Juricic, P;
Grönke, S;
Partridge, L;
(2020)
Branched-chain amino acids have equivalent effects to other essential amino acids on lifespan and ageing-related traits in Drosophila.
The Journals of Gerontology: Series A
, 75
(1)
pp. 24-31.
10.1093/gerona/glz080.
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Abstract
Branched-chain amino acids (BCAAs) have been suggested to be particularly potent activators of TOR signalling. Moreover, increased circulating BCAAs are associated with higher risk of insulin resistance and diabetes in both mice and humans, and with increased mortality in mice. However, it remains unknown if BCAAs play a more prominent role in longevity than do other essential amino acids (EAAs). To test for a more prominent role of BCAAs in lifespan and related traits in Drosophila, we restricted either BCAAs or a control group of three other EAAs, threonine, histidine and lysine (THK). BCAA restriction induced compensatory feeding, lipid accumulation, stress resistance and amelioration of age-related gut pathology. It also extended lifespan in a dietary-nitrogen-dependent manner. Importantly, the control restriction of THK had similar effects on these phenotypes. Our control diet was designed to have every EAA equally limiting for growth and reproduction, and our findings therefore suggest that the level of the most limiting EAAs in the diet, rather than the specific EAAs that are limiting, determines the response of these phenotypes to EAA restriction.
| Type: | Article |
|---|---|
| Title: | Branched-chain amino acids have equivalent effects to other essential amino acids on lifespan and ageing-related traits in Drosophila |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/gerona/glz080 |
| Publisher version: | https://doi.org/10.1093/gerona/glz080 |
| Language: | English |
| Additional information: | © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits noncommercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Fecundity, intestinal dysplasia, lipid metabolism |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10071282 |
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