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Number of items: 160.

Article

Afschar, S; Toivonen, JM; Hoffmann, JM; Tain, LS; Wieser, D; Finlayson, AJ; Driege, Y; ... Partridge, L; + view all Afschar, S; Toivonen, JM; Hoffmann, JM; Tain, LS; Wieser, D; Finlayson, AJ; Driege, Y; Alic, N; Emran, S; Stinn, J; Froehlich, J; Piper, MD; Partridge, L; - view fewer (2016) Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila. Proceedings of the National Academy of Sciences of the United States of America , 113 (5) pp. 1321-1326. 10.1073/pnas.1515137113.

Alic, N; Andrews, TD; Giannakou, ME; Papatheodorou, I; Slack, C; Hoddinott, MP; Cocheme, HM; ... Partridge, L; + view all Alic, N; Andrews, TD; Giannakou, ME; Papatheodorou, I; Slack, C; Hoddinott, MP; Cocheme, HM; Schuster, EF; Thornton, JM; Partridge, L; - view fewer (2011) Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. Molecular Systems Biology , 7 , Article 502. 10.1038/msb.2011.36.

Alic, N; Giannakou, ME; Papatheodorou, I; Hoddinott, MP; Andrews, TD; Bolukbasi, E; Partridge, L; (2014) Interplay of dFOXO and Two ETS-Family Transcription Factors Determines Lifespan in Drosophila melanogaster. PLoS Genet , 10 (9) , Article e1004619. 10.1371/journal.pgen.1004619.

Alic, N; Hoddinott, MP; Foley, A; Slack, C; Piper, MD; Partridge, L; (2012) Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies. PLOS One , 7 (9) , Article e45367. 10.1371/journal.pone.0045367.

Alic, N; Hoddinott, MP; Vinti, G; Partridge, L; (2011) Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. Aging Cell , 10 (1) 137 - 147. 10.1111/j.1474-9726.2010.00653.x.

Alic, N; Partridge, L; (2015) Myc mouse and anti-ageing therapy. Trends in Endocrinology & Metabolism , 26 (4) pp. 163-164. 10.1016/j.tem.2015.02.005.

Alic, N; Tullet, JM; Niccoli, T; Broughton, S; Hoddinott, MP; Slack, C; Gems, D; Alic, N; Tullet, JM; Niccoli, T; Broughton, S; Hoddinott, MP; Slack, C; Gems, D; Partridge, L; - view fewer (2014) Cell-Nonautonomous Effects of dFOXO/DAF-16 in Aging. Cell Rep , 6 (4) pp. 608-616. 10.1016/j.celrep.2014.01.015.

Aman, Y; Schmauck-Medina, T; Hansen, M; Morimoto, RI; Simon, AK; Bjedov, I; Palikaras, K; ... Fang, EF; + view all Aman, Y; Schmauck-Medina, T; Hansen, M; Morimoto, RI; Simon, AK; Bjedov, I; Palikaras, K; Simonsen, A; Johansen, T; Tavernarakis, N; Rubinsztein, DC; Partridge, L; Kroemer, G; Labbadia, J; Fang, EF; - view fewer (2021) Autophagy in healthy aging and disease. Nature Aging , 1 (8) pp. 634-650. 10.1038/s43587-021-00098-4.

Atilano, Magda L; Hull, Alexander; Romila, Catalina-Andreea; Adams, Mirjam L; Wildfire, Jacob; Ureña, Enric; Dyson, Miranda; ... Kinghorn, Kerri J; + view all Atilano, Magda L; Hull, Alexander; Romila, Catalina-Andreea; Adams, Mirjam L; Wildfire, Jacob; Ureña, Enric; Dyson, Miranda; Ivan-Castillo-Quan, Jorge; Partridge, Linda; Kinghorn, Kerri J; - view fewer (2023) Autophagic dysfunction and gut microbiota dysbiosis cause chronic immune activation in a Drosophila model of Gaucher disease. PLoS Genetics , 19 (12) , Article e1011063. 10.1371/journal.pgen.1011063.

Atilano, ML; Grönke, S; Niccoli, T; Kempthorne, L; Hahn, O; Morón-Oset, J; Hendrich, O; ... Partridge, L; + view all Atilano, ML; Grönke, S; Niccoli, T; Kempthorne, L; Hahn, O; Morón-Oset, J; Hendrich, O; Dyson, M; Adams, ML; Hull, A; Salcher-Konrad, M-T; Monaghan, A; Bictash, M; Glaria, I; Isaacs, AM; Partridge, L; - view fewer (2021) Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila. eLife , 10 , Article e58565. 10.7554/eLife.58565.

Augustin, H; Adcott, J; Elliott, CJH; Partridge, L; (2017) Complex Roles of Myoglianin in Regulating Adult Performance and Lifespan. Fly , 11 (4) pp. 284-289. 10.1080/19336934.2017.1369638.

Augustin, H; McGourty, K; Allen, MJ; Adcott, J; Wong, CT; Boucrot, E; Partridge, L; (2018) Impact of insulin signaling and proteasomal activity on physiological 2 output of a neuronal circuit in aging D. melanogaster. Neurobiology of Aging , 66 pp. 149-157. 10.1016/j.neurobiolaging.2018.02.027.

Augustin, H; McGourty, K; Steinert, JR; Cochemé, HM; Adcott, J; Cabecinha, M; Vincent, A; ... Partridge, L; + view all Augustin, H; McGourty, K; Steinert, JR; Cochemé, HM; Adcott, J; Cabecinha, M; Vincent, A; Halff, EF; Kittler, JT; Boucrot, E; Partridge, L; - view fewer (2017) Myostatin-like proteins regulate synaptic function and neuronal morphology. Development , 144 pp. 2445-2455. 10.1242/dev.152975.

Baghdadi, Maarouf; Mesaros, Andrea; Purrio, Martin; Partridge, Linda; (2023) Sex-specific effects of Cre expression in Syn1Cre mice. Scientific Reports , 13 , Article 10037. 10.1038/s41598-023-37029-9.

Baghdadi, Maarouf; Nespital, Tobias; Monzó, Carolina; Deelen, Joris; Grönke, Sebastian; Partridge, Linda; (2024) Intermittent rapamycin feeding recapitulates some effects of continuous treatment while maintaining lifespan extension. Molecular Metabolism , 81 , Article 101902. 10.1016/j.molmet.2024.101902.

Baghdadi, M; Hinterding, HM; Partridge, L; Deelen, J; (2021) From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing. Briefings in Functional Genomics 10.1093/bfgp/elab005. (In press).

Bass, TM; Grandison, RC; Wong, R; Martinez, P; Partridge, L; Piper, MDW; (2007) Optimization of dietary restriction protocols in Drosophila. Journal of Gerontology: Biological Sciences , 62 (10) 1071 - 1081.

Bjedov, I; Cochemé, HM; Foley, A; Wieser, D; Woodling, NS; Castillo-Quan, JI; Norvaisas, P; ... Partridge, L; + view all Bjedov, I; Cochemé, HM; Foley, A; Wieser, D; Woodling, NS; Castillo-Quan, JI; Norvaisas, P; Lujan, C; Regan, J; Toivonen, JM; Murphy, MP; Thornton, J; Kinghorn, KJ; Neufeld, TP; Cabreiro, F; Partridge, L; - view fewer (2020) Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila. PLOS Genetics , 16 (11) , Article e1009083. 10.1371/journal.pgen.1009083.

Bjedov, I; Toivonen, JM; Kerr, F; Slack, C; Jacobson, J; Foley, A; Partridge, L; (2010) Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster. Cell Metabolism , 11 (1) 35 - 46. 10.1016/j.cmet.2009.11.010.

Bolukbasi, E; Khericha, M; Regan, JC; Ivanov, DK; Adcott, J; Dyson, MC; Nespital, T; ... Partridge, L; + view all Bolukbasi, E; Khericha, M; Regan, JC; Ivanov, DK; Adcott, J; Dyson, MC; Nespital, T; Thornton, JM; Alic, N; Partridge, L; - view fewer (2017) Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity. Cell Reports , 21 (3) pp. 641-653. 10.1016/j.celrep.2017.09.042.

Bolukbasi, E; Woodling, NS; Ivanov, DK; Adcott, J; Foley, A; Rajasingam, A; Gittings, LM; ... Partridge, L; + view all Bolukbasi, E; Woodling, NS; Ivanov, DK; Adcott, J; Foley, A; Rajasingam, A; Gittings, LM; Aleyakpo, B; Niccoli, T; Thornton, JM; Partridge, L; - view fewer (2021) Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system. Proceedings of the National Academy of Sciences , 118 (8) , Article e2011491118. 10.1073/pnas.2011491118.

Brandt, T; Mourier, A; Tain, LS; Partridge, L; Larsson, N-G; Kühlbrandt, W; (2017) Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila. Elife , 6 , Article e24662. 10.7554/eLife.24662.

Bratic, A; Kauppila, TES; Macao, B; Grönke, S; Siibak, T; Stewart, JB; Baggio, F; ... Larsson, N-G; + view all Bratic, A; Kauppila, TES; Macao, B; Grönke, S; Siibak, T; Stewart, JB; Baggio, F; Dols, J; Partridge, L; Falkenberg, M; Wredenberg, A; Larsson, N-G; - view fewer (2015) Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies. Nature Communications , 6 , Article 8808. 10.1038/ncomms9808.

Broughton, S; Alic, N; Slack, C; Bass, T; Ikeya, T; Vinti, G; Tommasi, AM; ... Partridge, L; + view all Broughton, S; Alic, N; Slack, C; Bass, T; Ikeya, T; Vinti, G; Tommasi, AM; Driege, Y; Hafen, E; Partridge, L; - view fewer (2008) Reduction of DILP2 in Drosophila Triages a Metabolic Phenotype from Lifespan Revealing Redundancy and Compensation among DILPs. PLOS ONE , 3 (11) , Article e3721. 10.1371/journal.pone.0003721.

Broughton, S.; Alic, N.; Slack, C.; Bass, T.; Ikeya, T.; Vinti, G.; Tommasi, A.M.; ... Partridge, L.; + view all Broughton, S.; Alic, N.; Slack, C.; Bass, T.; Ikeya, T.; Vinti, G.; Tommasi, A.M.; Driege, Y.; Hafen, E.; Partridge, L.; - view fewer (2008) Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs. PLoS ONE , 3 (11) , Article e3721. 10.1371/journal.pone.0003721.

Burnouf, S; Gorsky, MK; Dols, J; Grönke, S; Partridge, L; (2015) Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivo. Acta Neuropathologica , 130 (1) pp. 35-47. 10.1007/s00401-015-1419-y.

Castillo-Quan, JI; Li, L; Kinghorn, KJ; Ivanov, DK; Tain, LS; Slack, C; Kerr, F; ... Partridge, L; + view all Castillo-Quan, JI; Li, L; Kinghorn, KJ; Ivanov, DK; Tain, LS; Slack, C; Kerr, F; Nespital, T; Thornton, J; Hardy, J; Bjedov, I; Partridge, L; - view fewer (2016) Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis. Cell Reports , 15 (3) pp. 638-650. 10.1016/j.celrep.2016.03.041.

Castillo-Quan, JI; Tain, LS; Kinghorn, KJ; Li, L; Grönke, S; Hinze, Y; Blackwell, TK; ... Partridge, L; + view all Castillo-Quan, JI; Tain, LS; Kinghorn, KJ; Li, L; Grönke, S; Hinze, Y; Blackwell, TK; Bjedov, I; Partridge, L; - view fewer (2019) A triple drug combination targeting components of the nutrient-sensing network maximizes longevity. Proceedings of the National Academy of Sciences of the United States of America , 116 (42) pp. 20817-20819. 10.1073/pnas.1913212116.

Catterson, James H; Minkley, Lucy; Aspe, Salomé; Judd-Mole, Sebastian; Moura, Sofia; Dyson, Miranda C; Rajasingam, Arjunan; ... Partridge, Linda; + view all Catterson, James H; Minkley, Lucy; Aspe, Salomé; Judd-Mole, Sebastian; Moura, Sofia; Dyson, Miranda C; Rajasingam, Arjunan; Woodling, Nathaniel S; Atilano, Magda L; Ahmad, Mumtaz; Durrant, Claire S; Spires-Jones, Tara L; Partridge, Linda; - view fewer (2023) Protein retention in the endoplasmic reticulum rescues Aβ toxicity in Drosophila. Neurobiol Aging , 132 pp. 154-174. 10.1016/j.neurobiolaging.2023.09.008.

Catterson, JH; Khericha, M; Dyson, MC; Vincent, AJ; Callard, R; Haveron, SM; Rajasingam, A; ... Partridge, L; + view all Catterson, JH; Khericha, M; Dyson, MC; Vincent, AJ; Callard, R; Haveron, SM; Rajasingam, A; Ahmad, M; Partridge, L; - view fewer (2018) Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension. Current Biology , 28 (11) pp. 1714-1724. 10.1016/j.cub.2018.04.015.

Chen, Y; Lee, SF; Blanc, E; Reuter, C; Wertheim, B; Martinez-Diaz, P; Hoffmann, AA; Chen, Y; Lee, SF; Blanc, E; Reuter, C; Wertheim, B; Martinez-Diaz, P; Hoffmann, AA; Partridge, L; - view fewer (2012) Genome-wide transcription analysis of clinal genetic variation in Drosophila. PLoS One , 7 (4) , Article e34620. 10.1371/journal.pone.0034620.

Debès, Cédric; Papadakis, Antonios; Grönke, Sebastian; Karalay, Özlem; Tain, Luke S; Mizi, Athanasia; Nakamura, Shuhei; ... Beyer, Andreas; + view all Debès, Cédric; Papadakis, Antonios; Grönke, Sebastian; Karalay, Özlem; Tain, Luke S; Mizi, Athanasia; Nakamura, Shuhei; Hahn, Oliver; Weigelt, Carina; Josipovic, Natasa; Zirkel, Anne; Brusius, Isabell; Sofiadis, Konstantinos; Lamprousi, Mantha; Lu, Yu-Xuan; Huang, Wenming; Esmaillie, Reza; Kubacki, Torsten; Späth, Martin R; Schermer, Bernhard; Benzing, Thomas; Müller, Roman-Ulrich; Antebi, Adam; Partridge, Linda; Papantonis, Argyris; Beyer, Andreas; - view fewer (2023) Ageing-associated changes in transcriptional elongation influence longevity. Nature 10.1038/s41586-023-05922-y. (In press).

Ding, X; Bloch, W; Iden, S; Rüegg, MA; Hall, MN; Leptin, M; Partridge, L; Ding, X; Bloch, W; Iden, S; Rüegg, MA; Hall, MN; Leptin, M; Partridge, L; Eming, SA; - view fewer (2016) mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nature Communications , 7 , Article 13226. 10.1038/ncomms13226.

Dönertaş, HM; Fabian, DK; Fuentealba, M; Partridge, L; Thornton, JM; (2021) Common genetic associations between age-related diseases. Nature Aging , 1 (4) pp. 400-412. 10.1038/s43587-021-00051-5.

Dönertaş, HM; Fuentealba, M; Partridge, L; Thornton, JM; (2019) Identifying Potential Ageing-Modulating Drugs In Silico. Trends in Endocrinology and Metabolism , 30 (2) pp. 118-131. 10.1016/j.tem.2018.11.005. (In press).

Dönertaş, HM; Fuentealba Valenzuela, M; Partridge, L; Thornton, JM; (2018) Gene expression-based drug repurposing to target aging. Aging Cell 10.1111/acel.12819.

Dzankic, Paula Juricic; Partridge, Linda; (2021) Clinical trials of mTOR inhibitors to boost immunity to viral infection in older adults. The Lancet Healthy Longevity , 2 (5) e232-e233. 10.1016/S2666-7568(21)00090-8.

Essers, P; Tain, LS; Nespital, T; Goncalves, J; Froehlich, J; Partridge, L; (2016) Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice. Scientific Reports , 6 , Article 30290. 10.1038/srep30290.

Fabian, DK; Dönertaş, HM; Fuentealba, M; Partridge, L; Thornton, JM; (2021) Transposable Element Landscape in Drosophila Populations Selected for Longevity. Genome Biology and Evolution , 13 (4) , Article evab031. 10.1093/gbe/evab031.

Fabian, DK; Fuentealba, M; Dönertaş, HM; Partridge, L; Thornton, JM; (2021) Functional conservation in genes and pathways linking ageing and immunity. Immunity & Aging , 18 , Article 23. 10.1186/s12979-021-00232-1.

Flatt, T; Partridge, L; (2018) Horizons in the evolution of aging. BMC Biology , 16 , Article 93. 10.1186/s12915-018-0562-z.

Fontana, L; Partridge, L; (2015) Promoting health and longevity through diet: From model organisms to humans. [Review]. Cell , 161 (1) 106 - 118. 10.1016/j.cell.2015.02.020.

Fraser, Helen C; Kuan, Valerie; Johnen, Ronja; Zwierzyna, Magdalena; Hingorani, Aroon D; Beyer, Andreas; Partridge, Linda; (2022) Biological mechanisms of aging predict age-related disease co-occurrence in patients. Aging Cell 10.1111/acel.13524. (In press).

Fuentealba, M; Dönertaş, HM; Williams, R; Labbadia, J; Thornton, JM; Partridge, L; (2019) Using the drug-protein interactome to identify anti-ageing compounds for humans. PLoS Computational Biology , 15 (1) , Article e1006639. 10.1371/journal.pcbi.1006639. (In press).

Fuentealba, M; Fabian, DK; Dönertaş, HM; Thornton, JM; Partridge, L; (2021) Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice. Mechanisms of Ageing and Development , 194 , Article 111437. 10.1016/j.mad.2021.111437.

Giblin, Ashling; Cammack, Alexander J; Blomberg, Niek; Anoar, Sharifah; Mikheenko, Alla; Carcole, Mireia; Atilano, Magda L; ... Isaacs, Adrian M; + view all Giblin, Ashling; Cammack, Alexander J; Blomberg, Niek; Anoar, Sharifah; Mikheenko, Alla; Carcole, Mireia; Atilano, Magda L; Hull, Alex; Shen, Dunxin; Wei, Xiaoya; Coneys, Rachel; Zhou, Lele; Mohammed, Yassene; Olivier-Jimenez, Damien; Wang, Lian Y; Kinghorn, Kerri J; Niccoli, Teresa; Coyne, Alyssa N; van der Kant, Rik; Lashley, Tammaryn; Giera, Martin; Partridge, Linda; Isaacs, Adrian M; - view fewer (2025) Neuronal polyunsaturated fatty acids are protective in ALS/FTD. Nature Neuroscience , 28 (4) pp. 737-747. 10.1038/s41593-025-01889-3.

Giblin, Ashling; Cammack, Alexander J; Blomberg, Niek; Anoar, Sharifah; Mikheenko, Alla; Carcole, Mireia; Atilano, Magda L; ... Isaacs, Adrian M; + view all Giblin, Ashling; Cammack, Alexander J; Blomberg, Niek; Anoar, Sharifah; Mikheenko, Alla; Carcole, Mireia; Atilano, Magda L; Hull, Alex; Shen, Dunxin; Wei, Xiaoya; Coneys, Rachel; Zhou, Lele; Mohammed, Yassene; Olivier-Jimenez, Damien; Wang, Lian Y; Kinghorn, Kerri J; Niccoli, Teresa; Coyne, Alyssa N; van der Kant, Rik; Lashley, Tammaryn; Giera, Martin; Partridge, Linda; Isaacs, Adrian M; - view fewer (2025) Neuronal polyunsaturated fatty acids are protective in ALS/FTD (Feb, 10.1038/s41593-025-01889-3, 2025). [Corrigendum]. Nature Neuroscience , 28 (4) p. 913. 10.1038/s41593-025-01926-1.

Gorsky, MK; Burnouf, S; Dols, J; Mandelkow, E; Partridge, L; (2016) Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo. Scientific Reports , 6 (22685) 10.1038/srep22685.

Gorsky, MK; Burnouf, S; Sofola-Adesakin, O; Dols, J; Augustin, H; Weigelt, CM; Grönke, S; Gorsky, MK; Burnouf, S; Sofola-Adesakin, O; Dols, J; Augustin, H; Weigelt, CM; Grönke, S; Partridge, L; - view fewer (2017) Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity. Scientific Reports , 7 , Article 9984. 10.1038/s41598-017-10225-0.

Grandison, R.C.; Wong, R.; Bass, T.M.; Partridge, L.; Piper, M.D.W.; Tanimoto, H.; (2009) Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster. PLoS ONE , 4 (1) , Article e4067. 10.1371/journal.pone.0004067.

Grandison, RC; Piper, MDW; Partridge, L; (2009) Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature , 462 (7276) 1061 - 1065. 10.1038/nature08619.

Grandison, RC; Wong, R; Bass, TM; Partridge, L; Piper, MDW; (2009) Effect of a Standardised Dietary Restriction Protocol on Multiple Laboratory Strains of Drosophila melanogaster. PLOS ONE , 4 (1) , Article e4067. 10.1371/journal.pone.0004067.

Gronke, S; Clarke, DF; Broughton, S; Andrews, TD; Partridge, L; (2010) Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides. PLOS GENET , 6 (2) , Article e1000857. 10.1371/journal.pgen.1000857.

Hahn, O; Foltz, AG; Atkins, M; Kedir, B; Moran-Losada, P; Guldner, IH; Munson, C; ... Wyss-Coray, T; + view all Hahn, O; Foltz, AG; Atkins, M; Kedir, B; Moran-Losada, P; Guldner, IH; Munson, C; Kern, F; Pálovics, R; Lu, N; Zhang, H; Kaur, A; Hull, J; Huguenard, JR; Grönke, S; Lehallier, B; Partridge, L; Keller, A; Wyss-Coray, T; - view fewer (2023) Atlas of the aging mouse brain reveals white matter as vulnerable foci. Cell , 186 (19) 4117-4133.e22. 10.1016/j.cell.2023.07.027.

Hahn, O; Drews, LF; Nguyen, A; Tatsuta, T; Gkioni, L; Hendrich, O; Zhang, Q; ... Partridge, L; + view all Hahn, O; Drews, LF; Nguyen, A; Tatsuta, T; Gkioni, L; Hendrich, O; Zhang, Q; Langer, T; Pletcher, S; Wakelam, MJO; Beyer, A; Grönke, S; Partridge, L; - view fewer (2019) A nutritional memory effect counteracts the benefits of dietary restriction in old mice. Nature Metabolism , 1 pp. 1059-1073. 10.1038/s42255-019-0121-0.

Hahn, O; Grönke, S; Stubbs, TM; Ficz, G; Hendrich, O; Krueger, F; Andrews, S; ... Partridge, L; + view all Hahn, O; Grönke, S; Stubbs, TM; Ficz, G; Hendrich, O; Krueger, F; Andrews, S; Zhang, Q; Wakelam, M; Beyer, A; Reik, W; Partridge, L; - view fewer (2017) Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism. Genome Biology , 18 , Article 56. 10.1186/s13059-017-1187-1.

Hoffmann, JM; Partridge, L; (2015) Nuclear hormone receptors: Roles of xenobiotic detoxification and sterol homeostasis in healthy aging. Critical Reviews in Biochemistry and Molecular Biology , 50 (5) pp. 380-392. 10.3109/10409238.2015.1067186.

Hölbling, BV; Gupta, Y; Marchi, PM; Atilano, ML; Flower, M; Ureña, E; Goulden, RA; ... Isaacs, AM; + view all Hölbling, BV; Gupta, Y; Marchi, PM; Atilano, ML; Flower, M; Ureña, E; Goulden, RA; Dobbs, HK; Katona, E; Mikheenko, A; Giblin, A; Awan, AR; Fisher-Ward, CL; O'Brien, N; Vaizoglu, D; Kempthorne, L; Wilson, KM; Gittings, LM; Carcolé, M; Ruepp, MD; Mizielinska, S; Partridge, L; Fratta, P; Tabrizi, SJ; Selvaraj, BT; Chandran, S; Armstrong, E; Whiting, P; Isaacs, AM; - view fewer (2025) A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons. Cell Reports , 44 (5) , Article 115695. 10.1016/j.celrep.2025.115695.

Ikeya, T.; Broughton, S.; Alic, N.; Grandison, R.; Partridge, L.; (2009) The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila. Proceedings of the Royal Society B: Biological Sciences , 276 (1674) pp. 3799-3807. 10.1098/rspb.2009.0778.

Ivanov, DK; Bostelmann, G; Lan-Leung, B; Williams, J; Partridge, L; Escott-Price, V; Thornton, JM; (2020) A novel computational approach for predicting complex phenotypes in Drosophila (starvation-sensitive and sterile) by deriving their gene expression signatures from public data. PLOS ONE , 15 (10) , Article e0240824. 10.1371/journal.pone.0240824.

Ivanov, DK; Escott-Price, V; Ziehm, M; Magwire, MM; Mackay, TF; Partridge, L; Thornton, JM; (2015) Longevity GWAS Using the Drosophila Genetic Reference Panel. Journals of Gerontology: Series A , 70 (12) pp. 1470-1478. 10.1093/gerona/glv047.

Iyer, J; Wang, Q; Le, T; Pizzo, L; Grönke, S; Ambegaokar, S; Imai, Y; ... Girirajan, S; + view all Iyer, J; Wang, Q; Le, T; Pizzo, L; Grönke, S; Ambegaokar, S; Imai, Y; Srivastava, A; Llamusí Troisí, B; Mardon, G; Artero, R; Jackson, GR; Isaacs, AM; Partridge, L; Kumar, JP; Girirajan, S; - view fewer (2016) Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies Using Drosophila melanogaster. G3 (Bethesda) , 6 (5) pp. 1427-1437. 10.1534/g3.116.027060.

Juricic, P; Lu, YX; Leech, T; Drews, LF; Paulitz, J; Lu, J; Nespital, T; ... Partridge, L; + view all Juricic, P; Lu, YX; Leech, T; Drews, LF; Paulitz, J; Lu, J; Nespital, T; Azami, S; Regan, JC; Funk, E; Fröhlich, J; Grönke, S; Partridge, L; - view fewer (2022) Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy. Nature Aging 10.1038/s43587-022-00278-w. (In press).

Juricic, P; Grönke, S; Partridge, L; (2020) Branched-chain amino acids have equivalent effects to other essential amino acids on lifespan and ageing-related traits in Drosophila. The Journals of Gerontology: Series A , 75 (1) pp. 24-31. 10.1093/gerona/glz080.

Kaeser, SA; Lehallier, B; Thinggaard, M; Häsler, LM; Apel, A; Bergmann, C; Berdnik, D; ... Jucker, M; + view all Kaeser, SA; Lehallier, B; Thinggaard, M; Häsler, LM; Apel, A; Bergmann, C; Berdnik, D; Jeune, B; Christensen, K; Grönke, S; Partridge, L; Wyss-Coray, T; Mengel-From, J; Jucker, M; - view fewer (2021) A neuronal blood marker is associated with mortality in old age. Nature Aging , 1 (2) pp. 218-225. 10.1038/s43587-021-00028-4.

Kakanj, P; Eming, SA; Partridge, L; Leptin, M; (2020) Long-term in vivo imaging of Drosophila larvae. Nature Protocols , 15 pp. 1158-1185. 10.1038/s41596-019-0282-z.

Kakanj, P; Moussian, B; Groenke, S; Bustos, V; Eming, SA; Partridge, L; Leptin, M; (2016) Insulin and TOR signal in parallel through FOXO and S6K to promote epithelial wound healing. Nature Communications , 7 , Article 12972. 10.1038/ncomms12972.

Kauppila, TES; Bratic, A; Jensen, MB; Baggio, F; Partridge, L; Jasper, H; Groenke, S; Kauppila, TES; Bratic, A; Jensen, MB; Baggio, F; Partridge, L; Jasper, H; Groenke, S; Larsson, N-G; - view fewer (2018) Mutations of Mitochondrial DNA Are Not Major Contributors to Aging of Fruit Flies. Proceedings of the National Academy of Sciences , 115 (41) E9620-E9629. 10.1073/pnas.1721683115.

Kerr, F; Sofola-Adesakin, O; Ivanov, DK; Gatliff, J; Gomez Perez-Nievas, B; Bertrand, HC; Martinez, P; ... Partridge, L; + view all Kerr, F; Sofola-Adesakin, O; Ivanov, DK; Gatliff, J; Gomez Perez-Nievas, B; Bertrand, HC; Martinez, P; Callard, R; Snoeren, I; Cochemé, HM; Adcott, J; Khericha, M; Castillo-Quan, JI; Wells, G; Noble, W; Thornton, J; Partridge, L; - view fewer (2017) Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease. PLoS Genetics , 13 (3) , Article e1006593. 10.1371/journal.pgen.1006593.

Kinghorn, KJ; Castillo-Quan, JI; Li, L; Bhatia, KP; Abramov, AY; Hardy, J; Partridge, L; (2016) Reply: Glial mitochondropathy in infantile neuroaxonal dystrophy: pathophysiological and therapeutic implications. Brain , 139 (12) , Article e68. 10.1093/brain/aww185.

Kinghorn, KJ; Groenke, S; Castillo-Quan, JI; Woodling, NS; Li, L; Sirka, E; Gegg, M; ... Partridge, L; + view all Kinghorn, KJ; Groenke, S; Castillo-Quan, JI; Woodling, NS; Li, L; Sirka, E; Gegg, M; Mills, K; Hardy, J; Bjedov, I; Partridge, L; - view fewer (2016) A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin. JOURNAL OF NEUROSCIENCE , 36 (46) pp. 11654-11670. 10.1523/JNEUROSCI.4527-15.2016.

Kuan, V; Fraser, HC; Hingorani, M; Denaxas, S; Gonzalez-Izquierdo, A; Direk, K; Nitsch, D; ... Hingorani, AD; + view all Kuan, V; Fraser, HC; Hingorani, M; Denaxas, S; Gonzalez-Izquierdo, A; Direk, K; Nitsch, D; Mathur, R; Parisinos, CA; Lumbers, RT; Sofat, R; Wong, ICK; Casas, JP; Thornton, JM; Hemingway, H; Partridge, L; Hingorani, AD; - view fewer (2021) Data-driven identification of ageing-related diseases from electronic health records. Scientific Reports , 11 , Article 2938. 10.1038/s41598-021-82459-y.

Laskovs, Mihails; Partridge, Linda; Slack, Cathy; (2022) Molecular inhibition of RAS signalling to target ageing and age-related health. Disease Models & Mechanisms , 15 (10) , Article dmm049627. 10.1242/dmm.049627.

Lee, SF; Eyre-Walker, YC; Rane, RV; Reuter, C; Vinti, G; Rako, L; Partridge, L; Lee, SF; Eyre-Walker, YC; Rane, RV; Reuter, C; Vinti, G; Rako, L; Partridge, L; Hoffmann, AA; - view fewer (2013) Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster. Molecular Ecology , 22 (10) pp. 2716-2725. 10.1111/mec.12301.

Li, L; Conradson, DM; Bharat, V; Kim, MJ; Hsieh, C-H; Minhas, PS; Papakyrikos, AM; ... Wang, X; + view all Li, L; Conradson, DM; Bharat, V; Kim, MJ; Hsieh, C-H; Minhas, PS; Papakyrikos, AM; Durairaj, AS; Ludlam, A; Andreasson, K; Partridge, L; Cianfrocco, MA; Wang, X; - view fewer (2021) A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation. Nature Metabolism , 3 pp. 1242-1258. 10.1038/s42255-021-00443-2.

Logan, A; Pell, VR; Shaffer, KJ; Evans, C; Stanley, NJ; Robb, EL; Prime, TA; ... Murphy, MP; + view all Logan, A; Pell, VR; Shaffer, KJ; Evans, C; Stanley, NJ; Robb, EL; Prime, TA; Chouchani, ET; Cocheme, HM; Fearnley, IM; Vidoni, S; James, AM; Porteous, CM; Partridge, L; Krieg, T; Smith, RAJ; Murphy, MP; - view fewer (2016) Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry. CELL METABOLISM , 23 (2) pp. 379-385. 10.1016/j.cmet.2015.11.014.

López-Otín, Carlos; Blasco, Maria A; Partridge, Linda; Serrano, Manuel; Kroemer, Guido; (2023) Hallmarks of aging: An expanding universe. Cell , 186 (2) pp. 243-278. 10.1016/j.cell.2022.11.001.

Lu, J; Temp, U; Müller-Hartmann, A; Esser, J; Grönke, S; Partridge, L; (2021) Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids. Nature Aging , 1 pp. 60-72. 10.1038/s43587-020-00001-7.

Lu, Y-X; Regan, JC; Eßer, J; Drews, LF; Weinseis, T; Stinn, J; Hahn, O; ... Partridge, L; + view all Lu, Y-X; Regan, JC; Eßer, J; Drews, LF; Weinseis, T; Stinn, J; Hahn, O; Miller, RA; Grönke, S; Partridge, L; - view fewer (2021) A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing. Elife , 10 10.7554/eLife.62233. (In press).

Mair, W; Piper, MDW; Partridge, L; (2005) Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biology , 3 (7) , Article e223. 10.1371/journal.pbio.0030223.

McElwee, JJ; Schuster, E; Blanc, E; Piper, MD; Thomas, JH; Patel, DS; Selman, C; ... Gems, D; + view all McElwee, JJ; Schuster, E; Blanc, E; Piper, MD; Thomas, JH; Patel, DS; Selman, C; Withers, DJ; Thornton, JM; Partridge, L; Gems, D; - view fewer (2007) Evolutionary conservation of regulated longevity assurance mechanisms. GENOME BIOL , 8 (7) , Article R132. 10.1186/gb-2007-8-7-r132.

Menger, KE; James, AM; Cochemé, HM; Harbour, ME; Chouchani, ET; Ding, S; Fearnley, IM; ... Murphy, MP; + view all Menger, KE; James, AM; Cochemé, HM; Harbour, ME; Chouchani, ET; Ding, S; Fearnley, IM; Partridge, L; Murphy, MP; - view fewer (2015) Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster. Cell Reports , 11 (12) pp. 1856-1865. 10.1016/j.celrep.2015.05.033.

Meron, Esther; Thaysen, Maria; Angeli, Suzanne; Antebi, Adam; Barzilai, Nir; Baur, Joseph A; Bekker-Jensen, Simon; ... Scheibye-Knudsen, Morten; + view all Meron, Esther; Thaysen, Maria; Angeli, Suzanne; Antebi, Adam; Barzilai, Nir; Baur, Joseph A; Bekker-Jensen, Simon; Birkisdottir, Maria; Bischof, Evelyne; Bruening, Jens; Brunet, Anne; Buchwalter, Abigail; Cabreiro, Filipe; Cai, Shiqing; Chen, Brian H; Ermolaeva, Maria; Ewald, Collin Y; Ferrucci, Luigi; Florian, Maria Carolina; Fortney, Kristen; Freund, Adam; Georgievskaya, Anastasia; Gladyshev, Vadim N; Glass, David; Golato, Tyler; Gorbunova, Vera; Hoejimakers, Jan; Houtkooper, Riekelt H; Jager, Sibylle; Jaksch, Frank; Janssens, Georges; Jensen, Martin Borch; Kaeberlein, Matt; Karsenty, Gerard; de Keizer, Peter; Kennedy, Brian; Kirkland, James L; Kjaer, Michael; Kroemer, Guido; Lee, Kai-Fu; Lemaitre, Jean-Marc; Liaskos, David; Longo, Valter D; Lu, Yu-Xuan; MacArthur, Michael R; Maier, Andrea B; Manakanatas, Christina; Mitchell, Sarah J; Moskalev, Alexey; Niedernhofer, Laura; Ozerov, Ivan; Partridge, Linda; Passegue, Emmanuelle; Petr, Michael A; Peyer, James; Radenkovic, Dina; Rando, Thomas A; Rattan, Suresh; Riedel, Christian G; Rudolph, Lenhard; Ai, Ruixue; Serrano, Manuel; Schumacher, Bjoern; Sinclair, David A; Smith, Ryan; Suh, Yousin; Taub, Pam; Trapp, Alexandre; Trendelenburg, Anne-Ulrike; Valenzano, Dario Riccardo; Verburgh, Kris; Verdin, Eric; Vijg, Jan; Westendorp, Rudi GJ; Zonari, Alessandra; Bakula, Daniela; Zhavoronkov, Alex; Scheibye-Knudsen, Morten; - view fewer (2022) Meeting Report: Aging Research and Drug Discovery. Aging , 14 (2) pp. 530-543. 10.18632/aging.203859.

Metaxakis, A; Partridge, L; (2013) Dietary Restriction Extends Lifespan in Wild-Derived Populations of Drosophila melanogaster. PLoS One , 8 (9) , Article e74681. 10.1371/journal.pone.0074681.

Milioto, Carmelo; Carcolé, Mireia; Giblin, Ashling; Coneys, Rachel; Attrebi, Olivia; Ahmed, Mhoriam; Harris, Samuel S; ... Isaacs, Adrian M; + view all Milioto, Carmelo; Carcolé, Mireia; Giblin, Ashling; Coneys, Rachel; Attrebi, Olivia; Ahmed, Mhoriam; Harris, Samuel S; Lee, Byung Il; Yang, Mengke; Ellingford, Robert A; Nirujogi, Raja S; Biggs, Daniel; Salomonsson, Sally; Zanovello, Matteo; De Oliveira, Paula; Katona, Eszter; Glaria, Idoia; Mikheenko, Alla; Geary, Bethany; Udine, Evan; Vaizoglu, Deniz; Anoar, Sharifah; Jotangiya, Khrisha; Crowley, Gerard; Smeeth, Demelza M; Adams, Mirjam L; Niccoli, Teresa; Rademakers, Rosa; Van Blitterswijk, Marka; Devoy, Anny; Hong, Soyon; Partridge, Linda; Coyne, Alyssa N; Fratta, Pietro; Alessi, Dario R; Davies, Ben; Busche, Marc Aurel; Greensmith, Linda; Fisher, Elizabeth MC; Isaacs, Adrian M; - view fewer (2024) PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons. Nature Neuroscience 10.1038/s41593-024-01589-4. (In press).

Mizielinska, S; Grönke, S; Niccoli, T; Ridler, CE; Clayton, EL; Devoy, A; Moens, T; ... Isaacs, AM; + view all Mizielinska, S; Grönke, S; Niccoli, T; Ridler, CE; Clayton, EL; Devoy, A; Moens, T; Norona, FE; Woollacott, IOC; Pietrzyk, J; Cleverley, K; Nicoll, AJ; Pickering-Brown, S; Dols, J; Cabecinha, M; Hendrich, O; Fratta, P; Fisher, EMC; Partridge, L; Isaacs, AM; - view fewer (2014) C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins. Science 10.1126/science.1256800.

Mizielinska, S; Ridler, CE; Balendra, R; Thoeng, A; Woodling, NS; Grässer, FA; Plagnol, V; ... Isaacs, AM; + view all Mizielinska, S; Ridler, CE; Balendra, R; Thoeng, A; Woodling, NS; Grässer, FA; Plagnol, V; Lashley, T; Partridge, L; Isaacs, AM; - view fewer (2017) Bidirectional nucleolar dysfunction in C9orf72 frontotemporal lobar degeneration. Acta Neuropathologica Communications , 5 , Article 29. 10.1186/s40478-017-0432-x.

Moens, TG; Mizielinska, S; Niccoli, T; Mitchell, JS; Thoeng, A; Ridler, CE; Grönke, S; ... Isaacs, AM; + view all Moens, TG; Mizielinska, S; Niccoli, T; Mitchell, JS; Thoeng, A; Ridler, CE; Grönke, S; Esser, J; Heslegrave, A; Zetterberg, H; Partridge, L; Isaacs, AM; - view fewer (2018) Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD. Acta Neuropathologica , 135 (3) pp. 445-457. 10.1007/s00401-017-1798-3.

Moens, TG; Niccoli, T; Wilson, KM; Atilano, ML; Birsa, N; Gittings, LM; Holbling, BV; ... Isaacs, AM; + view all Moens, TG; Niccoli, T; Wilson, KM; Atilano, ML; Birsa, N; Gittings, LM; Holbling, BV; Dyson, MC; Thoeng, A; Neeves, J; Glaria, I; Yu, L; Bussmann, J; Storkebaum, E; Pardo, M; Choudhary, JS; Fratta, P; Partridge, L; Isaacs, AM; - view fewer (2019) C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A. Acta Neuropathologica 10.1007/s00401-018-1946-4. (In press).

Moens, TG; Partridge, L; Isaacs, AM; (2017) Genetic models of C9orf72: What is toxic? Current Opinion in Genetics and Development , 44 pp. 92-101. 10.1016/j.gde.2017.01.006.

Monzó, Carolina; Gkioni, Lisonia; Beyer, Andreas; Valenzano, Dario Riccardo; Grönke, Sebastian; Partridge, Linda; (2023) Dietary restriction mitigates the age-associated decline in mouse B cell receptor repertoire diversity. Cell Reports , 42 (7) , Article 112722. 10.1016/j.celrep.2023.112722.

Morón-Oset, Javier; Fischer, Lilly Ks; Carcolé, Mireia; Giblin, Ashling; Zhang, Pingze; Isaacs, Adrian M; Grönke, Sebastian; Morón-Oset, Javier; Fischer, Lilly Ks; Carcolé, Mireia; Giblin, Ashling; Zhang, Pingze; Isaacs, Adrian M; Grönke, Sebastian; Partridge, Linda; - view fewer (2023) Toxicity of C9orf72-associated dipeptide repeat peptides is modified by commonly used protein tags. Life Science Alliance , 6 (9) , Article e202201739. 10.26508/lsa.202201739.

Morón-Oset, J; Supèr, T; Esser, J; Isaacs, AM; Grönke, S; Partridge, L; (2019) Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain. Acta Neuropathologica Communications , 7 , Article 209. 10.1186/s40478-019-0860-x.

Nespital, T; Neuhaus, B; Mesaros, A; Pahl, A; Partridge, L; (2021) Lithium can mildly increase health during ageing but not lifespan in mice. Aging Cell , Article e13479. 10.1111/acel.13479. (In press).

Niccoli, T; Cabecinha, M; Tillmann, A; Kerr, F; Wong, CT; Cardenes, D; Vincent, AJ; ... Partridge, L; + view all Niccoli, T; Cabecinha, M; Tillmann, A; Kerr, F; Wong, CT; Cardenes, D; Vincent, AJ; Bettedi, L; Li, L; Groenke, S; Dols, J; Partridge, L; - view fewer (2016) Increased Glucose Transport into Neurons Rescues A beta Toxicity in Drosophila. Current Biology , 26 (17) pp. 2291-2300. 10.1016/j.cub.2016.07.017.

Niccoli, T; Kerr, F; Snoeren, I; Fabian, D; Aleyakpo, B; Ivanov, D; Sofola-Adesakin, O; ... Partridge, L; + view all Niccoli, T; Kerr, F; Snoeren, I; Fabian, D; Aleyakpo, B; Ivanov, D; Sofola-Adesakin, O; Cryar, A; Adcott, J; Thornton, J; Partridge, L; - view fewer (2021) Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity. Brain Communications , 3 (2) , Article fcab053. 10.1093/braincomms/fcab053.

Niccoli, T; Partridge, L; Isaacs, A; (2019) RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats. Nature Neuroscience , 22 pp. 1383-1388. 10.1038/s41593-019-0455-7.

Niccoli, T; Partridge, L; Isaacs, AM; (2017) Ageing as a risk factor for ALS/FTD. Human Molecular Genetics , 26 (R2) R105-R113. 10.1093/hmg/ddx247.

Papatheodorou, I; Ziehm, M; Wieser, D; Alic, N; Partridge, L; Thornton, JM; (2012) Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing. PLoS One , 7 (12) , Article e50881. 10.1371/journal.pone.0050881.

Partridge, L; (2020) Longevity in response to lowered insulin signalling requires glycine N- methyltransferase-dependent spermidine production. Aging Cell , 19 (1) , Article e13043. 10.1111/acel.13043.

Partridge, L; (2019) A Computational Model of the Escape Response Latency in the Giant Fiber System of Drosophila melanogaster. eNeuro , 6 (2) , Article e0423-18. 10.1523/ENEURO.0423-18.2019.

Partridge, L; (2019) Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster. Life Sciences Alliance , 2 (1) , Article e201800149. 10.26508/lsa.201800149.

Partridge, L; (2018) Hepatic gene body hypermethylation is a shared epigenetic signature of murine longevity. PLoS Genetics , 14 (11) , Article e1007766. 10.1371/journal.pgen.1007766.

Partridge, L; (2018) Facing up to the global challenges of ageing. [Review]. Nature , 561 pp. 45-56. 10.1038/s41586-018-0457-8.

Partridge, L; (2017) Good ol' fat: links between lipid signaling and longevity. Trends in Biochemical Sciences , 42 (10) pp. 812-823. 10.1016/j.tibs.2017.07.001.

Partridge, L; (2015) Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation. Journal of Immunology , 195 (11) pp. 5296-5308. 10.4049/jimmunol.1501237.

Partridge, L; (2014) Intervening in ageing to prevent the diseases of ageing. Trends in Endocrinology & Metabolism , 25 (11) pp. 555-557. 10.1016/j.tem.2014.08.003.

Partridge, L; Alic, N; Bjedov, I; Piper, MDW; (2011) Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network. Experimental Gerontology , 46 (5) 376 - 381. 10.1016/j.exger.2010.09.003.

Partridge, L; Augustin, H; Adcott, J; Kerr, F; Vincent, A; Boucrot, E; (2017) Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies. PLOS 10.1371/journal.pbio.2001655.

Partridge, L; Augustin, H; Kerr, F; Alic, N; (2016) Deletion of endogenous Tau proteins is not detrimental in Drosophila. Scientific Reports , 6 , Article 23102. 10.1038/srep23102.

Partridge, L; Fuentealba, M; Kennedy, BK; (2020) The quest to slow ageing through drug discovery. Nature Reviews Drug Discovery , 19 pp. 513-522. 10.1038/s41573-020-0067-7.

Partridge, L; Kinghorn, K; Castillo, K; Li, L; Bartolome, F; Angelova, P; Pope, S; ... Abramov, A; + view all Partridge, L; Kinghorn, K; Castillo, K; Li, L; Bartolome, F; Angelova, P; Pope, S; Cochemé, H; Khan, S; Bhatia, K; Hardy, J; Abramov, A; - view fewer (2015) Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction. Brain , 138 (7) pp. 1801-1816. 10.1093/brain/awv132.

Piper, MD; Blanc, E; Leitão-Gonçalves, R; Yang, M; He, X; Linford, NJ; Hoddinott, MP; ... Partridge, L; + view all Piper, MD; Blanc, E; Leitão-Gonçalves, R; Yang, M; He, X; Linford, NJ; Hoddinott, MP; Hopfen, C; Soultoukis, GA; Niemeyer, C; Kerr, F; Pletcher, SD; Ribeiro, C; Partridge, L; - view fewer (2014) A holidic medium for Drosophila melanogaster. Nature Methods , 11 pp. 100-105. 10.1038/nmeth.2731.

Piper, MD; Selman, C; Speakman, JR; Partridge, L; (2014) Using Doubly-Labeled Water to Measure Energy Expenditure in an Important Small Ectotherm Drosophila melanogaster. Journal of Genetics and Genomics , 41 (9) 505 - 512. 10.1016/j.jgg.2014.07.004.

Piper, MDW; Partridge, L; (2018) Drosophila as a model for ageing. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease , 1864 (9) pp. 2707-2717. 10.1016/j.bbadis.2017.09.016.

Piper, MDW; Partridge, L; (2007) Dietary restriction in Drosophila: delayed aging or experimental artefact? PLoS Genetics , 3 (4) , Article e57. 10.1371/journal.pgen.0030057.

Piper, MDW; Soultoukis, GA; Blanc, E; Mesaros, A; Herbert, SL; Juricic, P; He, X; ... Partridge, L; + view all Piper, MDW; Soultoukis, GA; Blanc, E; Mesaros, A; Herbert, SL; Juricic, P; He, X; Atanassov, I; Salmonowicz, H; Yang, M; Simpson, SJ; Ribeiro, C; Partridge, L; - view fewer (2017) Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan. Cell Metabolism , 25 (3) pp. 610-621. 10.1016/j.cmet.2017.02.005.

Piper, MDW; Wong, R; Grandison, RC; Bass, TM; Martinez, PM; Partridge, L; (2010) Water-independent effects of dietary restriction in Drosophila. Proceedings of the National Academy of Sciences , 107 (14) E54 - E56. 10.1073/pnas.0914686107.

Pouikli, A; Parekh, S; Maleszewska, M; Nikopoulou, C; Baghdadi, M; Tripodi, I; Folz-Donahue, K; ... Tessarz, P; + view all Pouikli, A; Parekh, S; Maleszewska, M; Nikopoulou, C; Baghdadi, M; Tripodi, I; Folz-Donahue, K; Hinze, Y; Mesaros, A; Hoey, D; Giavalisco, P; Dowell, R; Partridge, L; Tessarz, P; - view fewer (2021) Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells. Nature Aging , 1 (9) pp. 810-825. 10.1038/s43587-021-00105-8.

Regan, Jennifer C; Lu, Yu-Xuan; Ureña, Enric; Meilenbrock, Ralf L; Catterson, James H; Kißler, Disna; Fröhlich, Jenny; ... Partridge, Linda; + view all Regan, Jennifer C; Lu, Yu-Xuan; Ureña, Enric; Meilenbrock, Ralf L; Catterson, James H; Kißler, Disna; Fröhlich, Jenny; Funk, Emilie; Partridge, Linda; - view fewer (2022) Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin. Nature Aging 10.1038/s43587-022-00308-7. (In press).

Regan, JC; Khericha, M; Dobson, AJ; Bolukbasi, E; Rattanavirotkul, N; Partridge, L; (2016) Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction. eLife , 5 , Article e10956. 10.7554/eLife.10956.

Rogers, I; Kerr, F; Martinez, P; Hardy, J; Lovestone, S; Partridge, L; (2012) Ageing increases vulnerability to aβ42 toxicity in Drosophila. PLOS One , 7 (7) , Article e40569. 10.1371/journal.pone.0040569.

Sahota, Virender K; Stone, Aelfwin; Woodling, Nathaniel S; Spiers, Jereme G; Steinert, Joern R; Partridge, Linda; Augustin, Hrvoje; (2023) Plum modulates Myoglianin and regulates synaptic function in D. melanogaster. Open Biology , 13 (9) , Article 230171. 10.1098/rsob.230171.

Scholes, HM; Cryar, A; Kerr, F; Sutherland, D; Gethings, LA; Vissers, JPC; Lees, JG; ... Thalassinos, K; + view all Scholes, HM; Cryar, A; Kerr, F; Sutherland, D; Gethings, LA; Vissers, JPC; Lees, JG; Orengo, CA; Partridge, L; Thalassinos, K; - view fewer (2020) Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila. Scientific Reports , 10 , Article 18517. 10.1038/s41598-020-74748-9.

Selman, C; Partridge, L; Withers, DJ; (2011) Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1. PLOS ONE , 6 (1) , Article e16144. 10.1371/journal.pone.0016144.

Simone, R; Balendra, R; Moens, TG; Preza, E; Wilson, KM; Heslegrave, A; Woodling, NS; ... Isaacs, AM; + view all Simone, R; Balendra, R; Moens, TG; Preza, E; Wilson, KM; Heslegrave, A; Woodling, NS; Niccoli, T; Gilbert-Jaramillo, J; Abdelkarim, S; Clayton, EL; Clarke, M; Konrad, M-T; Nicoll, AJ; Mitchell, JS; Calvo, A; Chio, A; Houlden, H; Polke, JM; Ismail, MA; Stephens, CE; Vo, T; Farahat, AA; Wilson, WD; Boykin, DW; Zetterberg, H; Partridge, L; Wray, S; Parkinson, G; Neidle, S; Patani, R; Fratta, P; Isaacs, AM; - view fewer (2018) G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo. EMBO Molecular Medicine , 10 (1) pp. 22-31. 10.15252/emmm.201707850.

Slack, C; Alic, N; Foley, A; Cabecinha, M; Hoddinott, MP; Partridge, L; (2015) The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity. Cell , 162 (1) pp. 72-83. 10.1016/j.cell.2015.06.023.

Slack, C; Alic, N; Partridge, L; (2016) Could cancer drugs provide ammunition against aging? Cell Cycle , 15 (2) pp. 153-155. 10.1080/15384101.2015.1118905.

Slack, C; Foley, A; Partridge, L; (2012) Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila. PLOS One , 7 (10) , Article e47699. 10.1371/journal.pone.0047699.

Slack, C; Werz, C; Wieser, D; Alic, N; Foley, A; Stocker, H; Withers, DJ; ... Partridge, L; + view all Slack, C; Werz, C; Wieser, D; Alic, N; Foley, A; Stocker, H; Withers, DJ; Thornton, JM; Hafen, E; Partridge, L; - view fewer (2010) Regulation of Lifespan, Metabolism, and Stress Responses by the Drosophila SH2B Protein, Lnk. PLoS Genetics , 6 (3) , Article e1000881. 10.1371/journal.pgen.1000881.

Sofola, O; Kerr, F; Rogers, I; Killick, R; Augustin, H; Gandy, C; Allen, MJ; ... Partridge, L; + view all Sofola, O; Kerr, F; Rogers, I; Killick, R; Augustin, H; Gandy, C; Allen, MJ; Hardy, J; Lovestone, S; Partridge, L; - view fewer (2010) Inhibition of GSK-3 ameliorates Aβ pathology in an adult-onset drosophila model of Alzheimer's Disease. PLoS Genetics , 6 (9) , Article e1001087. 10.1371/journal.pgen.1001087.

Sofola-Adesakin, O; Castillo-Quan, JI; Rallis, C; Tain, LS; Bjedov, I; Rogers, I; Li, L; ... Partridge, L; + view all Sofola-Adesakin, O; Castillo-Quan, JI; Rallis, C; Tain, LS; Bjedov, I; Rogers, I; Li, L; Martinez, P; Khericha, M; Cabecinha, M; Bähler, J; Partridge, L; - view fewer (2014) Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease. Front Aging Neurosci , 6 , Article 190. 10.3389/fnagi.2014.00190.

Sofola-Adesakin, O; Khericha, M; Snoeren, I; Tsuda, L; Partridge, L; (2016) pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicity. Acta Neuropathologica Communications , 4 , Article 109. 10.1186/s40478-016-0380-x.

Solon-Biet, SM; Cogger, VC; Pulpitel, T; Wahl, D; Clark, X; Bagley, E; Gregoriou, GC; ... Simpson, SJ; + view all Solon-Biet, SM; Cogger, VC; Pulpitel, T; Wahl, D; Clark, X; Bagley, E; Gregoriou, GC; Senior, AM; Wang, QP; Brandon, AE; Perks, R; O’Sullivan, J; Koay, YC; Bell-Anderson, B; Kebede, M; Yau, B; Atkinson, C; Svineng, G; Dodgson, T; Wali, JA; Piper, MDW; Juricic, P; Partridge, L; Rose, AJ; Raubenheimer, D; Cooney, GJ; Le Couteur, DG; Simpson, SJ; - view fewer (2019) Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature Metabolism , 1 pp. 532-454. 10.1038/s42255-019-0059-2.

Soultoukis, GA; Partridge, L; (2016) Dietary Protein, Metabolism and Aging. Annual Review of Biochemistry , 85 pp. 5-34. 10.1146/annurev-biochem-060815-014422.

Srivastava, A; Lu, J; Gadalla, DS; Hendrich, O; Grönke, S; Partridge, L; (2022) The Role of GCN2 Kinase in Mediating the Effects of Amino Acids on Longevity and Feeding Behaviour in Drosophila. Frontiers in Aging , 3 , Article 944466. 10.3389/fragi.2022.944466.

Tain, LS; Sehlke, R; Jain, C; Chokkalingam, M; Nagaraj, N; Essers, P; Rassner, M; ... Partridge, L; + view all Tain, LS; Sehlke, R; Jain, C; Chokkalingam, M; Nagaraj, N; Essers, P; Rassner, M; Grönke, S; Froelich, J; Dieterich, C; Mann, M; Alic, N; Beyer, A; Partridge, L; - view fewer (2017) A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance. Molecular Systems Biology , 13 (9) , Article 939. 10.15252/msb.20177663.

Tain, LS; Sehlke, R; Meilenbrock, RL; Leech, T; Paulitz, J; Chokkalingam, M; Nagaraj, N; ... Partridge, L; + view all Tain, LS; Sehlke, R; Meilenbrock, RL; Leech, T; Paulitz, J; Chokkalingam, M; Nagaraj, N; Grönke, S; Fröhlich, J; Atanassov, I; Mann, M; Beyer, A; Partridge, L; - view fewer (2021) Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila. eLife , 10 , Article e67275. 10.7554/eLife.67275.

Tiku, V; Jain, C; Raz, Y; Nakamura, S; Heestand, B; Liu, W; Späth, M; ... Antebi, A; + view all Tiku, V; Jain, C; Raz, Y; Nakamura, S; Heestand, B; Liu, W; Späth, M; Suchiman, HED; Müller, R-U; Slagboom, PE; Partridge, L; Antebi, A; - view fewer (2017) Small nucleoli are a cellular hallmark of longevity. Nature Communications , 8 , Article 16083. 10.1038/ncomms16083.

Toivonen, JM; Walker, GA; Martinez-Diaz, P; Bjedov, I; Driege, Y; Jacobs, HT; Gems, D; Toivonen, JM; Walker, GA; Martinez-Diaz, P; Bjedov, I; Driege, Y; Jacobs, HT; Gems, D; Partridge, L; - view fewer (2007) No influence of Indy on lifespan in drosophila after correction for genetic and cytoplasmic background effects. PLoS Genetics , 3 (6) , Article e95. 10.1371/journal.pgen.0030095.

Ureña, Enric; Xu, Bowen; Regan, Jennifer C; Atilano, Magda L; Minkley, Lucy J; Filer, Danny; Lu, Yu-Xuan; ... Partridge, Linda; + view all Ureña, Enric; Xu, Bowen; Regan, Jennifer C; Atilano, Magda L; Minkley, Lucy J; Filer, Danny; Lu, Yu-Xuan; Bolukbasi, Ekin; Khericha, Mobina; Alic, Nazif; Partridge, Linda; - view fewer (2024) Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells. Proceedings of the National Academy of Sciences (PNAS) , 121 (4) , Article e2311313121. 10.1073/pnas.2311313121.

Wang, He-Ling; Siow, Richard; Schmauck-Medina, Tomas; Zhang, Jianying; Sandset, Per Morten; Filshie, Clare; Lund, Oystein; ... Fang, Evandro F; + view all Wang, He-Ling; Siow, Richard; Schmauck-Medina, Tomas; Zhang, Jianying; Sandset, Per Morten; Filshie, Clare; Lund, Oystein; Partridge, Linda; Bergersen, Linda Hildegard; Juel Rasmussen, Lene; Palikaras, Konstantinos; Sotiropoulos, Ioannis; Storm-Mathisen, Jon; Rubinsztein, David C; Spillantini, Maria Grazia; De Zeeuw, Chris; Watne, Leiv Otto; Vyhnalek, Martin; Veverova, Katerina; Liang, Kristina Xiao; Tavernarakis, Nektarios; Bohr, Vilhelm A; Yokote, Koutaro; Saarela, Janna; Nilsen, Hilde; Gonos, Efstathios S; Scheibye-Knudsen, Morten; Chen, Guobing; Kato, Hisaya; Selbaek, Geir; Fladby, Tormod; Nilsson, Per; Simonsen, Anne; Aarsland, Dag; Lautrup, Sofie; Ottersen, Ole Petter; Cox, Lynne S; Fang, Evandro F; - view fewer (2024) Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies. The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences , 79 (4) , Article glae029. 10.1093/gerona/glae029.

Weigelt, CM; Sehgal, R; Tain, LS; Cheng, J; Eßer, J; Pahl, A; Dieterich, C; ... Partridge, L; + view all Weigelt, CM; Sehgal, R; Tain, LS; Cheng, J; Eßer, J; Pahl, A; Dieterich, C; Grönke, S; Partridge, L; - view fewer (2020) An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila. Molecular Cell , 79 (2) 268-279.e5. 10.1016/j.molcel.2020.06.011.

Wertheim, B; Kraaijeveld, AR; Schuster, E; Blanc, E; Hopkins, M; Pletcher, SD; Strand, MR; ... Godfray, HCJ; + view all Wertheim, B; Kraaijeveld, AR; Schuster, E; Blanc, E; Hopkins, M; Pletcher, SD; Strand, MR; Partridge, L; Godfray, HCJ; - view fewer (2005) Genome-wide gene expression in response to parasitoid attack in Drosophila. Genome Biology , 6 , Article R94. 10.1186/gb-2005-6-11-r94.

Wong, R; Piper, MDW; Blanc, E; Partridge, L; (2008) Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster. [Letter]. Nature Methods , 5 (3) 214 - 215. 10.1038/nmeth0308-214.

Wong, R; Piper, MDW; Wertheim, B; Partridge, L; (2009) Quantification of Food Intake in Drosophila. PLOS ONE , 4 (6) , Article e6063. 10.1371/journal.pone.0006063.

Wong, R.; Piper, M.D.W.; Wertheim, B.; Partridge, L.; Raine, N.E.; (2009) Quantification of food intake in Drosophila. PLoS ONE , 4 (6) , Article e6063. 10.1371/journal.pone.0006063.

Woodling, NS; Aleyakpo, B; Dyson, MC; Minkley, LJ; Rajasingam, A; Dobson, AJ; Leung, KHC; ... Partridge, L; + view all Woodling, NS; Aleyakpo, B; Dyson, MC; Minkley, LJ; Rajasingam, A; Dobson, AJ; Leung, KHC; Pomposova, S; Fuentealba, M; Alic, N; Partridge, L; - view fewer (2020) The neuronal receptor tyrosine kinase Alk is a target for longevity. Aging Cell , Article e13137. 10.1111/acel.13137. (In press).

Woodling, NS; Partridge, L; (2018) Parkinson's Disease: Mitochondria Parked at the ER Hit the Snooze Button. Neuron , 98 (6) pp. 1059-1061. 10.1016/j.neuron.2018.06.025.

Woodling, NS; Rajasingam, A; Minkley, LJ; Rizzo, A; Partridge, L; (2020) Independent glial subtypes delay development and extend healthy lifespan upon reduced insulin-PI3K signalling. BMC Biology , 18 , Article 124. 10.1186/s12915-020-00854-9.

Yu, Y; Niccoli, T; Ren, Z; Woodling, NS; Aleyakpo, B; Szabadkai, G; Partridge, L; (2020) PICALM rescues glutamatergic neurotransmission, behavioural function, and survival in a Drosophila model of Aβ42 toxicity. Human Molecular Genetics 10.1093/hmg/ddaa125. (In press).

Zhang, Pingze; Catterson, James H; Grönke, Sebastian; Partridge, Linda; (2024) Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system. Nature Aging 10.1038/s43587-024-00578-3. (In press).

Zhao, Y; Gilliat, AF; Ziehm, M; Turmaine, M; Wang, H; Ezcurra, M; Yang, C; ... Gems, D; + view all Zhao, Y; Gilliat, AF; Ziehm, M; Turmaine, M; Wang, H; Ezcurra, M; Yang, C; Phillips, G; McBay, D; Zhang, WB; Partridge, L; Pincus, Z; Gems, D; - view fewer (2017) Two forms of death in ageing Caenorhabditis elegans. Nature Communications , 8 , Article 15458. 10.1038/ncomms15458.

Ziehm, M; Ivanov, DK; Bhat, A; Partridge, L; Thornton, JM; SurvCurv database and online survival analysis platform update. Bioinformatics , 31 (23) pp. 3878-3880. 10.1093/bioinformatics/btv463.

Ziehm, M; Kaur, S; Ivanov, DK; Ballester, PJ; Marcus, D; Partridge, L; Thornton, JM; (2017) Drug repurposing for aging research using model organisms. Aging Cell , 16 (5) pp. 1006-1015. 10.1111/acel.12626.

Book chapter

Piper, MDW; Partridge, L; (2016) Protocols to Study Aging in Drosophila. In: Drosophila. (pp. 291-302). Springer: New York, NY, USA.

Proceedings paper

Kennedy, BK; Partridge, L; (2017) 2nd Interventions in Aging Conference. In: Proceedings of the 2nd Interventions in Aging Conference. 2nd Interventions in Aging Conference: Cancun, Mexico.

Working / discussion paper

Fraser, HC; Kuan, V; Johnen, R; Zwierzyna, M; Hingorani, AD; Beyer, A; Partridge, L; (2021) Biological mechanisms of aging predict age-related disease multimorbidities in patients. BioRxiv: Cold Spring Harbor, NY, USA.

Thesis

Cryar, AJ; (2015) Quantitative Proteomic Studies Of Protein Misfolding & Disease. Doctoral thesis , UCL (University College London).

Li, L; (2017) PGC-1α in neurodegeneration and ageing. Doctoral thesis , UCL (University College London).

This list was generated on Sun Jan 4 04:04:53 2026 GMT.