Browse by UCL people
Group by: Type | Date
Number of items: 45.
Article
Butler, MB;
Short, NE;
Maniou, E;
Alexandre, P;
Greene, NDE;
Copp, AJ;
Galea, GL;
(2019)
Rho kinase-dependent apical constriction counteracts M-phase apical expansion to enable mouse neural tube closure.
Journal of Cell Science
, 132
, Article jcs230300. 10.1242/jcs.230300.
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Cheng, Xiao;
Meng, Chao;
Galea, Gabriel L;
Nie, Lirong;
Wang, Duoduo;
Xia, Shuangbo;
Wei, Yuan;
... Li, Zhiwen; + view all
(2025)
Trends of neural tube defects in urban China and effects of socio-demographic factors, 2013–2022: a descriptive analysis.
BMJ Public Health
, 3
(2)
, Article e001489. 10.1136/bmjph-2024-001489.
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De Castro, SCP;
Gustavsson, P;
Marshall, AR;
Gordon, WM;
Galea, G;
Nikolopoulou, E;
Savery, D;
... Greene, NDE; + view all
(2018)
Over-expression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice.
Human Molecular Genetics
, 27
(24)
pp. 4218-4230.
10.1093/hmg/ddy313.
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Escuin, Sarah;
Raza-Knight, Saba Rose;
Savery, Dawn;
Gaston-Massuet, Carles;
Galea, Gabriel L;
Greene, Nicholas DE;
Copp, Andrew J;
(2023)
Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse.
Disease Models and Mechanisms
, 16
(3)
, Article dmm049858. 10.1242/dmm.049858.
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Galea, GL;
Zein, MR;
Allen, S;
Francis-West, P;
(2021)
Making and shaping endochondral and intramembranous bones.
Developmental Dynamics
, 250
(3)
pp. 414-449.
10.1002/dvdy.278.
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Galea, G;
Lanyon, LE;
Price, JS;
(2017)
Sclerostin's role in bone's adaptive response to mechanical loading.
Bone
, 96
pp. 38-44.
10.1016/j.bone.2016.10.008.
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Galea, GL;
Cho, Y-J;
Galea, G;
Mole, MA;
Rolo, A;
Savery, D;
Moulding, D;
... Copp, AJ; + view all
(2017)
Biomechanical coupling facilitates spinal neural tube closure in mouse embryos.
PNAS - Proceedings of the National Academy of Sciences of the United States of America
, 114
(26)
E5177-E5186.
10.1073/pnas.1700934114.
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Galea, GL;
Delisser, PJ;
Meakin, L;
Price, JS;
Windahl, SH;
(2020)
Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice.
Bone
, 133
, Article 115255. 10.1016/j.bone.2020.115255.
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Galea, GL;
Hannuna, S;
Meakin, LB;
Delisser, PJ;
Lanyon, LE;
Price, JS;
(2015)
Quantification of Alterations in Cortical Bone Geometry Using Site Specificity Software in Mouse models of Aging and the Responses to Ovariectomy and Altered Loading.
Frontiers in Endocrinolgy
, 6
, Article 52. 10.3389/fendo.2015.00052.
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Galea, GL;
Maniou, E;
Edwards, TJ;
Marshall, AR;
Ampartzidis, I;
Greene, NDE;
Copp, AJ;
(2021)
Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice.
Nature Communications
, 12
(1)
, Article 1159. 10.1038/s41467-021-21372-4.
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Galea, GL;
Meakin, LB;
Harris, MA;
Delisser, PJ;
Lanyon, LE;
Harris, SE;
Price, JS;
(2017)
Old age and the associated impairment of bones' adaptation to loading are associated with transcriptomic changes in cellular metabolism, cell-matrix interactions and the cell cycle.
Gene
, 599
pp. 36-52.
10.1016/j.gene.2016.11.006.
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Galea, GL;
Meakin, LB;
Savery, D;
Taipaleenmaki, H;
Delisser, P;
Stein, GS;
Copp, AJ;
... Price, JS; + view all
(2015)
Planar cell polarity aligns osteoblast division in response to substrate strain.
Journal of Bone and Mineral Research
, 30
(3)
pp. 423-435.
10.1002/jbmr.2377.
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Galea, GL;
Meakin, LB;
Williams, CM;
Hulin-Curtis, SL;
Lanyon, LE;
Poole, AW;
Price, JS;
(2014)
Protein kinase Cα (PKCα) regulates bone architecture and osteoblast activity.
J Biol Chem
, 289
(37)
pp. 25509-25522.
10.1074/jbc.M114.580365.
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Galea, GL;
Nychyk, O;
Mole, MA;
Moulding, D;
Savery, D;
Nikolopoulou, E;
Henderson, DJ;
... Copp, AJ; + view all
(2018)
Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos.
Disease Models & Mechanisms
, 11
(3)
, Article dmm032219. 10.1242/dmm.032219.
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Galea, GL;
Paradise, CR;
Meakin, LB;
Camilleri, ET;
Taipaleenmaki, H;
Stein, GS;
Lanyon, LE;
... Dudakovic, A; + view all
(2020)
Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2.
Gene: X
, 5
, Article 100027. 10.1016/j.gene.2020.100027.
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Gheasuddin, Yosuf;
Galea, Gabriel L;
(2022)
Cannabidiol impairs neural tube closure in mouse whole embryo culture.
Birth Defects Research
10.1002/bdr2.2013.
(In press).
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Hadjivasiliou, Z;
Moore, RE;
McIntosh, R;
Galea, GL;
Clarke, JDW;
Alexandre, P;
(2019)
Basal Protrusions Mediate Spatiotemporal Patterns of Spinal Neuron Differentiation.
Developmental Cell
, 49
(6)
907-919.e10.
10.1016/j.devcel.2019.05.035.
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Hughes, A;
Greene, NDE;
Copp, AJ;
Galea, GL;
(2017)
Valproic acid disrupts the biomechanics of late spinal neural tube closure in mouse embryos.
Mechanisms of Development
, 149
pp. 20-26.
10.1016/j.mod.2017.12.001.
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Jenkins, Dagan;
Chubb, Jonathan R;
Galea, Gabriel;
(2024)
Stochastic processes in development and disease.
Philosophical Transactions of the Royal Society B: Biological Sciences
, 379
(1900)
, Article 20230043. 10.1098/rstb.2023.0043.
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Knowler, SP;
Galea, GL;
Rusbridge, C;
(2018)
Morphogenesis of Canine Chiari Malformation and Secondary Syringomyelia: Disorders of Cerebrospinal Fluid Circulation.
Frontiers in Veterinary Science
, 5
, Article 171. 10.3389/fvets.2018.00171.
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Leung, K-Y;
De Castro, SCP;
Galea, GL;
Copp, AJ;
Greene, NDE;
(2021)
Glycine Cleavage System H Protein Is Essential for Embryonic Viability, Implying Additional Function Beyond the Glycine Cleavage System.
Frontiers in Genetics
, 12
, Article 625120. 10.3389/fgene.2021.625120.
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Maniou, Eirini;
Farah, Faduma;
Marshall, Abigail R;
Crane-Smith, Zoe;
Krstevski, Andrea;
Stathopoulou, Athanasia;
Greene, Nicholas DE;
... Galea, Gabriel L; + view all
(2023)
Caudal Fgfr1 disruption produces localised spinal mis-patterning and a terminal myelocystocele-like phenotype in mice.
Development
10.1242/dev.202139.
(In press).
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Maniou, Eirini;
Todros, Silvia;
Urciuolo, Anna;
Moulding, Dale A;
Magnussen, Michael;
Ampartzidis, Ioakeim;
Brandolino, Luca;
... Elvassore, Nicola; + view all
(2024)
Quantifying mechanical forces during vertebrate morphogenesis.
Nature Materials
10.1038/s41563-024-01942-9.
(In press).
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Maniou, E;
Staddon, MF;
Marshall, AR;
Greene, NDE;
Copp, AJ;
Banerjee, S;
Galea, GL;
(2021)
Hindbrain neuropore tissue geometry determines asymmetric cell-mediated closure dynamics in mouse embryos.
Proceedings of the National Academy of Sciences
, 118
(19)
, Article e2023163118. 10.1073/pnas.2023163118.
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Marshall, Abigail R;
Galea, Gabriel L;
Copp, Andrew J;
Greene, Nicholas DE;
(2023)
The surface ectoderm exhibits spatially heterogenous tension that correlates with YAP localisation during spinal neural tube closure in mouse embryos.
Cells & Development
, 174
, Article 203840. 10.1016/j.cdev.2023.203840.
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Marshall, Abigail R;
Maniou, Eirini;
Moulding, Dale;
Greene, Nicholas DE;
Copp, Andrew J;
Galea, Gabriel L;
(2022)
Two-Photon Cell and Tissue Level Laser Ablation Methods to Study Morphogenetic Biomechanics.
Methods in Molecular Biology
, 2438
pp. 217-230.
10.1007/978-1-0716-2035-9_14.
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Meakin, LB;
Galea, GL;
Sugiyama, T;
Lanyon, LE;
Price, JS;
(2014)
Age-related impairment of bones' adaptive response to loading in mice is associated with sex-related deficiencies in osteoblasts but no change in osteocytes.
Journal of Bone and Mineral Research
, 29
(8)
pp. 1859-1871.
10.1002/jbmr.2222.
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Meakin, LB;
Todd, H;
Delisser, PJ;
Galea, GL;
Moustafa, A;
Lanyon, LE;
Windahl, SH;
(2017)
Parathyroid hormone's enhancement of bones' osteogenic response to loading is affected by ageing in a dose- and time-dependent manner.
Bone
, 98
pp. 59-67.
10.1016/j.bone.2017.02.009.
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Meakin, LB;
Udeh, C;
Galea, GL;
Lanyon, LE;
Price, JS;
(2015)
Exercise does not enhance aged bone's impaired response to artificial loading in C57Bl/6 mice.
Bone
, 81
pp. 47-52.
10.1016/j.bone.2015.06.026.
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Molè, MA;
Galea, GL;
Copp, AJ;
(2023)
Live-Imaging Analysis of Epithelial Zippering During Mouse Neural Tube Closure.
Methods in Molecular Biology
, 2608
pp. 147-162.
10.1007/978-1-0716-2887-4_10.
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Molè, MA;
Galea, GL;
Rolo, A;
Weberling, A;
Nychyk, O;
De Castro, SC;
Savery, D;
... Copp, AJ; + view all
(2020)
Integrin-Mediated Focal Anchorage Drives Epithelial Zippering during Mouse Neural Tube Closure.
Developmental Cell
, 52
(3)
321-334.e6.
10.1016/j.devcel.2020.01.012.
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Nikolopoulou, E;
Galea, GL;
Rolo, A;
Greene, ND;
Copp, AJ;
(2017)
Neural tube closure: cellular, molecular and biomechanical mechanisms.
Development
, 144
(4)
pp. 552-566.
10.1242/dev.145904.
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Nikolopoulou, E;
Hirst, CS;
Galea, G;
Venturini, C;
Moulding, D;
Marshall, AR;
Rolo, A;
... Greene, NDE; + view all
(2019)
Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2.
Nature Communications
, 10
, Article 2487. 10.1038/s41467-019-10164-6.
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Nychyk, O;
Galea, GL;
Molè, M;
Savery, D;
Greene, NDE;
Stanier, P;
Copp, AJ;
(2021)
Vangl2-environment interaction causes severe neural tube defects, without abnormal neuroepithelial convergent extension.
Disease Models & Mechanisms
10.1242/dmm.049194.
(In press).
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Orriss, IR;
Lanham, S;
Savery, D;
Greene, NDE;
Stanier, P;
Oreffo, R;
Copp, AJ;
(2018)
Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.
Scientific Reports
, 8
, Article 3325. 10.1038/s41598-018-21718-x.
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Patel, A;
Anderson, G;
Galea, G;
Balys, M;
Sowden, JC;
(2020)
A molecular and cellular analysis of human embryonic optic fissure closure related to the eye malformation coloboma.
Development
, 147
(24)
, Article dev193649. 10.1242/dev.193649.
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Rolo, A;
Galea, GL;
Savery, D;
Greene, NDE;
Copp, AJ;
(2019)
Novel mouse model of encephalocele: post-neurulation origin and relationship to open neural tube defects.
Disease Models & Mechanisms
10.1242/dmm.040683.
(In press).
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Savery, D;
Maniou, E;
Culshaw, LH;
Greene, NDE;
Copp, AJ;
Galea, GL;
(2019)
Refinement of inducible gene deletion in embryos of pregnant mice.
Birth Defects Research
10.1002/bdr2.1628.
(In press).
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Sugiyama, T;
Meakin, LB;
Browne, WJ;
Galea, GL;
Price, JS;
Lanyon, LE;
(2012)
Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition.
Journal of Bone and Mineral Research
, 27
(8)
pp. 1784-1793.
10.1002/jbmr.1599.
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Sugiyama, T;
Meakin, LB;
Galea, GL;
Lanyon, LE;
Price, JS;
(2013)
The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice.
Osteoporosis International
, 24
(1)
pp. 383-388.
10.1007/s00198-012-1922-0.
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Urciuolo, Anna;
Giobbe, Giovanni Giuseppe;
Dong, Yixiao;
Michielin, Federica;
Brandolino, Luca;
Magnussen, Michael;
Gagliano, Onelia;
... Elvassore, Nicola; + view all
(2023)
Hydrogel-in-hydrogel live bioprinting for guidance and control of organoids and organotypic cultures.
Nature Communications
, 14
(1)
, Article 3128. 10.1038/s41467-023-37953-4.
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Windahl, SH;
Delisser, PJ;
Galea, GL;
(2021)
Mapping Regional Cortical Bone Responses to Local Changes in Loading and Systemic Stimuli.
Osteoporosis and Osteoarthritis
, 2221
pp. 275-289.
10.1007/978-1-0716-0989-7_16.
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Zekavat, Amir;
Lioliou, Grammatiki;
Roche I Morgo, Oriol;
Maughan Jones, Charlotte;
Galea, Gabriel;
Maniou, Eirini;
Doherty, Adam;
... Hagen, Charlotte Klara; + view all
(2024)
Phase contrast micro-CT with adjustable in-slice spatial resolution at constant magnification.
Physics in Medicine & Biology
, 69
(10)
, Article 105017. 10.1088/1361-6560/ad4000.
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Working / discussion paper
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Ampartzidis, Ioakeim;
Efstathiou, Christoforos;
Paonessa, Francesco;
Thompson, Elliott;
Wilson, Tyler;
McCann, Conor;
Greene, Nicholas DE;
... Galea, Gabriel; + view all
(2022)
Synchronisation of apical constriction and cell cycle progression is a conserved behaviour of pseudostratified neuroepithelia informed by their tissue geometry.
BioRxiv: Cold Spring Harbor, NY, USA.
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Poster
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Maniou, E;
Staddon, MF;
Banerjee, S;
Galea, GL;
(2021)
Morphometric biomechanics of mouse hindbrain neuropore closure.
Presented at: BSDB/Genetics Society Annual Spring Meeting 2021, Virtual conference.
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