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Impact of insulin signaling and proteasomal activity on physiological 2 output of a neuronal circuit in aging D. melanogaster

Augustin, H; McGourty, K; Allen, MJ; Adcott, J; Wong, CT; Boucrot, E; Partridge, L; (2018) Impact of insulin signaling and proteasomal activity on physiological 2 output of a neuronal circuit in aging D. melanogaster. Neurobiology of Aging , 66 pp. 149-157. 10.1016/j.neurobiolaging.2018.02.027. Green open access

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Abstract

The insulin family of growth factors plays an important role in development and function of the nervous system. Reduced insulin and insulin-growth-factor signaling (IIS), however, can improve symptoms of neurodegenerative diseases in laboratory model organisms and protect against age-associated decline in neuronal function. Recently, we showed that chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber escape response circuit. Here, we expand our initial findings by demonstrating that reduced functional output in the giant fiber system of aging flies can be prevented by increasing proteasomal activity within the circuit. Manipulations of IIS in neurons can also affect longevity, underscoring the relevance of the nervous system for aging.

Type: Article
Title: Impact of insulin signaling and proteasomal activity on physiological 2 output of a neuronal circuit in aging D. melanogaster
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neurobiolaging.2018.02.027
Publisher version: https://doi.org/10.1016/j.neurobiolaging.2018.02.0...
Language: English
Additional information: © 2018 Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Aging, Drosophila, Giant Fiber system, Gao junctions, Insulin signaling, Proteasomal activity, Recycling, Rab4, Rab11
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10045191
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