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Conformational States of macromolecular assemblies explored by integrative structure calculation.

Thalassinos, K; Pandurangan, AP; Xu, M; Alber, F; Topf, M; (2013) Conformational States of macromolecular assemblies explored by integrative structure calculation. Structure , 21 (9) 1500 - 1508. 10.1016/j.str.2013.08.006. Green open access

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Abstract

A detailed description of macromolecular assemblies in multiple conformational states can be very valuable for understanding cellular processes. At present, structural determination of most assemblies in different biologically relevant conformations cannot be achieved by a single technique and thus requires an integrative approach that combines information from multiple sources. Different techniques require different computational methods to allow efficient and accurate data processing and analysis. Here, we summarize the latest advances and future challenges in computational methods that help the interpretation of data from two techniques-mass spectrometry and three-dimensional cryo-electron microscopy (with focus on alignment and classification of heterogeneous subtomograms from cryo-electron tomography). We evaluate how new developments in these two broad fields will lead to further integration with atomic structures to broaden our picture of the dynamic behavior of assemblies in their native environment.

Type: Article
Title: Conformational States of macromolecular assemblies explored by integrative structure calculation.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.str.2013.08.006
Publisher version: http://dx.doi.org/10.1016/j.str.2013.08.006
Language: English
Additional information: © 2013 Elsevier Ltd All rights reserved. This work is licensed under a Creative Commons Attribution 3.0 Unported License.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1421393
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