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APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution

Venkatesan, S; Rosenthal, R; Kanu, N; McGranahan, N; Bartek, J; Quezada, SA; Hare, J; ... Swanton, C; + view all (2018) APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution. Annals of Oncology , 29 (3) pp. 563-572. 10.1093/annonc/mdy003. Green open access

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Abstract

The APOBEC mutational signature has only recently been detected in a multitude of cancers through next-generation sequencing. In contrast, APOBEC has been a focus of virology research for over a decade. Many lessons learnt regarding APOBEC within virology are likely to be applicable to cancer. In this review, we explore the parallels between the role of APOBEC enzymes in HIV and cancer evolution. We discuss data supporting the role of APOBEC mutagenesis in creating HIV genome heterogeneity, drug resistance, and immune escape variants. We hypothesize similar functions of APOBEC will also hold true in cancer.

Type: Article
Title: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/annonc/mdy003
Publisher version: http://dx.doi.org/10.1093/annonc/mdy003
Language: English
Additional information: © The Author 2018. Published by Oxford University Press on behalf of the European Society for Medical Oncology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: APOBEC, drug resistance, human immunodeficiency virus, immune escape, intratumour heterogeneity
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/10045599
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