Browse by UCL people
Group by: Type | Date
Number of items: 83.
2025
Naidoo, Kogieleum;
Zuma, Nonhlanhla Yende;
Moodley, Mikaila;
Made, Felix;
Perumal, Rubeshan;
Gengiah, Santhanalakshmi;
Ngozo, Jacqueline;
... Karim, Salim Abdool; + view all
(2025)
High mortality among patients with tuberculosis accessing primary care facilities: secondary analysis from an open-label cluster-randomised trial.
eClinicalMedicine
, 82
, Article 103151. 10.1016/j.eclinm.2025.103151.
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2024
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Chiang, CY;
Bern, H;
Goodall, R;
Chien, ST;
Rusen, ID;
Nunn, A;
(2024)
Radiographic characteristics of rifampicin-resistant tuberculosis in the STREAM stage 1 trial and their influence on time to culture conversion in the short regimen.
BMC Infectious Diseases
, 24
(1)
, Article 144. 10.1186/s12879-024-09039-z.
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Fabiane, SM;
Chiang, CY;
Meredith, SK;
Gurumurthy, M;
Bayissa, A;
Nunn, AJ;
Goodall, RL;
(2024)
Comparative Efficacy and Safety of Moxifloxacin and Levofloxacin in a Short Standardised Rifampicin Resistant TB Regimen: A STREAM 2 Secondary Analysis.
Tropical Medicine and Infectious Disease
, 9
(9)
, Article 211. 10.3390/tropicalmed9090211.
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Goodall, Ruth L;
Nunn, Andrew J;
Meredith, Sarah K;
Bayissa, Adamu;
Bhatnagar, Anuj K;
Chiang, Chen-Yuan;
Conradie, Francesca;
... STREAM study collaborators; + view all
(2024)
Long-term efficacy and safety of two short standardised regimens for the treatment of rifampicin-resistant tuberculosis (STREAM stage 2): extended follow-up of an open-label, multicentre, randomised, non-inferiority trial.
The Lancet Respiratory Medicine
10.1016/S2213-2600(24)00186-3.
(In press).
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Hughes, Gareth;
Young, William J;
Bern, Henry;
Crook, Angela;
Lambiase, Pier D;
Goodall, Ruth L;
Nunn, Andrew J;
(2024)
T-wave morphology abnormalities in the STREAM stage 1 trial.
Expert Opinion on Drug Safety
, 23
(4)
pp. 469-476.
10.1080/14740338.2024.2322116.
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Tweed, Conor D;
Quartagno, Matteo;
Clements, Michelle N;
Turner, Rebecca M;
Nunn, Andrew J;
Dunn, David T;
White, Ian R;
(2024)
Exploring different objectives in non-inferiority trials.
BMJ
, 385
, Article e078000. 10.1136/bmj-2023-078000.
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Yates, Tom A;
Barnes, Samara;
Dedicoat, Martin;
Kon, Onn Min;
Kunst, Heinke;
Lipman, Marc;
Millington, Kerry A;
... UK Academics and Professionals to end TB; + view all
(2024)
Drug-resistant tuberculosis treatments, the case for a phase III platform trial.
Bull World Health Organ
, 102
(9)
pp. 657-664.
10.2471/BLT.23.290948.
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2023
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Mitnick, Carole D;
Nunn, Andrew J;
(2023)
Ascertainment Bias in TB Treatment Trials: Can Systematic Assessment of Objective Endpoints Solve It?
American Journal of Respiratory and Critical Care Medicine
, 207
(10)
pp. 1269-1270.
10.1164/rccm.202303-0430ED.
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2022
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Esmail, Hanif;
Narendran, Gopalan;
Nunn, Andrew;
(2022)
Drug-resistant tuberculosis: Promising progress with a note of caution.
The Indian Journal of Medical Research
10.4103/ijmr.ijmr_677_22.
(In press).
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Goodall, Ruth L;
Sanders, Karen;
Bronson, Gay;
Gurumurthy, Meera;
Torrea, Gabriela;
Meredith, Sarah;
Nunn, Andrew;
... STREAM Trial Team; + view all
(2022)
Keeping up with the guidelines: design changes to the STREAM stage 2 randomised controlled non-inferiority trial for rifampicin-resistant tuberculosis.
Trials
, 23
(1)
, Article 474. 10.1186/s13063-022-06397-4.
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Hughes, G;
Bern, H;
Chiang, CY;
Goodall, RL;
Nunn, AJ;
Rusen, ID;
Meredith, SK;
(2022)
ECG monitoring in STREAM Stage 1: can we identify those at increased risk of QT prolongation?
The International Journal of Tuberculosis and Lung Disease
, 26
(11)
pp. 1065-1070.
10.5588/ijtld.22.0063.
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Hughes, G;
Bern, H;
Chiang, CY;
Goodall, RL;
Nunn, AJ;
Rusen, ID;
Meredith, SK;
(2022)
QT prolongation in the STREAM Stage 1 Trial.
The International Journal of Tuberculosis and Lung Disease
, 26
(4)
pp. 334-340.
10.5588/ijtld.21.0403.
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Kokebu, DM;
Ahmed, S;
Moodliar, R;
Chiang, C-Y;
Torrea, G;
Van Deun, A;
Goodall, RL;
... Nunn, AJ; + view all
(2022)
Failure or relapse predictors for the STREAM Stage 1 short regimen for RR-TB.
International Journal of Tuberculosis and Lung Disease
, 26
(8)
pp. 753-759.
10.5588/ijtld.22.0073.
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Molloy, SF;
White, IR;
Nunn, AJ;
Hayes, R;
Wang, D;
Harrison, TS;
(2022)
Multiplicity adjustments in parallel-group multi-arm trials sharing a control group: Clear guidance is needed.
Contemporary Clinical Trials
, 113
, Article 106656. 10.1016/j.cct.2021.106656.
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Naidoo, Kogieleum;
Gengiah, Santhanalakshmi;
Yende-Zuma, Nonhlanhla;
Mlobeli, Regina;
Ngozo, Jacqueline;
Memela, Nhlakanipho;
Padayatchi, Nesri;
... Karim, Salim S Abdool; + view all
(2022)
Mortality in HIV and tuberculosis patients following implementation of integrated HIV-TB treatment: Results from an open-label cluster-randomized trial.
eClinicalMedicine
, 44
, Article 101298. 10.1016/j.eclinm.2022.101298.
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2021
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Ejo, M;
Van Deun, A;
Nunn, A;
Meredith, S;
Ahmed, S;
Dalai, D;
Tumenbayar, O;
... Torrea, G; + view all
(2021)
Effectiveness of GenoType MTBDRsl in excluding TB drug resistance in a clinical trial.
The International Journal of Tuberculosis and Lung Disease
, 25
(10)
pp. 839-845.
10.5588/ijtld.21.0212.
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Gengiah, S;
Barker, PM;
Yende‐Zuma, N;
Mbatha, M;
Naidoo, S;
Taylor, M;
Loveday, M;
... Naidoo, K; + view all
(2021)
A cluster‐randomized controlled trial to improve the quality of integrated HIV‐tuberculosis services in primary healthcareclinics in South Africa.
Journal of the International AIDS Society
, 24
(9)
, Article e25803. 10.1002/jia2.25803.
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Gengiah, S;
Connolly, C;
Yende-Zuma, N;
Barker, PM;
Nunn, AJ;
Padayatchi, N;
Taylor, M;
... Naidoo, K; + view all
(2021)
Organizational contextual factors that predict success of a quality improvement collaborative approach to enhance integrated HIV-tuberculosis services: a sub-study of the Scaling up TB/HIV Integration trial.
Implementation Science
, 16
(1)
, Article 88. 10.1186/s13012-021-01155-7.
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Gengiah, S;
Naidoo, K;
Mlobeli, R;
Tshabalala, MF;
Nunn, AJ;
Padayatchi, N;
Yende-Zuma, N;
... Loveday, M; + view all
(2021)
Open Access
A Quality Improvement Intervention to Inform Scale-Up of Integrated HIV-TB Services: Lessons Learned From KwaZulu-Natal, South Africa.
Global Health Science and Practice
, 9
(3)
pp. 444-458.
10.9745/GHSP-D-21-00157.
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Rao, CB;
Peatfield, JC;
McAdam, KPWJ;
Nunn, AJ;
Georgieva, DP;
(2021)
A Focus on the Reminiscence Bump to Personalize Music Playlists for Dementia.
Journal of Multidisciplinary Healthcare
, 14
pp. 2195-2204.
10.2147/JMDH.S312725.
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Tweed, CD;
Wills, GH;
Crook, AM;
Amukoye, E;
Balanag, V;
Ban, AYL;
Bateson, ALC;
... Gillespie, SH; + view all
(2021)
A partially randomised trial of pretomanid, moxifloxacin and pyrazinamide for pulmonary TB.
The International Journal of Tuberculosis and Lung Disease
, 25
(4)
pp. 305-314.
10.5588/ijtld.20.0513.
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2020
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Lienhardt, C;
Nunn, A;
Chaisson, R;
Vernon, AA;
Zignol, M;
Nahid, P;
Delaporte, E;
(2020)
Advances in clinical trial design: Weaving tomorrow's TB treatments.
PLOS Medicine
, 17
(2)
, Article e1003059. 10.1371/journal.pmed.1003059.
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Madan, JJ;
Rosu, L;
Tefera, MG;
van Rensburg, C;
Evans, D;
Langley, I;
Tomeny, EM;
... Squire, SB; + view all
(2020)
Economic evaluation of short treatment for multidrug-resistant tuberculosis, Ethiopia and South Africa: the STREAM trial.
Bulletin of the World Health Organization
, 98
(5)
pp. 306-314.
10.2471/blt.19.243584.
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Phillips, PPJ;
Van Deun, A;
Ahmed, S;
Goodall, RL;
Meredith, SK;
Conradie, F;
Chiang, C-Y;
... Nunn, AJ; + view all
(2020)
Investigation of the efficacy of the short regimen for rifampicin-resistant TB from the STREAM trial.
BMC Medicine
, 18
, Article 314. 10.1186/s12916-020-01770-z.
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Rosu, L;
Madan, J;
Worrall, E;
Tomeny, E;
Squire, B;
Ahmed, S;
(2020)
Economic evaluation protocol of a short, all-oral bedaquiline-containing regimen for the treatment of rifampicin-resistant tuberculosis from the STREAM trial.
BMJ Open
, 10
(12)
, Article e042390. 10.1136/bmjopen-2020-042390.
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2019
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Ahmed, S;
Moore, DA;
Nimmo, C;
Nunn, AJ;
Yates, TA;
North London TB Journal Club;
(2019)
Linezolid for drug-susceptible tuberculosis.
[Letter].
The Lancet Infectious Diseases
, 19
(4)
p. 357.
10.1016/S1473-3099(19)30110-0.
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Dheda, K;
Gumbo, T;
Maartens, G;
Dooley, KE;
Murray, M;
Furin, J;
Nardell, EA;
... Warren, RM; + view all
(2019)
The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis.
The Lancet Respiratory Medicine
, 7
(9)
pp. 820-826.
10.1016/s2213-2600(19)30263-2.
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Esmail, H;
Lipman, MC;
Nunn, A;
Walker, TM;
(2019)
Individualising therapy for drug-sensitive tuberculosis.
The Lancet Respiratory Medicine
, 7
(10)
pp. 834-835.
10.1016/S2213-2600(19)30247-4.
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Luengo-Fernandez, R;
Penz, E;
Dobson, M;
Psallidas, I;
Nunn, AJ;
Maskell, NA;
Rahman, NM;
(2019)
Cost-effectiveness of intrapleural use of tissue plasminogen activator and DNase in pleural infection: Evidence from the MIST2 randomised controlled trial.
European Respiratory Journal
, 54
(2)
, Article 1801550. 10.1183/13993003.01550-2018.
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Naidoo, K;
Gengiah, S;
Yende-Zuma, N;
Padayatchi, N;
Barker, P;
Nunn, A;
Subrayen, P;
(2019)
Addressing challenges in scaling up TB and HIV treatment integration in rural primary healthcare clinics in South Africa (SUTHI): a cluster randomized controlled trial protocol (vol 12, 129, 2017).
[Corrigendum].
Implementation Science
, 14
, Article 59. 10.1186/s13012-019-0915-1.
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Nunn, AJ;
Phillips, PPJ;
Meredith, SK;
Chiang, C-Y;
Conradie, F;
Dalai, D;
van Deun, A;
... STREAM Study Collaborators, .; + view all
(2019)
A Trial of a Shorter Regimen for Rifampin-Resistant Tuberculosis.
The New England Journal of Medicine
, 380
(13)
pp. 1201-1213.
10.1056/NEJMoa1811867.
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Phillips, PPJ;
Mitnick, CD;
Neaton, JD;
Nahid, P;
Lienhardt, C;
Nunn, AJ;
(2019)
Keeping phase III tuberculosis trials relevant: Adapting to a rapidly changing landscape.
PLOS Medicine
, 16
(3)
, Article e1002767. 10.1371/journal.pmed.1002767.
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Tweed, CD;
Crook, AM;
Dawson, R;
Diacon, AH;
McHugh, TD;
Mendel, CM;
Meredith, SK;
... Gillespie, SH; + view all
(2019)
Toxicity related to standard TB therapy for pulmonary tuberculosis and treatment outcomes in the REMoxTB study according to HIV status.
BMC Pulmonary Medicine
, 19
(1)
, Article 152. 10.1186/s12890-019-0907-6.
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2018
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Anywaine, Z;
Levin, J;
Kasirye, R;
Lutaakome, JK;
Abaasa, A;
Nunn, A;
Grosskurth, H;
... COSTOP research team, .; + view all
(2018)
Discontinuing cotrimoxazole preventive therapy in HIV-infected adults who are stable on antiretroviral treatment in Uganda (COSTOP): A randomised placebo controlled trial.
PLoS One
, 13
(12)
, Article e0206907. 10.1371/journal.pone.0206907.
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Fregonese, F;
Ahuja, SD;
Akkerman, OW;
Arakaki-Sanchez, D;
Ayakaka, I;
Baghaei, P;
Bang, D;
... Menzies, D; + view all
(2018)
Comparison of different treatments for isoniazid-resistant tuberculosis: an individual patient data meta-analysis.
The Lancet Respiratory Medicine
, 6
(4)
pp. 265-275.
10.1016/S2213-2600(18)30078-X.
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Mason, JM;
Chalmers, JR;
Godec, T;
Nunn, AJ;
Kirtschig, G;
Wojnarowska, F;
Childs, M;
... UK Dermatology Clinical Trials Network BLISTER Study Group, .; + view all
(2018)
Doxycycline compared to prednisolone therapy for patients with bullous pemphigoid: cost-effectiveness analysis of the BLISTER trial.
British Journal of Dermatology
, 178
(2)
pp. 415-423.
10.1111/bjd.16006.
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Mishra, EK;
Clive, AO;
Wills, GH;
Davies, HE;
Stanton, AE;
Al-Aloul, M;
Hart-Thomas, A;
... Rahman, NM; + view all
(2018)
Randomised Controlled Trial of Urokinase versus Placebo for Non-draining Malignant Pleural Effusion.
American Journal of Respiratory and Critical Care Medicine
, 197
(4)
pp. 502-508.
10.1164/rccm.201704-0809OC.
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Murphy, ME;
Wills, GH;
Murthy, S;
Louw, C;
Bateson, ALC;
Hunt, RD;
McHugh, TD;
... REMoxTB consortium, .; + view all
(2018)
Gender differences in tuberculosis treatment outcomes: a post hoc analysis of the REMoxTB study.
BMC Medicine
, 16
(189)
10.1186/s12916-018-1169-5.
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Murthy, SE;
Chatterjee, F;
Crook, A;
Dawson, R;
Mendel, C;
Murphy, ME;
Murray, SR;
... Gillespie, SH; + view all
(2018)
Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis.
BMC Medicine
, 16
(1)
, Article 73. 10.1186/s12916-018-1053-3.
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Tweed, C;
Nunn, A;
(2018)
Data in TB have to be both big and good.
The International Journal of Tuberculosis and Lung Disease
, 22
(5)
p. 476.
10.5588/ijtld.18.0200.
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Tweed, CD;
Crook, AM;
Amukoye, EI;
Dawson, R;
Diacon, AH;
Hanekom, M;
McHugh, TD;
... Gillespie, SH; + view all
(2018)
Toxicity associated with tuberculosis chemotherapy in the REMoxTB study.
BMC Infectious Diseases
, 18
, Article 317. 10.1186/s12879-018-3230-6.
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Tweed, CD;
Wills, GH;
Crook, AM;
Dawson, R;
Diacon, AH;
Louw, CE;
McHugh, TD;
... Gillespie, SH; + view all
(2018)
Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study.
BMC Medicine
, 16
(1)
, Article 46. 10.1186/s12916-018-1033-7.
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2017
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Abaasa, A;
Gafos, M;
Anywaine, Z;
Nunn, A;
Crook, A;
Levin, J;
McCormack, S;
(2017)
Uptake of hormonal contraceptives and correlates of uptake in a phase III clinical trial in rural South Western Uganda.
Reproductive Health
, 14
, Article 36. 10.1186/s12978-017-0296-3.
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Chalmers, JR;
Wojnarowska, F;
Kirtschig, G;
Mason, J;
Childs, M;
Whitham, D;
Harman, K;
... Williams, HC; + view all
(2017)
A randomised controlled trial to compare the safety, effectiveness and cost-effectiveness of doxycycline (200 mg/day) with that of oral prednisolone (0.5 mg/kg/day) for initial treatment of bullous pemphigoid: the Bullous Pemphigoid Steroids and Tetracyclines (BLISTER) trial.
Health Technology Assessment
, 21
(10)
10.3310/hta21100.
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Kasirye, RP;
Grosskurth, H;
Munderi, P;
Levin, J;
Anywaine, Z;
Nunn, A;
Kamali, A;
(2017)
Effect of antiretroviral therapy on malaria incidence in HIV-infected Ugandan adults.
AIDS
, 31
(4)
pp. 577-582.
10.1097/QAD.0000000000001344.
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Murphy, ME;
Phillips, PJ;
Mendel, CM;
Bongard, E;
Bateson, AL;
Hunt, R;
Murthy, S;
... Lipman, M; + view all
(2017)
Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis.
BMC Medicine
, 15
, Article 192. 10.1186/s12916-017-0947-9.
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Naidoo, K;
Gengiah, S;
Yende-Zuma, N;
Padayatchi, N;
Barker, P;
Nunn, A;
Subrayen, P;
(2017)
Addressing challenges in scaling up TB and HIV treatment integration in rural primary healthcare clinics in South Africa (SUTHI): a cluster randomized controlled trial protocol.
Implementation Science
, 12
, Article 129. 10.1186/s13012-017-0661-1.
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Phillips, PPJ;
Mendel, CM;
Nunn, AJ;
McHugh, TD;
Crook, AM;
Hunt, R;
Bateson, A;
(2017)
A comparison of liquid and solid culture for determining relapse and durable cure in phase III TB trials for new regimens.
BMC Medicine
, 15
, Article 207. 10.1186/s12916-017-0955-9.
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Ssali, A;
Nunn, A;
Mbonye, M;
Anywaine, Z;
Seeley, J;
(2017)
Reasons for participating in a randomised clinical trial: The volunteers' voices in the COSTOP trial in Uganda.
Contemporary Clinical Trials Communications
, 7
(C)
pp. 44-47.
10.1016/j.conctc.2017.05.007.
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Williams, HC;
Wojnarowska, F;
Kirtschig, G;
Mason, J;
Godec, TR;
Schmidt, E;
Chalmers, JR;
... Nunn, AJ; + view all
(2017)
Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial.
The Lancet
, 389
(10079)
pp. 1630-1638.
10.1016/S0140-6736(17)30560-3.
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2016
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Boeree, MJ;
Heinrich, H;
Rehal, S;
Phillips, PPJ;
(2016)
High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial.
Lancet Infectious Diseases
, 17
(1)
pp. 39-49.
10.1016/S1473-3099(16)30274-2.
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Briasoulis, O;
Breckenridge, R;
Nunn, A;
(2016)
External validity of trials should be taken into account before asthma drug candidates reach market authorisation.
The Lancet Respiratory Medicine
, 4
(8)
pp. 601-603.
10.1016/S2213-2600(16)30118-7.
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Furin, J;
Alirol, E;
Allen, E;
Fielding, K;
Merle, C;
Abubakar, I;
Andersen, J;
... Du Cros, P; + view all
(2016)
Drug-resistant tuberculosis clinical trials: Proposed core research definitions in adults.
International Journal of Tuberculosis and Lung Disease
, 20
(3)
pp. 290-294.
10.5588/ijtld.15.0490.
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Kasirye, RP;
Baisley, K;
Munderi, P;
Levin, J;
Anywaine, Z;
Nunn, A;
Kamali, A;
(2016)
Incidence of malaria by cotrimoxazole use in HIV-infected Ugandan adults on antiretroviral therapy.
AIDS
, 30
(4)
pp. 635-644.
10.1097/QAD.0000000000000956.
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Nunn, AJ;
Anywaine, A;
Seeley, J;
Munderi, P;
Levin, J;
Kasirye, R;
Kamali, A;
... Grosskurth, H; + view all
(2016)
Exit interviews administered to patients participating in the COSTOP placebo controlled randomised trial in Uganda.
Contemporary Clinical Trials Communications
, 3
pp. 142-146.
10.1016/j.conctc.2016.05.008.
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Nunn, AJ;
Kasirye, R;
Grosskurth, H;
Munderi, P;
Levin, J;
Anywaine, Z;
(2016)
Longitudinal effect of CD4 by cotrimoxazole use on malaria incidence among HIV‑infected Ugandan adults on antiretroviral therapy: a randomized controlled study.
Malaria Journal
, 15
(361)
10.1186/s12936-016-1426-z.
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Papineni, P;
Phillips, P;
Lu, Q;
Cheung, YB;
Nunn, A;
Paton, N;
(2016)
TRUNCATE-TB: an innovative trial design for drug-sensitive tuberculosis.
International Journal of Infectious Diseases
, 45
p. 404.
10.1016/j.ijid.2016.02.863.
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Phillips, Patrick PJ;
Nunn, Andrew J;
(2016)
Clinical Trials.
In: Abubakar, I and Stagg, HR and Cohen, T and Rodrigues, LC, (eds.)
Infectious Disease Epidemiology.
(pp. 71-86).
Oxford University Press: Oxford, United Kingdom.
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Phillips, PP;
Mendel, CM;
Burger, DA;
Crook, A;
Nunn, AJ;
Dawson, R;
Diacon, AH;
(2016)
Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials.
BMC Med
, 14
(1)
, Article 19. 10.1186/s12916-016-0565-y.
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Phillips, PP;
Mendel, CM;
Burger, DA;
Crook, AM;
Nunn, AJ;
Dawson, R;
Diacon, AH;
(2016)
Erratum to: Limited role of culture conversion for decision-making in individual patient care and for advancing novel regimens to confirmatory clinical trials.
[Corrigendum].
BMC Medicine
, 14
(1)
, Article 36. 10.1186/s12916-016-0585-7.
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Thomas, KS;
Batchelor, JM;
Bath-Hextall, F;
Chalmers, JR;
Clarke, T;
Crowe, S;
Delamere, FM;
... Williams, HC; + view all
(2016)
A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease.
Programme Grants for Applied Research
, 4
(18)
10.3310/pgfar04180.
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