Table 2.
        Characteristics of the University of Wisconsin and NIA DR Monkey Studies
,University of Wisconsin,National Institute on Aging
Rhesus monkeys (n),76 (46 m<comma> 30 f),120 (60 m<comma> 60 f)
Genetic origin of monkeys,India,China and India
Age at baseline,all adult,juvenile (20 m<comma> 20 f); adolescent (20 m<comma> 20 f); old (20 m<comma> 20 f)
Housing,single caged,single caged
Randomization,1 CR: 1 control,1 CR: 1 control
Dietary regimen of CR monkeys,30% restriction from a BL intake assessed individually,30% restriction from BL intake levels based on NRC guidelines
Dietary regimen of control monkeys,fed ad libitum,controlled allotment of food each day to avoid obesity (∼5%–10% CR)
Meal patterns,morning meal<comma> plus 100 Kcal integration of food at late afternoon,twice a day
Source of nutrients,semi-purified diet rich in refined foods,natural ingredients (pesco-vegetarian diet)
Macronutrient composition of diets,15% protein (lactalbumin); 10% fat (corn oil); 65% carb (cornstarch<comma> sucrose); 28.5% from sucrose; 5% fiber,17.3% protein (fish<comma> soybean<comma> wheat<comma> corn); 5% fat (fish<comma> soy oil<comma> wheat<comma> corn<comma> alfalfa); 56.9% carb (ground wheat and corn); 3.9% from sucrose; 5%–7% crude fiber
Vitamin supplements,only for CR monkeys,40% of RDA in vitamin in both control and CR monkeys
Food intake measurement,daily quantification for each animal,1 week per year