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A declining CD4 count and diagnosis of HIV-associated hodgkin Lymphoma: Do prior clinical symptoms and laboratory abnormalities aid diagnosis?

Gupta, RK; Marks, M; Edwards, SG; Smith, K; Fletcher, K; Lee, SM; Ramsay, A; ... Miller, RF; + view all (2014) A declining CD4 count and diagnosis of HIV-associated hodgkin Lymphoma: Do prior clinical symptoms and laboratory abnormalities aid diagnosis? PLoS One , 9 (2) , Article e87442. 10.1371/journal.pone.0087442. Green open access

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Abstract

The incidence of Hodgkin lymphoma (HL) among HIV-infected individuals remains unchanged since the introduction of combination antiretroviral therapy (cART). Recent epidemiological data suggest that CD4 count decline over a year is associated with subsequent diagnosis of HL. In an era of economic austerity monitoring the efficacy of cART by CD4 counts may no longer be required where CD4 count>350 cells/µl and viral load is suppressed (<50 copies/ml).

Type: Article
Title: A declining CD4 count and diagnosis of HIV-associated hodgkin Lymphoma: Do prior clinical symptoms and laboratory abnormalities aid diagnosis?
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1371/journal.pone.0087442
Publisher version: http://dx.doi.org/10.1371/journal.pone.0087442
Language: English
Additional information: © 2014 Gupta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1418966
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