Browse by UCL people
Group by: Type | Date
Jump to: Article | Book chapter
Number of items: 98.
Article
Abbas, SH;
Pickett, E;
Lomas, DA;
Thorburn, D;
Gooptu, B;
Hurst, JR;
Marshall, A;
(2020)
Non-invasive testing for liver pathology in alpha-1 antitrypsin deficiency.
BMJ Open Respiratory Research
, 7
(1)
, Article e000820. 10.1136/bmjresp-2020-000820.
|
 |
|
Agustí, A;
Edwards, LD;
Rennard, SI;
MacNee, W;
Tal-Singer, R;
Miller, BE;
Vestbo, J;
... Evaluation of COPD Longitudinally to Identify Predictive Surroga; + view all
(2012)
Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype.
PLoS One
, 7
(5)
, Article e37483. 10.1371/journal.pone.0037483.
|
 |
|
Bafadhel, M;
Barnes, N;
Bourke, SC;
Compton, C;
Criner, GJ;
Dransfield, MT;
Halpin, DMG;
... Singh, D; + view all
(2021)
A single blood eosinophil count measurement is as good as two for prediction of ICS treatment response in the IMPACT trial.
European Respiratory Journal
, 58
(3)
, Article 2004522. 10.1183/13993003.04522-2020.
|
|
Bazzan, E;
Tinè, M;
Biondini, D;
Benetti, R;
Baraldo, S;
Turato, G;
Fagiuoli, S;
... Cosio, MG; + view all
(2018)
α1-Antitrypsin Polymerizes in Alveolar Macrophages of Smokers With and Without α1-Antitrypsin Deficiency.
Chest
, 154
(3)
pp. 607-616.
10.1016/j.chest.2018.04.039.
|
|
Bourdin, A;
Criner, G;
Devouassoux, G;
Dransfield, M;
Halpin, DMG;
Han, MK;
Jones, CE;
... Hanania, NA; + view all
(2021)
InforMing the PAthway of COPD Treatment (IMPACT Trial) Single-Inhaler Triple Therapy (Fluticasone Furoate/Umeclidinium/Vilanterol) Versus Fluticasone Furoate/Vilanterol and Umeclidinium/Vilanterol in Patients With COPD: Analysis o the Western Europe and North America Regions.
Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
, 8
(1)
pp. 76-90.
10.15326/jcopdf.2020.0158.
|
|
Bouton, Marie-Christine;
Geiger, Margarethe;
Sheffield, William P;
Irving, James A;
Lomas, David A;
Song, Sihong;
Satyanarayanan, Ritvik S;
... Lucas, Alexandra R; + view all
(2023)
The under-appreciated world of the serpin family of serine proteinase inhibitors.
EMBO Molecular Medicine
, Article e17144. 10.15252/emmm.202217144.
|
|
|
Briggs, AH;
Baker, T;
Risebrough, NA;
Chambers, M;
Gonzalez-McQuire, S;
Ismaila, AS;
Exuzides, A;
... Lomas, DA; + view all
(2017)
Development of the Galaxy Chronic Obstructive Pulmonary Disease (COPD) Model Using Data from ECLIPSE: Internal Validation of a Linked-Equations Cohort Model.
Medical Decision Making
, 37
(4)
pp. 469-480.
10.1177/0272989X16653118.
|
|
|
Brightling, CE;
Evans, RA;
Singapuri, A;
Smith, N;
Wain, LV;
Brightling, CE;
Evans, RA;
... Barker, RE; + view all
(2023)
Long COVID research: an update from the PHOSP-COVID Scientific Summit.
The Lancet Respiratory Medicine
, 11
(11)
e93-e94.
10.1016/S2213-2600(23)00341-7.
|
|
Busch, R;
Hobbs, BD;
Zhou, J;
Castaldi, PJ;
McGeachie, MJ;
Hardin, ME;
Hawrylkiewicz, I;
... NETT Genetics, ECLIPSE, ICGN, and COPDGene Investigators, .; + view all
(2017)
Genetic Association and Risk Scores in a COPD Meta-Analysis of 16,707 Subjects.
American Journal of Respiratory Cell and Molecular Biology
, 57
(1)
pp. 35-46.
10.1165/rcmb.2016-0331OC.
|
|
|
Celli, B;
Locantore, N;
Yates, JC;
Bakke, P;
Calverley, PMA;
Crim, C;
Coxson, HO;
... Evaluation of COPD Longitudinally to Identify Predictive Surroga; + view all
(2021)
Markers of disease activity in COPD: an 8-year mortality study in the ECLIPSE cohort.
European Respiratory Journal
, 57
(3)
, Article 2001339. 10.1183/13993003.01339-2020.
|
|
Day, NC;
Kumar, S;
Criner, G;
Dransfield, M;
Halpin, DMG;
Han, MK;
Jones, CE;
... Lipson, DA; + view all
(2020)
Single-inhaler triple therapy fluticasone furoate/umeclidinium/vilanterol versus fluticasone furoate/vilanterol and umeclidinium/vilanterol in patients with COPD: results on cardiovascular safety from the IMPACT trial.
Respiratory Research
, 21
, Article 139. 10.1186/s12931-020-01398-w.
|
|
|
Dickens, JA;
Ordonez, A;
Chambers, JE;
Beckett, AJ;
Patel, V;
Malzer, E;
Dominicus, CS;
... Marciniak, SJ; + view all
(2016)
The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-alpha(1)-antitrypsin.
FASEB Journal
, 30
(12)
pp. 4083-4097.
10.1096/fj.201600430R.
|
|
|
Dransfield, MT;
Crim, C;
Criner, GJ;
Day, NC;
Halpin, DMG;
Han, MK;
Jones, CE;
... Lange, P; + view all
(2020)
Risk of Exacerbation and Pneumonia with Single Inhaler Triple Versus Dual Therapy in IMPACT.
Annals of the American Thoracic Society
10.1513/AnnalsATS.202002-096OC.
(In press).
|
|
|
Elliston, ELK;
Lomas, DA;
Irving, JA;
(2018)
In Vitro Approaches for the Assessment of Serpin Polymerization.
Methods in Molecular Biology
, 1826
pp. 87-107.
10.1007/978-1-4939-8645-3_6.
|
|
Faravelli, G;
Raimondi, S;
Marchese, L;
Partridge, FA;
Soria, C;
Mangione, PP;
Canetti, D;
... Giorgetti, S; + view all
(2019)
C. elegans expressing D76N β_{2}-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis.
Scientific Reports
, 9
, Article 19960. 10.1038/s41598-019-56498-5.
|
|
|
Faull, SV;
Elliston, ELK;
Gooptu, B;
Jagger, AM;
Aldobiyan, I;
Redzej, A;
Badaoui, M;
... Lomas, DA; + view all
(2020)
The structural basis for Z α₁-antitrypsin polymerization in the liver.
Science Advances
, 6
(43)
, Article eabc1370. 10.1126/sciadv.abc1370.
|
|
|
Fisk, M;
Cheriyan, J;
Mohan, D;
Forman, J;
Mäki-Petäjä, KM;
McEniery, CM;
Fuld, J;
... Wilkinson, IB; + view all
(2018)
The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen: A randomised double-blind placebo-controlled trial.
PLoS One
, 13
(3)
, Article e0194197. 10.1371/journal.pone.0194197.
|
|
|
Fisk, M;
McEniery, CM;
Gale, N;
Mäki-Petäjä, K;
Forman, JR;
Munnery, M;
Woodcock-Smith, J;
... ERICA Consortium and ACCT Investigators; + view all
(2018)
Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease: A Large Case-Controlled Study.
Hypertension
, 71
(3)
pp. 499-506.
10.1161/HYPERTENSIONAHA.117.10151.
|
|
|
Fromme, M;
Schneider, CV;
Pereira, V;
Hamesch, K;
Pons, M;
Reichert, MC;
Benini, F;
... Strnad, P; + view all
(2021)
Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency.
Gut
10.1136/gutjnl-2020-323729.
(In press).
|
|
|
Gangemi, Roberto;
Bignotti, Mattia;
Denardo, Andrea;
Pearce, Claudia N;
Ronzoni, Riccardo;
Lomas, David A;
Irving, James A;
... Gangemi, Fabrizio; + view all
(2025)
Identification of an exosite at the neutrophil elastase/alpha-1-antitrypsin interface.
FEBS Journal
, 292
(8)
pp. 1887-1903.
10.1111/febs.17387.
|
|
|
Ghosh, AJ;
Hobbs, BD;
Moll, M;
Saferali, A;
Boueiz, A;
Yun, JH;
Sciurba, F;
... Hersh, CP; + view all
(2022)
Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease.
American Journal of Respiratory and Critical Care Medicine
, 205
(3)
pp. 313-323.
10.1164/rccm.202106-1404OC.
|
 |
|
Gordon, C;
Yardley, S;
Lomas, DA;
Edwards, SJL;
(2021)
Limitations to Contingency Measures: Reflections from COVID-19 Surges in the UK.
The American Journal of Bioethics
, 21
(8)
pp. 31-34.
10.1080/15265161.2021.1940365.
|
|
Greene, CM;
Marciniak, SJ;
Teckman, J;
Ferrarotti, I;
Brantly, ML;
Lomas, DA;
Stoller, JK;
(2018)
Author Correction: α1-Antitrypsin deficiency.
[Corrigendum].
Nature Reviews Disease Primers
, 4
, Article 40. 10.1038/s41572-018-0043-2.
|
|
Greene, CM;
Marciniak, SJ;
Teckman, J;
Ferrarotti, I;
Brantly, ML;
Lomas, DA;
Stoller, JK;
(2016)
α1-Antitrypsin deficiency.
Nature Reviews Disease Primers
, 2
, Article 16051. 10.1038/nrdp.2016.51.
|
|
|
Halpin, DMG;
Birk, R;
Brealey, N;
Criner, GJ;
Dransfield, MT;
Hilton, E;
Lomas, DA;
... Lipson, DA; + view all
(2018)
Single-inhaler triple therapy in symptomatic COPD patients: FULFIL subgroup analyses.
ERJ Open Research
, 4
(2)
, Article 00119-2017. 10.1183/23120541.00119-2017.
|
|
|
Halpin, DMG;
Criner, GJ;
Dransfield, MT;
Han, MK;
Hartley, B;
Harvey, C;
Jones, CE;
... Lipson, DA; + view all
(2020)
Triple Versus Dual Combination Therapy in Chronic Obstructive Pulmonary Disease in Asian Countries: Analysis of the IMPACT Trial.
Pulmonary Therapy
10.1007/s41030-020-00136-3.
(In press).
|
|
|
Halpin, DMG;
Dransfield, MT;
Han, MK;
Jones, CE;
Kilbride, S;
Lange, P;
Lipson, DA;
... Criner, GJ; + view all
(2020)
The Effect of Exacerbation History on Outcomes in the IMPACT Trial.
European Respiratory Journal
, 55
, Article 1901921. 10.1183/13993003.01921-2019.
|
|
Han, MK;
Criner, GJ;
Dransfield, MT;
Halpin, DMG;
Jones, CE;
Kilbride, S;
Lange, P;
... Singh, D; + view all
(2021)
Prognostic value of clinically important deterioration in COPD: IMPACT trial analysis.
ERJ Open Research
, 7
(1)
, Article 00663-2020. 10.1183/23120541.00663-2020.
|
|
|
Han, MK;
Criner, GJ;
Dransfield, MT;
Halpin, DMG;
Jones, CE;
Kilbride, S;
Lange, P;
... Martinez, FJ; + view all
(2020)
The Effect of ICS Withdrawal and Baseline Inhaled Treatment on Exacerbations in the IMPACT Study: A Randomized, Double-blind Multicenter Trial.
American Journal of Respiratory and Critical Care Medicine
10.1164/rccm.201912-2478OC.
(In press).
|
|
Hanania, NA;
Mannino, DM;
Criner, GJ;
Dransfield, MT;
Han, MK;
Jones, CE;
Kilbride, S;
... Lipson, DA; + view all
(2021)
Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of the IMPACT Trial.
Chest
, 159
(3)
pp. 985-995.
10.1016/j.chest.2020.09.253.
|
|
Haq, I;
Irving, JA;
Faull, SV;
Dickens, JA;
Ordóñez, A;
Belorgey, D;
Gooptu, B;
(2013)
Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway.
Bioscience Reports
, 33
(3)
, Article e00046. 10.1042/BSR20130038.
|
|
|
Haq, I;
Irving, JA;
Saleh, AD;
Dron, L;
Regan-Mochrie, GL;
Motamedi-Shad, N;
Hurst, JR;
... Lomas, DA; + view all
(2016)
Deficiency Mutations of α1-antitrypsin Differentially Affect Folding, Function and Polymerization.
American Journal of Respiratory Cell and Molecular Biology
, 54
(1)
pp. 71-80.
10.1165/rcmb.2015-0154OC.
|
|
|
Hardin, M;
Cho, MH;
Sharma, S;
Glass, K;
Castaldi, PJ;
McDonald, M-L;
Aschard, H;
... COPDGene and Evaluation of COPD Longitudinally to Identify Predi; + view all
(2017)
Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.
American Journal of Respiratory Cell and Molecular Biology
, 56
(3)
pp. 332-341.
10.1165/rcmb.2016-0172OC.
|
 |
|
Hartley, B;
Criner, GJ;
Dransfield, MT;
Halpin, DMG;
Han, MK;
Jones, CE;
Kilbride, S;
... Lettis, S; + view all
(2019)
Misinterpretation of time-to-first event curves can lead to inappropriate treatment.
[Letter].
European Respiratory Journal
, 54
(3)
, Article 1900634. 10.1183/13993003.00634-2019.
|
|
Hayden, Lystra P;
Hobbs, Brian D;
Busch, Robert;
Cho, Michael H;
Liu, Ming;
Lopes-Ramos, Camila M;
Lomas, David A;
... DeMeo, Dawn L; + view all
(2023)
X chromosome associations with chronic obstructive pulmonary disease and related phenotypes: an X chromosome-wide association study.
Respiratory Research
, 24
(1)
, Article 38. 10.1186/s12931-023-02337-1.
|
|
Hobbs, BD;
de Jong, K;
Lamontagne, M;
Bossé, Y;
Shrine, N;
Artigas, MS;
Wain, LV;
... International COPD Genetics Consortium, .; + view all
(2017)
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.
Nature Genetics
, 49
pp. 426-432.
10.1038/ng.3752.
|
|
Irving, JA;
Haq, I;
Dickens, JA;
Faull, SV;
Lomas, DA;
(2014)
Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerisation.
Biochem J
, 460
(1)
pp. 103-115.
10.1042/BJ20131650.
|
|
|
Irving, JA;
Miranda, E;
Haq, I;
Perez, J;
Kotov, VR;
Faull, SV;
Motamedi-Shad, N;
(2015)
An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein.
Biochem J
, 468
(1)
pp. 99-108.
10.1042/BJ20141569.
|
|
|
Ishii, T;
Angata, T;
Wan, ES;
Cho, MH;
Motegi, T;
Gao, C;
Ohtsubo, K;
... Kida, K; + view all
(2017)
Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency.
Respirology
, 22
(4)
pp. 684-690.
10.1111/resp.12952.
|
|
Ismaila, AS;
Risebrough, N;
Schroeder, M;
Shah, D;
Martin, A;
Goodall, EC;
Ndirangu, K;
... Lomas, DA; + view all
(2019)
Cost-Effectiveness Of Once-Daily Single-Inhaler Triple Therapy In COPD: The IMPACT Trial.
International Journal of Chronic Obstructive Pulmonary Disease
, 14
pp. 2681-2695.
10.2147/COPD.S216072.
|
|
|
Jagger, AM;
Waudby, CA;
Irving, JA;
Christodoulou, J;
Lomas, DA;
(2020)
High-resolution ex vivo NMR spectroscopy of human Z α1-antitrypsin.
Nature Communications
, 11
, Article 6371. 10.1038/s41467-020-20147-7.
|
|
|
Kamuda, Kamila;
Ronzoni, Riccardo;
Majumdar, Avik;
Guan, Fiona HX;
Irving, James A;
Lomas, David A;
(2024)
A novel pathological mutant reveals the role of torsional flexibility in the serpin breach in adoption of an aggregation-prone intermediate.
The FEBS Journal.
10.1111/febs.17121.
(In press).
|
|
Kent, Deniz;
Ng, Soon Seng;
Syanda, Adam M;
Khoshkenar, Payam;
Ronzoni, Riccardo;
Li, Chao Zheng;
Zieger, Marina;
... Rashid, S Tamir; + view all
(2025)
Reduction of Z alpha-1 antitrypsin polymers in human iPSC-hepatocytes and mice by LRRK2 inhibitors.
Hepatology
, 81
(3)
pp. 903-916.
10.1097/HEP.0000000000000969.
|
|
Kinsler, VA;
O'Hare, P;
Bulstrode, N;
Calonje, JE;
Chong, WK;
Hargrave, D;
Jacques, T;
... Slater, O; + view all
(2017)
Melanoma in congenital melanocytic naevi.
British Journal of Dermatology
, 176
(5)
pp. 1131-1143.
10.1111/bjd.15301.
|
|
|
Kruppa, AJ;
Ott, S;
Chandraratna, DS;
Irving, JA;
Page, RM;
Speretta, E;
Seto, T;
... Crowther, DC; + view all
(2013)
Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
, 1832
(12)
2115 - 2126.
10.1016/j.bbadis.2013.07.019.
|
|
Laffranchi, M;
Berardelli, R;
Ronzoni, R;
Lomas, DA;
Fra, A;
(2018)
Heteropolymerization of α-1-antitrypsin mutants in cell models mimicking heterozygosity.
Human Molecular Genetics
, 27
(10)
pp. 1785-1793.
10.1093/hmg/ddy090.
|
|
Laffranchi, M;
Elliston, EL;
Miranda, E;
Perez, J;
Ronzoni, R;
Jagger, AM;
Heyer-Chauhan, N;
... Irving, JA; + view all
(2020)
Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin.
JCI Insight
, 5
(14)
, Article e135459. 10.1172/jci.insight.135459.
|
|
|
Laffranchi, M;
Elliston, ELK;
Gangemi, F;
Berardelli, R;
Lomas, DA;
Irving, JA;
Fra, A;
(2019)
Characterisation of a type II functionally-deficient variant of alpha-1-antitrypsin discovered in the general population.
PLoS One
, 14
(1)
, Article e0206955. 10.1371/journal.pone.0206955.
|
|
|
Lakshman Kumar, P;
Wilson, AC;
Rocco, A;
Cho, MH;
Wan, E;
Hobbs, BD;
Washko, GR;
... McDonald, MLN; + view all
(2021)
Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.
Journal of Cachexia, Sarcopenia and Muscle
10.1002/jcsm.12782.
(In press).
|
|
|
Leeming, DJ;
Byrjalsen, I;
Sand, JMB;
Bihlet, AR;
Lange, P;
Evaluation of COPD Longitudinally to Identify Surrogate Endpoint;
Thal-Singer, R;
... Vestbo, J; + view all
(2017)
Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study.
BMC Pulmonary Medicine
, 17
, Article 164. 10.1186/s12890-017-0505-4.
|
|
|
Liddle, J;
Pearce, AC;
Arico-Muendel, C;
Belyanskaya, S;
Brewster, A;
Brown, M;
Chung, C-W;
... Lomas, DA; + view all
(2021)
The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding.
Bioorganic & Medicinal Chemistry Letters
, 41
, Article 127973. 10.1016/j.bmcl.2021.127973.
|
|
Lipson, DA;
Barnacle, H;
Birk, R;
Brealey, N;
Locantore, N;
Lomas, DA;
Ludwig-Sengpiel, A;
... Pascoe, SJ; + view all
(2017)
FULFIL Trial: Once-Daily Triple Therapy in Patients with Chronic Obstructive Pulmonary Disease.
American Journal of Respiratory and Critical Care Medicine
, 196
(4)
pp. 438-446.
10.1164/rccm.201703-0449OC.
|
|
|
Lipson, DA;
Barnacle, H;
Birk, R;
Brealey, N;
Locantore, N;
Lomas, DA;
Ludwig-Sengpiel, A;
... Pascoe, SJ; + view all
(2018)
Reply to Suissa and Ariel: The FULFIL Trial.
American Journal of Respiratory and Critical Care Medicine
, 197
(4)
pp. 542-543.
10.1164/rccm.201709-1831LE.
|
|
Lipson, DA;
Barnhart, F;
Brealey, N;
Brooks, J;
Criner, GJ;
Day, NC;
Dransfield, MT;
... IMPACT Investigators; + view all
(2018)
Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD.
The New England Journal of Medicine
, 378
(18)
pp. 1671-1680.
10.1056/NEJMoa1713901.
|
|
Lipson, DA;
Crim, C;
Criner, GJ;
Day, NC;
Dransfield, MT;
Halpin, DMG;
Han, MK;
... Martinez, FJ; + view all
(2020)
Reduction in All-Cause Mortality with Fluticasone Furoate/Umeclidinium/Vilanterol in COPD Patients.
American Journal of Respiratory and Critical Care Medicine
10.1164/rccm.201911-2207oc.
(In press).
|
|
Lomas, DA;
(2018)
New Therapeutic Targets for Alpha-1 Antitrypsin Deficiency.
Chronic Obstructive Pulmonary Diseases
, 5
(4)
pp. 233-243.
10.15326/jcopdf.5.4.2017.0165.
|
|
Lomas, DA;
Irving, JA;
Arico-Muendel, C;
Belyanskaya, S;
Brewster, A;
Brown, M;
Chung, C-W;
... Pearce, AC; + view all
(2021)
Development of a small molecule that corrects misfolding and increases secretion of Z α1 -antitrypsin.
EMBO Molecular Medicine
, Article e13167. 10.15252/emmm.202013167.
(In press).
|
|
|
Lowen, Sarah M;
Waudby, Christopher A;
Jagger, Alistair M;
Aldobiyan, Ibrahim;
Laffranchi, Mattia;
Fra, Annamaria;
Christodoulou, John;
... Lomas, David A; + view all
(2025)
High-resolution characterization of ex vivo AAT polymers by solution-state NMR spectroscopy.
Science Advances
, 11
(19)
, Article eadu7064. 10.1126/sciadv.adu7064.
|
|
|
Luheshi, LM;
Hoyer, W;
de Barros, TP;
van Dijk Härd, I;
Brorsson, AC;
Macao, B;
Persson, C;
... Härd, T; + view all
(2010)
Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo.
PLoS Biology
, 8
(3)
, Article e1000334. 10.1371/journal.pbio.1000334.
|
|
|
Luheshi, LM;
Tartaglia, GG;
Brorsson, AC;
Pawar, AP;
Watson, IE;
Chiti, F;
Vendruscolo, M;
... Crowther, DC; + view all
(2007)
Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity.
PLoS Biology
, 5
(11)
, Article e290. 10.1371/journal.pbio.0050290.
|
|
|
Lutz, SM;
Frederiksen, B;
Begum, F;
McDonald, M-L;
Cho, MH;
Hobbs, B;
Parker, MM;
... Hokanson, JE; + view all
(2019)
Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls.
Nicotine & Tobacco Research
, 21
(6)
pp. 714-722.
10.1093/ntr/nty095.
|
|
Malintan, NT;
Buckingham, SD;
Lomas, DA;
Sattelle, DB;
(2019)
Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin.
Scientific Reports
, 9
, Article 17293. 10.1038/s41598-019-53535-1.
|
|
|
McDonald, M-LN;
Won, S;
Mattheisen, M;
Castaldi, PJ;
Cho, MH;
Rutten, E;
Hardin, M;
... Silverman, EK; + view all
(2017)
Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1.
Journal of Cachexia, Sarcopenia and Muscle
, 8
(3)
pp. 428-436.
10.1002/jcsm.12171.
|
|
|
McDonald, M-LN;
Wouters, EFM;
Rutten, E;
Casaburi, R;
Rennard, SI;
Lomas, DA;
Bamman, M;
... Silverman, EK; + view all
(2019)
It’s more than low BMI: prevalence of cachexia and associated mortality in COPD.
Respiratory Research
, 20
(1)
, Article 100. 10.1186/s12931-019-1073-3.
|
|
|
McKimpson, WM;
Chen, Y;
Irving, JA;
Zheng, M;
Weinberger, J;
Tan, WLW;
Tiang, Z;
... Kitsis, RN; + view all
(2021)
Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes.
Developmental Cell
, 56
(6)
747-760.e6.
10.1016/j.devcel.2021.02.011.
|
|
Miranda, E;
Ferrarotti, I;
Berardelli, R;
Laffranchi, M;
Cerea, M;
Gangemi, F;
Haq, I;
... Fra, A; + view all
(2017)
The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization.
The FEBS Journal
, 284
(13)
pp. 2110-2126.
10.1111/febs.14111.
|
|
|
Mohan, D;
Forman, JR;
Allinder, M;
McEniery, CM;
Bolton, CE;
Cockcroft, JR;
MacNee, W;
... Polkey, MI; + view all
(2018)
Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study.
[Rapid communication].
Thorax
, 73
(12)
pp. 1182-1185.
10.1136/thoraxjnl-2018-211556.
|
|
|
Motamedi-Shad, N;
Jagger, AM;
Liedtke, M;
Faull, SV;
Nanda, AS;
Salvadori, E;
Wort, JL;
... Lomas, DA; + view all
(2016)
An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.
Biochemical Journal
, 473
(19)
pp. 3269-3290.
10.1042/BCJ20160159.
|
|
Nyon, MP;
Prentice, T;
Day, J;
Kirkpatrick, J;
Sivalingam, GN;
Levy, G;
Haq, I;
... Thalassinos, K; + view all
(2015)
An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding.
Protein Science
, 24
(8)
pp. 1301-1312.
10.1002/pro.2706.
|
|
Nyon, MP;
Segu, L;
Cabrita, LD;
Lévy, GR;
Kirkpatrick, J;
Roussel, BD;
Patschull, AO;
... Gooptu, B; + view all
(2012)
Structural dynamics associated with intermediate formation in an archetypal conformational disease.
Structure
, 20
(3)
pp. 504-512.
10.1016/j.str.2012.01.012.
|
|
Ordóñez, A;
Snapp, EL;
Tan, L;
Miranda, E;
Marciniak, SJ;
Lomas, DA;
(2013)
Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1-antitrypsin deficiency.
Hepatology
, 57
(5)
2049 - 2060.
10.1002/hep.26173.
|
|
|
Partridge, FA;
Brown, AE;
Buckingham, SD;
Willis, NJ;
Wynne, GM;
Forman, R;
Else, KJ;
... Sattelle, DB; + view all
(2018)
An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes.
International Journal for Parasitology: Drugs and Drug Resistance
, 8
(1)
pp. 8-21.
10.1016/j.ijpddr.2017.11.004.
|
|
|
Pascoe, S;
Barnes, N;
Brusselle, G;
Compton, C;
Criner, GJ;
Dransfield, MT;
Halpin, DMG;
... Singh, D; + view all
(2019)
Blood eosinophils and treatment response with triple and dual combination therapy in COPD: analysis of the IMPACT trial.
The Lancet Respiratory Medicine
, 7
(9)
pp. 745-756.
10.1016/S2213-2600(19)30190-0.
|
|
|
Pillai, SG;
Ge, D;
Zhu, G;
Kong, X;
Shianna, KV;
Need, AC;
Feng, S;
... ICGN Investigators; + view all
(2009)
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.
PLoS Genet
, 5
(3)
e1000421.
10.1371/journal.pgen.1000421.
|
|
|
Pranke, Iwona Maria;
Chevalier, Benoit;
Premchandar, Aiswarya;
Baatallah, Nesrine;
Tomaszewski, Kamil F;
Bitam, Sara;
Tondelier, Danielle;
... Edelman, Aleksander; + view all
(2022)
Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.
Cellular and Molecular Life Sciences
, 79
, Article 503. 10.1007/s00018-022-04528-3.
|
|
Qiao, D;
Ameli, A;
Prokopenko, D;
Chen, H;
Kho, AT;
Parker, MM;
Morrow, J;
... Cho, MH; + view all
(2018)
Whole exome sequencing analysis in severe chronic obstructive pulmonary disease.
Human Molecular Genetics
, 27
(21)
pp. 3801-3812.
10.1093/hmg/ddy269.
|
|
Qiu, W;
Cho, MH;
Riley, JH;
Anderson, WH;
Singh, D;
Bakke, P;
Gulsvik, A;
... ECLIPSE Investigators; + view all
(2011)
Genetics of sputum gene expression in chronic obstructive pulmonary disease.
PLoS One
, 6
(9)
, Article e24395. 10.1371/journal.pone.0024395.
|
|
|
Raccosta, S;
Librizzi, F;
Jagger, AM;
Noto, R;
Martorana, V;
Lomas, DA;
Irving, JA;
(2021)
Scaling Concepts in Serpin Polymer Physics.
Materials
, 14
(10)
, Article 2577. 10.3390/ma14102577.
|
|
|
Raman, B;
McCracken, C;
Cassar, MP;
Moss, AJ;
Finnigan, L;
Samat, AHA;
Ogbole, G;
... Bandula, S; + view all
(2023)
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study.
The Lancet Respiratory Medicine
, 11
(11)
pp. 1003-1019.
10.1016/S2213-2600(23)00262-X.
|
|
|
Ronzoni, R;
Ferrarotti, I;
D’Acunto, E;
Balderacchi, AM;
Ottaviani, S;
Lomas, DA;
Irving, JA;
... Fra, A; + view all
(2021)
The Importance of N186 in the Alpha-1-Antitrypsin Shutter Region Is Revealed by the Novel Bologna Deficiency Variant.
International Journal of Molecular Sciences
, 22
(11)
, Article 5668. 10.3390/ijms22115668.
|
|
|
Ronzoni, R;
Heyer‐Chauhan, N;
Fra, A;
Pearce, AC;
Rüdiger, M;
Miranda, E;
Irving, JA;
(2020)
The molecular species responsible for α₁‐antitrypsin deficiency are suppressed by a small molecule chaperone.
The FEBS Journal
10.1111/febs.15597.
(In press).
|
|
|
Roussel, BD;
Lomas, DA;
Crowther, DC;
(2016)
Progressive myoclonus epilepsy associated with neuroserpin inclusion bodies (neuroserpinosis).
Epileptic Disorders
, 18
(S2)
pp. 103-110.
10.1684/epd.2016.0847.
|
|
Roussel, BD;
Newton, TM;
Malzer, E;
Simecek, N;
Haq, I;
Thomas, SE;
Burr, ML;
... Lomas, DA; + view all
(2013)
Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.
Hum Mol Genet
, 22
(22)
pp. 4616-4626.
10.1093/hmg/ddt310.
|
|
|
Sakornsakolpat, P;
Prokopenko, D;
Lamontagne, M;
Reeve, NF;
Guyatt, AL;
Jackson, VE;
Shrine, N;
... International COPD Genetics Consortium; + view all
(2019)
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations.
Nature Genetics
, 51
pp. 494-505.
10.1038/s41588-018-0342-2.
|
|
|
Segertiz, C;
Rashid, T;
Miguel, M;
Serra Paola, M;
Ordonez, A;
Morell, C;
Kaserman, J;
... Vallier, L; + view all
(2018)
hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.
Journal of Hepatology
, 69
(4)
pp. 851-860.
10.1016/j.jhep.2018.05.028.
|
|
|
Shipley, RJ;
Brealey, D;
Haniffa, R;
Elwell, C;
Baker, T;
Lomas, DA;
Singer, M;
(2021)
Lessons and risks of medical device deployment in a global pandemic.
The Lancet Global Health
10.1016/S2214-109X(21)00028-0.
(In press).
|
|
|
Singer, M;
Shipley, R;
Baker, T;
Cowell, A;
Brealey, D;
Lomas, D;
(2020)
The UCL Ventura CPAP device for COVID-19.
The Lancet Respiratory Medicine
, 8
(11)
pp. 1076-1078.
10.1016/S2213-2600(20)30422-7.
|
|
|
Singh, D;
Criner, GJ;
Dransfield, MT;
Halpin, DMG;
Han, MLK;
Lange, P;
Lettis, S;
... Lomas, D; + view all
(2021)
InforMing the PAthway of COPD Treatment (IMPACT) trial: fibrinogen levels predict risk of moderate or severe exacerbations.
Respiratory Research
, 22
(1)
10.1186/s12931-021-01706-y.
|
|
|
Strnad, P;
McElvaney, NG;
Lomas, DA;
(2020)
Alpha₁-Antitrypsin Deficiency.
The New England Journal of Medicine
, 382
(15)
pp. 1443-1455.
10.1056/NEJMra1910234.
|
|
Suri, A;
Zhang, Z;
Neuschwander-Tetri, B;
Lomas, DA;
Heyer-Chauhan, N;
Burling, K;
Loomba, R;
... Teckman, J; + view all
(2024)
Fibrosis, biomarkers and liver biopsy in AAT deficiency and relation to liver Z protein polymer accumulation.
Liver International
, 44
(12)
pp. 3204-3213.
10.1111/liv.16094.
|
|
Tabberer, M;
Gonzalez-McQuire, S;
Muellerova, H;
Briggs, A;
Rutten-van Molken, M;
Chambers, M;
Lomas, DA;
(2016)
Development of a Conceptual Model of Disease Progression for Use in Economic Modeling of Chronic Obstructive Pulmonary Disease.
Med Decis Making
10.1177/0272989X16662009.
(In press).
|
|
|
Tabberer, M;
Jones, CE;
Kilbride, S;
Halpin, DMG;
Lomas, DA;
Pascoe, S;
Singh, D;
... Lipson, DA; + view all
(2020)
Single-Inhaler Triple Therapy and Health-Related Quality of Life in COPD: The IMPACT Study.
Advances in Therapy
10.1007/s12325-020-01409-8.
(In press).
|
|
|
Tabberer, M;
Lomas, DA;
Birk, R;
Brealey, N;
Zhu, C-Q;
Pascoe, S;
Locantore, N;
(2018)
Once-Daily Triple Therapy in Patients with COPD: Patient-Reported Symptoms and Quality of Life.
Advances in Therapy
, 35
(1)
pp. 56-71.
10.1007/s12325-017-0650-4.
|
|
|
Tan, L;
Perez, J;
Mela, M;
Miranda, E;
Burling, KA;
Rouhani, FN;
DeMeo, DL;
... Lomas, DA; + view all
(2015)
Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody.
Int J Biochem Cell Biol
, 58
81 - 91.
10.1016/j.biocel.2014.11.005.
|
 |
|
Vass, L;
Fisk, M;
Cheriyan, J;
Mohan, D;
Forman, J;
Oseni, A;
Devaraj, A;
... Wilkinson, IB; + view all
(2021)
Quantitative 18F-fluorodeoxyglucose positron emission tomography/computed tomography to assess pulmonary inflammation in COPD.
ERJ Open Research
, 7
(3)
, Article 00699-2020. 10.1183/23120541.00699-2020.
|
|
|
Vickers, Sarah;
Aldobiyan, Ibrahim;
Lowen, Sarah M;
Irving, James A;
Lomas, David A;
Thalassinos, Konstantinos;
(2025)
Top-Down Ion Mobility Mass Spectrometry Reveals a Disease Associated Conformational Ensemble of Alpha-1-antitrypsin.
Journal of the American Chemical Society
10.1021/jacs.4c18139.
(In press).
|
|
|
Wilson, AC;
Kumar, PL;
Lee, S;
Parker, MM;
Arora, I;
Morrow, JD;
Wouters, EFM;
... McDonald, M-LN; + view all
(2020)
Heme metabolism genes Downregulated in COPD Cachexia.
Respiratory
, 21
, Article 100. 10.1186/s12931-020-01336-w.
|
|
Book chapter
|
Vickers, Sarah;
Irving, James;
Lomas, David A;
Thalassinos, Konstantinos;
(2023)
Native and Ion Mobility Mass Spectrometry Characterization of Alpha 1 Antitrypsin Variants and Oligomers.
In: Bristow, Cynthia L, (ed.)
Alpha-1 Antitrypsin: Methods and Protocols.
(pp. 41-55).
Humana Press (Springer): New York, NY, USA.
|
