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Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network

Partridge, L; Alic, N; Bjedov, I; Piper, MDW; (2011) Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network. Experimental Gerontology , 46 (5) 376 - 381. 10.1016/j.exger.2010.09.003. Green open access

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Abstract

A remarkable discovery of recent years is that, despite the complexity of ageing, simple genetic interventions can increase lifespan and improve health during ageing in laboratory animals. The pathways involved have often proved to sense nutrients and to match costly activities of organisms, such as growth, metabolism and reproduction, to nutrient status. For instance, the insulin/insulin-like growth factor and Target of Rapamycin signalling network has proved to play a function in ageing, from yeast to mammals, seemingly including humans. In the fruit fly Drosophila, altered activity of several components of this network can increase lifespan and improve locomotor and cardiac function during ageing. The fly brain, fat body (equivalent of mammalian liver and white adipose tissue) and the germ line are important in determination of lifespan, with considerable communication between different tissues. Cellular detoxification pathways, increased autophagy and altered protein synthesis have all been implicated in increased lifespan from reduced IIS/TOR activity, with the role of defence against oxidative stress unresolved. Reduced IIS/TOR signalling can alter or block the response of lifespan to dietary restriction. Reduced IIS can act acutely to lower death rate, implying that it may ameliorate the effects of ageing-related damage, rather than preventing it. (C) 2010 Elsevier Inc. All rights reserved.

Type: Article
Title: Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.exger.2010.09.003
Publisher version: http://dx.doi.org/10.1016/j.exger.2010.09.003
Language: English
Additional information: Elsevier Open Access
Keywords: Aging, Drosophila, Insulin/Igf signalling, TOR, Dietary restriction, Life-span extension, Stem-cell maintenance, Dietary restriction, Germ-line, Oxidative stress, Fat-body, Dfoxo, Melanogaster, Mechanisms, Genetics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/168168
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