Ssali, A;
Nunn, A;
Mbonye, M;
Anywaine, Z;
Seeley, J;
(2017)
Reasons for participating in a randomised clinical trial: The volunteers' voices in the COSTOP trial in Uganda.
Contemporary Clinical Trials Communications
, 7
(C)
pp. 44-47.
10.1016/j.conctc.2017.05.007.
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Abstract
Introduction The reasons why research participants join clinical trials remains an area of inquiry especially in low and middle income countries. Methods We conducted exit interviews with participants who took part in a trial which aimed to evaluate whether long term prophylaxis with cotrimoxazole can be safely discontinued among adults who have been stabilised on antiretroviral therapy (ART). Participants were all reported to be stable on ART and had been participating in the trial for between 12 and 36 months; at the end of the trial participants were interviewed using a semi-structured questionnaire. One of the objectives of the exit interview was to find out what motivated the participants to join the research. Results Participants gave personal reasons for joining the trial, frequently linked to their health and well-being as well as reduction of pill burden. Conclusion We conclude that underlying reasons for joining clinical trials may extend beyond or can be different from the rationale given to the participants before enrolment by the research team. The reasons that motivate enrolment to clinical trials and research in general require further investigation in different settings. Trial registration number ISRCTN44723643.
| Type: | Article |
|---|---|
| Title: | Reasons for participating in a randomised clinical trial: The volunteers' voices in the COSTOP trial in Uganda |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.conctc.2017.05.007 |
| Publisher version: | http://doi.org/10.1016/j.conctc.2017.05.007 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Randomised clinical trials, Volunteers, Participants |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1575712 |
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