Browse by UCL people
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Number of items: 38.
Article
Antonelou, M;
Michaëlsson, E;
Evans, RDR;
Wang, CJ;
Henderson, SR;
Walker, LSK;
Unwin, RJ;
... RAVE-ITN Investigators; + view all
(2020)
Therapeutic Myeloperoxidase Inhibition Attenuates Neutrophil Activation, ANCA-Mediated Endothelial Damage, and Crescentic GN.
Journal of the American Society of Nephrology
, 31
(2)
pp. 350-364.
10.1681/ASN.2019060618.
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Attridge, K;
Kenefeck, R;
Wardzinski, L;
Qureshi, OS;
Wang, CJ;
Manzotti, C;
Okkenhaug, K;
(2014)
IL-21 Promotes CD4 T Cell Responses by Phosphatidylinositol 3-Kinase-Dependent Upregulation of CD86 on B Cells.
J Immunol
, 192
pp. 2195-2201.
10.4049/jimmunol.1302082.
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Attridge, K;
Walker, LS;
(2014)
Homeostasis and function of regulatory T cells (Tregs) in vivo: lessons from TCR-transgenic Tregs.
Immunol Rev
, 259
(1)
23 - 39.
10.1111/imr.12165.
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Edner, Natalie M;
Houghton, Luke P;
Ntavli, Elisavet;
Rees-Spear, Chloe;
Petersone, Lina;
Wang, Chunjing;
Fabri, Astrid;
... Walker, Lucy SK; + view all
(2024)
IGIT+Tfh show poor B-helper function and negatively correlate with SARS-CoV-2 antibody titre.
Frontiers in Immunology
, 15
, Article 1395684. 10.3389/fimmu.2024.1395684.
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Edner, NM;
Carlesso, G;
Rush, JS;
Walker, LSK;
(2020)
Targeting co-stimulatory molecules in autoimmune disease.
Nature Reviews Drug Discovery
, 19
(12)
pp. 860-883.
10.1038/s41573-020-0081-9.
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Edner, NM;
Heuts, F;
Thomas, N;
Wang, CJ;
Petersone, L;
Kenefeck, R;
Kogimtzis, A;
... Walker, LSK; + view all
(2020)
Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes.
Nature Immunology
, 21
pp. 1244-1255.
10.1038/s41590-020-0744-z.
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Halliday, N;
Williams, C;
Kennedy, A;
Waters, E;
Pesenacker, AM;
Soskic, B;
Hinze, C;
... Sansom, DM; + view all
(2020)
CD86 Is a Selective CD28 Ligand Supporting FoxP3+ Regulatory T Cell Homeostasis in the Presence of High Levels of CTLA-4.
Frontiers in Immunology
, 11
, Article 600000. 10.3389/fimmu.2020.600000.
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Herold, Kevan C;
Delong, Thomas;
Perdigoto, Ana Luisa;
Biru, Noah;
Brusko, Todd M;
Walker, Lucy SK;
(2024)
The immunology of type 1 diabetes.
Nature Reviews Immunology
, 24
pp. 435-451.
10.1038/s41577-023-00985-4.
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Heuts, F;
Edner, NM;
Walker, LS;
(2017)
Follicular T Helper Cells: A New Marker of Type 1 Diabetes Risk?
Diabetes
, 66
(2)
pp. 258-260.
10.2337/dbi16-0062.
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Hou, TZ;
Olbrich, P;
Soto, JML;
Sanchez, B;
Moreno, PS;
Borte, S;
Stauss, HJ;
... Neth, O; + view all
(2018)
Study of an extended family with CTLA-4 deficiency suggests a CD28/CTLA-4 independent mechanism responsible for differences in disease manifestations and severity.
Clinical Immunology
, 188
pp. 94-102.
10.1016/j.clim.2018.01.001.
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Hou, TZ;
Qureshi, OS;
Wang, CJ;
Baker, J;
Young, SP;
Walker, LSK;
Sansom, DM;
(2015)
A Transendocytosis Model of CTLA-4 Function Predicts Its Suppressive Behavior on Regulatory T Cells.
Journal of Immunology
, 194
(5)
pp. 2148-2159.
10.4049/jimmunol.1401876.
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Hou, TZ;
Verma, N;
Wanders, J;
Kennedy, A;
Soskic, B;
Janman, D;
Halliday, N;
... Sansom, DM; + view all
(2017)
Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.
Blood
, 129
pp. 1458-1468.
10.1182/blood-2016-10-745174.
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Joosse, ME;
Nederlof, I;
Walker, LSK;
Samsom, JN;
(2019)
Tipping the balance: inhibitory checkpoints in intestinal homeostasis.
Mucosal Immunology
, 12
pp. 21-35.
10.1038/s41385-018-0113-5.
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Kenefeck, R;
Wang, CJ;
Kapadi, T;
Wardzinski, L;
Attridge, K;
Clough, LE;
Heuts, F;
... Walker, LS; + view all
(2015)
Follicular helper T cell signature in type 1 diabetes.
Journal of Clinical Investigation
, 125
(1)
292- 303.
10.1172/JCI76238.
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Khailaie, S;
Rowshanravan, B;
Robert, PA;
Waters, E;
Halliday, N;
Herrera, JDB;
Walker, LSK;
... Meyer-Hermann, M; + view all
(2018)
Characterization of CTLA4 Trafficking and Implications for Its Function.
Biophysical Journal
, 115
(7)
pp. 1330-1343.
10.1016/j.bpj.2018.08.020.
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Lo, Jonathan W;
Schroeder, Jan-Hendrik;
Roberts, Luke B;
Mohamed, Rami;
Cozzetto, Domenico;
Beattie, Gordon;
Omer, Omer S;
... Lord, Graham M; + view all
(2024)
CTLA-4 expressing innate lymphoid cells modulate mucosal homeostasis in a microbiota dependent manner.
Nature Communications
, 15
(1)
, Article 9520. 10.1038/s41467-024-51719-6.
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Mazharian, Alexandra;
Maître, Blandine;
Bornert, Alicia;
Hennequin, Desline;
Lourenco-Rodrigues, Marc;
Geer, Mitchell Jon;
Smith, Christopher W;
... Senis, Yotis A; + view all
(2023)
Treatment of congenital thrombocytopenia and decreased collagen reactivity in G6b-B-deficient mice.
Blood Advances
, 7
(1)
pp. 46-59.
10.1182/bloodadvances.2022008873.
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Ovcinnikovs, V;
Ross, EM;
Petersone, L;
Edner, NM;
Heuts, F;
Ntavli, E;
Kogimtzis, A;
... Walker, LSK; + view all
(2019)
CTLA-4-mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells.
Science Immunology
, 4
(35)
, Article eaaw0902. 10.1126/sciimmunol.aaw0902.
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Ovcinnikovs, V;
Walker, LSK;
(2015)
Regulatory T Cells in Autoimmune Diabetes: Mechanisms of Action and Translational Potential.
[Review].
Progress in Molecular Biology and Translational Science
, 136
pp. 245-277.
10.1016/bs.pmbts.2015.08.004.
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Pearson, James A;
McKinney, Eoin F;
Walker, Lucy SK;
(2021)
100 years post-insulin: immunotherapy as the next frontier in type 1 diabetes.
Immunotherapy Advances
, 1
(1)
, Article ltab024. 10.1093/immadv/ltab024.
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Petersone, L;
Edner, NM;
Ovcinnikovs, V;
Heuts, F;
Ross, EM;
Ntavli, E;
Wang, CJ;
(2018)
T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship.
[Review].
Frontiers in Immunology
, 9
, Article 1941. 10.3389/fimmu.2018.01941.
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Petersone, L;
Walker, LSK;
(2017)
MAIT cells in type 1 diabetes: a good friend turned bad.
Nature Immunology
, 18
(12)
pp. 1283-1285.
10.1038/ni.3869.
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Quattrin, Teresa;
Mastrandrea, Lucy D;
Walker, Lucy SK;
(2023)
Type 1 diabetes.
The Lancet
, 401
(10394)
pp. 2149-2162.
10.1016/S0140-6736(23)00223-4.
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Sansom, DM;
Walker, LSK;
(2019)
Dimers Aren't Forever: CD80 Breaks up with PD-L1.
Immunity
, 51
(6)
pp. 972-974.
10.1016/j.immuni.2019.11.011.
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Verma, N;
Burns, SO;
Walker, LS;
Sansom, DM;
(2017)
Immune deficiency and autoimmunity in patients with CTLA-4 mutations.
Clinical & Experimental Immunology
, 190
(1)
pp. 1-7.
10.1111/cei.12997.
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Walker, LSK;
(2022)
The link between circulating follicular helper T cells and autoimmunity.
Nature Reviews Immunology
, 22
pp. 567-575.
10.1038/s41577-022-00693-5.
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Walker, LS;
(2017)
EFIS Lecture: Understanding the CTLA-4 checkpoint in the maintenance of immune homeostasis.
Immunology Letters
, 184
pp. 43-50.
10.1016/j.imlet.2017.02.007.
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Walker, LS;
(2015)
CTLA-4 and Autoimmunity: New Twists in the Tale.
Trends in Immunology
, 36
(12)
pp. 760-762.
10.1016/j.it.2015.11.002.
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Walker, LS;
(2013)
Treg and CTLA-4: Two intertwining pathways to immune tolerance.
J Autoimmun
, 45
pp. 49-57.
10.1016/j.jaut.2013.06.006.
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Walker, LS;
Sansom, DM;
(2015)
Confusing signals: recent progress in CTLA-4 biology.
Trends in Immunology
, 36
(2)
pp. 63-70.
10.1016/j.it.2014.12.001.
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Walker, LS;
Von Herrath, M;
(2016)
CD4 T cell differentiation in type 1 diabetes.
Clinical & Experimental Immunology
, 183
(1)
pp. 16-29.
10.1111/cei.12672.
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Walker, LSK;
(2017)
PD-1 and CTLA4: Two checkpoints, one pathway?
Science Immunology
, 2
(11)
, Article eaan3864. 10.1126/sciimmunol.aan3864.
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Wang, Chun Jing;
Petersone, Lina;
Edner, Natalie M;
Heuts, Frank;
Ovcinnikovs, Vitalijs;
Ntavli, Elisavet;
Kogimtzis, Alexandros;
... Walker, Lucy SK; + view all
(2023)
Author Correction: Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity.
Nature Communications
, 14
(1)
, Article 5724. 10.1038/s41467-023-41483-4.
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Wang, Chun Jing;
Petersone, Lina;
Edner, Natalie M;
Heuts, Frank;
Ovcinnikovs, Vitalijs;
Ntavli, Elisavet;
Kogimtzis, Alexandros;
... Walker, Lucy SK; + view all
(2022)
Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity.
Nature Communications
, 13
, Article 6757. 10.1038/s41467-022-34477-1.
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Wang, CJ;
Heuts, F;
Ovcinnikovs, V;
Wardzinski, L;
Bowers, C;
Schmidt, EM;
Kogimtzis, A;
... Walker, LS; + view all
(2015)
CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement.
Proceedings of the National Academy of Sciences of the U S A
, 112
(2)
pp. 524-529.
10.1073/pnas.1414576112.
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Willcox, A;
Richardson, SJ;
Walker, LS;
Kent, SC;
Morgan, NG;
Gillespie, KM;
(2017)
Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes.
Diabetologia
, 60
(7)
pp. 1294-1303.
10.1007/s00125-017-4221-7.
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Yu, Di;
Walker, Lucy SK;
Liu, Zheng;
Linterman, Michelle A;
Li, Zhanguo;
(2022)
Targeting TFH cells in human diseases and vaccination: rationale and practice.
Nature Immunology
, 23
(8)
pp. 1157-1168.
10.1038/s41590-022-01253-8.
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Zhang, Y;
Tech, L;
George, LA;
Acs, A;
Durrett, RE;
Hess, H;
Walker, LSK;
... Toellner, K-M; + view all
(2018)
Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells.
Journal of Experimental Medicine
, 215
(3)
10.1084/jem.20160832.
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