Bullock, JMA;
Thalassinos, K;
Topf, M;
(2018)
Jwalk and MNXL Web Server: Model Validation using Restraints from Crosslinking Mass Spectrometry.
Bioinformatics
, 34
(20)
pp. 3584-3585.
10.1093/bioinformatics/bty366.
Preview |
Text
Thalassinos VoR bty366.pdf - Published Version Download (220kB) | Preview |
Abstract
Motivation: Crosslinking Mass Spectrometry generates restraints that can be used to model proteins and protein complexes. Previously, we have developed two methods, to help users achieve better modelling performance from their crosslinking restraints: Jwalk, to estimate solvent accessible distances between crosslinked residues and MNXL, to assess the quality of the models based on these distances. Results: Here we present the Jwalk and MNXL webservers, which streamline the process of validating monomeric protein models using restraints from crosslinks. We demonstrate this by using the MNXL server to filter models made of varying quality, selecting the most native-like. Availability: The webserver and source code are freely available from jwalk.ismb.lon.ac.uk and mnxl.ismb.lon.ac.uk. Contact: m.topf@cryst.bbk.ac.uk, j.bullock@cryst.bbk.ac.uk.
| Type: | Article |
|---|---|
| Title: | Jwalk and MNXL Web Server: Model Validation using Restraints from Crosslinking Mass Spectrometry |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/bioinformatics/bty366 |
| Publisher version: | http://doi.org/10.1093/bioinformatics/bty366 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2018. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10053221 |
Archive Staff Only
 |
View Item |
