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Long-term consistent use of a vaginal microbicide gel among HIV-1 sero-discordant couples in a phase III clinical trial (MDP 301) in rural south-west Uganda

Abaasa, A; Crook, A; Gafos, M; Anywaine, Z; Levin, J; Wandiembe, S; Nanoo, A; ... Kamali, A; + view all (2013) Long-term consistent use of a vaginal microbicide gel among HIV-1 sero-discordant couples in a phase III clinical trial (MDP 301) in rural south-west Uganda. Trials , 14 , Article 33. 10.1186/1745-6215-14-33. Green open access

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Abstract

A safe and effective vaginal microbicide could substantially reduce HIV acquisition for women. Consistent gel use is, however, of great importance to ensure continued protection against HIV infection, even with a safe and effective microbicide. We assessed the long-term correlates of consistent gel use in the MDP 301 clinical trial among HIV-negative women in sero-discordant couples in south-west Uganda.

Type: Article
Title: Long-term consistent use of a vaginal microbicide gel among HIV-1 sero-discordant couples in a phase III clinical trial (MDP 301) in rural south-west Uganda
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/1745-6215-14-33
Publisher version: http://dx.doi.org/10.1186/1745-6215-14-33
Language: English
Additional information: © 2013 Abaasa et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC3564905
Keywords: Administration, Intravaginal, Adolescent, Adult, Age Factors, Anti-Infective Agents, Local, Female, HIV Infections, HIV Seronegativity, HIV Seropositivity, HIV-1, Housing, Humans, Likelihood Functions, Logistic Models, Male, Medication Adherence, Multivariate Analysis, Naphthalenesulfonates, Odds Ratio, Polymers, Pregnancy, Risk Factors, Rural Health, Sexual Partners, Socioeconomic Factors, Time Factors, Treatment Outcome, Uganda, Vaginal Creams, Foams, and Jellies, Young Adult
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/1418537
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