Browse by UCL people
Group by: Type | Date
Number of items: 177.
2025
Clark, Timothy P;
Wicentowski, Richard H;
Cro, Suzie;
Sydes, Matthew R;
Kahan, Brennan C;
(2025)
Are estimands being correctly used? A review of UK research protocols.
Trials
, 26
, Article 310. 10.1186/s13063-025-08991-8.
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Ravi, P;
Xie, W;
Buyse, M;
Halabi, S;
Kantoff, PW;
Sartor, O;
Attard, G;
... Sweeney, CJ; + view all
(2025)
Refining Risk Stratification of High-risk and Locoregional Prostate Cancer: A Pooled Analysis of Randomized Trials.
European Urology
, 87
(2)
pp. 217-224.
10.1016/j.eururo.2024.04.038.
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Thombs, BD;
Adams, C;
Nassar, EL;
Carrier, ME;
Golberg, M;
Bharthi, K;
Wurz, A;
... Benedetti, A; + view all
(2025)
Master protocol for a series of cohort-based randomized controlled trials to test tools to communicate research results to study participants and others with relevant lived experience: the SPIN-CLEAR Trials.
Trials
, 26
(1)
, Article 149. 10.1186/s13063-025-08846-2.
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2024
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Bhatty, Asad;
Wilkinson, Chris;
Sydes, Matt;
Gale, Chris P;
(2024)
Defining the need for cardiovascular event definitions.
European Heart Journal - Quality of Care and Clinical Outcomes
, 10
(2)
pp. 105-107.
10.1093/ehjqcco/qcae008.
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Chen, Yang;
Shah, Anoop;
Jani, Yogini;
Higgins, Daniel;
Saleem, Nausheen;
Chafer, Kris;
Sydes, Matthew Robert;
... Lumbers, R Thomas; + view all
(2024)
Rationale and design of the THIRST Alert feasibility study: a pragmatic, single-centre, parallel-group randomised controlled trial of an interruptive alert for oral fluid restriction in patients treated with intravenous furosemide.
BMJ Open
, 14
(1)
, Article e080410. 10.1136/bmjopen-2023-080410.
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Griffiths, Jessica;
Adshead, Fiona;
Al-Shahi Salman, Rustam;
Anderson, Craig;
Bedson, Emma;
Bliss, Judith;
Boshoff, Ana;
... Williamson, Paula R; + view all
(2024)
What is the carbon footprint of academic clinical trials? A study of hotspots in 10 trials.
BMJ Open
, 14
(10)
, Article e088600. 10.1136/bmjopen-2024-088600.
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James, Nicholas D;
Tannock, Ian;
N'Dow, James;
Feng, Felix;
Gillessen, Silke;
Ali, Syed Adnan;
Trujillo, Blanca;
... Xie, Li-Ping; + view all
(2024)
The Lancet Commission on prostate cancer: planning for the surge in cases.
The Lancet
10.1016/S0140-6736(24)00651-2.
(In press).
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Kwak, Lucia;
Ravi, Praful;
Armstrong, John G;
Beckendorf, Veronique;
Chin, Joseph L;
D'Amico, Anthony V;
Dearnaley, David P;
... Sweeney, Christopher J; + view all
(2024)
Prognostic Impact of Prostate-Specific Antigen at 6 Months After Radiotherapy in Localized Prostate Cancer: An Individual Patient Data Analysis of Randomized Trials.
Journal of Clinical Oncology
, 42
(18)
pp. 2132-2138.
10.1200/JCO.23.00762.
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Lensen, Sarah;
Sydes, Matthew R;
Polyakov, Alex;
Wilkinson, Jack;
(2024)
When to randomize patients in a randomized controlled trial?
Fertility and Sterility
, 121
(6)
pp. 902-904.
10.1016/j.fertnstert.2024.03.008.
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Parker, CC;
Catton, CN;
Clarke, N;
Meidahl, P;
Parmar, M;
Parulekar, W;
Sydes, M;
(2024)
Reply to "Letter to the Editor regarding "Timing of radiotherapy (RT) after radical prostatectomy (RP): Long-term outcomes in the RADICALS-RT trial [NCT00541047]", by C. C. Parker et al.".
Annals of Oncology
, 35
(8)
pp. 752-753.
10.1016/j.annonc.2024.05.001.
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Parker, CC;
Clarke, NW;
Cook, AD;
Petersen, PM;
Catton, CN;
Cross, WR;
Kynaston, H;
... Sydes, MR; + view all
(2024)
Randomised Trial of No, Short-term, or Long-term Androgen Deprivation Therapy with Postoperative Radiotherapy After Radical Prostatectomy: Results from the Three-way Comparison of RADICALS-HD (NCT00541047).
European Urology
10.1016/j.eururo.2024.07.026.
(In press).
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Parker, CC;
Petersen, PM;
Cook, AD;
Clarke, NW;
Catton, C;
Cross, WR;
Kynaston, H;
... Sydes, MR; + view all
(2024)
Timing of radiotherapy (RT) after radical prostatectomy (RP): long-term outcomes in the RADICALS-RT trial (NCT00541047).
Annals of Oncology
, 35
(7)
pp. 656-666.
10.1016/j.annonc.2024.03.010.
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South, A;
Snowdon, C;
Burnett, E;
Bierer, BE;
Gillies, K;
Isaacs, T;
Sydes, MR;
(2024)
The SHOW RESPECT adaptable framework of considerations for planning how to share trial results with participants, based on qualitative findings from trial participants and site staff.
Trials
, 25
, Article 467. 10.1186/s13063-024-08291-7.
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Sydes, Matthew R;
Murray, Macey L;
Ahmed, Saiam;
Apostolidou, Sophia;
Bliss, Judith M;
Bloomfield, Claire;
Cannings-John, Rebecca;
... Love, Sharon B; + view all
(2024)
Getting our ducks in a row: The need for data utility comparisons of healthcare systems data for clinical trials.
Contemporary Clinical Trials
, 141
, Article 107514. 10.1016/j.cct.2024.107514.
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Toader, Alice-Maria;
Campbell, Marion K;
Quint, Jennifer K;
Robling, Michael;
Sydes, Matthew R;
Thorn, Joanna;
Wright-Hughes, Alexandra;
... Williamson, Paula; + view all
(2024)
Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage.
Trials
, 25
(1)
, Article 94. 10.1186/s13063-024-07926-z.
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Twine, Christopher P;
Ahmed, Haroon;
Lugg-Widger, Fiona V;
Waldron, Cherry-Ann;
Bown, Matt J;
Sydes, Matthew R;
(2024)
Challenges of Using Routinely Collected Healthcare System Data in Randomised Trials.
European Journal of Vascular and Endovascular Surgery
, 68
(3)
pp. 416-417.
10.1016/j.ejvs.2024.05.010.
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2023
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Attard, G;
Murphy, L;
Clarke, NW;
Sachdeva, A;
Jones, C;
Hoyle, A;
Cross, W;
... McPhail, N; + view all
(2023)
Abiraterone acetate plus prednisolone with or without enzalutamide for patients with metastatic prostate cancer starting androgen deprivation therapy: final results from two randomised phase 3 trials of the STAMPEDE platform protocol.
The Lancet Oncology
, 24
(5)
pp. 443-456.
10.1016/S1470-2045(23)00148-1.
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Gillessen, Silke;
Bossi, Alberto;
Davis, Ian D;
de Bono, Johann;
Fizazi, Karim;
James, Nicholas D;
Mottet, Nicolas;
... Omlin, Aurelius; + view all
(2023)
Management of patients with advanced prostate cancer—metastatic and/or castration-resistant prostate cancer: report of the Advanced Prostate Cancer Consensus Conference (APCCC) 2022.
European Journal of Cancer
, 185
pp. 178-215.
10.1016/j.ejca.2023.02.018.
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Hsieh, Shao-Fan;
Yorke-Edwards, Victoria;
Murray, Macey L;
Diaz-Montana, Carlos;
Love, Sharon B;
Sydes, Matthew R;
(2023)
Lack of transparent reporting of trial monitoring approaches in randomised controlled trials: A systematic review of contemporary protocol papers.
Clinical Trials
10.1177/17407745221143449.
(In press).
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Law, Martin;
Couturier, Dominique‑Laurent;
Choodari-Oskooei, Babak;
Crout, Phillip;
Gamble, Carrol;
Jacko, Peter;
Pallmann, Philip;
... Jaki, Thomas; + view all
(2023)
Correction: Medicines and Healthcare products Regulatory Agency’s “Consultation on proposals for legislative changes for clinical trials”: a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing.
[Corrigendum].
Trials
, 24
, Article 744. 10.1186/s13063-023-07763-6.
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Mintz, Harriet Paige;
Dosanjh, Amandeep Raj Singh;
Parsons, Helen;
Sydes, Matthew;
Bryan, Richard T;
James, Nicholas D;
Patel, Prashant;
(2023)
Making administrative healthcare systems clinical data the future of clinical trials: lessons from BladderPath.
BMJ Oncology
, 2
(1)
, Article e000038. 10.1136/bmjonc-2023-000038.
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Mitchell, EJ;
Appelbe, D;
Bravery, A;
Culliford, L;
Evans, H;
Farrin, AJ;
Gillies, K;
... Wakefield, N; + view all
(2023)
e-Consent in UK academic-led clinical trials: current practice, challenges and the need for more evidence.
Trials
, 24
, Article 657. 10.1186/s13063-023-07656-8.
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Naderi, Elnaz;
Aguado-Barrera, Miguel E;
Schack, Line MH;
Dorling, Leila;
Rattay, Tim;
Fachal, Laura;
Summersgill, Holly;
... Radiogenomics Consortium; + view all
(2023)
Large-scale meta-genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types.
JNCI Cancer Spectrum
, 7
(6)
, Article pkad088. 10.1093/jncics/pkad088.
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Petersen, Peter Meidahl;
Cook, Adrian D;
Sydes, Matthew R;
Clarke, Noel;
Cross, William;
Kynaston, Howard;
Logue, John;
... Catton, Charles; + view all
(2023)
Salvage radiotherapy after radical prostatectomy: analysis of toxicity by dose-fractionation in the RADICALS-RT trial.
International Journal of Radiation: Oncology - Biology - Physics
10.1016/j.ijrobp.2023.04.032.
(In press).
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Roy, Soumyajit;
Romero, Tahmineh;
Michalski, Jeff M;
Feng, Felix Y;
Efstathiou, Jason A;
Lawton, Colleen AF;
Bolla, Michel;
... Meta-Analysis of Randomized Trials in Cancer of the Prostate, (MARCAP) consortium; + view all
(2023)
Biochemical Recurrence Surrogacy for Clinical Outcomes After Radiotherapy for Adenocarcinoma of the Prostate.
Journal of Clinical Oncology
10.1200/JCO.23.00617.
(In press).
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South, Annabelle;
Bailey, Julia;
Bierer, Barbara E;
Burnett, Eva;
Cragg, William J;
Diaz-Montana, Carlos;
Gillies, Katie;
... Copas, Andrew J; + view all
(2023)
Site staff perspectives on communicating trial results to participants: Cost and feasibility results from the Show RESPECT cluster randomised, factorial, mixed-methods trial.
Clinical Trials
10.1177/17407745231186088.
(In press).
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Sydes, Matthew;
(2023)
Qualitative data sharing practices in clinical trials in the UK and Ireland: towards the production of good practice guidance [version 1; peer review: awaiting peer review].
HRB Open Research
, 6
, Article 10. 10.12688/hrbopenres.13667.1.
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Williams, Adam DN;
Davies, Gwyneth;
Farrin, Amanda J;
Mafham, Marion;
Robling, Michael;
Sydes, Matthew R;
Lugg-Widger, Fiona V;
(2023)
A DELPHI study priority setting the remaining challenges for the use of routinely collected data in trials: COMORANT-UK.
Trials
, 24
(1)
, Article 243. 10.1186/s13063-023-07251-x.
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2022
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Budde, Axel;
Baust, Katja;
Weinhold, Leonie;
Bernstein, Mark;
Bielack, Stefan;
Dhooge, Catharina;
Hjorth, Lars;
... Schmid, Matthias; + view all
(2022)
Erratum to 'Linking EORTC QLQ-C-30 and PedsQL/PEDQOL physical functioning scores in patients with osteosarcoma' [Eur J Cancer 170 (2022) 209-235].
European Journal of Cancer
, 177
pp. 208-209.
10.1016/j.ejca.2022.06.053.
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Budde, Axel;
Baust, Katja;
Weinhold, Leonie;
Bernstein, Mark;
Bielack, Stefan;
Dhooge, Catharina;
Hjorth, Lars;
... Schmid, Matthias; + view all
(2022)
Linking EORTC QLQ-C-30 and PedsQL/PEDQOL physical functioning scores in patients with osteosarcoma.
European Journal of Cancer
, 170
pp. 209-235.
10.1016/j.ejca.2022.03.018.
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Clarke, Caroline S;
Hunter, Rachael M;
Gabrio, Andrea;
Brawley, Christopher D;
Ingleby, Fiona C;
Dearnaley, David P;
Matheson, David;
... James, Nicholas D; + view all
(2022)
Cost-utility analysis of adding abiraterone acetate plus prednisone/prednisolone to long-term hormone therapy in newly diagnosed advanced prostate cancer in England: Lifetime decision model based on STAMPEDE trial data.
PLoS One
, 17
(6)
, Article e0269192. 10.1371/journal.pone.0269192.
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Ebert, MA;
Marcello, M;
Kennedy, A;
Haworth, A;
Holloway, LC;
Greer, P;
Dowling, JA;
... Dearnaley, DP; + view all
(2022)
In Regard to Shortall et al.
International Journal of Radiation Oncology Biology Physics
, 112
(3)
pp. 831-833.
10.1016/j.ijrobp.2021.10.140.
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Gillessen, Silke;
Bossi, Alberto;
Davis, Ian D;
de Bono, Johann;
Fizazi, Karim;
James, Nicholas D;
Mottet, Nicolas;
... Omlin, Aurelius; + view all
(2022)
Management of Patients with Advanced Prostate Cancer. Part I: Intermediate-/High-risk and Locally Advanced Disease, Biochemical Relapse, and Side Effects of Hormonal Treatment: Report of the Advanced Prostate Cancer Consensus Conference 2022.
European Urology
10.1016/j.eururo.2022.11.002.
(In press).
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Grist, Emily;
Friedrich, Stefanie;
Brawley, Christopher;
Mendes, Larissa;
Parry, Marina;
Ali, Adnan;
Haran, Aine;
... Attard, Gerhardt; + view all
(2022)
Accumulation of copy number alterations and clinical progression across advanced prostate cancer.
Genome Medicine
, 14
, Article 102. 10.1186/s13073-022-01080-4.
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James, Nicholas D;
Clarke, Noel W;
Cook, Adrian;
Ali, Adnan;
Hoyle, Alex P;
Attard, Gert;
Brawley, Chris D;
... Sydes, Matthew R; + view all
(2022)
Abiraterone acetate plus prednisolone for metastatic patients starting hormone therapy: 5-year follow-up results from the STAMPEDE randomised trial (NCT00268476).
International Journal of Cancer
, 151
(3)
pp. 422-434.
10.1002/ijc.34018.
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James, Nicholas D;
Ingleby, Fiona C;
Clarke, Noel W;
Amos, Claire;
Attard, Gerhardt;
Brawley, Christopher D;
Chowdhury, Simon;
... Sydes, Matthew R; + view all
(2022)
Docetaxel for nonmetastatic prostate cancer: long-term survival outcomes in the STAMPEDE randomized controlled trial.
JNCI Cancer Spectrum
, 6
(4)
, Article pkac043. 10.1093/jncics/pkac043.
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Kishan, Amar U;
Wang, Xiaoyan;
Sun, Yilun;
Romero, Tahmineh;
Michalski, Jeff M;
Ma, Ting Martin;
Feng, Felix Y;
... Spratt, Daniel E; + view all
(2022)
High-dose Radiotherapy or Androgen Deprivation Therapy (HEAT) as Treatment Intensification for Localized Prostate Cancer: An Individual Patient–data Network Meta-analysis from the MARCAP Consortium.
European Urology
, 82
(1)
pp. 106-114.
10.1016/j.eururo.2022.04.003.
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Ma, Ting Martin;
Chu, Fang-I;
Sandler, Howard;
Feng, Felix Y;
Efstathiou, Jason A;
Jones, Christopher U;
Roach, Mack;
... Meta-analysis of Randomized trials in Cancer of the Prostate MAR; + view all
(2022)
Local Failure Events in Prostate Cancer Treated with Radiotherapy: A Pooled Analysis of 18 Randomized Trials from the Meta-analysis of Randomized Trials in Cancer of the Prostate Consortium (LEVIATHAN).
European Urology
10.1016/j.eururo.2022.07.011.
(In press).
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Ma, Ting Martin;
Sun, Yilun;
Malone, Shawn;
Roach, Mack;
Dearnaley, David;
Pisansky, Thomas M;
Feng, Felix Y;
... Meta-Analysis of Randomized Trials in Cancer of the Prostate (MA; + view all
(2022)
Sequencing of Androgen-Deprivation Therapy of Short Duration With Radiotherapy for Nonmetastatic Prostate Cancer (SANDSTORM): A Pooled Analysis of 12 Randomized Trials.
Journal of Clinical Oncology
10.1200/JCO.22.00970.
(In press).
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Murray, Macey L;
Love, Sharon B;
Carpenter, James R;
Hartley, Suzanne;
Landray, Martin J;
Mafham, Marion;
Parmar, Mahesh KB;
... Healthcare Systems Data for Clinical Trials Collaborative Group; + view all
(2022)
Data provenance and integrity of health-care systems data for clinical trials.
The Lancet Digital Health
, 4
(8)
e567-e568.
10.1016/S2589-7500(22)00122-4.
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Noor, Nurulamin M;
Love, Sharon B;
Isaacs, Talia;
Kaplan, Richard;
Parmar, Mahesh KB;
Sydes, Matthew R;
(2022)
Uptake of the multi-arm multi-stage (MAMS) adaptive platform approach: a trial-registry review of late-phase randomised clinical trials.
BMJ Open
, 12
(3)
, Article e055615. 10.1136/bmjopen-2021-055615.
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Parker, CC;
Clarke, NW;
Catton, C;
Kynaston, H;
Cook, A;
Cross, W;
Davidson, C;
... Sydes, MR; + view all
(2022)
RADICALS-HD: Reflections before the Results are Known.
Clinical Oncology
, 34
(9)
pp. 593-597.
10.1016/j.clon.2022.06.004.
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Parker, Chris C;
James, Nicholas D;
Brawley, Christopher D;
Clarke, Noel W;
Ali, Adnan;
Amos, Claire L;
Attard, Gerhardt;
... Sydes, Matthew R; + view all
(2022)
Radiotherapy to the prostate for men with metastatic prostate cancer in the UK and Switzerland: Long-term results from the STAMPEDE randomised controlled trial.
PLoS Medicine
, 19
(6)
, Article e1003998. 10.1371/journal.pmed.1003998.
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Sydes, MR;
Wong, WK;
Bakhai, A;
Joffe, N;
Love, SB;
(2022)
Protecting blinded trials in electronic hospital systems.
Clinical Trials
10.1177/17407745211069985.
(In press).
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Turco, F;
Smith, M;
Omlin, A;
Gillessen, S;
(2022)
Reply to Yu Wei, Yao Zhu, and Dingwei Ye's Letter to the Editor re: Fabio Turco, Andrew Armstrong, Gerhardt Attard, et al. What Experts Think About Prostate Cancer Management During the COVID-19 Pandemic: Report from the Advanced Prostate Cancer Consensus Conference 2021. Eur Urol. 2022;82:6–11.
European Urology
, 82
(1)
e13-e13.
10.1016/j.eururo.2022.03.029.
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Turco, Fabio;
Armstrong, Andrew;
Attard, Gerhardt;
Beer, Tomasz M;
Beltran, Himisha;
Bjartell, Anders;
Bossi, Alberto;
... Omlin, Aurelius; + view all
(2022)
What Experts Think About Prostate Cancer Management During the COVID-19 Pandemic: Report from the Advanced Prostate Cancer Consensus Conference 2021.
European Urology
10.1016/j.eururo.2022.02.010.
(In press).
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Vogl, UM;
Beer, TM;
Davis, ID;
Shore, ND;
Sweeney, CJ;
Ost, P;
Attard, G;
... APCCC 2019 expert panel, .; + view all
(2022)
Lack of consensus identifies important areas for future clinical research: Advanced Prostate Cancer Consensus Conference (APCCC) 2019 findings.
European Journal of Cancer
, 160
pp. 24-60.
10.1016/j.ejca.2021.09.036.
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Wason, James MS;
Dimairo, Munyaradzi;
Biggs, Katie;
Bowden, Sarah;
Brown, Julia;
Flight, Laura;
Hall, Jamie;
... Maier, Rebecca; + view all
(2022)
Practical guidance for planning resources required to support publicly-funded adaptive clinical trials.
BMC Medicine
, 20
(1)
, Article 254. 10.1186/s12916-022-02445-7.
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White, Ian;
Choodari-Oskooei, Babak;
Sydes, Matthew R;
Kahan, Brennan;
McCabe, Leanne;
Turkova, Anna;
Esmail, Hanif;
... Ford, Deborah; + view all
(2022)
Combining factorial and multi-arm multi-stage platform designs to evaluate multiple interventions efficiently.
Clinical Trials
10.1177/17407745221093577.
(In press).
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Yorke-Edwards, Victoria;
Diaz-Montana, Carlos;
Murray, Macey L;
Sydes, Matthew R;
Love, Sharon B;
(2022)
Monitoring metrics over time: Why clinical trialists need to systematically collect site performance metrics.
Research Methods in Medicine & Health Sciences
10.1177/26320843221147855.
(In press).
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2021
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Adshead, F;
Salman, RA-S;
Aumonier, S;
Collins, M;
Hood, K;
McNamara, C;
Moore, K;
... Williamson, PR; + view all
(2021)
A strategy to reduce the carbon footprint of clinical trials.
The Lancet
, 398
(10297)
pp. 281-282.
10.1016/s0140-6736(21)01384-2.
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Ali, A;
Hoyle, AP;
Parker, CC;
Brawley, CD;
Cook, A;
Amos, C;
Calvert, J;
... STAMPEDE investigators; + view all
(2021)
Bone metastatic burden as a predictor of survival benefit from prostate radiotherapy in newly-diagnosed metastatic prostate cancer.
JAMA oncology
, 7
(4)
pp. 555-563.
10.1001/jamaoncol.2020.7857.
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Attard, G;
Murphy, L;
Clarke, NW;
Cross, W;
Jones, RJ;
Parker, CC;
Gillessen, S;
... Systemic Therapy in Advancing or Metastatic Prostate cancer: Eva; + view all
(2021)
Abiraterone acetate and prednisolone with or without enzalutamide for high-risk non-metastatic prostate cancer: a meta-analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol.
The Lancet
10.1016/S0140-6736(21)02437-5.
(In press).
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Bass, EJ;
Klimowska-Nassar, N;
Sasikaran, T;
Day, E;
Fiorentino, F;
Sydes, MR;
Winkler, M;
... Ahmed, HU; + view all
(2021)
PROState pathway embedded comparative trial: The IP3-PROSPECT study.
Contemporary Clinical Trials
, 107
, Article 106485. 10.1016/j.cct.2021.106485.
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Day, E;
Prevost, AT;
Sydes, MR;
Reddy, D;
Shah, TT;
Winkler, M;
Dudderidge, T;
... Fiorentino, F; + view all
(2021)
Feasibility of Comparative Health Research Outcome of Novel Surgery in prostate cancer (IP4-CHRONOS): statistical analysis plan for the randomised feasibility phase of the CHRONOS study.
Trials
, 22
, Article 547. 10.1186/s13063-021-05509-w.
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Houghton, C;
McCarthy, M;
Gillies, K;
Rousseau, N;
Wade, J;
Gamble, C;
Toomey, E;
... Biesty, L; + view all
(2021)
A study protocol of qualitative data sharing practices in clinical trials in the UK and Ireland: towards the production of good practice guidance [version 2; peer review: 2 approved].
HRB Open Research
, 4
, Article 47. 10.12688/hrbopenres.13269.2.
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Ibrahim, H;
Liu, X;
Rivera, SC;
Moher, D;
Chan, A-W;
Sydes, MR;
Calvert, MJ;
(2021)
Reporting guidelines for clinical trials of artificial intelligence interventions: the SPIRIT-AI and CONSORT-AI guidelines.
Trials
, 22
(1)
p. 11.
10.1186/s13063-020-04951-6.
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Klatte, K;
Pauli-Magnus, C;
Love, SB;
Sydes, MR;
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Understanding and optimising patient and public involvement in trial oversight: an ethnographic study of eight clinical trials.
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The adaptive designs CONSORT extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design.
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Older Age, Early Symptoms and Physical Function are Associated with the Severity of Late Symptom Clusters for Men Undergoing Radiotherapy for Prostate Cancer.
Clinical Oncology
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Adaptive designs in clinical trials: why use them, and how to run and report them.
BMC Medicine
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Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial.
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Parker, CC;
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Salvage Treatment After Radical Prostatectomy.
European Urology
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Global health trials methodological research agenda: results from a priority setting exercise.
Trials
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Help for Future Research: Lessons Learned in Trial Design, Recruitment, and Delivery From the "hELP" Study.
Journal of Lower Genital Tract Disease
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Stenning, SP;
Cragg, WJ;
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Choudhury, R;
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Triggered or routine site monitoring visits for randomised controlled trials: results of TEMPER, a prospective, matched-pair study.
Clinical Trials
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Adding abiraterone or docetaxel to long-term hormone therapy for prostate cancer: directly randomised data from the STAMPEDE multi-arm, multi-stage platform protocol.
Annals Of Oncology
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Vale, C;
Fisher, D;
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White, I;
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Carpenter, J;
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Re: Christopher JD Wallis, Zachary Klaassen, Bimal Bhindi, et al. Comparison of Abiraterone Acetate and Docetaxel with Androgen Deprivation Therapy in High-risk and Metastatic Hormone-naive Prostate Cancer: A Systematic Review and Network Meta-analysis.
European Urology
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What is the optimal systemic treatment of men with metastatic, hormone-naive prostate cancer? A STOPCAP systematic review and network meta-analysis.
Annals of Oncology
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Alzouebi, M;
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Addition of Docetaxel to First-line Long-term Hormone Therapy in Prostate Cancer (STAMPEDE): Modelling to Estimate Long-term Survival, Quality-adjusted Survival, and Cost-effectiveness.
European Urology Oncology
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2017
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Conroy, JC;
Arch, B;
Harman, N;
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Norrie, J;
Sydes, MR;
Gamble, C;
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A Cohort Examination to Establish Reporting of the Remit and Function of Trial Steering Committees in Randomised Controlled Trials.
Trials
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Selman, LE;
Cramer, H;
McCann, S;
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'We all want to succeed, but we’ve also got to be realistic about what is happening': an ethnographic study of relationships in trial oversight and their impact.
Trials
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Eichenauer, D;
Sydes, MR;
Franklin, J;
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Secondary malignant neoplasms, progression-free survival and overall survival in patients treated for Hodgkin lymphoma: A systematic review and meta-analysis of randomized clinical trials.
Haematologica
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10.3324/haematol.2017.167478.
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Gilson, C;
Chowdhury, S;
Parmar, MKB;
Sydes, MR;
STAMPEDE Investigators;
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Incorporating Biomarker Stratification into STAMPEDE: an Adaptive Multi-arm, Multi-stage Trial Platform.
Clinical Oncology
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Mason, MD;
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Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy.
The New England Journal of Medicine
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Dr. James and colleagues reply:.
New England Journal of Medicine
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Lemanska, A;
Chen, T;
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Jena, R;
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Faithfull, S;
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Symptom clusters for revising scale membership in the analysis of prostate cancer patient reported outcome measures: a secondary data analysis of the Medical Research Council RT01 trial (ISCRTN47772397).
Quality of Life Research
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Attard, G;
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Adding Celecoxib With or Without Zoledronic Acid for Hormone-Naïve Prostate Cancer: Long-Term Survival Results From an Adaptive, Multiarm, Multistage, Platform, Randomized Controlled Trial.
Journal of Clincal Oncology
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Langley, RE;
Brown, L;
Phillips, PP;
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(2017)
Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols.
Clinical Trials
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10.1177/1740774517725697.
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Fizazi, K;
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Mason, MD;
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Adding abiraterone to androgen deprivation therapy in men with metastatic hormone-sensitive prostate cancer: A systematic review and meta-analysis.
European Journal of Cancer
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10.1016/j.ejca.2017.07.003.
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Spears, MR;
James, ND;
Sydes, MR;
(2017)
‘Thursday’s child has far to go’—interpreting subgroups and the STAMPEDE trial.
Annals of Oncology
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Sydes, MR;
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Data Authorship as an Incentive to Data Sharing.
New England Journal of Medicine
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Sydes, MR;
Ritchie, AW;
James, ND;
STAMPEDE Investigators;
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Reply to Che-Kai Tsao, Matthew D. Galsky, and William K. Oh's Platinum Opinion. Docetaxel for Metastatic Hormone-Sensitive Prostate Cancer: Urgent Need To Minimize The Risk Of Neutropenic Fever. Eur Urol 2016;70:707-708.
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Metastasis-Free Survival Is a Strong Surrogate of Overall Survival in Localized Prostate Cancer.
Journal of Clinical Oncology
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10.1200/JCO.2017.73.9987.
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Dorling, L;
Kerns, S;
Fachal, L;
Elliott, R;
Partliament, M;
Rosenstein, BS;
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Common genetic variation associated with increased susceptibility to prostate cancer does not increase risk of radiotherapy toxicity.
British Journal of Cancer
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Barnett, GC;
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Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients.
Radiotherapy and Oncology
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Selman, LE;
Cramer, H;
McCann, S;
Shorter, GW;
Sydes, MR;
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What are the roles and valued attributes of a Trial Steering Committee? Ethnographic study of eight clinical trials facing challenges.
Trials
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Gillessen, S;
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Adler, A;
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Clarke, N;
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Repurposing Metformin as Therapy for Prostate Cancer within the STAMPEDE Trial Platform.
European Urology
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Hollis, S;
Fletcher, C;
Lynn, F;
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Burger, HU;
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Best practice for analysis of shared clinical trial data.
BMC Medical Research Methodology
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Spears, MR;
Clarke, NW;
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Mason, MD;
Parker, CC;
Ritchie, AW;
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Failure-Free Survival and Radiotherapy in Patients With Newly Diagnosed Nonmetastatic Prostate Cancer: Data From Patients in the Control Arm of the STAMPEDE Trial.
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Dearnaley, DP;
Spears, MR;
Ritchie, AW;
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(2016)
Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial.
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Clarke, NW;
Mason, MD;
Parmar, MKB;
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STAMPEDE trial and patients with non-metastatic prostate cancer – Authors' reply.
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James, ND;
Sydes, MR;
Clarke, NW;
Parmar, MKB;
Ritchie, ASWR;
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Response to ‘High Risk of Neutropenia for Hormone-naive Prostate Cancer Patients Receiving STAMPEDE-style Upfront Docetaxel Chemotherapy in Usual Clinical Practice’, by Tanguay et al.
Clinical Oncology
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Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer.
EBioMedicine
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Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial.
The Lancet Oncology
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Parmar, MKB;
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How do you design randomised trials for smaller populations? A framework.
BMC Medicine
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Simpson, RC;
Murphy, R;
Bratton, DJ;
Sydes, MR;
Wilkes, S;
Nankervis, H;
Dowey, S;
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Systemic therapy for vulval Erosive Lichen Planus (the 'hELP' trial): study protocol for a randomised controlled trial.
Trials
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South, A;
Parulekar, WR;
Sydes, MR;
Chen, BE;
Parmar, MK;
Clarke, N;
Warde, P;
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Estimating the Impact of Randomised Control Trial Results on Clinical Practice: Results from a Survey and Modelling Study of Androgen Deprivation Therapy plus Radiotherapy for Locally Advanced Prostate Cancer.
European Urology Focus
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Disease free survival (DFS) as a surrogate for Overall Survival (OS) in Localized Prostate Cancer (CaP) - Intermediate Clinical Endpoints in Cancer of the Prostate (ICECaP) Working Group.
Presented at: 2016 ASCO Annual Meeting, Poster Discussion Session: Genitourinary (Prostate) Cancer, Chicago, Illinois, USA.
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Xie, W;
Regan, M;
Nakabayashi, M;
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Clarke, NW;
Collette, L;
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Disease-free survival (DFS) as a surrogate for overall survival (OS) in localized prostate cancer (CaP).
Journal of Clinical Oncology
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Sydes, MR;
Manamley, N;
Mallett, S;
Hollis, S;
Scrimgeour, A;
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Data Sharing and the Evolving Role of Statisticians.
BMC Medical Research Methodology
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Sylvester, RJ;
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Birtle, A;
Gudjonsson, S;
De Nunzio, C;
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(2016)
Systematic Review and Individual Patient Data Meta-analysis of Randomized Trials Comparing a Single Immediate Instillation of Chemotherapy After Transurethral Resection with Transurethral Resection Alone in Patients with Stage pTa-pT1 Urothelial Carcinoma of the Bladder: Which Patients Benefit from the Instillation?
European Urology
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Vale, CL;
Burdett, S;
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Albiges, L;
Clarke, NW;
Fisher, D;
Fizazi, K;
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(2016)
Addition of docetaxel or bisphosphonates to standard of care in men with localised or metastatic, hormone-sensitive prostate cancer: a systematic review and meta-analyses of aggregate data.
The Lancet Oncology
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2015
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Keat, N;
McConnell, A;
Benson, A;
Ho, A;
Roth, A;
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Clinical trial designs for rare diseases: studies developed and discussed by the International Rare Cancers Initiative.
Eur J Cancer
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Kirkbride, P;
Gospodarowicz, M;
Cowan, R;
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Final Report of the Intergroup Randomized Study of Combined Androgen-Deprivation Therapy Plus Radiotherapy Versus Androgen-Deprivation Therapy Alone in Locally Advanced Prostate Cancer.
Journal of Clinical Oncology
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Survival with Newly Diagnosed Metastatic Prostate Cancer in the “Docetaxel Era”: Data from 917 Patients in the Control Arm of the STAMPEDE Trial (MRC PR08, CRUK/06/019).
European Urology
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Sydes, MR;
Johnson, AL;
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South, A;
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Sharing data from clinical trials: the rationale for a controlled access approach.
Trials
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Tudur Smith, C;
Hopkins, C;
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Woolfall, K;
Clarke, M;
Murray, G;
Williamson, P;
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How should individual participant data (IPD) from publicly funded clinical trials be shared?
BMC Medicine
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2014
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Abdel-Rahman, ME;
Butler, J;
Sydes, MR;
Parmar, MK;
Gordon, E;
Harper, P;
Williams, C;
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No socioeconomic inequalities in ovarian cancer survival within two randomised clinical trials.
Br J Cancer
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Dearnaley, DP;
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Syndikus, I;
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Cowan, RA;
Graham, JD;
Aird, EG;
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(2014)
Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial.
The Lancet Oncology
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Marina, N;
Smeland, S;
Jovic, G;
Hook, JM;
Krailo, M;
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EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment.
Annals of Oncology
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2013
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Smeland, S;
Whelan, J;
Marina, N;
Hook, J;
Jovic, G;
Krailo, MD;
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MAP plus maintenance pegylated interferon alpha-2b (MAP-IFN) versus MAP alone in patients (pts) with resectable high-grade osteosarcoma and good histologic response to preoperative MAP: First results of the EURAMOS-1 good response randomization.
Journal of Clinical Oncology
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2012
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Jinks, RC;
Sydes, MR;
Uscinska, B;
Hook, JM;
van Glabbeke, M;
Bramwell, V;
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Presence of chemotherapy-induced toxicity predicts improved survival in patients with localised extremity osteosarcoma treated with doxorubicin and cisplatin: a report from the European Osteosarcoma Intergroup.
European Journal of Cancer
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Mason, MD;
Clarke, NW;
Amos, C;
Anderson, J;
de Bono, J;
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Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial.
Trials
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2009
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James, ND;
Clarke, NW;
Dearnaley, DP;
Mason, MD;
Morgan, RC;
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Issues in applying multi-arm multi-stage methodology to a clinical trial in prostate cancer: the MRC STAMPEDE trial.
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2007
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Tierney, JF;
Stewart, LA;
Ghersi, D;
Burdett, S;
Sydes, MR;
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Practical methods for incorporating summary time-to-event data into meta-analysis.
Trials
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