Browse by UCL people
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Number of items: 26.
Article
Bahou, C;
Love, EA;
Leonard, S;
Spears, RJ;
Maruani, A;
Armour, K;
Baker, JR;
(2019)
Disulfide Modified IgG1: An Investigation of Biophysical Profile and Clinically Relevant Fc Interactions.
Bioconjugate Chemistry
, 30
(4)
pp. 1048-1054.
10.1021/acs.bioconjchem.9b00174.
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Bahou, C;
Richards, DA;
Maruani, A;
Love, EA;
Javaid, F;
Caddick, S;
Baker, JR;
(2018)
Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones.
Organic & Biomolecular Chemistry
, 16
(8)
pp. 1359-1366.
10.1039/c7ob03138f.
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Bahou, C;
Spears, RJ;
Aliev, AE;
Maruani, A;
Fernandez, M;
Javaid, F;
Szijj, PA;
... Chudasama, V; + view all
(2019)
Use of pyridazinediones as extracellular cleavable linkers through reversible cysteine conjugation.
Chemical Communications
10.1039/c9cc08362f.
(In press).
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Barosi, A;
Dunkel, P;
Guénin, E;
Lalatonne, Y;
Zeitoun, P;
Fitton, I;
Journé, C;
... Dalko, PI; + view all
(2020)
Synthesis and activation of an iron oxide immobilized drug-mimicking reporter under conventional and pulsed X-ray irradiation conditions.
RSC Advances
, 10
(6)
pp. 3366-3370.
10.1039/c9ra09828c.
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Castañeda, L;
Maruani, A;
Schumacher, FF;
Miranda, E;
Chudasama, V;
Chester, KA;
Baker, JR;
... Caddick, S; + view all
(2013)
Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation.
Chemical Communications
, 49
pp. 8187-8189.
10.1039/c3cc45220d.
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Castaneda, L;
Wright, ZVF;
Marculescu, C;
Tran, TM;
Chudasama, V;
Maruani, A;
Hull, EA;
... Baker, JR; + view all
(2013)
A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones.
Tetrahedron Letters
, 54
(27)
3493 -3495.
10.1016/j.tetlet.2013.04.088.
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Cheng, MHY;
Maruani, A;
Savoie, H;
Chudasama, V;
Boyle, RW;
(2018)
Synthesis of a novel HER2 targeted aza-BODIPY-antibody conjugate: synthesis, photophysical characterisation and in vitro evaluation.
Organic & Biomolecular Chemistry
, 16
(7)
pp. 1144-1149.
10.1039/c7ob02957h.
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Chudasama, V;
Bryden, F;
Savoie, H;
Maruani, A;
Cheng, M;
Beeby, A;
Rodrigues, J;
(2017)
Assembly of high-potency photosensitiser-antibody conjugates through application of dendron multiplier technology.
Bioconjugate Chemistry
, 29
(1)
pp. 176-181.
10.1021/acs.bioconjchem.7b00678.
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Chudasama, V;
Maruani, A;
Caddick, S;
(2016)
Recent advances in the construction of antibody–drug conjugates.
Nature Chemistry
, 8
pp. 114-119.
10.1038/nchem.2415.
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Lee, MTW;
Maruani, A;
Baker, JR;
Caddick, S;
Chudasama, V;
(2015)
Next-generation disulfide stapling: reduction and functional re-bridging all in one.
Chemical Science
(1)
pp. 799-802.
10.1039/c5sc02666k.
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Lee, MTW;
Maruani, A;
Richards, DA;
Baker, JR;
Caddick, S;
Chudasama, V;
(2017)
Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering.
Chemical Science
, 8
(3)
pp. 2056-2060.
10.1039/c6sc03655d.
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Maruani, A;
(2018)
Bispecifics and antibody–drug conjugates: A positive synergy.
Drug Discovery Today: Technologies
, 30
pp. 55-61.
10.1016/j.ddtec.2018.09.003.
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Maruani, A;
Alom, S;
Canavelli, P;
Lee, MT;
Morgan, RE;
Chudasama, V;
Caddick, S;
(2015)
A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates.
Chemical Communications
, 51
(25)
pp. 5279-5282.
10.1039/c4cc08515a.
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Maruani, A;
Lee, MTW;
Watkins, G;
Akhbar, AR;
Baggs, H;
Shamsabadi, A;
Richards, DA;
(2016)
A facile, one-pot procedure for the conversion of aromatic aldehydes to esters, as well as thioesters and amides, via acyl hydrazide intermediates.
RSC Advances
, 6
(4)
pp. 3372-3376.
10.1039/C5RA26842G.
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Maruani, A;
Richards, DA;
Chudasama, V;
(2016)
Dual modification of biomolecules.
Organic & Biomolecular Chemistry
, 14
(26)
pp. 6165-6178.
10.1039/c6ob01010e.
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Maruani, A;
Savoie, H;
Bryden, F;
Caddick, S;
Boyle, R;
Chudasama, V;
(2015)
Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic.
Chemical Communications
, 51
(83)
pp. 15304-15307.
10.1039/c5cc06985h.
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Maruani, A;
Smith, ME;
Miranda, E;
Chester, KA;
Chudasama, V;
Caddick, S;
(2015)
A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy.
Nat Commun
, 6
, Article 6645. 10.1038/ncomms7645.
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Maruani, A;
Szijj, P;
Bahou, C;
Nogueira, J;
Caddick, S;
Baker, JR;
Chudasama, V;
(2020)
A Plug-and-Play Approach for the De Novo Generation of Dually Functionalized Bispecifics.
Bioconjugate Chemistry
, 31
(3)
pp. 520-529.
10.1021/acs.bioconjchem.0c00002.
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Moody, P;
Chudasama, V;
Nathani, RI;
Maruani, A;
Martin, S;
Smith, ME;
Caddick, S;
(2014)
A rapid, site-selective and efficient route to the dual modification of DARPins.
Chem Commun (Camb)
, 50
(38)
pp. 4898-4900.
10.1039/c4cc00053f.
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Pye, H;
Butt, MA;
Reinert, HW;
Maruani, A;
Nunes, JP;
Marklew, JS;
Qurashi, M;
... Lovat, LB; + view all
(2016)
A HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy.
Photochemical & Photobiological Sciences
, 15
(10)
pp. 1227-1238.
10.1039/c6pp00139d.
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Richards, DA;
Maruani, A;
Chudasama, V;
(2017)
Antibody fragments as nanoparticle targeting ligands: a step in the right direction.
Chemical Science
, 8
(1)
pp. 63-77.
10.1039/c6sc02403c.
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Robinson, E;
Nunes, JPM;
Vassileva, V;
Maruani, A;
Nogueira, JCF;
Smith, MEB;
Pedley, RB;
... Chudasama, V; + view all
(2017)
Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody.
RSC Advances
, 7
(15)
pp. 9073-9077.
10.1039/C7RA00788D.
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Schumacher, FF;
Nunes, JP;
Maruani, A;
Chudasama, V;
Smith, ME;
Chester, KA;
Baker, JR;
(2014)
Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging.
Organic & Biomolecular Chemistry
, 12
(37)
pp. 7261-7269.
10.1039/c4ob01550a.
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Shamsabadi, A;
Maruani, A;
Ahmed, N;
Chudasama, V;
(2020)
Aerobically-initiated C(sp³)–H bond amination through the use of activated azodicarboxylates.
Organic & Biomolecular Chemistry
10.1039/d0ob01562h.
(In press).
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Smith, ME;
Caspersen, MB;
Robinson, E;
Morais, M;
Maruani, A;
Nunes, JP;
Nicholls, K;
... Chudasama, V; + view all
(2015)
A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine.
Organic and Biomolecular Chemistry
, 13
(29)
pp. 7946-7949.
10.1039/c5ob01205h.
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Thesis
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Maruani, AGF;
(2016)
Pyridazinediones: A Novel Class of Tuneable Reagents for the Selective Dual Modification of Proteins.
Doctoral thesis , UCL (University College London).
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