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The Impact of HIV-1 Drug Escape on the Global Treatment Landscape

Collier, DA; Monit, C; Gupta, RK; (2019) The Impact of HIV-1 Drug Escape on the Global Treatment Landscape. Cell Host & Microbe , 26 (1) pp. 48-60. 10.1016/j.chom.2019.06.010. Green open access

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Abstract

The rising prevalence of HIV drug resistance (HIVDR) could threaten gains made in combating the HIV epidemic and compromise the 90-90-90 target proposed by United Nations Programme on HIV/AIDS (UNAIDS) to have achieved virological suppression in 90% of all persons receiving antiretroviral therapy (ART) by the year 2020. HIVDR has implications for the persistence of HIV, the selection of current and future ART drug regimens, and strategies of vaccine and cure development. Focusing on drug classes that are in clinical use, this Review critically summarizes what is known about the mechanisms the virus utilizes to escape drug control. Armed with this knowledge, strategies to limit the expansion of HIVDR are proposed.

Type: Article
Title: The Impact of HIV-1 Drug Escape on the Global Treatment Landscape
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.chom.2019.06.010
Publisher version: https://doi.org/10.1016/j.chom.2019.06.010
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10083660
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