Browse by UCL people
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Number of items: 40.
Article
Aitken, J;
Ambrose, K;
Barrell, S;
Beale, R;
Bineva-Todd, G;
Biswas, D;
Byrne, R;
... Wu, M; + view all
(2020)
Scalable and robust SARS-CoV-2 testing in an academic center.
Nature Biotechnology
, 38
(8)
pp. 927-931.
10.1038/s41587-020-0588-y.
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Anjos-Afonso, F;
Loizou, JI;
Bradburn, A;
Kanu, N;
Purewal, S;
Da Costa, C;
Bonnet, D;
(2016)
Perturbed hematopoiesis in mice lacking ATMIN.
Blood
, 128
(16)
pp. 2017-2021.
10.1182/blood-2015-09-672980.
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Bailey, Chris;
Pich, Oriol;
Thol, Kerstin;
Watkins, Thomas BK;
Luebeck, Jens;
Rowan, Andrew;
Stavrou, Georgia;
... Swanton, Charles; + view all
(2024)
Origins and impact of extrachromosomal DNA.
Nature
, 635
(8037)
pp. 193-200.
10.1038/s41586-024-08107-3.
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Bentham, R;
Litchfield, K;
Watkins, TBK;
Lim, EL;
Rosenthal, R;
Martinez-Ruiz, C;
Hiley, CT;
... McGranahan, N; + view all
(2021)
Using DNA sequencing data to quantify T cell fraction and therapy response.
Nature
, 597
pp. 555-560.
10.1038/s41586-021-03894-5.
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Berenjeno, IM;
Piñeiro, R;
Castillo, SD;
Pearce, W;
McGranahan, N;
Dewhurst, SM;
Meniel, V;
... Vanhaesebroeck, B; + view all
(2017)
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.
Nature Communications
, 8
, Article 1773. 10.1038/s41467-017-02002-4.
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Biswas, Dhruva;
Liu, Yun-Hsin;
Herrero, Javier;
Wu, Yin;
Moore, David A;
Karasaki, Takahiro;
Grigoriadis, Kristiana;
... Swanton, Charles; + view all
(2025)
Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma
adenocarcinoma.
Nature Cancer
, 6
pp. 86-101.
10.1038/s43018-024-00883-1.
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Blake, Sophia M;
Stricker, Stefan H;
Halavach, Hanna;
Poetsch, Anna R;
Cresswell, George;
Kelly, Gavin;
Kanu, Nnennaya;
... Behrens, Axel; + view all
(2016)
Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation.
eLife
, 5
, Article e08711. 10.7554/eLife.08711.
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Burrell, Rebecca A;
McClelland, Sarah E;
Endesfelder, David;
Groth, Petra;
Weller, Marie-Christine;
Shaikh, Nadeem;
Domingo, Enric;
... Swanton, Charles; + view all
(2013)
Replication stress links structural and numerical cancer chromosomal instability.
Nature
, 494
(7438)
pp. 492-496.
10.1038/nature11935.
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Chen, Kezhong;
Kang, Guannan;
Zhang, Zhihong;
Lizaso, Analyn;
Beck, Stephan;
Lyskjær, Iben;
Chervova, Olga;
... Wang, Jun; + view all
(2023)
Individualized dynamic methylation-based analysis of cell-free DNA in postoperative monitoring of lung cancer.
BMC Medicine
, 21
, Article 255. 10.1186/s12916-023-02954-z.
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Chen, Kezhong;
Yang, Fan;
Shen, Haifeng;
Wang, Chenyang;
Li, Xi;
Chervova, Olga;
Wu, Shuailai;
... Wang, Jun; + view all
(2023)
Individualized tumor-informed circulating tumor DNA analysis for postoperative monitoring of non-small cell lung cancer.
Cancer Cell
, 41
(10)
1749-1762.e6.
10.1016/j.ccell.2023.08.010.
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Dietzen, Michelle;
Zhai, Haoran;
Lucas, Olivia;
Pich, Oriol;
Barrington, Christopher;
Lu, Wei-Ting;
Ward, Sophia;
... Kanu, Nnennaya; + view all
(2024)
Replication timing alterations are associated with mutation acquisition during breast and lung cancer evolution.
Nature Communications
, 15
(1)
, Article 6039. 10.1038/s41467-024-50107-4.
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Endesfelder, David;
Burrell, Rebecca A;
Kanu, Nnennaya;
McGranahan, Nicholas;
Howell, Mike;
Parker, Peter J;
Downward, Julian;
... Kschischo, Maik; + view all
(2014)
Chromosomal instability selects gene copy number variants
encoding core regulators of proliferation in ER+ breast cancer.
Cancer Research
, 74
(17)
pp. 4853-4863.
10.1158/0008-5472.CAN-13-2664.
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Frankell, Alexander M;
Dietzen, Michelle;
Al Bakir, Maise;
Lim, Emilia L;
Karasaki, Takahiro;
Ward, Sophia;
Veeriah, Selvaraju;
... Swanton, Charles; + view all
(2024)
The evolution of lung cancer and impact of subclonal selection in TRACERx (vol 616, pg 525, 2023).
[Corrigendum].
Nature
, 631
, Article E15. 10.1038/s41586-024-07738-w.
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Gimeno-Valiente, Francisco;
Castignani, Carla;
Larose Cadieux, Elizabeth;
Mensah, Nana E;
Liu, Xiaohong;
Chen, Kezhong;
Chervova, Olga;
... Kanu, Nnennaya; + view all
(2025)
DNA methylation co-operates with genomic alterations during non-small cell lung cancer evolution.
Nature Genetics
, 57
pp. 2226-2237.
10.1038/s41588-025-02307-x.
(In press).
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Hobor, S;
Al Bakir, M;
Hiley, CT;
Skrzypski, M;
Frankell, AM;
Bakker, B;
Watkins, TBK;
... Clipson, A; + view all
(2024)
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling.
Nature Communications
, 15
, Article 4871. 10.1038/s41467-024-47606-9.
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Kanu, N;
Groenroos, E;
Martinez, P;
Burrell, RA;
Goh, X Yi;
Bartkova, J;
Maya-Mendoza, A;
... Swanton, C; + view all
(2015)
SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair.
Oncogene
, 34
(46)
pp. 5699-5708.
10.1038/onc.2015.24.
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Kanu, N;
Penicud, K;
Hristova, MD;
Wong, B;
Raivich, G;
Behrens, A;
(2010)
The ATM cofactor ATMIN protects against oxidative stress and prevents accumulation of DNA damage in the ageing brain.
Journal of Biological Chemistry
, 285
(49)
pp. 38534-38542.
10.1074/jbc.M110.145896.
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Kanu, N;
Zhang, T;
Burrell, RA;
Chakraborty, A;
Cronshaw, J;
DaCosta, C;
Grönroos, E;
... Behrens, A; + view all
(2015)
RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress.
Oncogene
, 35
(30)
pp. 4009-4019.
10.1038/onc.2015.427.
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Kanu, Nnennaya;
Lu, Wei-Ting;
Swanton, Charles;
Bartek, Jiri;
(2025)
TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling.
Nature Cell Biology
, 27
(1)
pp. 154-168.
10.1038/s41556-024-01558-w.
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Kanu, N;
Cerone, MA;
Goh, G;
Zalmas, L-P;
Bartkova, J;
Dietzen, M;
McGranahan, N;
... Swanton, C; + view all
(2016)
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer.
Genome Biology
, 17
, Article 185. 10.1186/s13059-016-1042-9.
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Li, Y;
Jiang, G;
Wu, W;
Yang, H;
Jin, Y;
Wu, M;
Liu, W;
... Chen, K; + view all
(2023)
Multi-omics integrated circulating cell-free DNA genomic signatures enhanced the diagnostic performance of early-stage lung cancer and postoperative minimal residual disease.
eBioMedicine
, 91
, Article 104553. 10.1016/j.ebiom.2023.104553.
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Litchfield, K;
Stanislaw, S;
Spain, L;
Gallegos, LL;
Rowan, A;
Schnidrig, D;
Rosenbaum, H;
... Turajlic, S; + view all
(2020)
Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue.
Cell Reports
, 31
(5)
p. 107550.
10.1016/j.celrep.2020.107550.
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Loennstedt, Ingrid M;
Caramia, Franco;
Li, Jason;
Fumagalli, Debora;
Salgado, Roberto;
Rowan, Andrew;
Salm, Max;
... Speed, Terence P; + view all
(2014)
Deciphering clonality in aneuploid breast tumors using SNP array and sequencing data.
Genome Biology
, 15
(9)
, Article 470. 10.1186/s13059-014-0470-7.
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Lu, Wei-Ting;
Kanu, Nnennaya;
(2025)
FAT1 alterations contribute to chromosomal instability in cancer cells.
Nature Cell Biology
, 27
(1)
pp. 12-13.
10.1038/s41556-024-01559-9.
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Lucas, Olivia;
Ward, Sophia;
Zaidi, Rija;
Bunkum, Abigail;
Frankell, Alexander M;
Moore, David A;
Hill, Mark S;
... Zaccaria, Simone; + view all
(2024)
Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER.
Nature Genetics
10.1038/s41588-024-01989-z.
(In press).
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Molnar, Janos;
Poti, Adam;
Pipek, Orsolya;
Krzystanek, Marcin;
Kanu, Nnennaya;
Swanton, Charles;
Tusnady, Gabor E;
... Szuets, David; + view all
(2014)
The Genome of the Chicken DT40 Bursal Lymphoma Cell Line.
G3-GENES GENOMES GENETICS
, 4
(11)
pp. 2231-2240.
10.1534/g3.114.013482.
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Przewrocka, J;
Rowan, A;
Rosenthal, R;
Kanu, N;
Swanton, C;
(2020)
Unintended on-target chromosomal instability following CRISPR/Cas9 single gene targeting.
Annals of Oncology
, 31
(9)
pp. 1270-1273.
10.1016/j.annonc.2020.04.480.
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Puttick, Clare;
Jones, Thomas P;
Leung, Michelle M;
Galvez-Cancino, Felipe;
Liu, Jiali;
Varas-Godoy, Manuel;
Rowan, Andrew;
... Mcgranahan, Nicholas; + view all
(2024)
MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution.
Nature Genetics
, 56
(10)
pp. 2121-2131.
10.1038/s41588-024-01883-8.
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Savas, Peter;
Teo, Zhi Ling;
Lefevre, Christophe;
Flensburg, Christoffer;
Caramia, Franco;
Alsop, Kathryn;
Mansour, Mariam;
... Loi, Sherene; + view all
(2017)
Correction: The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE".
[Corrigendum].
PLoS Med
, 14
(4)
e1002302.
10.1371/journal.pmed.1002302.
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Savas, P;
Teo, ZL;
Lefevre, C;
Flensburg, C;
Caramia, F;
Alsop, K;
Mansour, M;
... Loi, S; + view all
(2016)
The Subclonal Architecture of Metastatic Breast Cancer: Results from a Prospective Community-Based Rapid Autopsy Program "CASCADE".
PLoS Medicine
, 13
(12)
, Article e1002204. 10.1371/journal.pmed.1002204.
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Szikriszt, B;
Póti, Á;
Németh, E;
Kanu, N;
Swanton, C;
Szüts, D;
(2021)
A comparative analysis of the mutagenicity of platinum-containing chemotherapeutic agents reveals direct and indirect mutagenic mechanisms.
Mutagenesis
, 36
(1)
pp. 75-86.
10.1093/mutage/geab005.
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Szikriszt, B;
Poti, A;
Pipek, O;
Krzystanek, M;
Kanu, N;
Molnar, J;
Ribli, D;
... Szuts, D; + view all
(2016)
A comprehensive survey of the mutagenic impact of common cancer cytotoxics.
Genome Biology
, 17
, Article 99. 10.1186/s13059-016-0963-7.
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Turajlic, S;
Litchfield, K;
Xu, H;
Rosenthal, R;
McGranahan, N;
Reading, JL;
Wong, YNS;
... Swanton, C; + view all
(2017)
Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis.
The Lancet Oncology
, 18
(8)
pp. 1009-1021.
10.1016/S1470-2045(17)30516-8.
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Usaite, Ieva;
Biswas, Dhruva;
Dijkstra, Krijn;
Watkins, Thomas Bk;
Pich, Oriol;
Puttick, Clare;
Angelova, Mihaela;
... Kanu, Nnennaya; + view all
(2023)
Quantifying the impact of immunotherapy on RNA dynamics in cancer.
Journal for ImmunoTherapy of Cancer
, 11
(11)
, Article e007870. 10.1136/jitc-2023-007870.
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Venkatesan, S;
Angelova, M;
Bartkova, J;
Bakhoum, SF;
Bartek, J;
Kanu, N;
Swanton, C;
(2021)
APOBEC3 as a driver of genetic intratumor heterogeneity.
Molecular and Cellular Oncology
10.1080/23723556.2021.2014734.
(In press).
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Venkatesan, S;
Angelova, M;
Puttick, C;
Zhai, H;
Caswell, DR;
Lu, W-T;
Dietzen, M;
... Consortium, T; + view all
(2021)
Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution.
Cancer Discovery
, 11
(10)
pp. 2456-2473.
10.1158/2159-8290.CD-20-0725.
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Venkatesan, S;
Rosenthal, R;
Kanu, N;
McGranahan, N;
Bartek, J;
Quezada, SA;
Hare, J;
... Swanton, C; + view all
(2018)
APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution.
Annals of Oncology
, 29
(3)
pp. 563-572.
10.1093/annonc/mdy003.
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Wu, M;
Shen, H;
Wang, Z;
Kanu, N;
Chen, K;
(2022)
Research Progress on Postoperative Minimal/Molecular Residual Disease Detection in Lung Cancer.
Chronic Diseases and Translational Medicine
10.1002/cdt3.10.
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Zalmas, Lykourgos-Panagiotis;
Lu, Wei-Ting;
Kanu, Nnennaya;
(2019)
An emerging regulatory network of NHEJ via DYNLL1-mediated 53BP1 redistribution.
Annals of Translational Medicine
, 7
(Suppl 3)
, Article S93. 10.21037/atm.2019.04.39.
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Zhang, T;
Penicud, K;
Bruhn, C;
Loizou, JI;
Kanu, N;
Wang, ZQ;
Behrens, A;
(2012)
Competition between NBS1 and ATMIN Controls ATM Signaling Pathway Choice.
Cell Reports
, 2
(6)
pp. 1498-1504.
10.1016/j.celrep.2012.11.002.
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