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Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

Cantarutti, C; Raj, G; Fogolari, F; Giorgetti, S; Corazza, A; Bellotti, V; Naumov, P; (2018) Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association. Chemical Communication , 54 (43) pp. 5422-5425. 10.1039/c8cc01053f. Green open access

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Abstract

Protein fibrillation is involved in many serious diseases, and protein oligomers are proved to be precursors of amyloid fibrils. NMR and QCMD experiments allowed us to establish that the interaction between citrate-stabilized gold nanoparticles and a paradigmatic amyloidogenic protein, β2-microglobulin, is able to interfere with protein association into oligomers.

Type: Article
Title: Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c8cc01053f
Publisher version: http://dx.doi.org/10.1039/C8CC01053F
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10052343
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