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Number of items: 49.
Article
Brancolini, G;
Maschio, MC;
Cantarutti, C;
Corazza, A;
Fogolari, F;
Bellotti, V;
Corni, S;
(2018)
Citrate stabilized gold nanoparticles interfere with amyloid fibril formation: D76N and Delta N6 beta 2-microglobulin variants.
Nanoscale
, 10
(10)
pp. 4793-4806.
10.1039/c7nr06808e.
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Camilloni, C;
Sala, BM;
Sormanni, P;
Porcari, R;
Corazza, A;
De Rosa, M;
Zanini, S;
... Ricagno, S; + view all
(2016)
Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability.
Scientific Reports
, 6
, Article 25559. 10.1038/srep25559.
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Canetti, D;
Nocerino, P;
Rendell, NB;
Botcher, N;
Gilbertson, JA;
Blanco, A;
Rowczenio, D;
... Taylor, GW; + view all
(2021)
Clinical ApoA-IV amyloid is associated with fibrillogenic signal sequence.
The Journal of Pathology
, 255
(3)
pp. 311-318.
10.1002/path.5770.
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Canetti, D;
Brambilla, F;
Rendell, NB;
Nocerino, P;
Gilbertson, JA;
Di Silvestre, D;
Bergamaschi, A;
... Taylor, GW; + view all
(2021)
Clinical Amyloid Typing by Proteomics: Performance Evaluation and Data Sharing Between Two Centres.
Molecules
, 26
(7)
, Article 1913. 10.3390/molecules26071913.
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Canetti, D;
Rendell, NB;
Di Vagno, L;
Gilbertson, JA;
Rowczenio, D;
Rezk, T;
Gillmore, JD;
... Taylor, GW; + view all
(2017)
Misidentification of transthyretin and immunoglobulin variants by proteomics due to methyl lysine formation in formalin-fixed paraffin-embedded amyloid tissue.
Amyloid
, 27
(4)
pp. 229-237.
10.1080/13506129.2017.1385452.
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Canetti, D;
Rendell, NB;
Gilbertson, JA;
Botcher, N;
Nocerino, P;
Blanco, A;
Di Vagno, L;
... Taylor, GW; + view all
(2020)
Diagnostic amyloid proteomics: experience of the UK National Amyloidosis Centre.
Clinical Chemistry and Laboratory Medicine
, 58
(6)
pp. 948-957.
10.1515/cclm-2019-1007.
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Cantarutti, C;
Mimmi, MC;
Verona, G;
Mandaliti, W;
Taylor, GW;
Mangione, PP;
Giorgetti, S;
... Corazza, A; + view all
(2022)
Calcium Binds to Transthyretin with Low Affinity.
Biomolecules
, 12
(8)
, Article 1066. 10.3390/biom12081066.
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Cantarutti, C;
Bertoncin, P;
Corazza, A;
Giorgetti, S;
Mangione, PP;
Bellotti, V;
Fogolari, F;
(2017)
Short-Chain Alkanethiol Coating for Small-Size Gold Nanoparticles Supporting Protein Stability.
Magnetochemistry
, 3
(4)
, Article 40. 10.3390/magnetochemistry3040040.
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Cantarutti, C;
Bertoncin, P;
Posocco, P;
Hunashal, Y;
Giorgetti, S;
Bellotti, V;
Fogolari, F;
(2018)
The interaction of β2-microglobulin with gold nanoparticles: impact of coating, charge and size.
Journal of Materials Chemistry B
, 6
(37)
pp. 5964-5974.
10.1039/c8tb01129j.
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Cantarutti, C;
Raimondi, S;
Brancolini, G;
Corazza, A;
Giorgetti, S;
Ballico, M;
Zanini, S;
... Esposito, G; + view all
(2017)
Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin.
Nanoscale
, 9
(11)
pp. 3941-3951.
10.1039/c6nr09362k.
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Cantarutti, C;
Raj, G;
Fogolari, F;
Giorgetti, S;
Corazza, A;
Bellotti, V;
Naumov, P;
(2018)
Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association.
Chemical Communication
, 54
(43)
pp. 5422-5425.
10.1039/c8cc01053f.
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Corazza, A;
Verona, G;
Waudby, CA;
Mangione, PP;
Bingham, RP;
Uings, I;
Canetti, D;
... Bellotti, V; + view all
(2019)
Binding of monovalent and bivalent ligands by transthyretin causes different short and long distance conformational changes.
Journal of Medicinal Chemistry
, 62
(17)
pp. 8274-8283.
10.1021/acs.jmedchem.9b01037.
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De Franceschi, G;
Fecchio, C;
Sharon, R;
Schapira, AHV;
Proukakis, C;
Bellotti, V;
de laureto, PP;
(2017)
α-Synuclein structural features inhibit harmful polyunsaturated fatty acid oxidation, suggesting roles in neuroprotection.
Journal of Biological Chemistry
, 292
(17)
pp. 6927-6937.
10.1074/jbc.M116.765149.
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de Rosa, M;
Halabelian, L;
Barbiroli, A;
Bolognesi, M;
Bellotti, V;
Ricagno, S;
(2017)
An Asp to Asn mutation is a toxic trigger in beta-2 microglobulin: structure and biophysics.
Amyloid
, 24
(sup1)
pp. 15-16.
10.1080/13506129.2016.1272450.
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Di Silvestre, Dario;
Brambilla, Francesca;
Lavatelli, Francesca;
Chirivì, Maila;
Canetti, Diana;
Bearzi, Claudia;
Rizzi, Roberto;
... Mauri, Pierluigi; + view all
(2023)
The Protein Network in Subcutaneous Fat Biopsies from Patients with AL Amyloidosis: More Than Diagnosis?
Cells
, 12
(5)
, Article 699. 10.3390/cells12050699.
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Diomede, L;
Soria, C;
Romeo, M;
Giorgetti, S;
Marchese, L;
Mangione, PP;
Porcari, R;
... Stoppini, M; + view all
(2012)
C. elegans expressing human β2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype.
PLoS One
, 7
(12)
, Article e52314. 10.1371/journal.pone.0052314.
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Faravelli, G;
Raimondi, S;
Marchese, L;
Partridge, FA;
Soria, C;
Mangione, PP;
Canetti, D;
... Giorgetti, S; + view all
(2019)
C. elegans expressing D76N β_{2}-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis.
Scientific Reports
, 9
, Article 19960. 10.1038/s41598-019-56498-5.
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Halabelian, L;
Ricagno, S;
Giorgetti, S;
Santambrogio, C;
Barbiroli, A;
Pellegrino, S;
Achour, A;
... Bellotti, V; + view all
(2013)
Class I Major Histocompatibility Complex: the Trojan horse for secretion of amyloidogenic β2-microglobulin.
J Biol Chem
, 289
(6)
pp. 3318-3327.
10.1074/jbc.M113.524157.
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Izco, M;
Blesa, J;
Schleef, M;
Schmeer, M;
Porcari, R;
Al-Shawi, R;
Ellmerich, S;
... Alvarez-Erviti, L; + view all
(2019)
Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology.
Molecular Therapy
, 27
(12)
pp. 2111-2122.
10.1016/j.ymthe.2019.08.010.
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Kisilevsky, R;
Raimondi, S;
Bellotti, V;
(2016)
Historical and Current Concepts of Fibrillogenesis and In vivo Amyloidogenesis: Implications of Amyloid Tissue Targeting.
Frontiers in Molecular Biosciences
, 3
, Article 17. 10.3389/fmolb.2016.00017.
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Le Marchand, T;
de Rosa, M;
Salvi, N;
Sala, BM;
Andreas, LB;
Barbet-Massin, E;
Sormanni, P;
... Ricagno, S; + view all
(2018)
Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.
Nature Communications
, 9
, Article 1658. 10.1038/s41467-018-04078-y.
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Leri, M;
Bemporad, F;
Oropesa-Nunez, R;
Canale, C;
Calamai, M;
Nosi, D;
Ramazzotti, M;
... Bucciantini, M; + view all
(2016)
Molecular insights into cell toxicity of a novel familial amyloidogenic variant of beta 2-microglobulin.
Journal of Cellular and Molecular Medicine
, 20
(8)
pp. 1443-1456.
10.1111/jcmm.12833.
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Leri, M;
Oropesa-Nuñez, R;
Canale, C;
Raimondi, S;
Giorgetti, S;
Bruzzone, E;
Bellotti, V;
... Bucciantini, M; + view all
(2018)
Oleuropein aglycone: A polyphenol with different targets against amyloid toxicity.
Biochimica et Biophysica Acta (BBA) - General Subjects
, 1862
(6)
pp. 1432-1442.
10.1016/j.bbagen.2018.03.023.
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Liz, MA;
Coelho, T;
Bellotti, V;
Fernandez-Arias, MI;
Mallaina, P;
Obici, L;
(2020)
A Narrative Review of the Role of Transthyretin in Health and Disease.
Neurology and Therapy
10.1007/s40120-020-00217-0.
(In press).
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Mangione, PP;
Deroo, S;
Ellmerich, S;
Bellotti, V;
Kolstoe, S;
Wood, SP;
Robinson, CV;
... Taylor, GW; + view all
(2015)
Bifunctional crosslinking ligands for transthyretin.
Open Biology
, 5
(9)
, Article 150105. 10.1098/rsob.150105.
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Mangione, PP;
Esposito, G;
Relini, A;
Raimondi, S;
Porcari, R;
Giorgetti, S;
Corazza, A;
... Bellotti, V; + view all
(2013)
Structure, Folding Dynamics, and Amyloidogenesis of D76N β2-Microglobulin: ROLES OF SHEAR FLOW, HYDROPHOBIC SURFACES, AND α-CRYSTALLIN.
Journal of Biological Chemistry
, 288
(43)
30917- 30930.
10.1074/jbc.M113.498857.
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Mangione, PP;
Mazza, G;
Gilbertson, JA;
Rendell, NB;
Canetti, D;
Giorgetti, S;
Frenguelli, L;
... Bellotti, V; + view all
(2017)
Increasing the accuracy of proteomic typing by decellularisation of amyloid tissue biopsies.
Journal of Proteomics
, 165
pp. 113-118.
10.1016/j.jprot.2017.06.016.
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Mangione, PP;
Porcari, R;
Gillmore, JD;
Pucci, P;
Monti, M;
Porcari, M;
Giorgetti, S;
... Bellotti, V; + view all
(2014)
Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis.
Proceedings of the National Academy of Sciences of the United States of America
, 111
(4)
pp. 1539-1544.
10.1073/pnas.1317488111.
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Mangione, PP;
Verona, G;
Corazza, A;
Marcoux, J;
Canetti, D;
Giorgetti, S;
Raimondi, S;
... Bellotti, V; + view all
(2018)
Plasminogen activation triggers transthyretin amyloidogenesis in vitro.
Journal of Biological Chemistry
, 293
(37)
pp. 14192-14199.
10.1074/jbc.RA118.003990.
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Marcoux, J;
Mangione, PP;
Porcari, R;
Degiacomi, MT;
Verona, G;
Taylor, GW;
Giorgetti, S;
... Bellotti, V; + view all
(2015)
A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis.
EMBO Mol Med
, 7
(10)
pp. 1337-1349.
10.15252/emmm.201505357.
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Mazza, G;
Simons, JP;
Al-Shawi, R;
Ellmerich, S;
Urbani, L;
Giorgetti, S;
Taylor, GW;
... Mangione, PP; + view all
(2015)
Amyloid persistence in decellularized liver: biochemical and histopathological characterization.
Amyloid
, 23
(1)
pp. 1-7.
10.3109/13506129.2015.1110518.
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Migdalska-Richards, A;
Wegrzynowicz, M;
Harrison, IF;
Verona, G;
Bellotti, V;
Spillantini, MG;
Schapira, AHV;
(2020)
L444P Gba1 mutation increases formation and spread of α-synuclein deposits in mice injected with mouse α-synuclein pre-formed fibrils.
PLoS One
, 15
(8)
, Article e0238075. 10.1371/journal.pone.0238075.
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Moura, A;
Nocerino, P;
Gilbertson, JA;
Rendell, NB;
Mangione, PP;
Verona, G;
Rowczenio, D;
... Canetti, D; + view all
(2020)
Lysozyme amyloid: evidence for the W64R variant by proteomics in the absence of the wild type protein.
[Letter].
Amyloid
10.1080/13506129.2020.1720637.
(In press).
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Natalello, A;
Mangione, PP;
Giorgetti, S;
Porcari, R;
Marchese, L;
Zorzoli, I;
Relini, A;
... Raimondi, S; + view all
(2016)
Co-fibrillogenesis of Wild-type and D76N β₂-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS.
Journal of Biological Chemistry
, 291
(18)
pp. 9678-9689.
10.1074/jbc.M116.720573.
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Noji, M;
Samejima, T;
Yamaguchi, K;
So, M;
Yuzu, K;
Chatani, E;
Akazawa-Ogawa, Y;
... Goto, Y; + view all
(2021)
Breakdown of supersaturation barrier links protein folding to amyloid formation.
Communications Biology
, 4
, Article 120. 10.1038/s42003-020-01641-6.
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Ozawa, D;
Nomura, R;
Mangione, PP;
Hasegawa, K;
Okoshi, T;
Porcari, R;
Bellotti, V;
(2016)
Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro.
Scientific Reports
, 6
, Article 29077. 10.1038/srep29077.
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Porcari, R;
Proukakis, C;
Waudby, CA;
Bolognesi, B;
Mangione, PP;
Paton, JF;
Mullin, S;
... Bellotti, V; + view all
(2015)
The H50Q mutation induces a 10-fold decrease in the solubility of α-synuclein.
J Biol Chem
, 290
(4)
2395 - 2404.
10.1074/jbc.M114.610527.
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Prakasam, Thirumurugan;
Hunashal, Yamanappa;
Cantarutti, Cristina;
Giorgetti, Sofia;
Faravelli, Giulia;
Mondani, Valentina;
Sharma, Sudhir Kumar;
... Esposito, Gennaro; + view all
(2021)
Topologically non-trivial metal-organic assemblies inhibit beta(2)-microglobulin amyloidogenesis.
Cell Reports Physical Science
, 2
(7)
, Article 100477. 10.1016/j.xcrp.2021.100477.
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Raimondi, S;
Faravelli, G;
Nocerino, P;
Mondani, V;
Baruffaldi, A;
Marchese, L;
Mimmi, MC;
... Giorgetti, S; + view all
(2023)
Human wild-type and D76N β_{2}-microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans.
FASEB BioAdvances
, 5
(11)
pp. 484-505.
10.1096/fba.2023-00073.
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Raimondi, S;
Barbarini, N;
Mangione, P;
Esposito, G;
Ricagno, S;
Bolognesi, M;
Zorzoli, I;
... Bellotti, V; + view all
(2011)
The two tryptophans of β2-microglobulin have distinct roles in function and folding and might represent two independent responses to evolutionary pressure.
BMC Evolutionary Biology
, 11
(June 2)
, Article 159. 10.1186/1471-2148-11-159.
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Raimondi, S;
Mangione, PP;
Verona, G;
Canetti, D;
Nocerino, P;
Marchese, L;
Piccarducci, R;
... Bellotti, V; + view all
(2020)
Comparative study of the stabilities of synthetic in vitro and natural ex vivo transthyretin amyloid fibrils.
Journal of Biological Chemistry
, 295
(33)
pp. 11379-11387.
10.1074/jbc.RA120.014026.
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Raimondi, S;
Porcari, R;
Mangione, PP;
Verona, G;
Marcoux, J;
Giorgetti, S;
Taylor, GW;
... Bellotti, V; + view all
(2017)
A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.
Scientific Reports
, 7
, Article 46711. 10.1038/srep46711.
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Rezk, T;
Gilbertson, JA;
Mangione, PP;
Rowczenio, D;
Rendell, N;
Canetti, D;
Lachmann, HJ;
... Gillmore, JD; + view all
(2019)
The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis.
Journal of Pathology: Clinical Research
, 5
(3)
pp. 145-153.
10.1002/cjp2.126.
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Sartiani, L;
Bucciantini, M;
Spinelli, V;
Leri, M;
Natalello, A;
Nosi, D;
Maria Doglia, S;
... Stefani, M; + view all
(2016)
Biochemical and Electrophysiological Modification of Amyloid Transthyretin on Cardiomyocytes.
Biophys J
, 111
(9)
pp. 2024-2038.
10.1016/j.bpj.2016.09.010.
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Slamova, I;
Adib, R;
Ellmerich, S;
Golos, MR;
Gilbertson, JA;
Botcher, N;
Canetti, D;
... Simons, JP; + view all
(2021)
Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis.
Nature Communications
, 12
(1)
, Article 7112. 10.1038/s41467-021-27416-z.
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Solomon, Miriam;
Foderà, Vito;
Langkilde, Annette Eva;
Elliott, Perry;
Tagliavini, Fabrizio;
Forsyth, Trevor;
Klementieva, Oxana;
(2022)
Recommendations for addressing the translational gap between experimental and clinical research on amyloid diseases.
Journal of Translational Medicine
, 20
, Article 213. 10.1186/s12967-022-03420-9.
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Stoppini, M;
Bellotti, V;
(2015)
Systemic amyloidosis: lessons from β2-microglobulin.
Journal of Biological Chemistry
, 290
(16)
pp. 9951-9958.
10.1074/jbc.R115.639799.
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Valleix, S;
Verona, G;
Jourde-Chiche, N;
Nédelec, B;
Mangione, PP;
Bridoux, F;
Mangé, A;
... Bellotti, V; + view all
(2016)
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile.
Nature Communications
, 7
, Article 10353. 10.1038/ncomms10353.
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Verona, G;
Mangione, P;
Raimondi, S;
Giorgetti, S;
Faravelli, G;
Porcari, R;
Corazza, A;
... Bellotti, VL; + view all
(2017)
Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel.
Scientific Reports
, 7
, Article 182. 10.1038/s41598-017-00338-x.
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