Browse by UCL people
Group by: Type | Date
Number of items: 54.
Article
Allison, TM;
Barran, P;
Benesch, JLP;
Cianferani, S;
Degiacomi, MT;
Gabelica, V;
Grandori, R;
... Thalassinos, K; + view all
(2020)
Software Requirements for the Analysis and Interpretation of Native Ion Mobility Mass Spectrometry Data.
Analytical Chemistry
, 92
(16)
pp. 10881-10890.
10.1021/acs.analchem.9b05792.
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Allison, TM;
Barran, P;
Cianférani, S;
Degiacomi, MT;
Gabelica, V;
Grandori, R;
Marklund, EG;
... Benesch, JLP; + view all
(2020)
Computational Strategies and Challenges for Using Native Ion Mobility Mass Spectrometry in Biophysics and Structural Biology.
Analytical Chemistry
, 92
(16)
pp. 10872-10880.
10.1021/acs.analchem.9b05791.
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Bagnéris, Claire;
Senthil Kumar, Swathi L;
Baratchian, Mehdi;
Britt, Hannah M;
Assafa, Tufa E;
Thalassinos, Konstantinos;
Collins, Mary K;
(2022)
Mechanistic insights into the activation of the IKK kinase complex by the Kaposi’s Sarcoma Herpes virus oncoprotein vFLIP.
Journal of Biological Chemistry
, 298
(6)
, Article 102012. 10.1016/j.jbc.2022.102012.
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Blombach, F;
Ausiannikava, D;
Figueiredo, AM;
Soloviev, Z;
Prentice, T;
Zhang, M;
Zhou, N;
... Werner, F; + view all
(2018)
Structural and functional adaptation of Haloferax volcanii TFEα/β.
Nucleic Acids Research
, 46
(5)
pp. 2308-2320.
10.1093/nar/gkx1302.
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Blombach, F;
Salvadori, E;
Fouqueau, T;
Yan, J;
Reimann, J;
Sheppard, C;
Smollett, KL;
... Werner, F; + view all
(2015)
Archaeal TFE alpha/beta is a hybrid of TFIIE and the RNA polymerase III subcomplex hRPC62/39.
ELIFE
, 4
(ARTN e08)
10.7554/eLife.08378.
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Bradford, HF;
Lalaurie, CJ;
Gor, J;
Gao, X;
Pericleous, C;
Perkins, SJ;
Britt, H;
... McDonnell, TCR; + view all
(2025)
Plasmin cleavage of β2-glycoprotein I alters its structure and ability to bind to pathogenic antibodies.
Journal of Thrombosis and Haemostasis
, 23
(6)
pp. 1864-1878.
10.1016/j.jtha.2025.02.015.
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Britt, HM;
Cragnolini, T;
Thalassinos, K;
(2022)
Integration of Mass Spectrometry Data for Structural Biology.
Chemical Reviews
, 122
(8)
pp. 7952-7986.
10.1021/acs.chemrev.1c00356.
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Bullock, JMA;
Schwab, J;
Thalassinos, K;
Topf, M;
(2016)
The Importance of Non-accessible Crosslinks and Solvent Accessible Surface Distance in Modeling Proteins with Restraints From Crosslinking Mass Spectrometry.
Molecular & Cellular Proteomics
, 15
(7)
pp. 2491-2500.
10.1074/mcp.M116.058560.
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Bullock, JMA;
Sen, N;
Thalassinos, K;
Topf, M;
(2018)
Modeling Protein Complexes Using Restraints from Crosslinking Mass Spectrometry.
Structure
, 26
(7)
pp. 1015-1024.
10.1016/j.str.2018.04.016.
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Bullock, JMA;
Thalassinos, K;
Topf, M;
(2018)
Jwalk and MNXL Web Server: Model Validation using Restraints from Crosslinking Mass Spectrometry.
Bioinformatics
, 34
(20)
pp. 3584-3585.
10.1093/bioinformatics/bty366.
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Chan, JJ;
Flatters, D;
Rodrigues-Lima, F;
Yan, J;
Thalassinos, K;
Katan, M;
(2013)
Comparative analysis of interactions of RASSF1-10.
Advances in Biological Regulation
, 53
(2)
190 - 201.
10.1016/j.jbior.2012.12.001.
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Davies, HM;
Thalassinos, K;
Osborne, AR;
(2016)
Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates Novel Localisation Sequences that Target the Periphery of the Host Erythrocyte.
Journal of Biological Chemistry
, 291
(50)
pp. 26188-26207.
10.1074/jbc.M116.761213.
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Eldrid, Charles;
Cragnolini, Tristan;
Ben-Younis, Aisha;
Zou, Junjie;
Raleigh, Daniel P;
Thalassinos, Konstantinos;
(2022)
Linking Gas-Phase and Solution-Phase Protein Unfolding via Mobile Proton Simulations.
Analytical Chemistry
, 94
(46)
pp. 16113-16121.
10.1021/acs.analchem.2c03352.
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Eldrid, C;
Ben-Younis, A;
Ujma, J;
Britt, H;
Cragnolini, T;
Kalfas, S;
Cooper-Shepherd, D;
... Thalassinos, K; + view all
(2021)
Cyclic Ion Mobility–Collision Activation Experiments Elucidate Protein Behavior in the Gas Phase.
Journal of the American Society for Mass Spectrometry
10.1021/jasms.1c00018.
(In press).
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Eldrid, C;
O'Connor, E;
Thalassinos, K;
(2020)
Concentration‐dependent coulombic effects in travelling wave ion mobility spectrometry collision cross section calibration.
Rapid Communications in Mass Spectrometry
, 34
(S4)
, Article e8613. 10.1002/rcm.8613.
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Eldrid, C;
Thalassinos, K;
(2020)
Developments in tandem ion mobility mass spectrometry.
Biochemical Society Transactions
, 48
(6)
pp. 2457-2466.
10.1042/BST20190788.
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Eldrid, CFS;
Ujma, J;
Kalfas, S;
Tomczyk, N;
Giles, K;
Morris, MR;
Thalassinos, K;
(2019)
Gas Phase Stability of Protein Ions in a Cyclic Ion Mobility Spectrometry Traveling Wave Device.
Analytical Chemistry
10.1021/acs.analchem.8b05641.
(In press).
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Erinjeri, Annmary Paul;
Wang, Xunyan;
Williams, Rhianna;
Chiozzi, Riccardo Zenezini;
Thalassinos, Konstantinos;
Labbadia, Johnathan;
(2024)
HSF-1 promotes longevity through ubiquilin-1-dependent mitochondrial network remodelling.
Nature Communications
, 15
, Article 9797. 10.1038/s41467-024-54136-x.
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Ferreira, APA;
Casamento, A;
Carrillo Roas, S;
Halff, EF;
Panambalana, J;
Subramaniam, S;
Schützenhofer, K;
... Boucrot, E; + view all
(2021)
Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis.
Nature Communications
, 12
, Article 2424. 10.1038/s41467-021-22603-4.
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Flomm, Felix J;
Soh, Timothy K;
Schneider, Carola;
Wedemann, Linda;
Britt, Hannah M;
Thalassinos, Konstantinos;
Pfitzner, Søren;
... Bosse, Jens B; + view all
(2022)
Intermittent bulk release of human cytomegalovirus.
PLoS Pathogens
, 18
(8)
, Article e1010575. 10.1371/journal.ppat.1010575.
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Gabelica, V;
Shvartsburg, AA;
Afonso, C;
Barran, P;
Benesch, JLP;
Bleiholder, C;
Bowers, MT;
... Wyttenbach, T; + view all
(2019)
Recommendations for reporting ion mobility Mass Spectrometry measurements.
Mass Spectrometry Review
, 38
(3)
pp. 291-320.
10.1002/mas.21585.
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Gardner, S;
Darrow, MC;
Lukoyanova, N;
Thalassinos, K;
Saibil, HR;
(2023)
Structural basis of substrate progression through the bacterial chaperonin cycle.
Proceedings of the National Academy of Sciences of the United States of America
, 120
(50)
, Article e2308933120. 10.1073/pnas.2308933120.
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Goold, R;
Hamilton, J;
Menneteau, T;
Flower, M;
Bunting, EL;
Aldous, SG;
Porro, A;
... Tabrizi, SJ; + view all
(2021)
FAN1 controls mismatch repair complex assembly via MLH1 retention to stabilize CAG repeat expansion in Huntington's disease.
Cell Reports
, 36
(9)
, Article 109649. 10.1016/j.celrep.2021.109649.
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Groves, K;
Ashcroft, AE;
Cryar, A;
Sula, A;
Wallace, BA;
Stocks, BB;
Burns, C;
... Quaglia, M; + view all
(2021)
Reference Protocol to Assess Analytical Performance of Higher Order Structural Analysis Measurements: Results from an Interlaboratory Comparison.
Analytical Chemistry
, 93
(26)
pp. 9041-9048.
10.1021/acs.analchem.0c04625.
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Harvey, DJ;
Scarff, CA;
Edgeworth, M;
Pagel, K;
Thalassinos, K;
Struwe, WB;
Crispin, M;
(2016)
Travelling-wave ion mobility mass spectrometry and negative ion fragmentation of hybrid and complex N-glycans.
Journal of Mass Spectrometry
, 51
(11)
pp. 1064-1079.
10.1002/jms.3828.
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Harvey, DJ;
Scarff, CA;
Edgeworth, M;
Struwe, WB;
Pagel, K;
Thalassinos, K;
Crispin, M;
(2016)
Travelling-wave ion mobility and negative ion fragmentation of high-mannose N-glycans.
Journal of Mass Spectrometry
, 51
(3)
pp. 219-235.
10.1002/jms.3738.
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Hui, GK;
Gardener, AD;
Begum, H;
Eldrid, C;
Thalassinos, K;
Gor, J;
Perkins, SJ;
(2019)
The solution structure of the human IgG2 subclass is distinct from those for human IgG1 and IgG4 providing an explanation for their discrete functions.
Journal of Biological Chemistry
10.1074/jbc.RA118.007134.
(In press).
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James, JMB;
Cryar, A;
Thalassinos, K;
(2019)
Optimization Workflow for the Analysis of Cross-Linked Peptides Using a Quadrupole Time-of-Flight Mass Spectrometer.
Analytical Chemistry
, 91
(3)
pp. 1808-1814.
10.1021/acs.analchem.8b02319.
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Leitner, Alexander;
Bonvin, Alexandre MJJ;
Borchers, Christoph H;
Chalkley, Robert J;
Chamot-Rooke, Julia;
Combe, Colin W;
Cox, Jürgen;
... Rappsilber, Juri; + view all
(2020)
Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry.
Structure
, 28
(11)
pp. 1259-1268.
10.1016/j.str.2020.09.011.
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Levray, Yvette S;
Bana, Bianca;
Tarr, Sarah J;
McLaughlin, Emilia J;
Rossi-Smith, Peter;
Waltho, Anita;
Charlton, Georgina H;
... Osborne, Andrew R; + view all
(2023)
Formation of ER-lumenal intermediates during export of Plasmodium proteins containing transmembrane-like hydrophobic sequences.
PLoS Pathogens
, 19
(3)
, Article e1011281. 10.1371/journal.ppat.1011281.
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McCarthy, S;
Robinson, J;
Thalassinos, K;
Tabor, AB;
(2020)
A Chemical Biology Approach to Probing the Folding Pathways of the Inhibitory Cystine Knot (ICK) Peptide ProTx-II.
Frontiers in Chemistry
, 8
, Article 228. 10.3389/fchem.2020.00228.
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Modi, T;
Gervais, D;
Smith, S;
Miller, J;
Subramaniam, S;
Thalassinos, K;
Shepherd, A;
(2020)
Characterization of the UK anthrax vaccine and human immunogenicity.
Human Vaccines & Immunotherapeutics
10.1080/21645515.2020.1799668.
(In press).
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Morfopoulou, Sofia;
Buddle, Sarah;
Montaguth, Oscar Enrique Torres;
Atkinson, Laura;
Guerra-Assunção, José Afonso;
Marjaneh, Mahdi Moradi;
Chiozzi, Riccardo Zenezini;
... Breuer, Judith; + view all
(2023)
Genomic investigations of unexplained acute hepatitis in children.
Nature
10.1038/s41586-023-06003-w.
(In press).
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Newton, Lydia S;
Gathmann, Clara;
Ridewood, Sophie;
Smith, Robert J;
Wijaya, Andre J;
Hornsby, Thomas W;
Morling, Kate L;
... Selwood, David L; + view all
(2025)
Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV.
Nature Communications
, 16
(1)
, Article 1484. 10.1038/s41467-025-56317-8.
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Nyon, MP;
Prentice, T;
Day, J;
Kirkpatrick, J;
Sivalingam, GN;
Levy, G;
Haq, I;
... Thalassinos, K; + view all
(2015)
An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding.
Protein Science
, 24
(8)
pp. 1301-1312.
10.1002/pro.2706.
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Nyon, MP;
Segu, L;
Cabrita, LD;
Lévy, GR;
Kirkpatrick, J;
Roussel, BD;
Patschull, AO;
... Gooptu, B; + view all
(2012)
Structural dynamics associated with intermediate formation in an archetypal conformational disease.
Structure
, 20
(3)
pp. 504-512.
10.1016/j.str.2012.01.012.
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Quay, DHX;
Cole, AR;
Cryar, A;
Thalassinos, K;
Williams, MA;
Bhakta, S;
Keep, NH;
(2015)
Structure of the stationary phase survival protein YuiC from B.subtilis.
BMC Structural Biology
, 15
, Article 12. 10.1186/s12900-015-0039-z.
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Redzej, A;
Ukleja, M;
Connery, S;
Trokter, M;
Felisberto-Rodrigues, C;
Cryar, A;
Thalassinos, K;
... Waksman, G; + view all
(2017)
Structure of a VirD4 coupling protein bound to a VirB type IV secretion machinery.
EMBO Journal
, 36
pp. 3080-3095.
10.15252/embj.201796629.
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Ridgway, Z;
Eldrid, CFS;
Zhyvoloup, A;
Ben-Younis, A;
Noh, D;
Thalassinos, K;
Raleigh, DP;
(2020)
Analysis of Proline Substitutions Reveals the Plasticity and Sequence Sensitivity of Human IAPP Amyloidogenicity and Toxicity.
Biochemistry
, 59
(6)
pp. 742-754.
10.1021/acs.biochem.9b01109.
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Romano, Lisa EL;
Aw, Wen Yih;
Hixson, Kathryn M;
Novoselova, Tatiana V;
Havener, Tammy M;
Howell, Stefanie;
Taylor-Blake, Bonnie;
... Wolter, Justin M; + view all
(2022)
Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization.
Cell Reports
, 41
(5)
, Article 111580. 10.1016/j.celrep.2022.111580.
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Scholes, HM;
Cryar, A;
Kerr, F;
Sutherland, D;
Gethings, LA;
Vissers, JPC;
Lees, JG;
... Thalassinos, K; + view all
(2020)
Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila.
Scientific Reports
, 10
, Article 18517. 10.1038/s41598-020-74748-9.
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Sinnott, M;
Malhotra, S;
Madhusudhan, MS;
Thalassinos, K;
Topf, M;
(2020)
Combining Information from Crosslinks and Monolinks in the Modeling of Protein Structures.
Structure
, 28
(9)
1061-1070.e3.
10.1016/j.str.2020.05.012.
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Sivalingam, GN;
Cryar, A;
Williams, MA;
Gooptu, B;
Thalassinos, K;
(2018)
Deconvolution of ion mobility mass spectrometry arrival time distributions using a genetic algorithm approach: Application to α1-antitrypsin peptide binding.
International Journal of Mass Spectrometry
, 426
pp. 29-37.
10.1016/j.ijms.2018.01.008.
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Soloviev, Zoja;
Bullock, Joshua MA;
James, Juliette MB;
Sauerwein, Andrea C;
Nettleship, Joanne E;
Owens, Raymond J;
Hansen, D Flemming;
... Thalassinos, Konstantinos; + view all
(2022)
Structural mass spectrometry decodes domain interaction and dynamics of the full-length Human Histone Deacetylase 2.
Biochimica et Biophysica Acta - Proteins and Proteomics
, 1870
(3)
, Article 140759. 10.1016/j.bbapap.2022.140759.
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Thalassinos, K;
Pandurangan, AP;
Xu, M;
Alber, F;
Topf, M;
(2013)
Conformational States of macromolecular assemblies explored by integrative structure calculation.
Structure
, 21
(9)
1500 - 1508.
10.1016/j.str.2013.08.006.
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Tosi, T;
Hoshiga, F;
Millership, C;
Singh, R;
Eldrid, C;
Patin, D;
Mengin-Lecreulx, D;
... Gründling, A; + view all
(2019)
Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM.
PLoS Pathogens
, 15
(1)
, Article e1007537. 10.1371/journal.ppat.1007537.
(In press).
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Vickers, Sarah;
Aldobiyan, Ibrahim;
Lowen, Sarah M;
Irving, James A;
Lomas, David A;
Thalassinos, Konstantinos;
(2025)
Top-Down Ion Mobility Mass Spectrometry Reveals a Disease Associated Conformational Ensemble of Alpha-1-antitrypsin.
Journal of the American Chemical Society
10.1021/jacs.4c18139.
(In press).
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Warelow, TP;
Oke, M;
Schoepp-Cothenet, B;
Dahl, JU;
Bruselat, N;
Sivalingam, GN;
Leimkühler, S;
... Santini, JM; + view all
(2013)
The Respiratory Arsenite Oxidase: Structure and the Role of Residues Surrounding the Rieske Cluster.
PLoS One
, 8
(8)
, Article e72535. 10.1371/journal.pone.0072535.
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Willhoft, O;
Kerr, R;
Patel, D;
Zhang, W;
Al-Jassar, C;
Daviter, T;
Millson, SH;
... Vaughan, CK; + view all
(2017)
The crystal structure of the Sgt1-Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores.
Scientific Reports
, 7
, Article 41626. 10.1038/srep41626.
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Wright, ZVF;
McCarthy, S;
Dickman, R;
Reyes, FE;
Sanchez-Martinez, S;
Cryar, A;
Kilford, I;
... Tabor, AB; + view all
(2017)
The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Na(v)1.7.
Journal of the American Chemical Society
, 139
(37)
pp. 13063-13075.
10.1021/jacs.7b06506.
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Book chapter
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Vickers, Sarah;
Irving, James;
Lomas, David A;
Thalassinos, Konstantinos;
(2023)
Native and Ion Mobility Mass Spectrometry Characterization of Alpha 1 Antitrypsin Variants and Oligomers.
In: Bristow, Cynthia L, (ed.)
Alpha-1 Antitrypsin: Methods and Protocols.
(pp. 41-55).
Humana Press (Springer): New York, NY, USA.
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Poster
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Bradford, Hannah F;
Lalaurie, Christophe J;
God, Jayesh;
Gao, Xin;
Pericleous, Charis;
Perkins, Stephen J;
Britt, Hannah;
... McDonnell, Thomas CR; + view all
(2024)
Plasmin-Clipped Beta-2-Glycoprotein I: Novel Structures Lead to Increased Antibody Binding.
Presented at: 7th European Conference of Immunology, Dublin, Ireland.
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Thesis
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Cryar, AJ;
(2015)
Quantitative Proteomic Studies Of Protein Misfolding & Disease.
Doctoral thesis , UCL (University College London).
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Soloviev, Z;
(2017)
Structural mass spectrometry studies of proteins and protein complexes involved in the regulation of gene expression.
Doctoral thesis , UCL (University College London).
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