.4672 0 Td
(and)Tj
1.8679 0 Td
(identifies)Tj
4.1117 0 Td
(areas)Tj
2.6914 0 Td
(requiring)Tj
4.0521 0 Td
(further)Tj
3.0793 0 Td
(study.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 411.9874 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 394.9795 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(HIV-1)Tj
2.8459 0 Td
(drug)Tj
2.1146 0 Td
(resistance)Tj
4.1329 0 Td
(is)Tj
0.8448 0 Td
(one)Tj
1.7007 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(main)Tj
2.2903 0 Td
(obstacles)Tj
3.7814 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(long-term)Tj
4.252 0 Td
(effectiveness)Tj
5.2043 0 Td
(of)Tj
1.0148 0 Td
(antiretro-)Tj
-33.1594 -1.2982 Td
(viral)Tj
1.9899 0 Td
(\(ARV\))Tj
2.9026 0 Td
(therapy.)Tj
3.4696 0 Td
(In)Tj
1.1112 0 Td
(upper-income)Tj
5.9187 0 Td
(countries,)Tj
4.1726 0 Td
(genotypic)Tj
4.1272 0 Td
(resistance)Tj
4.1272 0 Td
(testing)Tj
2.8856 0 Td
(\(GRT\))Tj
2.846 0 Td
(is)Tj
0.8504 0 Td
(per-)Tj
-34.401 -1.2983 Td
(formed)Tj
3.1577 0 Td
(routinely)Tj
3.8608 0 Td
(at)Tj
0.9524 0 Td
(diagnosis,)Tj
4.1839 0 Td
(treatment)Tj
4.1386 0 Td
(initiation,)Tj
4.1499 0 Td
(and)Tj
1.7291 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4684 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(virological)Tj
4.405 0 Td
(failure)Tj
2.7779 0 Td
(\(VF\).)Tj
-34.8205 -1.3039 Td
(In)Tj
1.1055 0 Td
(lower-)Tj
2.8062 0 Td
(and)Tj
1.7292 0 Td
(middle-income)Tj
6.3722 0 Td
(countries,)Tj
4.1726 0 Td
(it)Tj
0.7823 0 Td
(is)Tj
0.8504 0 Td
(performed)Tj
4.4674 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(public)Tj
2.7099 0 Td
(health)Tj
2.6759 0 Td
(sectors)Tj
2.965 0 Td
(for)Tj
/F9 1 Tf
1.389 0 Td
[()6()]TJ
1.2019 0 Td
[()6()4()]TJ
/F5 1 Tf
-35.7333 -1.2983 Td
(drug)Tj
2.1089 0 Td
(resistance)Tj
4.1329 0 Td
(surveillance)Tj
4.9493 0 Td
(and,)Tj
1.9559 0 Td
(increasingly,)Tj
5.2554 0 Td
(for)Tj
1.3833 0 Td
(managing)Tj
4.2065 0 Td
(patients)Tj
3.3676 0 Td
(with)Tj
1.9956 0 Td
(VF.)Tj
1.6667 0 Td
(Interpreting)Tj
-31.0221 -1.2982 Td
(GRT)Tj
2.1656 0 Td
(results)Tj
2.812 0 Td
(is)Tj
0.8447 0 Td
(one)Tj
1.7008 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(most)Tj
2.2053 0 Td
(difficult)Tj
3.3562 0 Td
(challenges)Tj
4.32 0 Td
(facing)Tj
2.6475 0 Td
(HIV)Tj
2.0183 0 Td
(care)Tj
1.8709 0 Td
(providers)Tj
4.0251 0 Td
(because)Tj
3.3165 0 Td
(there)Tj
2.2677 0 Td
(are)Tj
-36.0337 -1.2983 Td
(many)Tj
2.4774 0 Td
(drug-resistance)Tj
6.3723 0 Td
(mutations)Tj
4.2802 0 Td
(\(DRMs\))Tj
3.515 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(each)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(ARV)Tj
2.2223 0 Td
(classes.)Tj
3.0501 0 Td
(These)Tj
-32.6832 -1.3039 Td
(DRMs)Tj
2.8289 0 Td
(have)Tj
2.0636 0 Td
(variable)Tj
3.3562 0 Td
(effects)Tj
2.7269 0 Td
(on)Tj
/F9 1 Tf
1.2756 0 Td
[()12()]TJ
1.0148 0 Td
[()-13()14( )7(\n)20()]TJ
/F5 1 Tf
2.0409 0 Td
(ARV)Tj
2.2224 0 Td
(susceptibility)Tj
5.4425 0 Td
(and)Tj
1.7291 0 Td
(occur)Tj
2.4718 0 Td
(in)Tj
1.0375 0 Td
(many)Tj
2.4774 0 Td
(different)Tj
-30.6876 -1.2983 Td
(combinations.)Tj
1.1962 -1.2982 Td
(Because)Tj
3.3958 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(complexity)Tj
4.6431 0 Td
(inherent)Tj
3.6283 0 Td
(in)Tj
1.0375 0 Td
(GRT)Tj
2.1657 0 Td
(interpretation,)Tj
6.0207 0 Td
(automated)Tj
4.4901 0 Td
(interpretation)Tj
5.7939 0 Td
(sys-)Tj
-34.8545 -1.304 Td
(tems)Tj
2.1203 0 Td
(have)Tj
2.0636 0 Td
(been)Tj
2.1203 0 Td
(developed)Tj
4.2689 0 Td
(to)Tj
1.0261 0 Td
(infer)Tj
2.1203 0 Td
(the)Tj
1.4684 0 Td
(extent)Tj
2.6759 0 Td
(of)Tj
1.0148 0 Td
(ARV)Tj
2.2223 0 Td
(resistance)Tj
4.1329 0 Td
(from)Tj
2.2053 0 Td
(DRMs)Tj
2.829 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(targets)Tj
2.8743 0 Td
(of)Tj
-35.6482 -1.2982 Td
(ARV)Tj
2.2166 0 Td
(therapy)Tj
3.2485 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2643 0 Td
(2)Tj
0 g
(].)Tj
1.2585 0 Td
(The)Tj
1.7802 0 Td
(Stanford)Tj
3.6737 0 Td
(HIV)Tj
2.0239 0 Td
(Drug)Tj
2.3187 0 Td
(Resistance)Tj
4.3823 0 Td
(Database)Tj
3.8495 0 Td
(\(HIVDB\))Tj
4.0138 0 Td
(GRT)Tj
2.1713 0 Td
(interpreta-)Tj
-32.2013 -1.2983 Td
(tion)Tj
1.8425 0 Td
(system)Tj
2.9366 0 Td
(\(GRT-IS\))Tj
4.0139 0 Td
(is)Tj
0.8447 0 Td
(a)Tj
0.6576 0 Td
(rule-based)Tj
4.3937 0 Td
(system)Tj
2.9367 0 Td
(in)Tj
1.0374 0 Td
(which)Tj
2.6476 0 Td
(penalties)Tj
3.7417 0 Td
(are)Tj
1.4457 0 Td
(assigned)Tj
3.6113 0 Td
(to)Tj
1.0204 0 Td
(DRMs)Tj
2.8347 0 Td
(and)Tj
1.7291 0 Td
(to)Tj
-35.6936 -1.3039 Td
(DRM)Tj
2.4717 0 Td
(combinations)Tj
5.7033 0 Td
(for)Tj
1.389 0 Td
(ARVs)Tj
2.5795 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(four)Tj
1.9162 0 Td
(most)Tj
2.2054 0 Td
(commonly)Tj
4.5467 0 Td
(used)Tj
2.0579 0 Td
(ARV)Tj
2.2224 0 Td
(classes)Tj
2.8289 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(]:)Tj
1.5988 0 Td
(nucleoside)Tj
-32.0256 -1.2983 Td
(RT)Tj
1.4513 0 Td
(inhibitors)Tj
4.1442 0 Td
(\(NRTIs\),)Tj
3.7927 0 Td
(nonnucleoside)Tj
6.0831 0 Td
(RT)Tj
1.4514 0 Td
(inhibitors)Tj
4.1385 0 Td
(\(NNRTIs\),)Tj
4.5354 0 Td
(protease)Tj
3.5547 0 Td
(inhibitors)Tj
4.1442 0 Td
(\(PIs\),)Tj
2.3811 0 Td
(and)Tj
-35.6766 -1.2982 Td
(integrase)Tj
3.8097 0 Td
(strand)Tj
2.7609 0 Td
(transfer)Tj
3.3165 0 Td
(inhibitors)Tj
4.1443 0 Td
(\(INSTIs\).)Tj
3.9911 0 Td
(The)Tj
1.7802 0 Td
(resistance)Tj
4.1328 0 Td
(interpretation)Tj
5.794 0 Td
(is)Tj
0.8447 0 Td
(determined)Tj
4.8529 0 Td
(by)Tj
-35.4271 -1.3039 Td
(adding)Tj
2.9876 0 Td
(the)Tj
1.4684 0 Td
(DRM)Tj
2.4718 0 Td
(penalties)Tj
3.7417 0 Td
(for)Tj
1.3833 0 Td
(each)Tj
2.0296 0 Td
(ARV.)Tj
2.4491 0 Td
(The)Tj
1.7801 0 Td
(HIVDB)Tj
3.3392 0 Td
(GRT-IS)Tj
3.3336 0 Td
(also)Tj
1.7688 0 Td
(provides)Tj
3.651 0 Td
(comments)Tj
4.4163 0 Td
(about)Tj
-34.8205 -1.2983 Td
(each)Tj
2.0295 0 Td
(DRM)Tj
2.4662 0 Td
(in)Tj
1.0374 0 Td
(a)Tj
0.652 0 Td
(submitted)Tj
4.2519 0 Td
(HIV-1)Tj
2.8517 0 Td
(sequence.)Tj
-12.0925 -1.2983 Td
(The)Tj
1.7858 0 Td
(HIVDB)Tj
3.3392 0 Td
(GRT-IS)Tj
3.3335 0 Td
(DRM)Tj
2.4718 0 Td
(includes)Tj
3.5433 0 Td
(penalty)Tj
3.1407 0 Td
(scores)Tj
2.6703 0 Td
(and)Tj
1.7291 0 Td
(comments)Tj
4.422 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2756 0 Td
(several)Tj
2.9367 0 Td
(types)Tj
2.2733 0 Td
(of)Tj
-36.5893 -1.2982 Td
(data)Tj
1.9105 0 Td
(including)Tj
4.0422 0 Td
(the)Tj
1.474 0 Td
(relative)Tj
3.1351 0 Td
(frequency)Tj
4.1896 0 Td
(of)Tj
1.0147 0 Td
(a)Tj
0.652 0 Td
(DRM)Tj
2.4718 0 Td
(in)Tj
1.0375 0 Td
(ARV-na)Tj
/F10 1 Tf
[()]TJ
/F5 1 Tf
(ve)Tj
4.6885 0 Td
(and)Tj
1.7291 0 Td
(ARV-experienced)Tj
7.387 0 Td
(individu-)Tj
-33.732 -1.304 Td
(als;)Tj
1.4853 0 Td
(the)Tj
1.4683 0 Td
(contribution)Tj
5.2951 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(DRM)Tj
2.4717 0 Td
(to)Tj
1.0205 0 Td
(reduced)Tj
/F9 1 Tf
3.4469 0 Td
[()12()]TJ
1.0148 0 Td
[()-13()14( )7(\n)20()]TJ
/F5 1 Tf
2.0466 0 Td
(susceptibility;)Tj
5.6636 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(association)Tj
4.6261 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-35.24 -1.2982 Td
(DRM)Tj
2.4717 0 Td
(with)Tj
1.9956 0 Td
(reduced)Tj
3.4469 0 Td
(virological)Tj
4.405 0 Td
(response)Tj
3.7361 0 Td
(to)Tj
1.0261 0 Td
(an)Tj
1.2019 0 Td
(ARV)Tj
2.2167 0 Td
(regimen.)Tj
3.7644 0 Td
(This)Tj
1.9899 0 Td
(system)Tj
2.9366 0 Td
(requires)Tj
3.4753 0 Td
(updates)Tj
3.3052 0 Td
(as)Tj
-35.9714 -1.2983 Td
(new)Tj
1.8765 0 Td
(studies)Tj
2.982 0 Td
(on)Tj
1.2756 0 Td
(HIV)Tj
2.0239 0 Td
(drug)Tj
2.1146 0 Td
(resistance)Tj
4.1273 0 Td
(are)Tj
1.4513 0 Td
(published)Tj
4.1272 0 Td
(and)Tj
1.7291 0 Td
(as)Tj
1.0148 0 Td
(treatment)Tj
4.1329 0 Td
(guidelines)Tj
4.2803 0 Td
(evolve.)Tj
2.9537 0 Td
(Three)Tj
2.5795 0 Td
(of)Tj
-36.6687 -1.3039 Td
(the)Tj
1.4683 0 Td
(authors)Tj
3.2485 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6724 0 Td
(study)Tj
2.3924 0 Td
(\(RP,)Tj
1.9616 0 Td
(JMS,)Tj
2.143 0 Td
(and)Tj
1.7348 0 Td
(RWS\))Tj
2.6192 0 Td
(organized)Tj
4.1782 0 Td
(a)Tj
0.652 0 Td
(group)Tj
2.6135 0 Td
(of)Tj
1.0148 0 Td
(international)Tj
5.4085 0 Td
(experts)Tj
3.084 0 Td
(to)Tj
-35.206 -1.2983 Td
(assist)Tj
2.3017 0 Td
(with)Tj
1.9955 0 Td
(updating)Tj
3.8098 0 Td
(the)Tj
1.4683 0 Td
(HIVDB)Tj
3.3392 0 Td
(GRT)Tj
2.1657 0 Td
(system.)Tj
3.1634 0 Td
(These)Tj
2.5682 0 Td
(experts,)Tj
3.3052 0 Td
(who)Tj
1.9388 0 Td
(regularly)Tj
3.7588 0 Td
(attend)Tj
2.7496 0 Td
(HIV)Tj
2.0239 0 Td
(drug)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 420.8314 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(HIV-1)Tj
2.7354 0 Td
(genotypic)Tj
4.4221 0 Td
(resistance)Tj
4.6984 0 Td
(test)Tj
1.8142 0 Td
(interpreta)Tj
4.1387 0 Td
(tion)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01813)Tj
4.089 0 Td
(57)Tj
0 g
2.0906 0 Td
(July)Tj
1.9701 0 Td
(28,)Tj
1.5874 0 Td
(2017)Tj
35.3483 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(31)Tj
/F8 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(Gilead)Tj
2.5086 0 Td
(Sciences,)Tj
3.7418 0 Td
(Bristol)Tj
2.5937 0 Td
(Myers)Tj
2.5441 0 Td
(Squibb,)Tj
3.0544 0 Td
(Merck)Tj
-14.4426 -1.3748 Td
(Pharmaceu)Tj
4.2165 0 Td
(ticals)Tj
2.126 0 Td
(and)Tj
1.5874 0 Td
(has)Tj
1.5378 0 Td
(received)Tj
3.3024 0 Td
(consulting)Tj
4.0749 0 Td
(fees)Tj
-16.845 -1.3749 Td
(from)Tj
2.0126 0 Td
(ViiV)Tj
1.6512 0 Td
(Health)Tj
2.5724 0 Td
(Care.)Tj
2.1189 0 Td
(PR)Tj
1.3394 0 Td
(Harrigan)Tj
3.4016 0 Td
(has)Tj
1.5378 0 Td
(received)Tj
-14.6339 -1.3748 Td
(grants)Tj
2.5724 0 Td
(from,)Tj
2.2323 0 Td
(served)Tj
2.6859 0 Td
(as)Tj
1.063 0 Td
(an)Tj
1.1197 0 Td
(ad)Tj
1.1126 0 Td
(hoc)Tj
1.5874 0 Td
(advisor)Tj
2.9339 0 Td
(to,)Tj
1.1693 0 Td
(or)Tj
-16.4765 -1.3748 Td
(spoke)Tj
2.4307 0 Td
(at)Tj
0.9 0 Td
(various)Tj
2.9268 0 Td
(events)Tj
2.6362 0 Td
(sponsored)Tj
4.1599 0 Td
(by)Tj
1.1126 0 Td
(Abbott,)Tj
-14.1662 -1.3748 Td
(Merck,)Tj
2.7708 0 Td
(and)Tj
1.5875 0 Td
(Gilead.)Tj
2.7354 0 Td
(He)Tj
1.226 0 Td
(has)Tj
1.5378 0 Td
(also)Tj
1.7292 0 Td
(served)Tj
2.6858 0 Td
(as)Tj
1.063 0 Td
(a)Tj
-15.3355 -1.3748 Td
(consultant)Tj
4.0819 0 Td
(for)Tj
1.2543 0 Td
(ViiV)Tj
1.6583 0 Td
(Health)Tj
2.5725 0 Td
(Care,)Tj
2.1189 0 Td
(and)Tj
1.5874 0 Td
(Gilead.)Tj
2.7354 0 Td
(DRK)Tj
-16.0087 -1.3748 Td
(has)Tj
1.5378 0 Td
(received)Tj
3.3023 0 Td
(consulti)Tj
2.8985 0 Td
(ng)Tj
1.1693 0 Td
(fees)Tj
1.7433 0 Td
(and)Tj
1.5874 0 Td
(research)Tj
3.4158 0 Td
(support)Tj
-15.6544 -1.3748 Td
(from)Tj
2.0126 0 Td
(Gilead,)Tj
2.7283 0 Td
(Janssen,)Tj
3.5008 0 Td
(Merck)Tj
2.5442 0 Td
(and)Tj
1.5874 0 Td
(ViiV.)Tj
1.885 0 Td
(JMS)Tj
1.9205 0 Td
(has)Tj
-16.1788 -1.3748 Td
(received)Tj
3.3023 0 Td
(research)Tj
3.4158 0 Td
(support,)Tj
3.3237 0 Td
(honorari)Tj
3.1181 0 Td
(um)Tj
1.4457 0 Td
(or)Tj
-14.6056 -1.3749 Td
(consulting)Tj
4.0748 0 Td
(fees)Tj
1.7362 0 Td
(from)Tj
2.0126 0 Td
(the)Tj
1.3678 0 Td
(following:)Tj
3.8126 0 Td
(Abbvie,)Tj
2.948 0 Td
(Merck,)Tj
-15.952 -1.3748 Td
(Gilead)Tj
2.5086 0 Td
(Sciences,)Tj
3.7418 0 Td
(GlaxoSmithKl)Tj
5.0174 0 Td
(ine,)Tj
1.5307 0 Td
(Tibotec-)Tj
-12.7985 -1.3748 Td
(Janssen,)Tj
3.5008 0 Td
(BMS,)Tj
2.2464 0 Td
(Teva,)Tj
2.1827 0 Td
(Virology)Tj
3.2812 0 Td
(Education)Tj
3.8764 0 Td
(and)Tj
1.5874 0 Td
(ViiV)Tj
-16.6749 -1.3748 Td
(Healthcare.)Tj
4.3653 0 Td
(This)Tj
1.7859 0 Td
(does)Tj
2.0055 0 Td
(not)Tj
1.4244 0 Td
(alter)Tj
1.8213 0 Td
(our)Tj
1.474 0 Td
(adherenc)Tj
3.4087 0 Td
(e)Tj
0.6449 0 Td
(to)Tj
-16.93 -1.3748 Td
(PLOS)Tj
2.3315 0 Td
(ONE)Tj
1.8708 0 Td
(policies)Tj
3.0119 0 Td
(on)Tj
1.1622 0 Td
(sharing)Tj
2.9835 0 Td
(data)Tj
1.7929 0 Td
(and)Tj
ET
endstream
endobj
21 0 obj
<>stream
endstream
endobj
22 0 obj
<>stream
endstream
endobj
23 0 obj
<>stream
endstream
endobj
24 0 obj
<>stream
BT
14.7402 64.843 Td
(materials.)Tj
ET
Q
endstream
endobj
25 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 29 0 R/Contents 30 0 R/TrimBox[0 0 612 792]>>
endobj
29 0 obj
[31 0 R 32 0 R 33 0 R 34 0 R]
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.t001)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Lpone.0181357.t001)>>
endobj
33 0 obj
<>/Border[0 0 0]/A 35 0 R>>
endobj
35 0 obj
<>
endobj
34 0 obj
<>/Border[0 0 0]/A 36 0 R>>
endobj
36 0 obj
<>
endobj
30 0 obj
[37 0 R 38 0 R 39 0 R 40 0 R 41 0 R]
endobj
37 0 obj
<>stream
q
0.83 0.64 0.02 0 k
203.4142 574.2992 m
232.5543 574.2992 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(resistance)Tj
4.1328 0 Td
(meetings)Tj
3.8268 0 Td
(and)Tj
1.7291 0 Td
(have)Tj
2.0579 0 Td
(published)Tj
4.1273 0 Td
(one)Tj
1.6951 0 Td
(or)Tj
1.0998 0 Td
(more)Tj
2.3414 0 Td
(peer-reviewed)Tj
5.8847 0 Td
(papers)Tj
2.8403 0 Td
(on)Tj
1.2756 0 Td
(HIV)Tj
2.0239 0 Td
(drug)Tj
2.1146 0 Td
(resis-)Tj
-35.1493 -1.3039 Td
(tance,)Tj
2.5738 0 Td
(were)Tj
2.1203 0 Td
(polled)Tj
2.6872 0 Td
(on)Tj
1.2756 0 Td
(a)Tj
0.6576 0 Td
(variety)Tj
2.9197 0 Td
(of)Tj
1.0148 0 Td
(aspects)Tj
3.0387 0 Td
(of)Tj
1.0148 0 Td
(GRT)Tj
2.1713 0 Td
(interpretation)Tj
5.794 0 Td
(including)Tj
4.0422 0 Td
(the)Tj
1.4683 0 Td
(analysis)Tj
3.3279 0 Td
(of)Tj
1.0148 0 Td
(spe-)Tj
-35.121 -1.2982 Td
(cific)Tj
1.8878 0 Td
(DRM)Tj
2.4718 0 Td
(patterns.)Tj
3.6964 0 Td
(This)Tj
1.9842 0 Td
(manuscript)Tj
4.7905 0 Td
(describes)Tj
3.8835 0 Td
(the)Tj
1.474 0 Td
(HIVDB)Tj
3.3392 0 Td
(GRT-IS)Tj
3.3335 0 Td
(and)Tj
1.7291 0 Td
(summarizes)Tj
5.0173 0 Td
(the)Tj
-33.6073 -1.2983 Td
(authors')Tj
3.4582 0 Td
(opinions)Tj
3.7474 0 Td
(on)Tj
1.2756 0 Td
(some)Tj
2.33 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(most)Tj
2.2053 0 Td
(relevant)Tj
3.4242 0 Td
(clinical)Tj
3.0728 0 Td
(topics)Tj
2.5965 0 Td
(in)Tj
1.0318 0 Td
(HIV)Tj
2.0239 0 Td
(GRT)Tj
2.1713 0 Td
(interpretation)Tj
5.794 0 Td
(in)Tj
-35.6142 -1.2983 Td
(light)Tj
2.0239 0 Td
(of)Tj
1.0148 0 Td
(recent)Tj
2.7099 0 Td
(publications)Tj
5.125 0 Td
(and)Tj
1.7291 0 Td
(publicly)Tj
3.4072 0 Td
(available)Tj
3.668 0 Td
(in)Tj
1.0375 0 Td
(vitro)Tj
2.1146 0 Td
(susceptibility)Tj
5.4425 0 Td
(data.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 623.3952 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Methods)Tj
/F0 1 Tf
0 -1.5023 Td
(HIVDB)Tj
3.2504 0 Td
(genotypic)Tj
4.4457 0 Td
(resistance)Tj
4.7244 0 Td
(test)Tj
1.8237 0 Td
(\(GRT\))Tj
2.9811 0 Td
(interpretation)Tj
5.9811 0 Td
(system)Tj
3.3638 0 Td
(\(IS\))Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 588.359 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(HIVDB)Tj
3.3392 0 Td
(GRT)Tj
2.1656 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(rules-based)Tj
4.7565 0 Td
(system)Tj
2.9367 0 Td
(in)Tj
1.0374 0 Td
(which)Tj
2.6476 0 Td
(the)Tj
1.4683 0 Td
(resistance)Tj
4.1329 0 Td
(interpretation)Tj
5.794 0 Td
(for)Tj
1.389 0 Td
(22)Tj
1.1678 0 Td
(ARVs)Tj
-34.1175 -1.2982 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7779 0 Td
(1)Tj
0 g
(\))Tj
1.0375 0 Td
(is)Tj
0.8503 0 Td
(determined)Tj
4.8473 0 Td
(by)Tj
1.1848 0 Td
(adding)Tj
2.9877 0 Td
(the)Tj
1.474 0 Td
(ARV)Tj
2.2167 0 Td
(penalties)Tj
3.7417 0 Td
(for)Tj
1.3833 0 Td
(each)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(DRMs)Tj
2.8346 0 Td
(present)Tj
3.1634 0 Td
(in)Tj
1.0318 0 Td
(a)Tj
0.6577 0 Td
(virus)Tj
-34.7015 -1.2983 Td
(sample.)Tj
3.2484 0 Td
(A)Tj
0.9014 0 Td
(total)Tj
2.0013 0 Td
(penalty)Tj
3.1464 0 Td
(score)Tj
2.3074 0 Td
(of)Tj
/F11 1 Tf
0 Tc
1.0148 0 Td
(<)Tj
/F5 1 Tf
-0.004 Tc
(10)Tj
1.9389 0 Td
(indicates)Tj
3.7701 0 Td
(susceptibility;)Tj
5.6692 0 Td
(10)Tj
1.1679 0 Td
(to)Tj
1.0261 0 Td
(14)Tj
1.1735 0 Td
(indicates)Tj
3.7701 0 Td
(potential)Tj
3.7587 0 Td
(low-)Tj
-34.8942 -1.2982 Td
(level)Tj
2.0125 0 Td
(resistance;)Tj
4.3597 0 Td
(15)Tj
1.1679 0 Td
(to)Tj
1.0261 0 Td
(29)Tj
1.1735 0 Td
(indicates)Tj
3.7701 0 Td
(low-level)Tj
3.7984 0 Td
(resistance;)Tj
4.3596 0 Td
(30)Tj
1.1736 0 Td
(to)Tj
1.0204 0 Td
(59)Tj
1.1736 0 Td
(indicates)Tj
3.77 0 Td
(intermediate)Tj
5.3235 0 Td
(resis-)Tj
-34.1289 -1.304 Td
(tance;)Tj
2.5681 0 Td
(and)Tj
/F12 1 Tf
0 Tc
1.7291 0 Td
()Tj
/F5 1 Tf
-0.004 Tc
(60)Tj
1.9446 0 Td
(indicates)Tj
3.7701 0 Td
(high-level)Tj
4.1499 0 Td
(resistance.)Tj
4.3539 0 Td
(Mutation)Tj
3.9912 0 Td
(penalties)Tj
3.7417 0 Td
(are)Tj
1.4457 0 Td
(assigned)Tj
3.6056 0 Td
(both)Tj
2.058 0 Td
(to)Tj
1.0261 0 Td
(individ-)Tj
-34.384 -1.2982 Td
(ual)Tj
1.4286 0 Td
(DRMs)Tj
2.829 0 Td
(and)Tj
1.7291 0 Td
(to)Tj
1.0261 0 Td
(combinations)Tj
5.709 0 Td
(of)Tj
1.0148 0 Td
(DRMs.)Tj
-12.5404 -1.2983 Td
(The)Tj
1.7858 0 Td
(HIVDB)Tj
3.3392 0 Td
(GRT-IS)Tj
3.3335 0 Td
(classification)Tj
5.3461 0 Td
("Susceptible")Tj
5.3291 0 Td
(is)Tj
0.8447 0 Td
(assigned)Tj
3.6113 0 Td
(when)Tj
2.4038 0 Td
(a)Tj
0.652 0 Td
(virus)Tj
2.2053 0 Td
(displays)Tj
3.3846 0 Td
(no)Tj
1.2755 0 Td
(evi-)Tj
-34.7071 -1.3039 Td
(dence)Tj
2.5681 0 Td
(reduced)Tj
3.4413 0 Td
(susceptibility)Tj
5.4424 0 Td
(when)Tj
2.4038 0 Td
(compared)Tj
4.2406 0 Td
(with)Tj
2.0013 0 Td
(a)Tj
0.6519 0 Td
(wild-type)Tj
3.9912 0 Td
(virus.)Tj
2.4264 0 Td
("Potential)Tj
4.1216 0 Td
(low-level)Tj
3.7984 0 Td
(resis-)Tj
-35.087 -1.2983 Td
(tance")Tj
2.6645 0 Td
(is)Tj
0.8504 0 Td
(assigned)Tj
3.6056 0 Td
(when)Tj
2.4038 0 Td
(a)Tj
0.6576 0 Td
(virus)Tj
2.1997 0 Td
(has)Tj
1.542 0 Td
(DRMs)Tj
2.8347 0 Td
(consistent)Tj
4.2519 0 Td
(with)Tj
2.0013 0 Td
(previous)Tj
3.6453 0 Td
(ARV)Tj
2.2223 0 Td
(exposure)Tj
3.8154 0 Td
(or)Tj
1.0999 0 Td
(contains)Tj
-33.7944 -1.2982 Td
(DRMs)Tj
2.8289 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(resistance)Tj
4.1329 0 Td
(only)Tj
1.9786 0 Td
(when)Tj
2.4037 0 Td
(they)Tj
1.9219 0 Td
(occur)Tj
2.4718 0 Td
(with)Tj
2.0012 0 Td
(other)Tj
2.3471 0 Td
(DRMs.)Tj
3.0557 0 Td
("Low-level)Tj
4.4164 0 Td
(resis-)Tj
-33.8114 -1.304 Td
(tance")Tj
2.6645 0 Td
(is)Tj
0.8504 0 Td
(assigned)Tj
3.6056 0 Td
(when)Tj
2.4038 0 Td
(a)Tj
0.6576 0 Td
(virus)Tj
2.1997 0 Td
(has)Tj
1.542 0 Td
(DRMs)Tj
2.8347 0 Td
(associated)Tj
4.2519 0 Td
(with)Tj
2.0013 0 Td
(reduced)Tj
/F9 1 Tf
3.4412 0 Td
[()12()]TJ
1.0148 0 Td
[()-13()14( )7(\n)20()]TJ
/F5 1 Tf
2.0466 0 Td
(ARV)Tj
2.2223 0 Td
(susceptibility)Tj
-31.7364 -1.2982 Td
(or)Tj
1.0941 0 Td
(a)Tj
0.6576 0 Td
(suboptimal)Tj
4.7055 0 Td
(virological)Tj
4.4107 0 Td
(response)Tj
3.7304 0 Td
(to)Tj
1.0261 0 Td
(ARV)Tj
2.2167 0 Td
(treatment.)Tj
4.3653 0 Td
("Intermediate)Tj
5.7146 0 Td
(resistance")Tj
4.4504 0 Td
(is)Tj
0.8447 0 Td
(assigned)Tj
-33.2161 -1.2983 Td
(when,)Tj
2.6305 0 Td
(although)Tj
3.753 0 Td
(there)Tj
2.2621 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.6519 0 Td
(high)Tj
2.0069 0 Td
(likelihood)Tj
4.235 0 Td
(that)Tj
1.7801 0 Td
(an)Tj
1.2019 0 Td
(ARV's)Tj
2.7949 0 Td
(activity)Tj
3.1181 0 Td
(would)Tj
2.7156 0 Td
(be)Tj
1.1509 0 Td
(reduced)Tj
3.4412 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(pres-)Tj
-35.0983 -1.3039 Td
(ence)Tj
2.0352 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(virus's)Tj
2.778 0 Td
(DRMs,)Tj
3.0557 0 Td
(the)Tj
1.4683 0 Td
(ARV)Tj
2.2224 0 Td
(would)Tj
2.7099 0 Td
(likely)Tj
2.3584 0 Td
(still)Tj
1.6384 0 Td
(retain)Tj
2.5625 0 Td
(significant)Tj
4.388 0 Td
(antiviral)Tj
3.5376 0 Td
(activity)Tj
3.1181 0 Td
(against)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 391.2752 m
576 391.2752 l
576 390.7752 l
36 390.7752 l
f*
268.2621 390.7752 m
268.2621 378.2752 l
267.762 378.2752 l
267.762 390.7752 l
f*
267.762 378.2752 m
36 378.2752 l
36 378.7753 l
267.762 378.7753 l
f*
395.9101 390.7752 m
395.9101 378.2752 l
395.4101 378.2752 l
395.4101 390.7752 l
f*
395.4101 378.2752 m
268.2621 378.2752 l
268.2621 378.7753 l
395.4101 378.7753 l
f*
575.9994 378.2752 m
395.9101 378.2752 l
395.9101 378.7753 l
575.9994 378.7753 l
f*
268.2621 378.2752 m
268.2621 365.7753 l
267.762 365.7753 l
267.762 378.2752 l
f*
267.762 365.7753 m
36 365.7753 l
36 366.2753 l
267.762 366.2753 l
f*
395.9101 378.2752 m
395.9101 365.7753 l
395.4101 365.7753 l
395.4101 378.2752 l
f*
395.4101 365.7753 m
268.2621 365.7753 l
268.2621 366.2753 l
395.4101 366.2753 l
f*
575.9994 365.7753 m
395.9101 365.7753 l
395.9101 366.2753 l
575.9994 366.2753 l
f*
268.2621 365.7753 m
268.2621 353.2754 l
267.762 353.2754 l
267.762 365.7753 l
f*
267.762 353.2754 m
36 353.2754 l
36 353.7754 l
267.762 353.7754 l
f*
395.9101 365.7753 m
395.9101 353.2754 l
395.4101 353.2754 l
395.4101 365.7753 l
f*
395.4101 353.2754 m
268.2621 353.2754 l
268.2621 353.7754 l
395.4101 353.7754 l
f*
575.9994 353.2754 m
395.9101 353.2754 l
395.9101 353.7754 l
575.9994 353.7754 l
f*
268.2621 353.2754 m
268.2621 340.7754 l
267.762 340.7754 l
267.762 353.2754 l
f*
267.762 340.7754 m
36 340.7754 l
36 341.2755 l
267.762 341.2755 l
f*
395.9101 353.2754 m
395.9101 340.7754 l
395.4101 340.7754 l
395.4101 353.2754 l
f*
395.4101 340.7754 m
268.2621 340.7754 l
268.2621 341.2755 l
395.4101 341.2755 l
f*
575.9994 340.7754 m
395.9101 340.7754 l
395.9101 341.2755 l
575.9994 341.2755 l
f*
268.2621 340.7754 m
268.2621 328.2755 l
267.762 328.2755 l
267.762 340.7754 l
f*
267.762 328.2755 m
36 328.2755 l
36 328.7755 l
267.762 328.7755 l
f*
395.9101 340.7754 m
395.9101 328.2755 l
395.4101 328.2755 l
395.4101 340.7754 l
f*
395.4101 328.2755 m
268.2621 328.2755 l
268.2621 328.7755 l
395.4101 328.7755 l
f*
575.9994 328.2755 m
395.9101 328.2755 l
395.9101 328.7755 l
575.9994 328.7755 l
f*
268.2621 328.2755 m
268.2621 315.7756 l
267.762 315.7756 l
267.762 328.2755 l
f*
267.762 315.7756 m
36 315.7756 l
36 316.2756 l
267.762 316.2756 l
f*
395.9101 328.2755 m
395.9101 315.7756 l
395.4101 315.7756 l
395.4101 328.2755 l
f*
395.4101 315.7756 m
268.2621 315.7756 l
268.2621 316.2756 l
395.4101 316.2756 l
f*
575.9994 315.7756 m
395.9101 315.7756 l
395.9101 316.2756 l
575.9994 316.2756 l
f*
268.2621 315.7756 m
268.2621 303.2756 l
267.762 303.2756 l
267.762 315.7756 l
f*
267.762 303.2756 m
36 303.2756 l
36 303.7757 l
267.762 303.7757 l
f*
395.9101 315.7756 m
395.9101 303.2756 l
395.4101 303.2756 l
395.4101 315.7756 l
f*
395.4101 303.2756 m
268.2621 303.2756 l
268.2621 303.7757 l
395.4101 303.7757 l
f*
575.9994 303.2756 m
395.9101 303.2756 l
395.9101 303.7757 l
575.9994 303.7757 l
f*
268.2621 303.2756 m
268.2621 290.7757 l
267.762 290.7757 l
267.762 303.2756 l
f*
267.762 290.7757 m
36 290.7757 l
36 291.2757 l
267.762 291.2757 l
f*
395.9101 303.2756 m
395.9101 290.7757 l
395.4101 290.7757 l
395.4101 303.2756 l
f*
395.4101 290.7757 m
268.2621 290.7757 l
268.2621 291.2757 l
395.4101 291.2757 l
f*
575.9994 290.7757 m
395.9101 290.7757 l
395.9101 291.2757 l
575.9994 291.2757 l
f*
268.2621 290.7757 m
268.2621 278.2757 l
267.762 278.2757 l
267.762 290.7757 l
f*
267.762 278.2757 m
36 278.2757 l
36 278.7758 l
267.762 278.7758 l
f*
395.9101 290.7757 m
395.9101 278.2757 l
395.4101 278.2757 l
395.4101 290.7757 l
f*
395.4101 278.2757 m
268.2621 278.2757 l
268.2621 278.7758 l
395.4101 278.7758 l
f*
575.9994 278.2757 m
395.9101 278.2757 l
395.9101 278.7758 l
575.9994 278.7758 l
f*
268.2621 278.2757 m
268.2621 265.7758 l
267.762 265.7758 l
267.762 278.2757 l
f*
267.762 265.7758 m
36 265.7758 l
36 266.2758 l
267.762 266.2758 l
f*
395.9101 278.2757 m
395.9101 265.7758 l
395.4101 265.7758 l
395.4101 278.2757 l
f*
395.4101 265.7758 m
268.2621 265.7758 l
268.2621 266.2758 l
395.4101 266.2758 l
f*
575.9994 265.7758 m
395.9101 265.7758 l
395.9101 266.2758 l
575.9994 266.2758 l
f*
268.2621 265.7758 m
268.2621 253.2759 l
267.762 253.2759 l
267.762 265.7758 l
f*
267.762 253.2759 m
36 253.2759 l
36 253.7759 l
267.762 253.7759 l
f*
395.9101 265.7758 m
395.9101 253.2759 l
395.4101 253.2759 l
395.4101 265.7758 l
f*
395.4101 253.2759 m
268.2621 253.2759 l
268.2621 253.7759 l
395.4101 253.7759 l
f*
575.9994 253.2759 m
395.9101 253.2759 l
395.9101 253.7759 l
575.9994 253.7759 l
f*
268.2621 253.2759 m
268.2621 240.7759 l
267.762 240.7759 l
267.762 253.2759 l
f*
267.762 240.7759 m
36 240.7759 l
36 241.276 l
267.762 241.276 l
f*
395.9101 253.2759 m
395.9101 240.7759 l
395.4101 240.7759 l
395.4101 253.2759 l
f*
395.4101 240.7759 m
268.2621 240.7759 l
268.2621 241.276 l
395.4101 241.276 l
f*
575.9994 240.7759 m
395.9101 240.7759 l
395.9101 241.276 l
575.9994 241.276 l
f*
268.2621 240.7759 m
268.2621 228.276 l
267.762 228.276 l
267.762 240.7759 l
f*
267.762 228.276 m
36 228.276 l
36 228.776 l
267.762 228.776 l
f*
395.9101 240.7759 m
395.9101 228.276 l
395.4101 228.276 l
395.4101 240.7759 l
f*
395.4101 228.276 m
268.2621 228.276 l
268.2621 228.776 l
395.4101 228.776 l
f*
575.9994 228.276 m
395.9101 228.276 l
395.9101 228.776 l
575.9994 228.776 l
f*
268.2621 228.276 m
268.2621 215.7761 l
267.762 215.7761 l
267.762 228.276 l
f*
267.762 215.7761 m
36 215.7761 l
36 216.2761 l
267.762 216.2761 l
f*
395.9101 228.276 m
395.9101 215.7761 l
395.4101 215.7761 l
395.4101 228.276 l
f*
395.4101 215.7761 m
268.2621 215.7761 l
268.2621 216.2761 l
395.4101 216.2761 l
f*
575.9994 215.7761 m
395.9101 215.7761 l
395.9101 216.2761 l
575.9994 216.2761 l
f*
268.2621 215.7761 m
268.2621 203.2761 l
267.762 203.2761 l
267.762 215.7761 l
f*
267.762 203.2761 m
36 203.2761 l
36 203.7762 l
267.762 203.7762 l
f*
395.9101 215.7761 m
395.9101 203.2761 l
395.4101 203.2761 l
395.4101 215.7761 l
f*
395.4101 203.2761 m
268.2621 203.2761 l
268.2621 203.7762 l
395.4101 203.7762 l
f*
575.9994 203.2761 m
395.9101 203.2761 l
395.9101 203.7762 l
575.9994 203.7762 l
f*
268.2621 203.2761 m
268.2621 190.7762 l
267.762 190.7762 l
267.762 203.2761 l
f*
267.762 190.7762 m
36 190.7762 l
36 191.2762 l
267.762 191.2762 l
f*
395.9101 203.2761 m
395.9101 190.7762 l
395.4101 190.7762 l
395.4101 203.2761 l
f*
395.4101 190.7762 m
268.2621 190.7762 l
268.2621 191.2762 l
395.4101 191.2762 l
f*
575.9994 190.7762 m
395.9101 190.7762 l
395.9101 191.2762 l
575.9994 191.2762 l
f*
268.2621 190.7762 m
268.2621 178.2763 l
267.762 178.2763 l
267.762 190.7762 l
f*
267.762 178.2763 m
36 178.2763 l
36 178.7763 l
267.762 178.7763 l
f*
395.9101 190.7762 m
395.9101 178.2763 l
395.4101 178.2763 l
395.4101 190.7762 l
f*
395.4101 178.2763 m
268.2621 178.2763 l
268.2621 178.7763 l
395.4101 178.7763 l
f*
575.9994 178.2763 m
395.9101 178.2763 l
395.9101 178.7763 l
575.9994 178.7763 l
f*
268.2621 178.2763 m
268.2621 165.7763 l
267.762 165.7763 l
267.762 178.2763 l
f*
267.762 165.7763 m
36 165.7763 l
36 166.2763 l
267.762 166.2763 l
f*
395.9101 178.2763 m
395.9101 165.7763 l
395.4101 165.7763 l
395.4101 178.2763 l
f*
395.4101 165.7763 m
268.2621 165.7763 l
268.2621 166.2763 l
395.4101 166.2763 l
f*
575.9994 165.7763 m
395.9101 165.7763 l
395.9101 166.2763 l
575.9994 166.2763 l
f*
268.2621 165.7763 m
268.2621 153.2764 l
267.762 153.2764 l
267.762 165.7763 l
f*
267.762 153.2764 m
36 153.2764 l
36 153.7764 l
267.762 153.7764 l
f*
395.9101 165.7763 m
395.9101 153.2764 l
395.4101 153.2764 l
395.4101 165.7763 l
f*
395.4101 153.2764 m
268.2621 153.2764 l
268.2621 153.7764 l
395.4101 153.7764 l
f*
575.9994 153.2764 m
395.9101 153.2764 l
395.9101 153.7764 l
575.9994 153.7764 l
f*
268.2621 153.2764 m
268.2621 140.7764 l
267.762 140.7764 l
267.762 153.2764 l
f*
267.762 140.7764 m
36 140.7764 l
36 141.2765 l
267.762 141.2765 l
f*
395.9101 153.2764 m
395.9101 140.7764 l
395.4101 140.7764 l
395.4101 153.2764 l
f*
395.4101 140.7764 m
268.2621 140.7764 l
268.2621 141.2765 l
395.4101 141.2765 l
f*
575.9994 140.7764 m
395.9101 140.7764 l
395.9101 141.2765 l
575.9994 141.2765 l
f*
268.2621 140.7764 m
268.2621 128.2765 l
267.762 128.2765 l
267.762 140.7764 l
f*
267.762 128.2765 m
36 128.2765 l
36 128.7765 l
267.762 128.7765 l
f*
395.9101 140.7764 m
395.9101 128.2765 l
395.4101 128.2765 l
395.4101 140.7764 l
f*
395.4101 128.2765 m
268.2621 128.2765 l
268.2621 128.7765 l
395.4101 128.7765 l
f*
575.9994 128.2765 m
395.9101 128.2765 l
395.9101 128.7765 l
575.9994 128.7765 l
f*
268.2621 128.2765 m
268.2621 115.7766 l
267.762 115.7766 l
267.762 128.2765 l
f*
267.762 115.7766 m
36 115.7766 l
36 116.2766 l
267.762 116.2766 l
f*
395.9101 128.2765 m
395.9101 115.7766 l
395.4101 115.7766 l
395.4101 128.2765 l
f*
395.4101 115.7766 m
268.2621 115.7766 l
268.2621 116.2766 l
395.4101 116.2766 l
f*
575.9994 115.7766 m
395.9101 115.7766 l
395.9101 116.2766 l
575.9994 116.2766 l
f*
268.2621 115.7766 m
268.2621 103.2766 l
267.762 103.2766 l
267.762 115.7766 l
f*
267.762 103.2766 m
36 103.2766 l
36 103.7767 l
267.762 103.7767 l
f*
395.9101 115.7766 m
395.9101 103.2766 l
395.4101 103.2766 l
395.4101 115.7766 l
f*
395.4101 103.2766 m
268.2621 103.2766 l
268.2621 103.7767 l
395.4101 103.7767 l
f*
575.9994 103.2766 m
395.9101 103.2766 l
395.9101 103.7767 l
575.9994 103.7767 l
f*
575.9994 69.5265 m
36 69.5265 l
36 70.0265 l
575.9994 70.0265 l
f*
0.83 0.64 0.02 0 k
36 56.4661 m
186.7465 56.4661 l
h
f*
0 g
7.9999 0 0 7.9999 36 396.1133 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(1.)Tj
1.2614 0 Td
(List)Tj
1.9772 0 Td
(of)Tj
1.1551 0 Td
(antiretrovi)Tj
4.8119 0 Td
(ral)Tj
1.4244 0 Td
(\(ARV\))Tj
2.9551 0 Td
(drugs)Tj
2.9693 0 Td
(and)Tj
1.9772 0 Td
(their)Tj
2.3599 0 Td
(abbre)Tj
2.6787 0 Td
(viations)Tj
3.9544 0 Td
(by)Tj
1.3677 0 Td
(ARV)Tj
2.3032 0 Td
(class.)Tj
0 Tc
-33.9947 -1.8567 Td
(ARV)Tj
2.3244 0 Td
(Class)Tj
26.9577 0 Td
(Abbreviati)Tj
4.8685 0 Td
(on)Tj
11.0907 0 Td
(Generic)Tj
3.9331 0 Td
(Name)Tj
/F0 1 Tf
-49.1744 -1.559 Td
(Nucleoside)Tj
5.1307 0 Td
(RT)Tj
1.5591 0 Td
(Inhibitors)Tj
4.2591 0 Td
(\(NRTIs\))Tj
18.4607 0 Td
(3TC)Tj
15.9521 0 Td
(Lamivudine)Tj
-15.9521 -1.5662 Td
(ABC)Tj
15.9521 0 Td
(Abacavir)Tj
-15.9521 -1.559 Td
(AZT)Tj
15.9521 0 Td
(Zidovudine)Tj
-15.9521 -1.5662 Td
(D4T)Tj
15.9521 0 Td
(Stavudine)Tj
-15.9521 -1.5591 Td
(DDI)Tj
15.9521 0 Td
(Didanosine)Tj
-15.9521 -1.5661 Td
(FTC)Tj
15.9521 0 Td
(Emtricitabi)Tj
4.6418 0 Td
(ne)Tj
-20.5939 -1.5591 Td
(TDF)Tj
15.9521 0 Td
(Tenofovir)Tj
4.3725 0 Td
(disoproxil)Tj
4.415 0 Td
(fumarate)Tj
-54.1492 -1.5661 Td
(Nonnucleo)Tj
4.7338 0 Td
(side)Tj
2.0481 0 Td
(RT)Tj
1.5591 0 Td
(Inhibitors)Tj
4.259 0 Td
(\(NNRTIs\))Tj
16.8096 0 Td
(EFV)Tj
15.9521 0 Td
(Efavirenz)Tj
-15.9521 -1.5591 Td
(ETR)Tj
15.9521 0 Td
(Etravirine)Tj
-15.9521 -1.5662 Td
(NVP)Tj
15.9521 0 Td
(Nevirapine)Tj
-15.9521 -1.559 Td
(RPV)Tj
15.9521 0 Td
(Rilpivirine)Tj
-45.3617 -1.5662 Td
(Protease)Tj
4.2094 0 Td
(Inhibitors)Tj
4.2591 0 Td
(\(PIs\))Tj
/F4 1 Tf
[()]TJ
/F0 1 Tf
20.9411 0 Td
(ATV)Tj
15.9521 0 Td
(Atazanavir)Tj
-15.9521 -1.5591 Td
(DRV)Tj
15.9521 0 Td
(Darunavir)Tj
-15.9521 -1.5661 Td
(FPV)Tj
15.9521 0 Td
(Fosamprena)Tj
5.5772 0 Td
(vir)Tj
-21.5293 -1.5591 Td
(IDV)Tj
15.9521 0 Td
(Indinavir)Tj
-15.9521 -1.559 Td
(LPV)Tj
15.9521 0 Td
(Lopinavir)Tj
-15.9521 -1.5662 Td
(NFV)Tj
15.9521 0 Td
(Nelfinavir)Tj
-15.9521 -1.5591 Td
(SQV)Tj
15.9521 0 Td
(Saquinavir)Tj
-15.9521 -1.5661 Td
(TPV)Tj
15.9521 0 Td
(Tipranavir)Tj
-45.3617 -1.5591 Td
(Integrase)Tj
4.3724 0 Td
(Strand-Tra)Tj
4.7552 0 Td
(nsfer)Tj
2.4449 0 Td
(Inhibitors)Tj
4.2591 0 Td
(\(INSTIs)Tj
3.3803 0 Td
(\))Tj
10.1977 0 Td
(DTG)Tj
15.9521 0 Td
(Dolutegrav)Tj
4.7977 0 Td
(ir)Tj
-20.7498 -1.5661 Td
(EVG)Tj
15.9521 0 Td
(Elvitegravir)Tj
-15.9521 -1.5591 Td
(RAL)Tj
15.9521 0 Td
(Raltegravi)Tj
4.4646 0 Td
(r)Tj
/F4 1 Tf
-49.8263 -2.3457 Td
[()]TJ
/F0 1 Tf
(With)Tj
2.7708 0 Td
(the)Tj
1.6158 0 Td
(exceptio)Tj
3.6922 0 Td
(n)Tj
0.7866 0 Td
(of)Tj
1.0559 0 Td
(NFV,)Tj
2.5087 0 Td
(each)Tj
2.374 0 Td
(of)Tj
1.063 0 Td
(the)Tj
1.6087 0 Td
(PIs)Tj
1.6724 0 Td
(are)Tj
1.6654 0 Td
(usually)Tj
3.3166 0 Td
(administ)Tj
3.6921 0 Td
(ered)Tj
2.2181 0 Td
(with)Tj
1.9914 0 Td
(a)Tj
0.7795 0 Td
(drug)Tj
2.2182 0 Td
(to)Tj
1.0559 0 Td
(boost)Tj
2.6646 0 Td
(PI)Tj
1.1763 0 Td
(levels.)Tj
3.0402 0 Td
(Ritonavir)Tj
3.9119 0 Td
(,)Tj
0.5102 0 Td
(usually)Tj
3.3166 0 Td
(indicated)Tj
4.1953 0 Td
(by)Tj
1.2827 0 Td
(/r)Tj
1.5023 0 Td
(is)Tj
0.9497 0 Td
(available)Tj
4.1315 0 Td
(for)Tj
1.3961 0 Td
(ATV,)Tj
-64.1627 -1.5024 Td
(DRV,)Tj
2.6078 0 Td
(FPV,)Tj
2.452 0 Td
(IDV,)Tj
2.1686 0 Td
(LPV,)Tj
2.3952 0 Td
(SQV,)Tj
2.615 0 Td
(and)Tj
1.8851 0 Td
(TPV.)Tj
2.452 0 Td
(Cobicis)Tj
3.2457 0 Td
(tat,)Tj
1.6228 0 Td
(usually)Tj
3.3166 0 Td
(indicated)Tj
4.1953 0 Td
(by)Tj
1.2756 0 Td
(/c)Tj
1.6724 0 Td
(or)Tj
1.1126 0 Td
(/cobi)Tj
2.9977 0 Td
(is)Tj
0.9425 0 Td
(available)Tj
4.1386 0 Td
(for)Tj
1.389 0 Td
(ATV)Tj
2.1756 0 Td
(and)Tj
1.878 0 Td
(DRV.)Tj
0.83 0.64 0.02 0 k
/F8 1 Tf
-0.025 Tc
-46.5381 -2.2464 Td
(https://do)Tj
3.5575 0 Td
(i.org/10.1371/j)Tj
5.4425 0 Td
(ournal.pone)Tj
4.4079 0 Td
(.0181357.t001)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 420.8314 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(HIV-1)Tj
2.7354 0 Td
(genotypic)Tj
4.4221 0 Td
(resistance)Tj
4.6984 0 Td
(test)Tj
1.8142 0 Td
(interpreta)Tj
4.1387 0 Td
(tion)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01813)Tj
4.089 0 Td
(57)Tj
0 g
2.0906 0 Td
(July)Tj
1.9701 0 Td
(28,)Tj
1.5874 0 Td
(2017)Tj
35.3483 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
BT
66.402 0 Td
(31)Tj
ET
Q
endstream
endobj
42 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 44 0 R/Contents 45 0 R/TrimBox[0 0 612 792]>>
endobj
44 0 obj
[46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R 65 0 R 66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R]
endobj
46 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.ref003)>>
endobj
47 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.t002)>>
endobj
48 0 obj
<>/Border[0 0 0]/Dest(Lpone.0181357.t002)>>
endobj
49 0 obj
<>/Border[0 0 0]/A 83 0 R>>
endobj
83 0 obj
<>
endobj
50 0 obj
<>/Border[0 0 0]/A 84 0 R>>
endobj
84 0 obj
<>
endobj
51 0 obj
<>/Border[0 0 0]/A 85 0 R>>
endobj
85 0 obj
<>
endobj
52 0 obj
<>/Border[0 0 0]/A 86 0 R>>
endobj
86 0 obj
<>
endobj
53 0 obj
<>/Border[0 0 0]/A 87 0 R>>
endobj
87 0 obj
<>
endobj
54 0 obj
<>/Border[0 0 0]/A 88 0 R>>
endobj
88 0 obj
<>
endobj
55 0 obj
<>/Border[0 0 0]/A 89 0 R>>
endobj
89 0 obj
<>
endobj
56 0 obj
<>/Border[0 0 0]/A 90 0 R>>
endobj
90 0 obj
<>
endobj
57 0 obj
<>/Border[0 0 0]/A 91 0 R>>
endobj
91 0 obj
<>
endobj
58 0 obj
<>/Border[0 0 0]/A 92 0 R>>
endobj
92 0 obj
<>
endobj
59 0 obj
<>/Border[0 0 0]/A 93 0 R>>
endobj
93 0 obj
<>
endobj
60 0 obj
<>/Border[0 0 0]/A 94 0 R>>
endobj
94 0 obj
<>
endobj
61 0 obj
<>/Border[0 0 0]/A 95 0 R>>
endobj
95 0 obj
<>
endobj
62 0 obj
<>/Border[0 0 0]/A 96 0 R>>
endobj
96 0 obj
<>
endobj
63 0 obj
<>/Border[0 0 0]/A 97 0 R>>
endobj
97 0 obj
<>
endobj
64 0 obj
<>/Border[0 0 0]/A 98 0 R>>
endobj
98 0 obj
<>
endobj
65 0 obj
<>/Border[0 0 0]/A 99 0 R>>
endobj
99 0 obj
<>
endobj
66 0 obj
<>/Border[0 0 0]/A 100 0 R>>
endobj
100 0 obj
<>
endobj
67 0 obj
<>/Border[0 0 0]/A 101 0 R>>
endobj
101 0 obj
<>
endobj
68 0 obj
<>/Border[0 0 0]/A 102 0 R>>
endobj
102 0 obj
<>
endobj
69 0 obj
<>/Border[0 0 0]/A 103 0 R>>
endobj
103 0 obj
<>
endobj
70 0 obj
<>/Border[0 0 0]/A 104 0 R>>
endobj
104 0 obj
<>
endobj
71 0 obj
<>/Border[0 0 0]/A 105 0 R>>
endobj
105 0 obj
<>
endobj
72 0 obj
<>/Border[0 0 0]/A 106 0 R>>
endobj
106 0 obj
<>
endobj
73 0 obj
<>/Border[0 0 0]/A 107 0 R>>
endobj
107 0 obj
<>
endobj
74 0 obj
<>/Border[0 0 0]/A 108 0 R>>
endobj
108 0 obj
<>
endobj
75 0 obj
<>/Border[0 0 0]/A 109 0 R>>
endobj
109 0 obj
<>
endobj
76 0 obj
<>/Border[0 0 0]/A 110 0 R>>
endobj
110 0 obj
<>
endobj
77 0 obj
<>/Border[0 0 0]/A 111 0 R>>
endobj
111 0 obj
<>
endobj
78 0 obj
<>/Border[0 0 0]/A 112 0 R>>
endobj
112 0 obj
<>
endobj
79 0 obj
<>/Border[0 0 0]/A 113 0 R>>
endobj
113 0 obj
<>
endobj
80 0 obj
<>/Border[0 0 0]/A 114 0 R>>
endobj
114 0 obj
<>
endobj
81 0 obj
<>/Border[0 0 0]/A 115 0 R>>
endobj
115 0 obj
<>
endobj
82 0 obj
<>/Border[0 0 0]/A 116 0 R>>
endobj
116 0 obj
<>
endobj
45 0 obj
[117 0 R 118 0 R 119 0 R 120 0 R]
endobj
117 0 obj
<>stream
q
0.83 0.64 0.02 0 k
533.8772 680.315 m
538.6394 680.315 l
h
f*
244.5165 654.3496 m
272.8063 654.3496 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(the)Tj
1.4683 0 Td
(virus.)Tj
2.4264 0 Td
("High-level)Tj
4.7112 0 Td
(resistance")Tj
4.4503 0 Td
(is)Tj
0.8504 0 Td
(assigned)Tj
3.6057 0 Td
(when)Tj
2.4037 0 Td
(a)Tj
0.6577 0 Td
(virus)Tj
2.1996 0 Td
(has)Tj
1.5421 0 Td
(DRMs)Tj
2.8346 0 Td
(predicted)Tj
3.9968 0 Td
(to)Tj
1.0262 0 Td
(confer)Tj
2.7836 0 Td
(a)Tj
0.6519 0 Td
(level)Tj
-35.6085 -1.3039 Td
(of)Tj
1.0147 0 Td
(resistance)Tj
4.1329 0 Td
(similar)Tj
2.9821 0 Td
(to)Tj
1.0261 0 Td
(that)Tj
1.7801 0 Td
(observed)Tj
3.7928 0 Td
(in)Tj
1.0374 0 Td
(viruses)Tj
2.9877 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4684 0 Td
(highest)Tj
3.0897 0 Td
(levels)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(reduced)Tj
/F9 1 Tf
3.4469 0 Td
[()12()]TJ
1.0148 0 Td
[()-13()14( )7(\n)20()]TJ
/F5 1 Tf
2.0466 0 Td
(sus-)Tj
-35.206 -1.2982 Td
(ceptibility)Tj
4.1895 0 Td
(or)Tj
1.0999 0 Td
(in)Tj
1.0318 0 Td
(viruses)Tj
2.9877 0 Td
(that)Tj
1.7801 0 Td
(have)Tj
2.058 0 Td
(little)Tj
2.0012 0 Td
(or)Tj
1.0998 0 Td
(no)Tj
1.2756 0 Td
(virological)Tj
4.405 0 Td
(response)Tj
3.7361 0 Td
(to)Tj
1.0261 0 Td
(ARV)Tj
2.2167 0 Td
(treatment)Tj
4.1385 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
-0.019 Tc
-31.8498 -1.2983 Td
(In)Tj
1.0828 0 Td
(June)Tj
1.9899 0 Td
(2016,)Tj
2.2734 0 Td
(the)Tj
1.423 0 Td
(expert)Tj
2.6305 0 Td
(panel)Tj
2.313 0 Td
(was)Tj
1.6555 0 Td
(provided)Tj
3.6963 0 Td
(access)Tj
2.5569 0 Td
(to)Tj
0.9921 0 Td
(the)Tj
1.423 0 Td
(five)Tj
1.593 0 Td
(sources)Tj
3.0898 0 Td
(of)Tj
0.9864 0 Td
(background)Tj
4.8812 0 Td
(material)Tj
-33.783 -1.2983 Td
(outlined)Tj
3.4469 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0034 0 Td
(Table)Tj
2.3698 0 Td
(2)Tj
0 g
(:)Tj
0.89 0 Td
(\(i\))Tj
1.1226 0 Td
(DRM)Tj
2.4207 0 Td
(penalty)Tj
3.0387 0 Td
(scores)Tj
2.5796 0 Td
(for)Tj
1.3379 0 Td
(HIVDB)Tj
3.2655 0 Td
(version)Tj
3.05 0 Td
(7.0)Tj
1.3493 0 Td
(\(February)Tj
4.0422 0 Td
(2014\))Tj
2.3868 0 Td
(and)Tj
1.6894 0 Td
(an)Tj
-33.9928 -1.3039 Td
(interim)Tj
3.1067 0 Td
(update)Tj
2.863 0 Td
(\(version)Tj
3.3732 0 Td
(8.0;)Tj
1.559 0 Td
(June)Tj
1.9899 0 Td
(2016\);)Tj
2.5966 0 Td
(\(ii\))Tj
1.3776 0 Td
(A)Tj
0.8901 0 Td
(list)Tj
1.3322 0 Td
(of)Tj
0.9808 0 Td
(the)Tj
1.4287 0 Td
(calculated)Tj
4.0535 0 Td
(summed)Tj
3.6113 0 Td
(version)Tj
3.0444 0 Td
(8.0)Tj
1.3549 0 Td
(DRM)Tj
-33.5619 -1.2982 Td
(penalty)Tj
3.0387 0 Td
(scores)Tj
2.5738 0 Td
(for)Tj
1.3436 0 Td
(each)Tj
1.9673 0 Td
(of)Tj
0.9864 0 Td
(the)Tj
1.423 0 Td
(distinct)Tj
3.0897 0 Td
(DRM)Tj
2.4265 0 Td
(patterns)Tj
3.3562 0 Td
(present)Tj
3.0557 0 Td
(in)Tj
1.0035 0 Td
(sequences)Tj
4.0875 0 Td
(in)Tj
1.0035 0 Td
(HIVDB;)Tj
3.4752 0 Td
(\(iii\))Tj
1.6271 0 Td
(Muta-)Tj
-34.4577 -1.2983 Td
(tion)Tj
1.7801 0 Td
(classifications)Tj
5.4822 0 Td
(updated)Tj
3.3732 0 Td
(in)Tj
1.0034 0 Td
(June)Tj
1.9899 0 Td
(2016;)Tj
2.2734 0 Td
(\(iv\))Tj
1.5591 0 Td
(Mutation)Tj
3.8777 0 Td
(comments)Tj
4.2973 0 Td
(updated)Tj
3.3732 0 Td
(in)Tj
1.0035 0 Td
(June)Tj
1.9899 0 Td
(2016;)Tj
2.2734 0 Td
(and)Tj
1.6837 0 Td
(\(v\))Tj
-35.96 -1.3039 Td
(Mutation)Tj
3.8721 0 Td
(notes)Tj
2.2847 0 Td
(updated)Tj
3.3675 0 Td
(June)Tj
1.9899 0 Td
(2016.)Tj
2.2734 0 Td
(These)Tj
2.4945 0 Td
(five)Tj
1.593 0 Td
(sources)Tj
3.0898 0 Td
(of)Tj
0.9864 0 Td
(background)Tj
4.8756 0 Td
(material)Tj
3.3959 0 Td
(were)Tj
2.0636 0 Td
(compiled)Tj
3.8324 0 Td
(by)Tj
-36.1188 -1.2983 Td
(RWS)Tj
2.2393 0 Td
(and)Tj
1.6838 0 Td
(reviewed)Tj
3.6737 0 Td
(by)Tj
1.1508 0 Td
(RP)Tj
1.372 0 Td
(and)Tj
1.6837 0 Td
(JMS)Tj
1.8766 0 Td
(to)Tj
0.9921 0 Td
(extract)Tj
2.8289 0 Td
(specific)Tj
3.0728 0 Td
(material)Tj
3.3959 0 Td
(to)Tj
0.9921 0 Td
(be)Tj
1.1225 0 Td
(evaluated)Tj
3.8551 0 Td
(by)Tj
1.1508 0 Td
(the)Tj
1.423 0 Td
(expert)Tj
2.6306 0 Td
(panel.)Tj
-0.004 Tc
-33.9475 -1.2983 Td
(The)Tj
1.7858 0 Td
(expert)Tj
2.7156 0 Td
(panel)Tj
2.3924 0 Td
(was)Tj
1.7008 0 Td
(asked)Tj
2.4604 0 Td
(to)Tj
1.0261 0 Td
(provide)Tj
3.2882 0 Td
(feedback)Tj
3.7417 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(following)Tj
3.9799 0 Td
(aspects)Tj
3.0387 0 Td
(of)Tj
1.0148 0 Td
(GRT)Tj
2.1713 0 Td
(interpreta-)Tj
-33.2558 -1.3039 Td
(tion:)Tj
2.0636 0 Td
(\(i\))Tj
1.1678 0 Td
(The)Tj
1.7858 0 Td
(ARVs)Tj
2.5796 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(extent)Tj
2.6816 0 Td
(to)Tj
1.0204 0 Td
(which)Tj
2.6532 0 Td
(pharmacologic)Tj
6.1625 0 Td
(considerations)Tj
6.0661 0 Td
(should)Tj
2.914 0 Td
(be)Tj
1.1509 0 Td
(included)Tj
-33.4429 -1.2982 Td
(in)Tj
1.0318 0 Td
(a)Tj
0.6576 0 Td
(GRT)Tj
2.1656 0 Td
(report;)Tj
2.9367 0 Td
(\(ii\))Tj
1.4343 0 Td
(The)Tj
1.7802 0 Td
(predicted)Tj
4.0025 0 Td
(drug)Tj
2.1089 0 Td
(resistance)Tj
4.1329 0 Td
(levels)Tj
2.3754 0 Td
(associated)Tj
4.2577 0 Td
(with)Tj
1.9955 0 Td
(52)Tj
1.1736 0 Td
(NRTI)Tj
2.5285 0 Td
(DRM)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
199.9998 519.6847 m
575.9997 519.6847 l
575.9997 519.1846 l
199.9998 519.1846 l
f*
430.6436 519.1846 m
430.6436 506.6847 l
430.1436 506.6847 l
430.1436 519.1846 l
f*
430.1436 506.6847 m
199.9998 506.6847 l
199.9998 507.1847 l
430.1436 507.1847 l
f*
575.9997 506.6847 m
430.6436 506.6847 l
430.6436 507.1847 l
575.9997 507.1847 l
f*
430.6436 506.6847 m
430.6436 389.6844 l
430.1436 389.6844 l
430.1436 506.6847 l
f*
430.1436 389.6844 m
199.9998 389.6844 l
199.9998 390.1844 l
430.1436 390.1844 l
f*
575.9997 389.6844 m
430.6436 389.6844 l
430.6436 390.1844 l
575.9997 390.1844 l
f*
430.6436 389.6844 m
430.6436 310.6843 l
430.1436 310.6843 l
430.1436 389.6844 l
f*
430.1436 310.6843 m
199.9998 310.6843 l
199.9998 311.1843 l
430.1436 311.1843 l
f*
575.9997 310.6843 m
430.6436 310.6843 l
430.6436 311.1843 l
575.9997 311.1843 l
f*
430.6436 310.6843 m
430.6436 269.6842 l
430.1436 269.6842 l
430.1436 310.6843 l
f*
430.1436 269.6842 m
199.9998 269.6842 l
199.9998 270.1843 l
430.1436 270.1843 l
f*
575.9997 269.6842 m
430.6436 269.6842 l
430.6436 270.1843 l
575.9997 270.1843 l
f*
430.6436 269.6842 m
430.6436 190.6841 l
430.1436 190.6841 l
430.1436 269.6842 l
f*
430.1436 190.6841 m
199.9998 190.6841 l
199.9998 191.1841 l
430.1436 191.1841 l
f*
575.9997 190.6841 m
430.6436 190.6841 l
430.6436 191.1841 l
575.9997 191.1841 l
f*
430.6436 190.6841 m
430.6436 111.6839 l
430.1436 111.6839 l
430.1436 190.6841 l
f*
430.1436 111.6839 m
199.9998 111.6839 l
199.9998 112.1839 l
430.1436 112.1839 l
f*
575.9997 111.6839 m
430.6436 111.6839 l
430.6436 112.1839 l
575.9997 112.1839 l
f*
575.9997 77.9338 m
199.9998 77.9338 l
199.9998 78.4338 l
575.9997 78.4338 l
f*
0.83 0.64 0.02 0 k
438.2929 496.1197 m
539.6598 496.1197 l
h
f*
433.6441 486.5953 m
531.0992 486.5953 l
h
f*
438.2929 477.1276 m
539.6598 477.1276 l
h
f*
433.6441 467.6031 m
536.8252 467.6031 l
h
f*
438.2929 458.1354 m
539.6598 458.1354 l
539.6598 458.0787 l
438.2929 458.0787 l
f*
433.6441 448.611 m
520.0441 448.611 l
h
f*
438.2929 439.0866 m
539.6598 439.0866 l
h
f*
433.6441 429.6189 m
532.9134 429.6189 l
h
f*
438.2929 379.1055 m
539.6598 379.1055 l
h
f*
433.6441 369.5811 m
542.5512 369.5811 l
h
f*
438.2929 360.1134 m
539.6598 360.1134 l
h
f*
433.6441 350.589 m
548.2772 350.589 l
h
f*
438.2929 341.1213 m
539.6598 341.1213 l
h
f*
433.6441 331.5969 m
531.4961 331.5969 l
h
f*
438.2929 322.1291 m
539.6598 322.1291 l
h
f*
433.6441 312.6047 m
544.3654 312.6047 l
h
f*
438.2929 259.0866 m
539.6598 259.0866 l
h
f*
433.6441 249.6189 m
528.4346 249.6189 l
h
f*
438.2929 240.0945 m
539.6598 240.0945 l
h
f*
433.6441 230.6268 m
534.1606 230.6268 l
h
f*
438.2929 221.1024 m
539.6598 221.1024 l
h
f*
433.6441 211.6346 m
517.3795 211.6346 l
h
f*
438.2929 202.1102 m
539.6598 202.1102 l
h
f*
433.6441 192.5858 m
530.2488 192.5858 l
h
f*
438.2929 180.1134 m
539.6598 180.1134 l
h
f*
433.6441 170.589 m
550.0346 170.589 l
h
f*
438.2929 161.1213 m
539.6598 161.1213 l
h
f*
433.6441 151.5969 m
555.7606 151.5969 l
h
f*
438.2929 142.1291 m
539.6598 142.1291 l
h
f*
433.6441 132.6047 m
538.9795 132.6047 l
h
f*
438.2929 123.0803 m
539.6598 123.0803 l
h
f*
433.6441 113.6126 m
551.8488 113.6126 l
h
f*
200.0126 64.8567 m
350.7591 64.8567 l
h
f*
0 g
7.9999 0 0 7.9999 200.0125 524.5228 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(2.)Tj
1.2614 0 Td
(Materials)Tj
4.4859 0 Td
(available)Tj
4.3795 0 Td
(for)Tj
1.5308 0 Td
(review)Tj
3.2882 0 Td
(by)Tj
1.3748 0 Td
(the)Tj
1.6937 0 Td
(expert)Tj
3.1748 0 Td
(panel.)Tj
0 Tc
-15.534 -1.8567 Td
(Material)Tj
3.9898 0 Td
(and)Tj
2.0056 0 Td
(Descriptio)Tj
4.8685 0 Td
(n)Tj
17.5679 0 Td
(Link)Tj
-36.8861 -1.559 Td
(Mutation)Tj
4.3937 0 Td
(Scores:)Tj
/F0 1 Tf
3.8764 0 Td
(For)Tj
1.7221 0 Td
(each)Tj
2.3811 0 Td
(ARV)Tj
2.2748 0 Td
(class,)Tj
2.7709 0 Td
(a)Tj
0.7795 0 Td
(table)Tj
2.3811 0 Td
(contained)Tj
4.5284 0 Td
(lists)Tj
1.9489 0 Td
(of)Tj
-27.0569 -1.1906 Td
(individual)Tj
4.3512 0 Td
(DRMs)Tj
2.9905 0 Td
(and)Tj
1.8851 0 Td
(their)Tj
2.1614 0 Td
(associa)Tj
3.3591 0 Td
(ted)Tj
1.6158 0 Td
(scores,)Tj
3.437 0 Td
(followed)Tj
3.8622 0 Td
(by)Tj
1.2827 0 Td
(a)Tj
0.7796 0 Td
(list)Tj
1.4456 0 Td
(of)Tj
-27.1702 -1.1835 Td
(DRM)Tj
2.4945 0 Td
(combinat)Tj
4.0252 0 Td
(ions)Tj
2.048 0 Td
(and)Tj
1.8851 0 Td
(their)Tj
2.1543 0 Td
(associated)Tj
4.982 0 Td
(scores.)Tj
3.437 0 Td
(Mutation)Tj
4.0394 0 Td
(penalty)Tj
-25.0655 -1.1905 Td
(scores)Tj
3.1535 0 Td
(were)Tj
2.3811 0 Td
(multiples)Tj
4.1457 0 Td
(of)Tj
1.063 0 Td
(5)Tj
0.7796 0 Td
(and)Tj
1.8779 0 Td
(ranged)Tj
3.3166 0 Td
(from)Tj
2.2252 0 Td
(-15)Tj
1.6583 0 Td
(\(increased)Tj
4.8615 0 Td
(ARV)Tj
-25.4624 -1.1835 Td
(activity\))Tj
3.6 0 Td
(to)Tj
1.063 0 Td
(60)Tj
1.3323 0 Td
(\(loss)Tj
2.3244 0 Td
(of)Tj
1.063 0 Td
(ARV)Tj
2.2748 0 Td
(activity\).)Tj
3.8835 0 Td
(ARV)Tj
2.2748 0 Td
(activity)Tj
3.2741 0 Td
(was)Tj
1.9984 0 Td
(estimate)Tj
3.756 0 Td
(d)Tj
-26.8443 -1.1906 Td
(by)Tj
1.2756 0 Td
(adding)Tj
3.2031 0 Td
(the)Tj
1.6087 0 Td
(penalties)Tj
4.1953 0 Td
(for)Tj
1.3961 0 Td
(each)Tj
2.3811 0 Td
(DRM)Tj
2.4874 0 Td
(in)Tj
0.9992 0 Td
(a)Tj
0.7796 0 Td
(sequence)Tj
4.5354 0 Td
(and)Tj
-22.8615 -1.1905 Td
(convertin)Tj
4.0252 0 Td
(g)Tj
0.7795 0 Td
(the)Tj
1.6158 0 Td
(total)Tj
2.1047 0 Td
(score)Tj
2.6646 0 Td
(to)Tj
1.0559 0 Td
(one)Tj
1.8851 0 Td
(of)Tj
1.063 0 Td
(five)Tj
1.7716 0 Td
(interpretatio)Tj
5.2442 0 Td
(ns:)Tj
1.559 0 Td
(\(i\))Tj
-23.7686 -1.1835 Td
(Susce)Tj
3.0897 0 Td
(ptible,)Tj
3.2103 0 Td
(total)Tj
2.1118 0 Td
(score)Tj
/F6 1 Tf
2.6575 0 Td
[( )]TJ
/F0 1 Tf
(10;)Tj
2.1969 0 Td
(\(ii\))Tj
1.3323 0 Td
(Potent)Tj
3.2032 0 Td
(ial)Tj
1.2189 0 Td
(low-level)Tj
4.0819 0 Td
(resistance,)Tj
-23.1025 -1.1905 Td
(total)Tj
2.1047 0 Td
(score)Tj
2.6646 0 Td
(between)Tj
3.9756 0 Td
(10)Tj
1.3323 0 Td
(and)Tj
1.878 0 Td
(14;)Tj
1.6157 0 Td
(\(iii\))Tj
1.5449 0 Td
(Low-level)Tj
4.7481 0 Td
(resistance,)Tj
5.3717 0 Td
(total)Tj
-25.2356 -1.1835 Td
(score)Tj
2.6575 0 Td
(between)Tj
3.9827 0 Td
(15)Tj
1.3252 0 Td
(and)Tj
1.885 0 Td
(29;)Tj
1.6087 0 Td
(\(iv\))Tj
1.6087 0 Td
(Intermediat)Tj
5.3079 0 Td
(e)Tj
0.7795 0 Td
(resistance,)Tj
5.3717 0 Td
(total)Tj
-24.5269 -1.1906 Td
(score)Tj
2.6575 0 Td
(between)Tj
3.9827 0 Td
(30)Tj
1.3252 0 Td
(and)Tj
1.885 0 Td
(59;)Tj
1.6087 0 Td
(and)Tj
1.885 0 Td
(\(v\))Tj
1.389 0 Td
(High-leve)Tj
4.5142 0 Td
(l)Tj
0.4536 0 Td
(resistance)Tj
4.8544 0 Td
(,)Tj
0.5102 0 Td
(total)Tj
-25.0655 -1.1835 Td
(score)Tj
/F12 1 Tf
2.6575 0 Td
()Tj
/F0 1 Tf
(60.)Tj
26.5466 13.0608 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1906 Td
(summary)Tj
4.089 0 Td
(/mut-scores)Tj
5.2016 0 Td
(/NRTI/)Tj
0 g
-9.2906 -1.1835 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1905 Td
(summary)Tj
4.089 0 Td
(/mut-scores)Tj
5.2016 0 Td
(/NNRTI/)Tj
0 g
-9.2906 -1.1835 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1906 Td
(summary)Tj
4.089 0 Td
(/mut-scores)Tj
5.2016 0 Td
(/PI/)Tj
0 g
-9.2906 -1.1905 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1835 Td
(summary)Tj
4.089 0 Td
(/mut-scores)Tj
5.2016 0 Td
(/INSTI/)Tj
0 g
/F2 1 Tf
-38.4947 -6.3142 Td
(Mutation)Tj
4.3937 0 Td
(Pattern)Tj
3.6567 0 Td
(Scores:)Tj
/F0 1 Tf
3.8764 0 Td
(A)Tj
0.8929 0 Td
(list)Tj
1.4457 0 Td
(of)Tj
1.0559 0 Td
(the)Tj
1.6158 0 Td
(calculat)Tj
3.3591 0 Td
(ed)Tj
1.3323 0 Td
(summed)Tj
4.0394 0 Td
(DRM)Tj
-25.6679 -1.1906 Td
(penalty)Tj
3.4299 0 Td
(scores)Tj
3.1536 0 Td
(for)Tj
1.396 0 Td
(each)Tj
2.3812 0 Td
(of)Tj
1.0559 0 Td
(the)Tj
1.6157 0 Td
(distinct)Tj
3.3237 0 Td
(DRM)Tj
2.4945 0 Td
(pattern)Tj
3.0898 0 Td
(s)Tj
0.7299 0 Td
(present)Tj
3.5433 0 Td
(in)Tj
-26.2135 -1.1834 Td
(HIVDB)Tj
3.274 0 Td
(sequen)Tj
3.2457 0 Td
(ces.)Tj
22.6844 2.374 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1906 Td
(summary)Tj
4.089 0 Td
(/pattern-score)Tj
6.1371 0 Td
(s/NRTI/)Tj
0 g
-10.2261 -1.1834 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1906 Td
(summary)Tj
4.089 0 Td
(/pattern-score)Tj
6.1371 0 Td
(s/NNRTI/)Tj
0 g
-10.2261 -1.1835 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1905 Td
(summary)Tj
4.089 0 Td
(/pattern-score)Tj
6.1371 0 Td
(s/PI/)Tj
0 g
-10.2261 -1.1835 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1906 Td
(summary)Tj
4.089 0 Td
(/pattern-score)Tj
6.1371 0 Td
(s/INSTI/)Tj
0 g
/F2 1 Tf
-39.4302 -1.559 Td
(Mutation)Tj
4.3937 0 Td
(Classifi)Tj
3.5362 0 Td
(cations:)Tj
/F0 1 Tf
4.0536 0 Td
(\(i\))Tj
1.1126 0 Td
(PR)Tj
1.6087 0 Td
(mutations)Tj
4.5425 0 Td
(were)Tj
2.3812 0 Td
(classified)Tj
4.3087 0 Td
(as)Tj
-25.9372 -1.1906 Td
(Major,)Tj
3.6567 0 Td
(Access)Tj
3.5362 0 Td
(ory,)Tj
2.2252 0 Td
(or)Tj
1.1126 0 Td
(Other;)Tj
3.3379 0 Td
(\(ii\))Tj
1.3323 0 Td
(RT)Tj
1.559 0 Td
(mutation)Tj
3.8056 0 Td
(s)Tj
0.7299 0 Td
(were)Tj
2.3811 0 Td
(classified)Tj
-23.6765 -1.1906 Td
(as)Tj
1.2756 0 Td
(NRTI,)Tj
3.5008 0 Td
(`NNRTI,)Tj
4.1031 0 Td
(or)Tj
1.1127 0 Td
(Other;)Tj
3.6708 0 Td
(and)Tj
1.878 0 Td
(\(iii\))Tj
1.552 0 Td
(IN)Tj
1.226 0 Td
(Mutations)Tj
4.5355 0 Td
(were)Tj
-22.8545 -1.1834 Td
(classified)Tj
4.3086 0 Td
(as)Tj
1.2827 0 Td
(Major,)Tj
3.6568 0 Td
(Access)Tj
3.5362 0 Td
(ory,)Tj
2.2252 0 Td
(or)Tj
1.1126 0 Td
(Other.)Tj
13.082 3.5646 Td
(In)Tj
1.063 0 Td
(the)Tj
1.6087 0 Td
(comment)Tj
4.089 0 Td
(s)Tj
0.7299 0 Td
(sections)Tj
3.8764 0 Td
(\(below\))Tj
/F2 1 Tf
-40.5711 -5.1308 Td
(Mutation)Tj
4.3937 0 Td
(Comm)Tj
3.0898 0 Td
(ents:)Tj
/F0 1 Tf
2.6079 0 Td
(For)Tj
1.7291 0 Td
(each)Tj
2.3811 0 Td
(ARV)Tj
2.2749 0 Td
(class,)Tj
2.7708 0 Td
(there)Tj
2.4946 0 Td
(was)Tj
1.9984 0 Td
(a)Tj
-23.7403 -1.1835 Td
(comment)Tj
4.3228 0 Td
(for)Tj
1.389 0 Td
(each)Tj
2.3811 0 Td
(mutation)Tj
4.0394 0 Td
(with)Tj
1.9985 0 Td
(a)Tj
0.7795 0 Td
(penalty)Tj
3.43 0 Td
(score)Tj
2.6575 0 Td
(and)Tj
1.8779 0 Td
(for)Tj
1.3961 0 Td
(several)Tj
-24.2718 -1.1905 Td
(mutations)Tj
4.5354 0 Td
(without)Tj
3.3804 0 Td
(mutation)Tj
4.0394 0 Td
(penalty)Tj
3.4299 0 Td
(scores,)Tj
3.437 0 Td
(which)Tj
2.7638 0 Td
(were)Tj
2.3812 0 Td
(once)Tj
-23.9671 -1.1835 Td
(considere)Tj
4.2945 0 Td
(d)Tj
0.7866 0 Td
(to)Tj
1.0559 0 Td
(be)Tj
1.3323 0 Td
(associated)Tj
4.9748 0 Td
(resistance.)Tj
16.76 3.5575 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1835 Td
(summary)Tj
4.089 0 Td
(/comments/)Tj
5.152 0 Td
(NRTI/)Tj
0 g
-9.241 -1.1905 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1835 Td
(summary)Tj
4.089 0 Td
(/comments/)Tj
5.152 0 Td
(NNRTI/)Tj
0 g
-9.241 -1.1906 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1834 Td
(summary)Tj
4.089 0 Td
(/comments/)Tj
5.152 0 Td
(PI/)Tj
0 g
-9.241 -1.1906 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1906 Td
(summary)Tj
4.089 0 Td
(/comments/)Tj
5.152 0 Td
(INSTI/)Tj
0 g
/F2 1 Tf
-38.4451 -1.559 Td
(Mutation)Tj
4.3937 0 Td
(Notes:)Tj
/F0 1 Tf
3.3236 0 Td
(For)Tj
1.7221 0 Td
(each)Tj
2.3811 0 Td
(ARV)Tj
2.2748 0 Td
(class,)Tj
2.778 0 Td
(there)Tj
2.4945 0 Td
(was)Tj
1.9914 0 Td
(an)Tj
1.3323 0 Td
(HTML)Tj
2.9409 0 Td
(page)Tj
-25.6324 -1.1906 Td
(containing)Tj
4.748 0 Td
(a)Tj
0.7796 0 Td
(summary)Tj
4.3228 0 Td
(of)Tj
1.0559 0 Td
(the)Tj
1.6158 0 Td
(DRMs)Tj
2.9906 0 Td
(associated)Tj
4.9748 0 Td
(with)Tj
1.9914 0 Td
(that)Tj
1.8921 0 Td
(class.)Tj
4.8331 1.1906 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1906 Td
(summary)Tj
4.089 0 Td
(/resistance-n)Tj
5.6906 0 Td
(otes/NRTI/)Tj
0 g
-9.7796 -1.1835 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1905 Td
(summary)Tj
4.089 0 Td
(/resistance-n)Tj
5.6906 0 Td
(otes/NNR)Tj
4.3087 0 Td
(TI/)Tj
0 g
-14.0883 -1.1835 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1906 Td
(summary)Tj
4.089 0 Td
(/resistance-n)Tj
5.6906 0 Td
(otes/PI/)Tj
0 g
-9.7796 -1.1905 Td
()Tj
0.83 0.64 0.02 0 k
0.5811 0 Td
(https://hiv)Tj
4.2662 0 Td
(db.stanford)Tj
4.9748 0 Td
(.edu/dr-)Tj
-9.8221 -1.1835 Td
(summary)Tj
4.089 0 Td
(/resistance-n)Tj
5.6906 0 Td
(otes/INSTI/)Tj
0 g
-38.9837 -2.3457 Td
(ARV:)Tj
2.5512 0 Td
(antiretrovira)Tj
5.2441 0 Td
(l;)Tj
0.7299 0 Td
(DRM:)Tj
2.778 0 Td
(drug)Tj
2.211 0 Td
(resistance)Tj
4.7552 0 Td
(mutation;)Tj
4.3229 0 Td
(NRTI:)Tj
2.8346 0 Td
(nucleoside)Tj
4.9678 0 Td
(RT)Tj
1.559 0 Td
(inhibitor;)Tj
3.9757 0 Td
(NNRTI:)Tj
3.5575 0 Td
(nonnuc)Tj
3.2457 0 Td
(leoside)Tj
-42.7326 -1.5023 Td
(RT)Tj
1.559 0 Td
(inhibitor;)Tj
3.9756 0 Td
(PI:)Tj
1.4599 0 Td
(protease)Tj
4.089 0 Td
(inhibitor;)Tj
3.9827 0 Td
(INSTI:)Tj
3.0615 0 Td
(integrase)Tj
4.3086 0 Td
(strand)Tj
2.9977 0 Td
(transfer)Tj
3.6 0 Td
(inhibitor)Tj
0.83 0.64 0.02 0 k
/F8 1 Tf
-0.025 Tc
-29.034 -2.2465 Td
(https://d)Tj
3.0827 0 Td
(oi.org/10.1371/j)Tj
5.9173 0 Td
(ournal.pon)Tj
3.9827 0 Td
(e.0181357.t00)Tj
5.3859 0 Td
(2)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 420.8314 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(HIV-1)Tj
2.7354 0 Td
(genotypic)Tj
4.4221 0 Td
(resistance)Tj
4.6984 0 Td
(test)Tj
1.8142 0 Td
(interpreta)Tj
4.1387 0 Td
(tion)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01813)Tj
4.089 0 Td
(57)Tj
0 g
2.0906 0 Td
(July)Tj
1.9701 0 Td
(28,)Tj
1.5874 0 Td
(2017)Tj
35.3483 0 Td
(4)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
118 0 obj
<>stream
endstream
endobj
119 0 obj
<>stream
endstream
endobj
120 0 obj
<>stream
BT
66.402 0 Td
(31)Tj
ET
Q
endstream
endobj
121 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 122 0 R/Contents 123 0 R/TrimBox[0 0 612 792]>>
endobj
122 0 obj
[124 0 R 125 0 R 126 0 R 127 0 R]
endobj
124 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.s001)>>
endobj
125 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.t002)>>
endobj
126 0 obj
<>/Border[0 0 0]/A 128 0 R>>
endobj
128 0 obj
<>
endobj
127 0 obj
<>/Border[0 0 0]/A 129 0 R>>
endobj
129 0 obj
<>
endobj
123 0 obj
[130 0 R 131 0 R 132 0 R 133 0 R 134 0 R]
endobj
130 0 obj
<>stream
q
0.83 0.64 0.02 0 k
400.989 667.3323 m
427.3512 667.3323 l
h
f*
203.4142 251.1496 m
232.5543 251.1496 l
h
f*
242.1921 186.1228 m
570.5575 186.1228 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(pattern-ARV)Tj
5.4594 0 Td
(combinations)Tj
5.709 0 Td
(\(13)Tj
1.5137 0 Td
(patterns)Tj
3.4696 0 Td
(x)Tj
0.6859 0 Td
(4)Tj
0.6974 0 Td
(NRTIs\),)Tj
3.4525 0 Td
(27)Tj
1.1736 0 Td
(NNRTI)Tj
3.2655 0 Td
(DRM)Tj
2.4718 0 Td
(pattern-ARV)Tj
5.4595 0 Td
(combina-)Tj
-33.3579 -1.3039 Td
(tions)Tj
2.1996 0 Td
(\(9)Tj
1.0375 0 Td
(patterns)Tj
3.4696 0 Td
(x)Tj
0.686 0 Td
(3)Tj
0.6973 0 Td
(NNRTIs\),)Tj
4.1896 0 Td
(39)Tj
1.1735 0 Td
(PI)Tj
1.1168 0 Td
(DRM)Tj
2.4718 0 Td
(pattern-ARV)Tj
5.4652 0 Td
(combinations)Tj
5.7033 0 Td
(\(13)Tj
1.5137 0 Td
(patterns)Tj
3.4752 0 Td
(x)Tj
0.6803 0 Td
(3)Tj
0.6973 0 Td
(PIs\))Tj
-34.5767 -1.2982 Td
(and)Tj
1.7291 0 Td
(42)Tj
1.1735 0 Td
(INSTI)Tj
2.7213 0 Td
(DRM)Tj
2.4717 0 Td
(pattern-ARV)Tj
5.4595 0 Td
(combinations)Tj
5.709 0 Td
(\(14)Tj
1.5137 0 Td
(patterns)Tj
3.4696 0 Td
(x)Tj
0.6859 0 Td
(3)Tj
0.6974 0 Td
(INSTIs\).)Tj
3.6453 0 Td
(Feedback)Tj
3.9855 0 Td
(was)Tj
1.7007 0 Td
(solic-)Tj
-34.9622 -1.2983 Td
(ited)Tj
1.7347 0 Td
(through)Tj
3.4469 0 Td
(the)Tj
1.4684 0 Td
(distribution)Tj
4.9663 0 Td
(of)Tj
1.0148 0 Td
(blank)Tj
2.4547 0 Td
(worksheets)Tj
4.6715 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(S1)Tj
1.5137 0 Td
(File)Tj
0 g
(\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 633.2031 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(DRM)Tj
2.4756 0 Td
(patterns:)Tj
4.0724 0 Td
(Selection)Tj
4.2804 0 Td
(and)Tj
1.8661 0 Td
(analysis)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 616.1952 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(DRM)Tj
2.4718 0 Td
(patterns)Tj
3.4696 0 Td
(were)Tj
2.1259 0 Td
(selected)Tj
3.3449 0 Td
(to)Tj
1.0261 0 Td
(reflect)Tj
2.6929 0 Td
(several)Tj
2.9367 0 Td
(challenges)Tj
4.32 0 Td
(in)Tj
1.0375 0 Td
(GRT)Tj
2.1656 0 Td
(interpretation:)Tj
6.0208 0 Td
(\(i\))Tj
1.1678 0 Td
(The)Tj
-34.5597 -1.2982 Td
(extent)Tj
2.6758 0 Td
(to)Tj
1.0262 0 Td
(which)Tj
2.6475 0 Td
(the)Tj
1.474 0 Td
(most)Tj
2.2054 0 Td
(commonly)Tj
4.5467 0 Td
(occurring)Tj
4.1216 0 Td
(TDF-associated)Tj
6.4856 0 Td
(DRMs)Tj
2.8289 0 Td
(are)Tj
1.4514 0 Td
(likely)Tj
2.3527 0 Td
(to)Tj
1.0261 0 Td
(interfere)Tj
-32.8419 -1.3039 Td
(with)Tj
1.9899 0 Td
(the)Tj
1.457 0 Td
(success)Tj
3.0954 0 Td
(of)Tj
1.0034 0 Td
(TDF-containing)Tj
6.7464 0 Td
(regimens;)Tj
4.1159 0 Td
(\(ii\))Tj
1.4287 0 Td
(The)Tj
1.7745 0 Td
(clinical)Tj
3.067 0 Td
(significance)Tj
4.9266 0 Td
(of)Tj
1.0091 0 Td
(thymidine)Tj
4.3483 0 Td
(analog)Tj
-34.9622 -1.2983 Td
(mutations)Tj
4.2802 0 Td
(\(TAMs\))Tj
3.4469 0 Td
(for)Tj
1.389 0 Td
(TDF,)Tj
2.3187 0 Td
(ABC,)Tj
2.3755 0 Td
(and)Tj
1.7291 0 Td
(cytosine-analog)Tj
6.4913 0 Td
(\(3TC)Tj
2.3074 0 Td
(and)Tj
1.7291 0 Td
(FTC\)-containing)Tj
7.0242 0 Td
(regimens;)Tj
-33.0914 -1.2983 Td
(\(iii\))Tj
1.7007 0 Td
(The)Tj
1.7802 0 Td
(DRM)Tj
2.4718 0 Td
(patterns)Tj
3.4752 0 Td
(associated)Tj
4.252 0 Td
(with)Tj
2.0012 0 Td
(high-level)Tj
4.1499 0 Td
(resistance)Tj
4.1329 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(ARVs)Tj
2.5795 0 Td
(with)Tj
2.0012 0 Td
(the)Tj
1.4684 0 Td
(highest)Tj
-32.5075 -1.2982 Td
(genetic)Tj
3.067 0 Td
(barrier)Tj
2.965 0 Td
(to)Tj
1.0262 0 Td
(resistance)Tj
4.1329 0 Td
(\(DTG)Tj
2.6248 0 Td
(and)Tj
1.7291 0 Td
(pharmacologically)Tj
7.5458 0 Td
(boosted)Tj
3.3506 0 Td
(DRV)Tj
2.2733 0 Td
(and)Tj
1.7292 0 Td
(LPV\);)Tj
2.5738 0 Td
(and)Tj
1.7348 0 Td
(\(iv\))Tj
-34.7525 -1.3039 Td
(The)Tj
1.7801 0 Td
(extent)Tj
2.6759 0 Td
(to)Tj
1.0261 0 Td
(which)Tj
2.6532 0 Td
(certain)Tj
2.9877 0 Td
(polymorphic)Tj
5.3745 0 Td
(DRMs)Tj
2.8346 0 Td
(\(i.e.,)Tj
1.9276 0 Td
(DRMs)Tj
2.8289 0 Td
(that)Tj
1.7802 0 Td
(are)Tj
1.4456 0 Td
(selected)Tj
3.3506 0 Td
(by)Tj
1.1792 0 Td
(ARV)Tj
2.2223 0 Td
(therapy)Tj
-34.0665 -1.2983 Td
(but)Tj
1.5533 0 Td
(that)Tj
1.7745 0 Td
(also)Tj
1.7688 0 Td
(occur)Tj
2.4718 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(absence)Tj
3.3449 0 Td
(of)Tj
1.0148 0 Td
(therapy\))Tj
3.5829 0 Td
(might)Tj
2.6022 0 Td
(interfere)Tj
3.634 0 Td
(with)Tj
1.9956 0 Td
(success)Tj
3.1011 0 Td
(of)Tj
1.0148 0 Td
(NNRTI-)Tj
3.617 0 Td
(and)Tj
-33.9815 -1.2983 Td
(INSTI-containing)Tj
7.3813 0 Td
(regimens.)Tj
-6.1851 -1.3039 Td
(The)Tj
1.7858 0 Td
(expert)Tj
2.7156 0 Td
(panel)Tj
2.3924 0 Td
(members)Tj
3.9458 0 Td
(were)Tj
2.1203 0 Td
(asked)Tj
2.4661 0 Td
(to)Tj
1.0261 0 Td
(assign)Tj
2.6533 0 Td
(interpretations)Tj
6.1568 0 Td
(of)Tj
1.0148 0 Td
(susceptible,)Tj
4.8018 0 Td
(potential)Tj
-32.275 -1.2983 Td
(low-level)Tj
3.7984 0 Td
(resistance,)Tj
4.3596 0 Td
(low-level)Tj
3.8041 0 Td
(resistance,)Tj
4.354 0 Td
(intermediate)Tj
5.3234 0 Td
(resistance,)Tj
4.3597 0 Td
(or)Tj
1.0941 0 Td
(high-level)Tj
4.1556 0 Td
(resistance)Tj
4.1329 0 Td
(to)Tj
-35.3818 -1.2982 Td
(five)Tj
1.6497 0 Td
(NRTIs)Tj
2.8913 0 Td
(\(3TC,)Tj
2.5342 0 Td
(ABC,)Tj
2.3754 0 Td
(AZT,)Tj
2.3414 0 Td
(FTC,)Tj
2.245 0 Td
(and)Tj
1.7348 0 Td
(TDF\),)Tj
2.6589 0 Td
(three)Tj
2.262 0 Td
(NNRTIs)Tj
3.6284 0 Td
(\(EFV,)Tj
2.5795 0 Td
(RPV,)Tj
2.3187 0 Td
(and)Tj
1.7291 0 Td
(ETR\),)Tj
2.5909 0 Td
(three)Tj
2.262 0 Td
(PIs)Tj
-35.8013 -1.3039 Td
(\(ATV/r,)Tj
3.4752 0 Td
(DRV/r,)Tj
3.1975 0 Td
(and)Tj
1.7291 0 Td
(LPV/r\),)Tj
3.2825 0 Td
(and)Tj
1.7291 0 Td
(three)Tj
2.262 0 Td
(INSTIs)Tj
3.0841 0 Td
(\(DTG,)Tj
2.8517 0 Td
(EVG,)Tj
2.4207 0 Td
(and)Tj
1.7348 0 Td
(RAL\).)Tj
2.6249 0 Td
(The)Tj
1.7858 0 Td
(cytosine)Tj
3.5036 0 Td
(analogs)Tj
-33.681 -1.2983 Td
(3TC)Tj
1.9672 0 Td
(and)Tj
1.7291 0 Td
(FTC)Tj
2.0239 0 Td
(were)Tj
2.126 0 Td
(considered)Tj
4.5978 0 Td
(by)Tj
1.1848 0 Td
(each)Tj
2.024 0 Td
(expert)Tj
2.7212 0 Td
(to)Tj
1.0261 0 Td
(have)Tj
2.058 0 Td
(similar)Tj
2.9877 0 Td
(drug-resistance)Tj
6.3722 0 Td
(interpretations)Tj
-30.818 -1.2983 Td
(and)Tj
1.7291 0 Td
(are)Tj
1.4513 0 Td
(henceforth)Tj
4.5581 0 Td
(referred)Tj
3.4185 0 Td
(to)Tj
1.0262 0 Td
(as)Tj
1.0148 0 Td
(3FTC.)Tj
2.7212 0 Td
(ATV,)Tj
2.4378 0 Td
(DRV,)Tj
2.4945 0 Td
(and)Tj
1.7348 0 Td
(LPV)Tj
2.0069 0 Td
(were)Tj
2.126 0 Td
(each)Tj
2.0295 0 Td
(considered)Tj
4.5978 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
-34.3726 -1.3039 Td
(pharmacologically)Tj
7.5457 0 Td
(boosted)Tj
3.3506 0 Td
(by)Tj
1.1792 0 Td
(either)Tj
2.5341 0 Td
(ritonavir)Tj
3.7361 0 Td
(or)Tj
1.0998 0 Td
(cobicistat.)Tj
-18.2493 -1.2982 Td
(Expert)Tj
2.8686 0 Td
(panel)Tj
2.3868 0 Td
(members)Tj
3.9458 0 Td
(were)Tj
2.1259 0 Td
(instructed)Tj
4.2633 0 Td
(to)Tj
1.0262 0 Td
(leave)Tj
2.2053 0 Td
(an)Tj
1.2019 0 Td
(ARV)Tj
2.2167 0 Td
(interpretation)Tj
5.7939 0 Td
(for)Tj
1.389 0 Td
(a)Tj
0.652 0 Td
(DRM)Tj
2.4718 0 Td
(pattern)Tj
-33.7434 -1.2983 Td
(blank)Tj
2.4491 0 Td
(if)Tj
0.7767 0 Td
(they)Tj
1.9218 0 Td
(were)Tj
2.126 0 Td
(uncertain)Tj
4.0592 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(pattern's)Tj
3.685 0 Td
(effect)Tj
2.3641 0 Td
(on)Tj
1.2756 0 Td
(that)Tj
1.7801 0 Td
(ARV.)Tj
2.4435 0 Td
(Each)Tj
2.177 0 Td
(panel)Tj
2.3867 0 Td
(member's)Tj
4.1613 0 Td
(scores)Tj
-34.0949 -1.2983 Td
(were)Tj
2.1203 0 Td
(anonymous)Tj
4.9265 0 Td
(to)Tj
1.0262 0 Td
(all)Tj
1.1452 0 Td
(but)Tj
1.5533 0 Td
(RP,)Tj
1.6271 0 Td
(JMS,)Tj
2.143 0 Td
(and)Tj
1.7291 0 Td
(RWS.)Tj
2.5115 0 Td
(After)Tj
2.2847 0 Td
(all)Tj
1.1452 0 Td
(interpretations)Tj
6.1568 0 Td
(were)Tj
2.1203 0 Td
(submitted,)Tj
4.4787 0 Td
(those)Tj
-34.9679 -1.3039 Td
(who)Tj
1.9388 0 Td
(provided)Tj
3.8154 0 Td
(an)Tj
1.2019 0 Td
(outlier)Tj
2.863 0 Td
(interpretationdefined)Tj
9.3146 0 Td
(as)Tj
1.0148 0 Td
(differing)Tj
3.668 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4684 0 Td
(median)Tj
3.2428 0 Td
(interpretation)Tj
5.794 0 Td
(by)Tj
-36.527 -1.2983 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0295 0 Td
(one)Tj
1.6952 0 Td
(levelwere)Tj
4.4333 0 Td
(asked)Tj
2.4661 0 Td
(to)Tj
1.0262 0 Td
(review)Tj
2.8403 0 Td
(their)Tj
2.1089 0 Td
(interpretation)Tj
5.794 0 Td
(to)Tj
1.0261 0 Td
(exclude)Tj
3.2599 0 Td
(the)Tj
1.4683 0 Td
(possibility)Tj
4.2746 0 Td
(that)Tj
-34.7638 -1.2982 Td
(the)Tj
1.4683 0 Td
(submitted)Tj
4.2519 0 Td
(result)Tj
2.4491 0 Td
(was)Tj
1.6952 0 Td
(an)Tj
1.2018 0 Td
(error.)Tj
-9.8701 -1.3039 Td
(For)Tj
1.627 0 Td
(each)Tj
2.0296 0 Td
(DRM)Tj
2.4718 0 Td
(pattern-ARV)Tj
5.4595 0 Td
(combination,)Tj
5.5729 0 Td
(consistency)Tj
4.8359 0 Td
(among)Tj
2.999 0 Td
(panel)Tj
2.3868 0 Td
(members)Tj
3.9458 0 Td
(was)Tj
1.7007 0 Td
(assessed)Tj
-34.2252 -1.2983 Td
(using)Tj
2.3867 0 Td
(the)Tj
1.4683 0 Td
(mean)Tj
2.4492 0 Td
(absolute)Tj
3.5262 0 Td
(deviation)Tj
3.9458 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(median)Tj
3.2428 0 Td
(expert)Tj
2.7213 0 Td
(level.)Tj
2.2393 0 Td
(All)Tj
1.3947 0 Td
(differences)Tj
4.5637 0 Td
(between)Tj
-31.6117 -1.2983 Td
(HIVDB)Tj
3.3335 0 Td
(7.0)Tj
1.3889 0 Td
(and)Tj
1.7235 0 Td
(the)Tj
1.4627 0 Td
(median)Tj
3.2371 0 Td
(expert)Tj
2.7099 0 Td
(panel)Tj
2.3868 0 Td
(level)Tj
2.0069 0 Td
(were)Tj
2.1146 0 Td
(reviewed)Tj
3.7927 0 Td
(by)Tj
1.1736 0 Td
(RP,)Tj
1.6214 0 Td
(JMS,)Tj
2.1373 0 Td
(and)Tj
1.7235 0 Td
(RWS.)Tj
2.5001 0 Td
(The)Tj
1.7745 0 Td
(effects)Tj
-35.087 -1.3039 Td
(of)Tj
1.0147 0 Td
(proposed)Tj
3.9515 0 Td
(HIVDB)Tj
3.3392 0 Td
(scoring)Tj
3.1635 0 Td
(changes)Tj
3.4015 0 Td
(were)Tj
2.1203 0 Td
(evaluated)Tj
3.9912 0 Td
(by)Tj
1.1848 0 Td
(re-interpreting)Tj
6.1625 0 Td
(the)Tj
1.4684 0 Td
(complete)Tj
3.8834 0 Td
(set)Tj
1.2983 0 Td
(of)Tj
1.0148 0 Td
(dis-)Tj
-35.9941 -1.2983 Td
(tinct)Tj
2.0522 0 Td
(DRM)Tj
2.4718 0 Td
(patterns)Tj
3.4753 0 Td
(in)Tj
1.0318 0 Td
(HIVDB)Tj
3.3392 0 Td
(using)Tj
2.3924 0 Td
(the)Tj
1.4683 0 Td
(updated)Tj
3.4753 0 Td
(scores.)Tj
2.8913 0 Td
(This)Tj
1.9899 0 Td
(process)Tj
3.1861 0 Td
(generated)Tj
4.1329 0 Td
(tables)Tj
2.4888 0 Td
(for)Tj
1.389 0 Td
(each)Tj
-35.7843 -1.2982 Td
(ARV)Tj
2.2166 0 Td
(class)Tj
2.0466 0 Td
(that)Tj
1.7802 0 Td
(were)Tj
2.1203 0 Td
(identical)Tj
3.6566 0 Td
(in)Tj
1.0375 0 Td
(format)Tj
2.9367 0 Td
(to)Tj
1.0261 0 Td
(those)Tj
2.3358 0 Td
(on)Tj
1.2755 0 Td
(the)Tj
1.4684 0 Td
(four)Tj
1.9162 0 Td
(Mutation)Tj
3.9968 0 Td
(Pattern)Tj
3.1521 0 Td
(Scores)Tj
2.778 0 Td
(pages)Tj
-33.7434 -1.2983 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7779 0 Td
(2)Tj
0 g
(\).)Tj
1.2642 0 Td
(DRM)Tj
2.4718 0 Td
(patterns)Tj
3.4696 0 Td
(influenced)Tj
4.4447 0 Td
(by)Tj
1.1849 0 Td
(a)Tj
0.6519 0 Td
(scoring)Tj
3.1635 0 Td
(change)Tj
3.0444 0 Td
(\(i.e.,)Tj
1.9219 0 Td
(a)Tj
0.6576 0 Td
(scoring)Tj
3.1634 0 Td
(change)Tj
3.0388 0 Td
(that)Tj
1.7801 0 Td
(resulted)Tj
3.4016 0 Td
(in)Tj
-36.4363 -1.3039 Td
(a)Tj
0.6519 0 Td
(changed)Tj
3.5716 0 Td
(resistance)Tj
4.1329 0 Td
(level\))Tj
2.3528 0 Td
(were)Tj
2.1203 0 Td
(sorted)Tj
2.7099 0 Td
(by)Tj
1.1849 0 Td
(their)Tj
2.1032 0 Td
(frequency.)Tj
4.4164 0 Td
(The)Tj
1.7801 0 Td
(updated)Tj
3.4753 0 Td
(scoring)Tj
3.1634 0 Td
(system)Tj
2.9424 0 Td
(was)Tj
-34.6051 -1.2983 Td
(called)Tj
2.5171 0 Td
(HIVDB)Tj
3.3392 0 Td
(version)Tj
3.1578 0 Td
(8.1)Tj
1.3946 0 Td
(because)Tj
3.3165 0 Td
(it)Tj
0.788 0 Td
(replaced)Tj
3.5887 0 Td
(the)Tj
1.4683 0 Td
(interim)Tj
3.2145 0 Td
(version)Tj
3.1521 0 Td
(HIVDB)Tj
3.3392 0 Td
(8.0)Tj
1.4003 0 Td
(completed)Tj
4.405 0 Td
(in)Tj
-35.0813 -1.2982 Td
(June)Tj
2.0466 0 Td
(2016.)Tj
2.347 0 Td
(HIVDB)Tj
3.3392 0 Td
(8.1)Tj
1.4003 0 Td
(was)Tj
1.6951 0 Td
(released)Tj
3.4299 0 Td
(online)Tj
2.761 0 Td
(September)Tj
4.4843 0 Td
(19,)Tj
1.3947 0 Td
(2016.)Tj
2.347 0 Td
(Each)Tj
2.177 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(HIVDB)Tj
3.3392 0 Td
(8.1)Tj
1.3946 0 Td
(scores)Tj
-34.6391 -1.3039 Td
(and)Tj
1.7291 0 Td
(each)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(changes)Tj
3.4016 0 Td
(between)Tj
3.5319 0 Td
(HIVDB)Tj
3.3392 0 Td
(7.0)Tj
1.3946 0 Td
(and)Tj
1.7292 0 Td
(8.1)Tj
1.4003 0 Td
(are)Tj
1.4456 0 Td
(available)Tj
3.668 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(supplementary)Tj
6.1625 0 Td
(mate-)Tj
-34.8205 -1.2983 Td
(rial)Tj
1.5363 0 Td
(and)Tj
1.7291 0 Td
(at)Tj
0.83 0.64 0.02 0 k
0.9525 0 Td
(https://hivdb.stanfor)Tj
8.2091 0 Td
(d.edu/page/version-updates/)Tj
11.4348 0 Td
(#version.8.1.1.update.2016-09-15)Tj
0 g
(.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 151.9937 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Relative)Tj
3.7842 0 Td
(ARV)Tj
2.2583 0 Td
(susceptibility)Tj
5.8158 0 Td
(profiles)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 134.9858 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(For)Tj
1.627 0 Td
(each)Tj
2.024 0 Td
(ARV)Tj
2.2223 0 Td
(class,)Tj
2.2734 0 Td
(we)Tj
1.3266 0 Td
(tabulated)Tj
3.9174 0 Td
(the)Tj
1.4684 0 Td
(proportion)Tj
4.6318 0 Td
(of)Tj
1.0147 0 Td
(viruses)Tj
2.9877 0 Td
(in)Tj
1.0318 0 Td
(HIVDB)Tj
3.3392 0 Td
(with)Tj
2.0013 0 Td
(each)Tj
2.0239 0 Td
(distinct)Tj
3.2145 0 Td
(pat-)Tj
-35.104 -1.2982 Td
(tern)Tj
1.8595 0 Td
(of)Tj
1.0148 0 Td
(DRMs)Tj
2.8346 0 Td
(for)Tj
1.3833 0 Td
(that)Tj
1.7801 0 Td
(class.)Tj
2.2677 0 Td
(We)Tj
1.6101 0 Td
(then)Tj
2.0183 0 Td
(determined)Tj
4.8528 0 Td
(the)Tj
1.4684 0 Td
(HIVDB)Tj
3.3392 0 Td
(8.1)Tj
1.3946 0 Td
(resistance)Tj
4.1329 0 Td
(interpretation)Tj
5.794 0 Td
(for)Tj
-35.7503 -1.2983 Td
(the)Tj
1.4683 0 Td
(NRTIs)Tj
2.8913 0 Td
(3TC,)Tj
2.194 0 Td
(ABC,)Tj
2.3754 0 Td
(AZT,)Tj
2.3414 0 Td
(FTC,)Tj
2.2451 0 Td
(and)Tj
1.7291 0 Td
(TDF)Tj
2.0976 0 Td
(for)Tj
1.3833 0 Td
(each)Tj
2.0296 0 Td
(NRTI)Tj
2.5285 0 Td
(DRM)Tj
2.4718 0 Td
(pattern;)Tj
3.3392 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4683 0 Td
(NNRTIs)Tj
3.6283 0 Td
(EFV,)Tj
-35.5745 -1.3039 Td
(ETR,)Tj
2.245 0 Td
(and)Tj
1.7291 0 Td
(RPV)Tj
2.0976 0 Td
(for)Tj
1.389 0 Td
(each)Tj
2.0239 0 Td
(NNRTI)Tj
3.2655 0 Td
(DRM)Tj
2.4718 0 Td
(pattern;)Tj
3.3392 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4683 0 Td
(PIs)Tj
1.4797 0 Td
(ATV/r,)Tj
3.1408 0 Td
(DRV/r,)Tj
3.1974 0 Td
(and)Tj
1.7292 0 Td
(LPV/r)Tj
2.7155 0 Td
(for)Tj
1.3833 0 Td
(each)Tj
-35.0586 -1.2983 Td
(PI)Tj
1.1168 0 Td
(DRM)Tj
2.4718 0 Td
(pattern;)Tj
3.3392 0 Td
(and)Tj
1.7291 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4683 0 Td
(INSTIs)Tj
3.0841 0 Td
(DTG,)Tj
2.5115 0 Td
(EVG,)Tj
2.4264 0 Td
(and)Tj
1.7292 0 Td
(RAL)Tj
2.0636 0 Td
(for)Tj
1.3833 0 Td
(each)Tj
2.0296 0 Td
(INSTI)Tj
2.7269 0 Td
(DRM)Tj
2.4661 0 Td
(pattern.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 420.8314 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(HIV-1)Tj
2.7354 0 Td
(genotypic)Tj
4.4221 0 Td
(resistance)Tj
4.6984 0 Td
(test)Tj
1.8142 0 Td
(interpreta)Tj
4.1387 0 Td
(tion)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01813)Tj
4.089 0 Td
(57)Tj
0 g
2.0906 0 Td
(July)Tj
1.9701 0 Td
(28,)Tj
1.5874 0 Td
(2017)Tj
35.3483 0 Td
(5)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
131 0 obj
<>stream
endstream
endobj
132 0 obj
<>stream
endstream
endobj
133 0 obj
<>stream
endstream
endobj
134 0 obj
<>stream
BT
66.402 0 Td
(31)Tj
ET
Q
endstream
endobj
135 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 137 0 R/Contents 138 0 R/TrimBox[0 0 612 792]>>
endobj
137 0 obj
[139 0 R 140 0 R 141 0 R 142 0 R 143 0 R 144 0 R 145 0 R 146 0 R]
endobj
139 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.ref004)>>
endobj
140 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.ref005)>>
endobj
141 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.ref006)>>
endobj
142 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.ref007)>>
endobj
143 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.ref005)>>
endobj
144 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.ref008)>>
endobj
145 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.ref013)>>
endobj
146 0 obj
<>/Border[0 0 0]/A 147 0 R>>
endobj
147 0 obj
<>
endobj
138 0 obj
[148 0 R 149 0 R 150 0 R 151 0 R 152 0 R 153 0 R 154 0 R 155 0 R 156 0 R 157 0 R]
endobj
148 0 obj
<>stream
q
0.83 0.64 0.02 0 k
290.948 403.1433 m
295.6535 403.1433 l
h
f*
300.1323 403.1433 m
304.8945 403.1433 l
h
f*
261.1276 364.1386 m
265.8898 364.1386 l
h
f*
499.2378 182.0976 m
503.8866 182.0976 l
h
f*
530.3055 156.1323 m
534.9543 156.1323 l
h
f*
539.263 156.1323 m
543.9118 156.1323 l
h
f*
548.9575 156.1323 m
558.1984 156.1323 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 211.9748 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Sequences)Tj
4.3369 0 Td
(with)Tj
1.9956 0 Td
(DRM)Tj
2.4718 0 Td
(patterns)Tj
3.4696 0 Td
(resulting)Tj
3.7304 0 Td
(in)Tj
1.0374 0 Td
(similar)Tj
2.9877 0 Td
(profiles)Tj
3.1975 0 Td
(of)Tj
1.0148 0 Td
(relative)Tj
3.1408 0 Td
(ARV)Tj
2.2223 0 Td
(susceptibility)Tj
-30.801 -1.3039 Td
(were)Tj
2.1202 0 Td
(pooled)Tj
2.9481 0 Td
(to)Tj
1.0261 0 Td
(determine)Tj
4.3256 0 Td
(the)Tj
1.4684 0 Td
(frequency)Tj
4.1895 0 Td
(of)Tj
1.0148 0 Td
(each)Tj
2.024 0 Td
(distinct)Tj
3.2144 0 Td
(cross-resistance)Tj
6.5083 0 Td
(profile)Tj
2.8403 0 Td
(within)Tj
2.812 0 Td
(each)Tj
-34.4917 -1.2982 Td
(ARV)Tj
2.2166 0 Td
(class.)Tj
2.2734 0 Td
(To)Tj
1.3379 0 Td
(reduce)Tj
2.9197 0 Td
(the)Tj
1.4683 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(potential)Tj
3.7587 0 Td
(relative)Tj
3.1408 0 Td
(susceptibility)Tj
5.4368 0 Td
(profiles)Tj
3.2031 0 Td
(\(i.e.)Tj
1.7008 0 Td
(number)Tj
-31.8895 -1.2983 Td
(ARVs)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 225.8078 672.8314 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(number)Tj
3.4847 0 Td
(of)Tj
1.081 0 Td
(ARV)Tj
2.2904 0 Td
(levels)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 293.3291 668.4094 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\))Tj
0.5612 0 Td
(from)Tj
2.2053 0 Td
(5)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 325.7574 672.8314 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(4)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 331.5401 668.4094 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\(625\))Tj
2.3243 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(NRTIs)Tj
2.8914 0 Td
(and)Tj
1.7291 0 Td
(5)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 434.3244 672.8314 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 440.0503 668.4094 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\(125\))Tj
2.33 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.474 0 Td
(NNRTIs,)Tj
3.8494 0 Td
(PIs)Tj
1.4797 0 Td
(and)Tj
-34.52 -1.2982 Td
(INSTIs)Tj
3.0841 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(more)Tj
2.3414 0 Td
(manageable)Tj
4.9549 0 Td
(number,)Tj
3.6454 0 Td
(we)Tj
1.3266 0 Td
(pooled)Tj
2.948 0 Td
(viruses)Tj
2.9877 0 Td
(with)Tj
1.9955 0 Td
(potential)Tj
3.7587 0 Td
(low-level)Tj
3.804 0 Td
(and)Tj
1.7292 0 Td
(low-)Tj
-34.2536 -1.3039 Td
(level)Tj
2.0126 0 Td
(susceptibility)Tj
5.4425 0 Td
(which)Tj
2.6475 0 Td
(resulted)Tj
3.4016 0 Td
(in)Tj
1.0318 0 Td
(4)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 350.1354 646.8661 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(4)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 355.9181 642.3874 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\(256\))Tj
2.3243 0 Td
(potential)Tj
3.7644 0 Td
(profiles)Tj
3.1975 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(NRTIs)Tj
2.8913 0 Td
(and)Tj
1.7291 0 Td
(4)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 528.3212 646.8661 cm
BT
/F5 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 534.0472 642.3874 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(\(64\))Tj
-33.4032 -1.2982 Td
(potential)Tj
3.7587 0 Td
(profiles)Tj
3.2031 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4684 0 Td
(NNRTIs,)Tj
3.8551 0 Td
(PIs,)Tj
1.7064 0 Td
(and)Tj
1.7291 0 Td
(INSTIs.)Tj
-15.9079 -1.2983 Td
(The)Tj
1.7858 0 Td
(most)Tj
2.2054 0 Td
(common)Tj
3.8437 0 Td
(relative)Tj
3.1408 0 Td
(ARV)Tj
2.2167 0 Td
(susceptibility)Tj
5.4425 0 Td
(profiles)Tj
3.2031 0 Td
(are)Tj
1.4456 0 Td
(listed)Tj
2.3471 0 Td
(in)Tj
1.0318 0 Td
(separate)Tj
3.4866 0 Td
(tables)Tj
2.4887 0 Td
(for)Tj
1.3833 0 Td
(each)Tj
-35.2173 -1.3039 Td
(ARV)Tj
2.2167 0 Td
(class)Tj
2.0466 0 Td
(in)Tj
1.0374 0 Td
(which)Tj
2.6476 0 Td
(each)Tj
2.0296 0 Td
(profile)Tj
2.8403 0 Td
(is)Tj
0.8504 0 Td
(also)Tj
1.7688 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4683 0 Td
(three)Tj
2.262 0 Td
(most)Tj
2.211 0 Td
(common)Tj
3.8438 0 Td
(DRM)Tj
2.4717 0 Td
(patterns)Tj
-33.9474 -1.2983 Td
(responsible)Tj
4.7508 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(profile.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 564.2078 cm
BT
/F13 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(In)Tj
1.0441 0 Td
(vitro)Tj
/F0 1 Tf
2.0882 0 Td
(susceptibility)Tj
5.8158 0 Td
(\(phenotype\))Tj
5.4898 0 Td
(data)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 547.2 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Following)Tj
4.2179 0 Td
(the)Tj
1.4683 0 Td
(expert)Tj
2.7213 0 Td
(panel's)Tj
2.965 0 Td
(assessments,)Tj
5.1987 0 Td
(we)Tj
1.3266 0 Td
(created)Tj
3.1237 0 Td
(tabular)Tj
3.0388 0 Td
(summaries)Tj
4.6034 0 Td
(of)Tj
1.0148 0 Td
(phenotypic)Tj
4.7055 0 Td
(data)Tj
-34.384 -1.2982 Td
(from)Tj
2.2053 0 Td
(HIVDB)Tj
3.3392 0 Td
(for)Tj
1.3833 0 Td
(each)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(NRTI,)Tj
2.7553 0 Td
(NNRTI,)Tj
3.4922 0 Td
(PI,)Tj
1.3436 0 Td
(and)Tj
1.7292 0 Td
(INSTI)Tj
2.7269 0 Td
(DRM)Tj
2.4661 0 Td
(patterns)Tj
3.4753 0 Td
(selected)Tj
3.3448 0 Td
(for)Tj
1.389 0 Td
(analysis.)Tj
-34.1629 -1.3039 Td
(Each)Tj
2.1713 0 Td
(tabular)Tj
3.0387 0 Td
(summary)Tj
4.0082 0 Td
(contained)Tj
4.2009 0 Td
(the)Tj
1.4683 0 Td
(DRM)Tj
2.4718 0 Td
(pattern,)Tj
3.3335 0 Td
(the)Tj
1.474 0 Td
(proportion)Tj
4.6318 0 Td
(of)Tj
1.0148 0 Td
(viruses)Tj
2.982 0 Td
(in)Tj
1.0375 0 Td
(HIVDB)Tj
3.3392 0 Td
(that)Tj
-35.172 -1.2983 Td
(exactly)Tj
2.965 0 Td
(matched)Tj
3.6736 0 Td
(the)Tj
1.4684 0 Td
(DRM)Tj
2.4718 0 Td
(pattern,)Tj
3.3392 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(median)Tj
3.2428 0 Td
(fold)Tj
1.7859 0 Td
(reduction)Tj
4.1158 0 Td
(in)Tj
1.0375 0 Td
(susceptibility)Tj
5.4368 0 Td
(produced)Tj
-32.7342 -1.2983 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4626 0 Td
(pattern)Tj
3.1124 0 Td
(for)Tj
1.3833 0 Td
(each)Tj
2.024 0 Td
(ARV.)Tj
2.4434 0 Td
(Exactly)Tj
3.1068 0 Td
(matching)Tj
4.0025 0 Td
(DRM)Tj
2.4661 0 Td
(patterns)Tj
3.4696 0 Td
(were)Tj
2.1203 0 Td
(defined)Tj
3.2201 0 Td
(as)Tj
1.0148 0 Td
(not)Tj
1.5704 0 Td
(having)Tj
2.914 0 Td
(addi-)Tj
-35.4895 -1.3039 Td
(tional)Tj
2.5171 0 Td
(major)Tj
2.6135 0 Td
(DRMs.)Tj
3.0558 0 Td
(For)Tj
1.627 0 Td
(the)Tj
1.4684 0 Td
(NRTIs,)Tj
3.1124 0 Td
(these)Tj
2.2564 0 Td
(included)Tj
3.7133 0 Td
(DRMs)Tj
2.829 0 Td
(at)Tj
0.9524 0 Td
(RT)Tj
1.4513 0 Td
(positions)Tj
3.8551 0 Td
(41,)Tj
1.4003 0 Td
(65,)Tj
1.3947 0 Td
(67,)Tj
1.3946 0 Td
(70,)Tj
1.4003 0 Td
(74,)Tj
-35.0416 -1.2982 Td
(115,)Tj
1.8708 0 Td
(184,)Tj
1.8709 0 Td
(210,)Tj
1.8765 0 Td
(and)Tj
1.7291 0 Td
(215.)Tj
1.8709 0 Td
(For)Tj
1.627 0 Td
(the)Tj
1.4684 0 Td
(NNRTIs,)Tj
3.8494 0 Td
(these)Tj
2.2564 0 Td
(included)Tj
3.7133 0 Td
(DRMs)Tj
2.829 0 Td
(at)Tj
0.9524 0 Td
(RT)Tj
1.4513 0 Td
(positions)Tj
3.8551 0 Td
(100,)Tj
1.8766 0 Td
(101,)Tj
1.8708 0 Td
(103,)Tj
-34.9679 -1.2983 Td
(106,)Tj
1.8708 0 Td
(181,)Tj
1.8709 0 Td
(188,)Tj
1.8765 0 Td
(190,)Tj
1.8708 0 Td
(and)Tj
1.7292 0 Td
(230.)Tj
1.8708 0 Td
(For)Tj
1.6271 0 Td
(the)Tj
1.4683 0 Td
(PIs,)Tj
1.7065 0 Td
(these)Tj
2.2563 0 Td
(included)Tj
3.7077 0 Td
(DRMs)Tj
2.8347 0 Td
(at)Tj
0.9524 0 Td
(protease)Tj
3.5546 0 Td
(positions)Tj
3.8551 0 Td
(30,)Tj
1.3946 0 Td
(32,)Tj
1.4004 0 Td
(46,)Tj
-35.8467 -1.2983 Td
(47,)Tj
1.3946 0 Td
(48,)Tj
1.3946 0 Td
(50,)Tj
1.4003 0 Td
(54,)Tj
1.3947 0 Td
(76,)Tj
1.4003 0 Td
(82,)Tj
1.3946 0 Td
(84,)Tj
1.3946 0 Td
(88,)Tj
1.4004 0 Td
(and)Tj
1.7291 0 Td
(90.)Tj
1.3946 0 Td
(For)Tj
1.6271 0 Td
(the)Tj
1.4683 0 Td
(INSTIs,)Tj
3.3109 0 Td
(these)Tj
2.2563 0 Td
(included)Tj
3.7077 0 Td
(DRMs)Tj
2.8347 0 Td
(at)Tj
0.9524 0 Td
(integrase)Tj
3.8097 0 Td
(posi-)Tj
-34.2649 -1.3039 Td
(tions)Tj
2.1996 0 Td
(66,)Tj
1.4003 0 Td
(92,)Tj
1.3947 0 Td
(118,)Tj
1.8708 0 Td
(121,)Tj
1.8709 0 Td
(138,)Tj
1.8765 0 Td
(140,)Tj
1.8709 0 Td
(143,)Tj
1.8708 0 Td
(147,)Tj
1.8709 0 Td
(148,)Tj
1.8765 0 Td
(155,)Tj
1.8708 0 Td
(and)Tj
1.7292 0 Td
(263.)Tj
-20.5057 -1.2983 Td
(For)Tj
1.627 0 Td
(the)Tj
1.4684 0 Td
(NRTI,)Tj
2.7552 0 Td
(NNRTI,)Tj
3.4923 0 Td
(and)Tj
1.7291 0 Td
(PI)Tj
1.1225 0 Td
(classes,)Tj
3.0558 0 Td
(the)Tj
1.4683 0 Td
(tables)Tj
2.4888 0 Td
(contained)Tj
4.2009 0 Td
(phenotypic)Tj
4.6998 0 Td
(data)Tj
1.9162 0 Td
(determined)Tj
4.8529 0 Td
(by)Tj
-36.0734 -1.2982 Td
(the)Tj
1.4683 0 Td
(PhenoSense)Tj
5.0173 0 Td
(assay)Tj
2.2677 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(5)Tj
0 g
(].)Tj
1.2585 0 Td
(Because)Tj
3.3959 0 Td
(fewer)Tj
2.4094 0 Td
(phenotypic)Tj
4.7055 0 Td
(data)Tj
1.9162 0 Td
(were)Tj
2.1203 0 Td
(available)Tj
3.668 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4684 0 Td
(INSTI)Tj
2.7269 0 Td
(class,)Tj
-35.0643 -1.3039 Td
(the)Tj
1.4683 0 Td
(INSTI)Tj
2.7212 0 Td
(table)Tj
2.1317 0 Td
(contained)Tj
4.1952 0 Td
(susceptibility)Tj
5.4425 0 Td
(data)Tj
1.9162 0 Td
(determined)Tj
4.8472 0 Td
(by)Tj
1.1849 0 Td
(the)Tj
1.4683 0 Td
(PhenoSense)Tj
5.0173 0 Td
(assay)Tj
2.2621 0 Td
(and)Tj
1.7348 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
-35.5689 -1.2983 Td
(ViiV)Tj
2.1429 0 Td
(HeLa-CD4)Tj
4.6091 0 Td
(reporter)Tj
3.5036 0 Td
(gene)Tj
2.0807 0 Td
(assay,)Tj
2.4888 0 Td
(which)Tj
2.6475 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(INSTIs)Tj
3.0841 0 Td
(provides)Tj
3.651 0 Td
(results)Tj
2.8063 0 Td
(similar)Tj
2.9877 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(Phe-)Tj
-35.3534 -1.2983 Td
(noSense)Tj
3.5035 0 Td
(assay)Tj
2.2678 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
1.5987 0 Td
(Virus)Tj
2.4434 0 Td
(isolates)Tj
3.1181 0 Td
(containing)Tj
4.5298 0 Td
(electrophoretic)Tj
6.2475 0 Td
(mixtures)Tj
3.753 0 Td
(at)Tj
0.9525 0 Td
(DRM)Tj
2.4718 0 Td
(positions)Tj
3.855 0 Td
(were)Tj
-34.7411 -1.3039 Td
(excluded.)Tj
4.0081 0 Td
(For)Tj
1.6271 0 Td
(composite)Tj
4.3426 0 Td
(DRM)Tj
2.4718 0 Td
(patterns,)Tj
3.6964 0 Td
(separate)Tj
3.4866 0 Td
(rows)Tj
2.143 0 Td
(of)Tj
1.0148 0 Td
(data)Tj
1.9105 0 Td
(were)Tj
2.126 0 Td
(provided)Tj
3.8154 0 Td
(for)Tj
1.3833 0 Td
(each)Tj
2.0296 0 Td
(individ-)Tj
-34.0552 -1.2982 Td
(ual)Tj
1.4286 0 Td
(pattern.)Tj
3.3335 0 Td
(For)Tj
1.6271 0 Td
(example,)Tj
3.7757 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.474 0 Td
(NRTI)Tj
2.5285 0 Td
(DRM)Tj
2.4661 0 Td
(pattern)Tj
3.1125 0 Td
(T215YF,)Tj
4.4277 0 Td
(there)Tj
2.2677 0 Td
(were)Tj
2.1203 0 Td
(separate)Tj
3.4809 0 Td
(rows)Tj
2.1486 0 Td
(for)Tj
-35.5745 -1.2983 Td
(T215Y)Tj
3.6736 0 Td
(and)Tj
1.7292 0 Td
(T215F.)Tj
3.7984 0 Td
(The)Tj
1.7801 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(phenotypic)Tj
4.7054 0 Td
(tests)Tj
1.9616 0 Td
(for)Tj
1.3833 0 Td
(a)Tj
0.6576 0 Td
(pattern)Tj
3.1125 0 Td
(was)Tj
1.6951 0 Td
(indicated)Tj
3.9401 0 Td
(by)Tj
1.1792 0 Td
(a)Tj
0.6576 0 Td
(sub-)Tj
-34.7071 -1.2983 Td
(script)Tj
2.4547 0 Td
(following)Tj
3.9799 0 Td
(the)Tj
1.474 0 Td
(median)Tj
3.2371 0 Td
(fold)Tj
1.7915 0 Td
(reduction)Tj
4.1159 0 Td
(in)Tj
1.0318 0 Td
(susceptibility.)Tj
-0.017 Tc
-16.8887 -1.3039 Td
(Fold-reductions)Tj
6.4346 0 Td
(in)Tj
1.0034 0 Td
(susceptibility)Tj
5.2498 0 Td
(considered)Tj
4.4617 0 Td
(to)Tj
0.9921 0 Td
(be)Tj
1.1168 0 Td
(associated)Tj
4.1216 0 Td
(with)Tj
1.9389 0 Td
(partial)Tj
2.6929 0 Td
(loss)Tj
1.6327 0 Td
(of)Tj
0.9808 0 Td
(clinical)Tj
2.965 0 Td
(activity)Tj
-34.7865 -1.2983 Td
(were)Tj
2.0636 0 Td
(indicated)Tj
3.8154 0 Td
(in)Tj
1.0091 0 Td
(bold)Tj
1.9502 0 Td
(whereas)Tj
3.3505 0 Td
(those)Tj
2.2678 0 Td
(considered)Tj
4.4673 0 Td
(to)Tj
0.9921 0 Td
(be)Tj
1.1226 0 Td
(associated)Tj
4.1215 0 Td
(with)Tj
1.9389 0 Td
(near-complete)Tj
5.8337 0 Td
(loss)Tj
1.6384 0 Td
(of)Tj
0.9864 0 Td
(clini-)Tj
-35.5575 -1.2982 Td
(cal)Tj
1.2812 0 Td
(activity)Tj
3.016 0 Td
(were)Tj
2.0693 0 Td
(indicated)Tj
3.8211 0 Td
(in)Tj
1.0091 0 Td
(bold)Tj
1.9559 0 Td
(and)Tj
1.6951 0 Td
(underlined.)Tj
4.7112 0 Td
(Such)Tj
2.126 0 Td
(ARV-specific)Tj
5.3857 0 Td
(clinical)Tj
3.3506 0 Td
(cut-offs)Tj
3.5376 0 Td
(are)Tj
1.4116 0 Td
(com-)Tj
-35.3704 -1.3039 Td
(monly)Tj
2.7325 0 Td
(used)Tj
2.0069 0 Td
(because)Tj
3.2259 0 Td
(the)Tj
1.4343 0 Td
(clinical)Tj
2.9707 0 Td
(significance)Tj
4.7791 0 Td
(of)Tj
0.9922 0 Td
(different)Tj
3.5376 0 Td
(levels)Tj
2.296 0 Td
(of)Tj
0.9922 0 Td
(reduction)Tj
3.9968 0 Td
(in)Tj
1.0091 0 Td
(susceptibility)Tj
-29.9733 -1.2983 Td
(differs)Tj
2.6532 0 Td
(among)Tj
2.931 0 Td
(ARVs.)Tj
2.7439 0 Td
(These)Tj
2.5001 0 Td
(cut-offs,)Tj
3.3732 0 Td
(however,)Tj
3.7304 0 Td
(should)Tj
2.8403 0 Td
(be)Tj
1.1225 0 Td
(considered)Tj
4.4731 0 Td
(rough)Tj
2.5568 0 Td
(guides)Tj
2.7099 0 Td
(of)Tj
0.9921 0 Td
(expected)Tj
-32.6265 -1.2983 Td
(clinical)Tj
2.9706 0 Td
(activity)Tj
3.0161 0 Td
(for)Tj
1.3436 0 Td
(the)Tj
1.4343 0 Td
(following)Tj
3.8608 0 Td
(reasons.)Tj
3.3448 0 Td
(First,)Tj
2.194 0 Td
(these)Tj
2.1884 0 Td
(cut-offs)Tj
3.1634 0 Td
(have)Tj
2.0069 0 Td
(usually)Tj
2.9254 0 Td
(been)Tj
2.0693 0 Td
(derived)Tj
3.1294 0 Td
(from)Tj
2.1543 0 Td
(the)Tj
-35.8013 -1.3039 Td
(retrospective)Tj
5.193 0 Td
(analysis)Tj
3.2201 0 Td
(of)Tj
0.9865 0 Td
(just)Tj
1.6157 0 Td
(a)Tj
0.6406 0 Td
(single)Tj
2.4548 0 Td
(clinical)Tj
2.9707 0 Td
(trial.)Tj
1.9843 0 Td
(Second,)Tj
3.2598 0 Td
(for)Tj
1.3493 0 Td
(some)Tj
2.279 0 Td
(ARVs,)Tj
2.7383 0 Td
(there)Tj
2.1996 0 Td
(is)Tj
0.8221 0 Td
(only)Tj
1.9275 0 Td
(one)Tj
1.6554 0 Td
(cut-)Tj
-35.2967 -1.2983 Td
(off)Tj
1.2642 0 Td
(\(rather)Tj
2.8913 0 Td
(than)Tj
1.9786 0 Td
(separate)Tj
3.3789 0 Td
(low)Tj
1.6214 0 Td
(and)Tj
1.6894 0 Td
(high)Tj
1.9559 0 Td
(cut-offs\).)Tj
3.6964 0 Td
(Finally,)Tj
3.067 0 Td
(for)Tj
1.3493 0 Td
(other)Tj
2.2847 0 Td
(ARVs,)Tj
2.7383 0 Td
(there)Tj
2.1996 0 Td
(is)Tj
0.8221 0 Td
(only)Tj
1.9275 0 Td
(a)Tj
0.6407 0 Td
(biologi-)Tj
-33.5053 -1.2982 Td
(cal)Tj
1.661 0 Td
(cut-off,)Tj
3.0274 0 Td
(designed)Tj
3.6567 0 Td
(to)Tj
1.0035 0 Td
(distinguish)Tj
4.4957 0 Td
(reduced)Tj
3.3505 0 Td
(susceptibility)Tj
5.2611 0 Td
(from)Tj
2.1543 0 Td
(the)Tj
1.4286 0 Td
(naturally)Tj
3.6624 0 Td
(occurring)Tj
4.0081 0 Td
(variation)Tj
-33.7093 -1.3039 Td
(in)Tj
1.0091 0 Td
(susceptibility)Tj
5.2554 0 Td
(observed)Tj
3.6963 0 Td
(in)Tj
1.0092 0 Td
(viruses)Tj
2.8913 0 Td
(from)Tj
2.1543 0 Td
(ARV-na)Tj
/F10 1 Tf
[()]TJ
/F5 1 Tf
(ve)Tj
4.5751 0 Td
(persons)Tj
3.2145 0 Td
(lacking)Tj
3.0103 0 Td
(DRMs)Tj
2.7836 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
1.5477 0 Td
(In)Tj
1.0829 0 Td
(this)Tj
1.6214 0 Td
(paper,)Tj
2.6305 0 Td
(we)Tj
-36.4816 -1.2983 Td
(define)Tj
2.6191 0 Td
(two)Tj
1.6725 0 Td
(cut-offs)Tj
3.1578 0 Td
(for)Tj
1.3492 0 Td
(each)Tj
1.9729 0 Td
(ARV)Tj
2.1827 0 Td
(relying)Tj
2.9083 0 Td
(primarily)Tj
3.8495 0 Td
(on)Tj
1.2529 0 Td
(published)Tj
4.0081 0 Td
(studies,)Tj
3.1068 0 Td
(the)Tj
1.4286 0 Td
(Monogram)Tj
4.6602 0 Td
(Biosci-)Tj
-34.1686 -1.2983 Td
(ences)Tj
2.3357 0 Td
(template)Tj
3.5773 0 Td
(report,)Tj
2.8403 0 Td
(and)Tj
1.6894 0 Td
(in)Tj
1.0148 0 Td
(some)Tj
2.2791 0 Td
(cases)Tj
2.1543 0 Td
(by)Tj
1.1565 0 Td
(extrapolating)Tj
5.3291 0 Td
(from)Tj
2.1543 0 Td
(closely)Tj
2.7893 0 Td
(related)Tj
2.8516 0 Td
(ARVs)Tj
2.5342 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2189 0 Td
(8)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 131.0173 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
/F0 1 Tf
0 -1.5023 Td
(ARVs)Tj
2.7543 0 Td
(to)Tj
1.0488 0 Td
(include)Tj
3.3402 0 Td
(in)Tj
0.9827 0 Td
(a)Tj
0.7654 0 Td
(GRT)Tj
2.3244 0 Td
(interpretation)Tj
5.9811 0 Td
(system)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 95.9811 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Each)Tj
2.1713 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(16)Tj
1.1678 0 Td
(panel)Tj
2.3925 0 Td
(members)Tj
3.9458 0 Td
(recommended)Tj
6.0321 0 Td
(reporting)Tj
3.9911 0 Td
(susceptibility)Tj
5.4425 0 Td
(estimates)Tj
3.9061 0 Td
(for)Tj
1.3833 0 Td
(each)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-35.9657 -1.2982 Td
(four)Tj
1.9105 0 Td
(NNRTIs)Tj
3.6283 0 Td
(and)Tj
1.7291 0 Td
(three)Tj
2.2677 0 Td
(INSTIs)Tj
3.0841 0 Td
(currently)Tj
3.8835 0 Td
(reported)Tj
3.6623 0 Td
(by)Tj
1.1792 0 Td
(HIVDB)Tj
3.3392 0 Td
(7.0.)Tj
1.6214 0 Td
(Each)Tj
2.177 0 Td
(also)Tj
1.7631 0 Td
(recommended)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 420.8314 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(HIV-1)Tj
2.7354 0 Td
(genotypic)Tj
4.4221 0 Td
(resistance)Tj
4.6984 0 Td
(test)Tj
1.8142 0 Td
(interpreta)Tj
4.1387 0 Td
(tion)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01813)Tj
4.089 0 Td
(57)Tj
0 g
2.0906 0 Td
(July)Tj
1.9701 0 Td
(28,)Tj
1.5874 0 Td
(2017)Tj
35.3483 0 Td
(6)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
149 0 obj
<>stream
endstream
endobj
150 0 obj
<>stream
endstream
endobj
151 0 obj
<>stream
endstream
endobj
152 0 obj
<>stream
endstream
endobj
153 0 obj
<>stream
endstream
endobj
154 0 obj
<>stream
endstream
endobj
155 0 obj
<>stream
endstream
endobj
156 0 obj
<>stream
endstream
endobj
157 0 obj
<>stream
BT
66.402 0 Td
(31)Tj
ET
Q
endstream
endobj
158 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 159 0 R/Contents 160 0 R/TrimBox[0 0 612 792]>>
endobj
159 0 obj
[161 0 R 162 0 R 163 0 R 164 0 R 165 0 R 166 0 R 167 0 R 168 0 R 169 0 R]
endobj
161 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.ref012)>>
endobj
162 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.ref014)>>
endobj
163 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.g001)>>
endobj
164 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.t003)>>
endobj
165 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.t004)>>
endobj
166 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.t005)>>
endobj
167 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.ref015)>>
endobj
168 0 obj
<>/Border[0 0 0]/Dest(Rpone.0181357.g002)>>
endobj
169 0 obj
<>/Border[0 0 0]/A 170 0 R>>
endobj
170 0 obj
<>
endobj
160 0 obj
[171 0 R 172 0 R 173 0 R 174 0 R 175 0 R 176 0 R 177 0 R 178 0 R 179 0 R 180 0 R 181 0 R]
endobj
171 0 obj
<>stream
q
0.83 0.64 0.02 0 k
313.852 576.3402 m
323.3764 576.3402 l
h
f*
327.7984 576.3402 m
337.3228 576.3402 l
h
f*
200.0126 504.6236 m
219.5717 504.6236 l
h
f*
538.0724 400.6488 m
567.2693 400.6488 l
h
f*
420.0378 335.622 m
449.2913 335.622 l
h
f*
211.9748 257.6126 m
241.2283 257.6126 l
h
f*
527.6976 218.6079 m
537.1654 218.6079 l
h
f*
200.0126 172.9134 m
219.5717 172.9134 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(reporting)Tj
3.9911 0 Td
(susceptibility)Tj
5.4368 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(five)Tj
1.6498 0 Td
(NRTIs:)Tj
3.1181 0 Td
(3FTC,)Tj
2.7212 0 Td
(ABC,)Tj
2.3754 0 Td
(AZT,)Tj
2.3414 0 Td
(and)Tj
1.7292 0 Td
(TDF.)Tj
2.3187 0 Td
(However,)Tj
4.0762 0 Td
(just)Tj
1.6667 0 Td
(11)Tj
1.1736 0 Td
(and)Tj
-35.4555 -1.3039 Td
(five)Tj
1.6497 0 Td
(members,)Tj
4.1726 0 Td
(respectively,)Tj
5.108 0 Td
(recommended)Tj
6.0377 0 Td
(reporting)Tj
3.9912 0 Td
(susceptibility)Tj
5.4368 0 Td
(estimates)Tj
3.9061 0 Td
(for)Tj
1.389 0 Td
(d4T)Tj
1.8368 0 Td
(and)Tj
1.7292 0 Td
(ddI,)Tj
-35.2571 -1.2982 Td
(which)Tj
2.6475 0 Td
(are)Tj
1.4513 0 Td
(no)Tj
1.2756 0 Td
(longer)Tj
2.7779 0 Td
(recommended)Tj
6.0378 0 Td
(for)Tj
1.389 0 Td
(routine)Tj
3.1634 0 Td
(use.)Tj
1.7575 0 Td
(Each)Tj
2.1713 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(panel)Tj
2.3925 0 Td
(members)Tj
3.9458 0 Td
(recommended)Tj
-31.4927 -1.2983 Td
(reporting)Tj
3.9911 0 Td
(results)Tj
2.8063 0 Td
(for)Tj
1.389 0 Td
(ATV/r,)Tj
3.1351 0 Td
(DRV/r,)Tj
3.1974 0 Td
(and)Tj
1.7291 0 Td
(LPV/r.)Tj
2.9367 0 Td
(However,)Tj
4.0819 0 Td
(just)Tj
1.6611 0 Td
(12,)Tj
1.3946 0 Td
(nine,)Tj
2.2337 0 Td
(seven,)Tj
2.6589 0 Td
(three,)Tj
2.4888 0 Td
(and)Tj
1.7291 0 Td
(one)Tj
-35.4328 -1.2983 Td
(panel)Tj
2.3867 0 Td
(member)Tj
3.5886 0 Td
(recommended)Tj
6.0321 0 Td
(reporting)Tj
3.9912 0 Td
(results)Tj
2.8063 0 Td
(for)Tj
1.3889 0 Td
(TPV/r,)Tj
3.0104 0 Td
(FPV/r,)Tj
2.931 0 Td
(SQV/r,)Tj
3.0614 0 Td
(IDV/r,)Tj
2.914 0 Td
(and)Tj
1.7348 0 Td
(NFV,)Tj
-33.8454 -1.3039 Td
(respectively.)Tj
1.1962 -1.2982 Td
(The)Tj
1.7858 0 Td
(panel)Tj
2.3867 0 Td
(members)Tj
3.9458 0 Td
(each)Tj
2.0296 0 Td
(recommended)Tj
6.0378 0 Td
(that)Tj
1.7745 0 Td
(PI)Tj
1.1225 0 Td
(interpretations)Tj
6.1568 0 Td
(should)Tj
2.914 0 Td
(be)Tj
1.1508 0 Td
(for)Tj
1.389 0 Td
(boosted)Tj
3.3505 0 Td
(PIs.)Tj
-35.24 -1.2983 Td
(Six)Tj
1.4286 0 Td
(panel)Tj
2.3868 0 Td
(members)Tj
3.9458 0 Td
(recommended)Tj
6.0377 0 Td
(that)Tj
1.7745 0 Td
(the)Tj
1.474 0 Td
(type)Tj
1.9105 0 Td
(of)Tj
1.0148 0 Td
(PI)Tj
1.1226 0 Td
(boosting)Tj
3.6793 0 Td
(\(ritonavir)Tj
4.0819 0 Td
(vs.)Tj
1.2585 0 Td
(cobicistat\))Tj
4.3484 0 Td
(should)Tj
-34.4634 -1.3039 Td
(be)Tj
1.1508 0 Td
(indicated)Tj
3.9345 0 Td
(even)Tj
2.0693 0 Td
(though)Tj
3.0784 0 Td
(it)Tj
0.7823 0 Td
(would)Tj
2.7156 0 Td
(not)Tj
1.5704 0 Td
(affect)Tj
2.3754 0 Td
(susceptibility)Tj
5.4425 0 Td
(estimates.)Tj
4.1329 0 Td
(Eleven)Tj
2.8856 0 Td
(panel)Tj
2.3868 0 Td
(members)Tj
-32.5245 -1.2983 Td
(recommended)Tj
6.032 0 Td
(indicating)Tj
4.269 0 Td
(when)Tj
2.4038 0 Td
(DRV/r)Tj
2.9763 0 Td
(and)Tj
1.7291 0 Td
(DTG)Tj
2.2847 0 Td
(should)Tj
2.914 0 Td
(be)Tj
1.1509 0 Td
(administered)Tj
5.4878 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.474 0 Td
(higher)Tj
2.8006 0 Td
(of)Tj
1.0148 0 Td
(their)Tj
-35.4895 -1.2983 Td
(two)Tj
1.7064 0 Td
(recommended)Tj
6.0378 0 Td
(dosages)Tj
3.2995 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(14)Tj
0 g
(].)Tj
1.7404 0 Td
(Three)Tj
2.5739 0 Td
(panel)Tj
2.3924 0 Td
(members)Tj
3.9458 0 Td
(advised)Tj
3.2145 0 Td
(distinguishing)Tj
5.9187 0 Td
(between)Tj
-32.5642 -1.3039 Td
(TDF)Tj
2.0919 0 Td
(and)Tj
1.7348 0 Td
(TAF)Tj
2.0409 0 Td
(but)Tj
1.5534 0 Td
(no)Tj
1.2756 0 Td
(panel)Tj
2.3867 0 Td
(member)Tj
3.5887 0 Td
(recommended)Tj
6.0321 0 Td
(different)Tj
3.6566 0 Td
(susceptibility)Tj
5.4425 0 Td
(estimates)Tj
3.9061 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
-35.0926 -1.2982 Td
(two)Tj
1.7064 0 Td
(tenofovir)Tj
3.8891 0 Td
(prodrugs.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 522.7086 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Effects)Tj
3.2551 0 Td
(of)Tj
1.0441 0 Td
(DRM)Tj
2.4803 0 Td
(patterns)Tj
3.7938 0 Td
(on)Tj
1.3181 0 Td
(predicted)Tj
4.2803 0 Td
(NRTI)Tj
2.5371 0 Td
(susceptibility)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
10 0 0 10 200.0125 505.7007 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Fig)Tj
1.4796 0 Td
(1)Tj
0 g
0.6973 0 Td
(summarizes)Tj
5.0173 0 Td
(the)Tj
1.4684 0 Td
(expert)Tj
2.7212 0 Td
(panel's)Tj
2.965 0 Td
(NRTI)Tj
2.5285 0 Td
(interpretations.)Tj
6.3779 0 Td
(The)Tj
1.7859 0 Td
(completion)Tj
4.7735 0 Td
(rate)Tj
1.7518 0 Td
(was)Tj
1.6951 0 Td
(97.4%)Tj
2.6305 0 Td
(for)Tj
-35.892 -1.2982 Td
(the)Tj
1.4683 0 Td
(832)Tj
1.6441 0 Td
(DRM)Tj
2.4718 0 Td
(pattern-ARV-interpret)Tj
9.1161 0 Td
(ations)Tj
2.6362 0 Td
(\(13)Tj
1.5081 0 Td
(patterns)Tj
3.4752 0 Td
(x)Tj
0.6803 0 Td
(4)Tj
0.6973 0 Td
(NRTIs)Tj
2.8914 0 Td
(x)Tj
0.6859 0 Td
(16)Tj
1.1679 0 Td
(experts\).)Tj
3.6453 0 Td
(Originally,)Tj
4.4958 0 Td
(46)Tj
-36.5837 -1.3039 Td
(\(5.5%\))Tj
2.8346 0 Td
(pattern-ARV-interpretations)Tj
11.7467 0 Td
(differed)Tj
3.3335 0 Td
(from)Tj
2.211 0 Td
(the)Tj
1.4683 0 Td
(expert)Tj
2.7156 0 Td
(median)Tj
3.2428 0 Td
(by)Tj
1.1792 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(one-level.)Tj
-33.1027 -1.2983 Td
(Following)Tj
4.2179 0 Td
(re-evaluation)Tj
5.5048 0 Td
(of)Tj
1.0148 0 Td
(outliers,)Tj
3.4469 0 Td
(32)Tj
1.1736 0 Td
(\(3.8%\))Tj
2.8346 0 Td
(pattern-ARV-interpretation)Tj
11.1684 0 Td
(s)Tj
0.5783 0 Td
(differed)Tj
3.3392 0 Td
(by)Tj
1.1792 0 Td
(more)Tj
-34.4577 -1.2983 Td
(than)Tj
2.0295 0 Td
(one)Tj
1.6952 0 Td
(level.)Tj
-2.5285 -1.3039 Td
(Overall,)Tj
3.3732 0 Td
(the)Tj
1.4683 0 Td
(mean)Tj
2.4435 0 Td
(absolute)Tj
3.5262 0 Td
(deviation)Tj
3.9458 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.474 0 Td
(expert)Tj
2.7156 0 Td
(panel)Tj
2.3924 0 Td
(median)Tj
3.2371 0 Td
(was)Tj
1.7008 0 Td
(0.34)Tj
1.8709 0 Td
(levels:)Tj
/F11 1 Tf
0 Tc
2.6021 0 Td
(<)Tj
/F5 1 Tf
-0.004 Tc
(0.5)Tj
-34.1515 -1.2982 Td
(levels)Tj
2.3754 0 Td
(for)Tj
1.3833 0 Td
(38)Tj
1.1735 0 Td
(pattern-ARV)Tj
5.4595 0 Td
(combinations)Tj
5.7089 0 Td
(and)Tj
1.7292 0 Td
(0.5)Tj
1.4003 0 Td
(to)Tj
1.0261 0 Td
(1.0)Tj
1.3946 0 Td
(for)Tj
1.3833 0 Td
(14)Tj
1.1736 0 Td
(pattern-ARV)Tj
5.4651 0 Td
(combinations.)Tj
-29.6728 -1.2983 Td
(There)Tj
2.5738 0 Td
(was)Tj
1.7008 0 Td
(a)Tj
0.6519 0 Td
(one-level)Tj
3.8438 0 Td
(difference)Tj
4.2066 0 Td
(between)Tj
3.5263 0 Td
(the)Tj
1.474 0 Td
(expert)Tj
2.7155 0 Td
(median)Tj
3.2428 0 Td
(and)Tj
1.7292 0 Td
(HIVDB)Tj
3.3392 0 Td
(7.0)Tj
1.3946 0 Td
(for)Tj
1.389 0 Td
(12)Tj
1.1678 0 Td
(of)Tj
1.0148 0 Td
(52)Tj
1.1736 0 Td
(pat-)Tj
-35.1437 -1.2983 Td
(tern-ARV)Tj
4.2122 0 Td
(combinations:)Tj
5.9357 0 Td
(six)Tj
1.3096 0 Td
(for)Tj
1.389 0 Td
(TDF,)Tj
2.3187 0 Td
(four)Tj
1.9162 0 Td
(for)Tj
1.3833 0 Td
(ABC,)Tj
2.3754 0 Td
(one)Tj
1.6951 0 Td
(for)Tj
1.389 0 Td
(3FTC,)Tj
2.7213 0 Td
(and)Tj
1.7291 0 Td
(one)Tj
1.7008 0 Td
(for)Tj
1.3889 0 Td
(AZT.)Tj
0.83 0.64 0.02 0 k
2.3414 0 Td
(Table)Tj
2.4378 0 Td
(3)Tj
0 g
-36.2435 -1.3039 Td
(lists)Tj
1.7517 0 Td
(these)Tj
2.2507 0 Td
(differences)Tj
4.5638 0 Td
(and)Tj
1.7348 0 Td
(indicates)Tj
3.7644 0 Td
(that)Tj
1.7801 0 Td
(for)Tj
1.3833 0 Td
(each)Tj
2.0296 0 Td
(a)Tj
0.652 0 Td
(change)Tj
3.0444 0 Td
(was)Tj
1.6951 0 Td
(made)Tj
2.4264 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.4683 0 Td
(HIVDB)Tj
3.3392 0 Td
(scoring)Tj
3.1635 0 Td
(sys-)Tj
-36.0678 -1.2983 Td
(tem)Tj
1.7574 0 Td
(such)Tj
2.0636 0 Td
(that)Tj
1.7802 0 Td
(HIVDB)Tj
3.3335 0 Td
(8.1)Tj
1.4003 0 Td
(yielded)Tj
3.0897 0 Td
(a)Tj
0.652 0 Td
(result)Tj
2.4491 0 Td
(that)Tj
1.7802 0 Td
(matched)Tj
3.6737 0 Td
(the)Tj
1.4683 0 Td
(expert)Tj
2.7212 0 Td
(median.)Tj
-24.973 -1.2982 Td
(After)Tj
2.2903 0 Td
(updating)Tj
3.8041 0 Td
(the)Tj
1.4683 0 Td
(scoring)Tj
3.1635 0 Td
(system,)Tj
3.1634 0 Td
(we)Tj
1.3266 0 Td
(determined)Tj
4.8529 0 Td
(the)Tj
1.4684 0 Td
(relative)Tj
3.1407 0 Td
(NRTI)Tj
2.5285 0 Td
(susceptibility)Tj
5.4425 0 Td
(profiles)Tj
-33.8454 -1.3039 Td
(of)Tj
1.0147 0 Td
(35,377)Tj
2.8233 0 Td
(viruses)Tj
2.9877 0 Td
(in)Tj
1.0318 0 Td
(HIVDB)Tj
3.3392 0 Td
(with)Tj
1.9956 0 Td
(4,749)Tj
2.3527 0 Td
(distinct)Tj
3.2088 0 Td
(NRTI)Tj
2.5285 0 Td
(DRM)Tj
2.4718 0 Td
(patterns.)Tj
3.6964 0 Td
(Of)Tj
1.2586 0 Td
(the)Tj
1.4683 0 Td
(256)Tj
1.6441 0 Td
(possible)Tj
3.4129 0 Td
(pro-)Tj
-35.2344 -1.2983 Td
(files,)Tj
2.0295 0 Td
(21)Tj
1.1736 0 Td
(occurred)Tj
3.7927 0 Td
(in)Tj
1.0375 0 Td
(at)Tj
0.9524 0 Td
(least)Tj
1.9843 0 Td
(1%)Tj
1.4513 0 Td
(of)Tj
1.0148 0 Td
(published)Tj
4.1215 0 Td
(sequences.)Tj
0.83 0.64 0.02 0 k
4.4447 0 Td
(Table)Tj
2.4435 0 Td
(4)Tj
0 g
0.6973 0 Td
(displays)Tj
3.3902 0 Td
(these)Tj
2.2507 0 Td
(21)Tj
1.1735 0 Td
(profiles,)Tj
-31.9575 -1.2983 Td
(which)Tj
2.6475 0 Td
(accounted)Tj
4.337 0 Td
(for)Tj
1.3833 0 Td
(93.3%)Tj
2.6305 0 Td
(of)Tj
1.0148 0 Td
(viruses)Tj
2.9877 0 Td
(with)Tj
1.9956 0 Td
(one)Tj
1.7008 0 Td
(or)Tj
1.0941 0 Td
(more)Tj
2.3414 0 Td
(NRTI)Tj
2.5342 0 Td
(DRM.)Tj
2.6929 0 Td
(The)Tj
1.7858 0 Td
(most)Tj
2.2053 0 Td
(common)Tj
3.8438 0 Td
(rela-)Tj
-35.1947 -1.3039 Td
(tively)Tj
2.364 0 Td
(susceptibility)Tj
5.4368 0 Td
(profilesusceptibil)Tj
7.3417 0 Td
(ity)Tj
1.2359 0 Td
(to)Tj
1.0262 0 Td
(AZT)Tj
2.1146 0 Td
(and)Tj
1.7348 0 Td
(TDF,)Tj
2.3187 0 Td
(low-level)Tj
3.8041 0 Td
(resistance)Tj
4.1272 0 Td
(to)Tj
1.0261 0 Td
(ABC,)Tj
2.3755 0 Td
(and)Tj
-34.9056 -1.2982 Td
(high-level)Tj
4.1498 0 Td
(resistance)Tj
4.1329 0 Td
(to)Tj
1.0262 0 Td
(3FTCoccurred)Tj
6.5876 0 Td
(in)Tj
1.0375 0 Td
(23.7%)Tj
2.6306 0 Td
(of)Tj
1.0147 0 Td
(all)Tj
1.1452 0 Td
(viruses)Tj
2.9877 0 Td
(with)Tj
1.9956 0 Td
(one)Tj
1.7008 0 Td
(or)Tj
1.0998 0 Td
(more)Tj
2.3414 0 Td
(NRTI)Tj
2.5285 0 Td
(DRMs.)Tj
-34.3783 -1.2983 Td
(This)Tj
1.9842 0 Td
(profile)Tj
2.8403 0 Td
(was)Tj
1.7008 0 Td
(usually)Tj
3.016 0 Td
(caused)Tj
2.9197 0 Td
(by)Tj
1.1792 0 Td
(M184V/I)Tj
3.9061 0 Td
(alone)Tj
2.3754 0 Td
(or)Tj
1.0998 0 Td
(M184V/I)Tj
3.9062 0 Td
(in)Tj
1.0318 0 Td
(combination)Tj
5.3517 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.652 0 Td
(second)Tj
-33.9588 -1.3039 Td
(DRM)Tj
2.4717 0 Td
(with)Tj
1.9956 0 Td
(low)Tj
1.6554 0 Td
(mutation)Tj
3.9232 0 Td
(penalty)Tj
3.1407 0 Td
(scores.)Tj
0.83 0.64 0.02 0 k
-11.9904 -1.2983 Td
(Table)Tj
2.4434 0 Td
(5)Tj
0 g
0.6973 0 Td
(summarizes)Tj
5.0173 0 Td
(available)Tj
3.668 0 Td
(phenotypic)Tj
4.7055 0 Td
(data)Tj
1.9106 0 Td
(in)Tj
1.0374 0 Td
(HIVDB)Tj
3.3392 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4684 0 Td
(13)Tj
1.1735 0 Td
(DRM)Tj
2.4718 0 Td
(patterns.)Tj
3.6963 0 Td
(HIVDB)Tj
-34.2082 -1.2983 Td
(contained)Tj
4.1952 0 Td
(many)Tj
2.4775 0 Td
(phenotypic)Tj
4.7054 0 Td
(results)Tj
2.812 0 Td
(for)Tj
1.3833 0 Td
(M184V)Tj
3.2371 0 Td
(alone,)Tj
2.6022 0 Td
(K65R)Tj
2.4662 0 Td
(alone,)Tj
2.6078 0 Td
(M184V+K65R,)Tj
6.2815 0 Td
(and)Tj
1.7292 0 Td
(for)Tj
1.3889 0 Td
(sev-)Tj
-35.8863 -1.2982 Td
(eral)Tj
1.6951 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(patterns)Tj
3.4696 0 Td
(with)Tj
2.0012 0 Td
(multiple)Tj
3.566 0 Td
(TAMs)Tj
/F10 1 Tf
2.7666 0 Td
[()]TJ
/F5 1 Tf
0.788 0 Td
(M184V.)Tj
3.4639 0 Td
(However,)Tj
4.0762 0 Td
(HIVDB)Tj
3.3392 0 Td
(contained)Tj
4.1953 0 Td
(few)Tj
1.6157 0 Td
(results)Tj
2.8119 0 Td
(for)Tj
-36.2718 -1.3039 Td
(several)Tj
2.931 0 Td
(other)Tj
2.347 0 Td
(patterns)Tj
3.4753 0 Td
(including)Tj
4.0422 0 Td
(the)Tj
1.4683 0 Td
(TDF-associated)Tj
6.4856 0 Td
(DRMs)Tj
2.829 0 Td
(K65N)Tj
2.5795 0 Td
(and)Tj
1.7348 0 Td
(K70E/Q/G)Tj
4.5354 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 190.9984 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Effects)Tj
3.2551 0 Td
(of)Tj
1.0441 0 Td
(DRM)Tj
2.4803 0 Td
(patterns)Tj
3.7938 0 Td
(on)Tj
1.3181 0 Td
(predicted)Tj
4.2803 0 Td
(NNRTI)Tj
3.2505 0 Td
(susceptibility)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
10 0 0 10 200.0125 173.9905 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Fig)Tj
1.4796 0 Td
(2)Tj
0 g
0.6973 0 Td
(summarizes)Tj
5.0173 0 Td
(the)Tj
1.4684 0 Td
(expert)Tj
2.7212 0 Td
(panel's)Tj
2.965 0 Td
(NNRTI)Tj
3.2655 0 Td
(interpretations.)Tj
6.3779 0 Td
(The)Tj
1.7802 0 Td
(completion)Tj
4.7792 0 Td
(rate)Tj
1.7461 0 Td
(was)Tj
1.7008 0 Td
(91.4%)Tj
-33.9985 -1.2982 Td
(for)Tj
1.3832 0 Td
(the)Tj
1.4741 0 Td
(432)Tj
1.644 0 Td
(DRM)Tj
2.4718 0 Td
(pattern-ARV-interpretation)Tj
11.1685 0 Td
(s)Tj
0.5782 0 Td
(\(9)Tj
1.0375 0 Td
(patterns)Tj
3.4696 0 Td
(x)Tj
0.686 0 Td
(3)Tj
0.6973 0 Td
(NNRTIs)Tj
3.6226 0 Td
(x)Tj
0.686 0 Td
(16)Tj
1.1736 0 Td
(experts\).)Tj
3.6453 0 Td
(Origi-)Tj
-33.7377 -1.2983 Td
(nally,)Tj
2.3754 0 Td
(25)Tj
1.1678 0 Td
(\(5.8%\))Tj
2.8347 0 Td
(pattern-ARV-interpret)Tj
9.1161 0 Td
(ations)Tj
2.6306 0 Td
(differed)Tj
3.3392 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4683 0 Td
(expert)Tj
2.7213 0 Td
(median)Tj
3.2428 0 Td
(by)Tj
1.1792 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
-34.6221 -1.3039 Td
(one-level.)Tj
4.0705 0 Td
(Following)Tj
4.2179 0 Td
(re-evaluation)Tj
5.5048 0 Td
(of)Tj
1.0148 0 Td
(outliers,)Tj
3.447 0 Td
(16)Tj
1.1735 0 Td
(\(3.7%\))Tj
2.8346 0 Td
(pattern-ARV-interpretations)Tj
11.7467 0 Td
(differed)Tj
-34.0098 -1.2983 Td
(by)Tj
1.1792 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(one)Tj
1.7007 0 Td
(level.)Tj
-6.0547 -1.2982 Td
(The)Tj
1.7858 0 Td
(mean)Tj
2.4434 0 Td
(absolute)Tj
3.5263 0 Td
(deviation)Tj
3.9458 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4741 0 Td
(expert)Tj
2.7155 0 Td
(median)Tj
3.2428 0 Td
(was)Tj
1.7008 0 Td
(0.43)Tj
1.8709 0 Td
(levels:)Tj
/F11 1 Tf
0 Tc
2.6022 0 Td
(<)Tj
/F5 1 Tf
-0.004 Tc
(0.5)Tj
2.1656 0 Td
(levels)Tj
2.3754 0 Td
(for)Tj
1.3833 0 Td
(16)Tj
1.1736 0 Td
(pat-)Tj
-35.807 -1.3039 Td
(tern-ARV)Tj
4.2122 0 Td
(combinations)Tj
5.7089 0 Td
(and)Tj
1.7292 0 Td
(0.5)Tj
1.3946 0 Td
(to)Tj
1.0261 0 Td
(1.0)Tj
1.4003 0 Td
(for)Tj
1.3833 0 Td
(11)Tj
1.1736 0 Td
(pattern-ARV)Tj
5.4595 0 Td
(combinations.)Tj
5.9357 0 Td
(There)Tj
2.5738 0 Td
(was)Tj
1.7008 0 Td
(a)Tj
0.652 0 Td
(one-)Tj
-34.35 -1.2983 Td
(level)Tj
2.0125 0 Td
(difference)Tj
4.2066 0 Td
(between)Tj
3.5263 0 Td
(the)Tj
1.4683 0 Td
(expert)Tj
2.7213 0 Td
(median)Tj
3.2428 0 Td
(and)Tj
1.7291 0 Td
(HIVDB)Tj
3.3392 0 Td
(7.0)Tj
1.3946 0 Td
(for)Tj
1.389 0 Td
(two)Tj
1.7065 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(27)Tj
1.1735 0 Td
(pattern-ARV)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 420.8314 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(HIV-1)Tj
2.7354 0 Td
(genotypic)Tj
4.4221 0 Td
(resistance)Tj
4.6984 0 Td
(test)Tj
1.8142 0 Td
(interpreta)Tj
4.1387 0 Td
(tion)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01813)Tj
4.089 0 Td
(57)Tj
0 g
2.0906 0 Td
(July)Tj
1.9701 0 Td
(28,)Tj
1.5874 0 Td
(2017)Tj
35.3483 0 Td
(7)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
172 0 obj
<>stream
endstream
endobj
173 0 obj
<>stream
endstream
endobj
174 0 obj
<>stream
endstream
endobj
175 0 obj
<>stream
endstream
endobj
176 0 obj
<>stream
endstream
endobj
177 0 obj
<>stream
endstream
endobj
178 0 obj
<>stream
endstream
endobj
179 0 obj
<>stream
endstream
endobj
180 0 obj
<>stream
endstream
endobj
181 0 obj
<>stream
BT
66.402 0 Td
(31)Tj
ET
Q
endstream
endobj
182 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 184 0 R/Contents 185 0 R/TrimBox[0 0 612 792]>>
endobj
183 0 obj
<>stream
x TcǟE*[ER[PQ%kY#kIY"mdZFdڷd+$sq7f3s93y9=g}-~D@D@D@D@D@D@D@D@D@D@D@D rZG^u+G&?&m% wߥ-*AcPރO?%u%kCaJ֤$Ta6 wAmP|sU6[ڴIb(ŗe!*d6t+M6Y55wntu&?Ox q ^9'͎q'f0ߓOF]s?V0ډgj 0bDc帠fZ۱mW!(S^jbJsI5j䠃*w媫