Nunn, A;
McCormack, S;
Crook, AM;
Pool, R;
Rutterford, C;
Hayes, R;
(2009)
Microbicides Development Programme: design of a phase III trial to measure the efficacy of the vaginal microbicide PRO 2000/5 for HIV prevention.
Trials
, 10
, Article 99. 10.1186/1745-6215-10-99.
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Abstract
With 2.5 million new HIV infections per year, effective preventive methods against HIV are urgently needed, especially in sub-Saharan Africa. MDP301 is an ongoing trial of the vaginal microbicide PRO 2000/5 being conducted by the Microbicides Development Programme. The main objective of the trial is to determine the efficacy and safety of 0.5% and 2% concentrations of PRO 2000/5 gel compared to placebo in preventing vaginally acquired HIV infection.
| Type: | Article |
|---|---|
| Title: | Microbicides Development Programme: design of a phase III trial to measure the efficacy of the vaginal microbicide PRO 2000/5 for HIV prevention |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/1745-6215-10-99 |
| Publisher version: | http://dx.doi.org/10.1186/1745-6215-10-99 |
| Language: | English |
| Additional information: | © 2009 Nunn et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. PMCID: PMC2774685 |
| Keywords: | Administration, Intravaginal, Anti-Infective Agents, Local, Endpoint Determination, Female, HIV Infections, Humans, Naphthalenesulfonates, Polymers, Research Design, Sample Size, Sexual Behavior |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1308718 |
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