Soultoukis, GA;
Partridge, L;
(2016)
Dietary Protein, Metabolism and Aging.
Annual Review of Biochemistry
, 85
pp. 5-34.
10.1146/annurev-biochem-060815-014422.
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Abstract
Dietary restriction (DR), a moderate reduction in food intake, improves health during aging and extends life span across multiple species. Specific nutrients, rather than overall calories, mediate the effects of DR, with pro- tein and specific amino acids (AAs) playing a key role. Modulations of single dietary AAs affect traits including growth, reproduction, physiology, health, and longevity in animals. Epidemiological data in humans also link the quality and quantity of dietary proteins to long-term health. Intricate nutrient-sensing pathways fine tune the metabolic responses to dietary AAs in a highly conserved manner. In turn, these metabolic responses can affect the onset of insulin resistance, obesity, neurodegenerative disease, and other age-related diseases. In this review we discuss how AA requirements are shaped and how ingested AAs regulate a spectrum of homeostatic processes. Finally, we high-light the resulting opportunity to develop nutritional strategies to improve human health during aging.
| Type: | Article |
|---|---|
| Title: | Dietary Protein, Metabolism and Aging |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1146/annurev-biochem-060815-014422 |
| Publisher version: | http://dx.doi.org/10.1146/annurev-biochem-060815-0... |
| Language: | English |
| Additional information: | This pre-print version (with title: Dietary Protein, Metabolism and Ageing) of the article is posted with permission from the Annual Review of Biochemistry, Volume 85. Copyright © 2016 by Annual Reviews. All rights reserved. Complimentary one-time access to the article as a PDF file (http://arjournals.annualreviews.org/eprint/eBg5QmNB8W633rE5gkVZ/full/10.1146/annurev-biochem-060815-014422) is provided for personal use. Any further/multiple distribution, publication, or commercial usage of this copyrighted material requires submission of a permission request addressed to the Copyright Clearance Center (http://www.copyright.com/) |
| Keywords: | dietary restriction, macronutrients, protein and amino acid requirement, nutrient-sensing signaling, anabolism, aging |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1489795 |
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