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APOBEC3 as a driver of genetic intratumor heterogeneity

Venkatesan, S; Angelova, M; Bartkova, J; Bakhoum, SF; Bartek, J; Kanu, N; Swanton, C; (2021) APOBEC3 as a driver of genetic intratumor heterogeneity. Molecular and Cellular Oncology 10.1080/23723556.2021.2014734. (In press). Green open access

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Abstract

Our recent study revealed that APOBEC3B is upregulated during the preinvasive stages of non-small cell lung cancer and breast cancer. In addition to its role in mediating single nucleotide variants, we propose that APOBEC3 promotes copy number intratumor heterogeneity prior to invasion, providing a substrate for cancer evolution.

Type: Article
Title: APOBEC3 as a driver of genetic intratumor heterogeneity
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/23723556.2021.2014734
Publisher version: https://doi.org/10.1080/23723556.2021.2014734
Language: English
Additional information: © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Keywords: APOBEC, non-small cell lung cancer, breast cancer, intratumor heterogeneity, chromosomal instability
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10142128
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