Petersone, L;
Edner, NM;
Ovcinnikovs, V;
Heuts, F;
Ross, EM;
Ntavli, E;
Wang, CJ;
(2018)
T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship.
[Review].
Frontiers in Immunology
, 9
, Article 1941. 10.3389/fimmu.2018.01941.
Preview |
Text
Petersone Frontiers Immunol 2018.pdf - Published Version Download (1MB) | Preview |
Abstract
Co-ordinated interaction between distinct cell types is a hallmark of successful immune function. A striking example of this is the carefully orchestrated cooperation between helper T cells and B cells that occurs during the initiation and fine-tuning of T-cell dependent antibody responses. While these processes have evolved to permit rapid immune defense against infection, it is becoming increasingly clear that such interactions can also underpin the development of autoimmunity. Here we discuss a selection of cellular and molecular pathways that mediate T cell/B cell collaboration and highlight how in vivo models and genome wide association studies link them with autoimmune disease. In particular, we emphasize how CTLA-4-mediated regulation of CD28 signaling controls the engagement of secondary costimulatory pathways such as ICOS and OX40, and profoundly influences the capacity of T cells to provide B cell help. While our molecular understanding of the co-operation between T cells and B cells derives from analysis of secondary lymphoid tissues, emerging evidence suggests that subtly different rules may govern the interaction of T and B cells at ectopic sites during autoimmune inflammation. Accordingly, the phenotype of the T cells providing help at these sites includes notable distinctions, despite sharing core features with T cells imparting help in secondary lymphoid tissues. Finally, we highlight the interdependence of T cell and B cell responses and suggest that a significant beneficial impact of B cell depletion in autoimmune settings may be its detrimental effect on T cells engaged in molecular conversation with B cells.
| Type: | Article |
|---|---|
| Title: | T Cell/B Cell Collaboration and Autoimmunity: An Intimate Relationship |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fimmu.2018.01941 |
| Publisher version: | http://doi.org/10.3389/fimmu.2018.01941 |
| Language: | English |
| Additional information: | Copyright © 2018 Petersone, Edner, Ovcinnikovs, Heuts, Ross, Ntavli, Wang and Walker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | follicular helper T cells (Tfh), B cells, germinal center, autoimmunity, costimulation, CD28, CTLA-4, immunotherapy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10056899 |
Archive Staff Only
 |
View Item |
