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Dimers Aren't Forever: CD80 Breaks up with PD-L1

Sansom, DM; Walker, LSK; (2019) Dimers Aren't Forever: CD80 Breaks up with PD-L1. Immunity , 51 (6) pp. 972-974. 10.1016/j.immuni.2019.11.011. Green open access

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Abstract

Targeting the CTLA-4 and PD-1 “checkpoints” is an effective treatment for a number of cancers. In this issue of Immunity, Hui et al. reveal that interaction between a CTLA-4 ligand, CD80, and its counterpart in the PD-1 pathway, PD-L1, affects both PD-1 and CTLA-4 function, raising new questions about the biological effects of using checkpoint inhibitors alone and in combination.

Type: Article
Title: Dimers Aren't Forever: CD80 Breaks up with PD-L1
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.immuni.2019.11.011
Publisher version: https://doi.org/10.1016/j.immuni.2019.11.011
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10090902
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