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Number of items: 75.
Article
Almada, P;
Pereira, PM;
Culley, S;
Caillol, G;
Boroni-Rueda, F;
Dix, CL;
Charras, G;
... Henriques, R; + view all
(2019)
Automating multimodal microscopy with NanoJ-Fluidics.
Nature Communications
, 10
(1)
, Article 1223. 10.1038/s41467-019-09231-9.
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Benedetto, A;
Accetta, G;
Fujita, Y;
Charras, G;
(2014)
Spatiotemporal control of gene expression using microfluidics.
Lab Chip
, 14
(7)
pp. 1336-1347.
10.1039/c3lc51281a.
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Bestembayeva, A;
Kramer, A;
Labokha, AA;
Osmanović, D;
Liashkovich, I;
Orlova, EV;
Ford, IJ;
... Hoogenboom, BW; + view all
(2015)
Nanoscale stiffness topography reveals structure and mechanics of the transport barrier in intact nuclear pore complexes.
Nature Nanotechnology
, 10
pp. 60-64.
10.1038/nnano.2014.262.
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Bichet, M;
Joly, C;
Henni, AH;
Guilbert, T;
Xémard, M;
Tafani, V;
Lagal, V;
... Tardieux, I; + view all
(2014)
The toxoplasma-host cell junction is anchored to the cell cortex to sustain parasite invasive force.
BMC Biology
, 12
, Article 773. 10.1186/s12915-014-0108-y.
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Bonfanti, Alessandra;
Duque, Julia;
Kabla, Alexandre;
Charras, Guillaume;
(2022)
Fracture in living tissues.
Trends in Cell Biology
, 32
(6)
pp. 537-551.
10.1016/j.tcb.2022.01.005.
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Bonfanti, A;
Fouchard, J;
Khalilgharibi, N;
Charras, G;
Kabla, A;
(2020)
A unified rheological model for cells and cellularised materials.
Royal Society Open Science
, 7
(1)
, Article 190920. 10.1098/rsos.190920.
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Bonfanti, A;
Kaplan, JL;
Charras, G;
Kabla, A;
(2020)
Fractional viscoelastic models for power-law materials.
Soft Matter
10.1039/d0sm00354a.
(In press).
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Bove, A;
Gradeci, D;
Fujita, Y;
Banerjee, S;
Charras, G;
Lowe, AR;
(2017)
Local cellular neighbourhood controls proliferation in cell competition.
Molecular Biology of the Cell
, 28
(23)
pp. 3215-3228.
10.1091/mbc.E17-06-0368.
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Bovellan, M;
Romeo, Y;
Biro, M;
Boden, A;
Chugh, P;
Yonis, A;
Vaghela, M;
... Charras, G; + view all
(2014)
Cellular control of cortical actin nucleation.
Curr Biol
, 24
(14)
1628 - 1635.
10.1016/j.cub.2014.05.069.
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Bubna-Litic, M;
Charras, G;
Mayor, R;
(2024)
Tissue mechanics modulate morphogen signalling to induce the head organiser.
Cells and Development
, Article 203984. 10.1016/j.cdev.2024.203984.
(In press).
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Cao, L;
Yonis, A;
Vaghela, M;
Barriga, EH;
Chugh, P;
Smith, MB;
Maufront, J;
... Charras, G; + view all
(2020)
SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization.
Nature Cell Biology
, 22
pp. 803-814.
10.1038/s41556-020-0531-y.
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Charras, GT;
Horton, MA;
(2002)
Determination of cellular strains by combined atomic force microscopy and finite element modeling.
BIOPHYSICAL JOURNAL
, 83
(2)
pp. 858-879.
10.1016/S0006-3495(02)75214-4.
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Charras, Guillaume;
Lenz, Martin;
(2022)
Biochemical timer phases condensates in and out.
Nature
, 609
pp. 469-470.
10.1038/d41586-022-01794-w.
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Charras, G;
(2021)
Stress fibres and the cortex work in tandem.
Nature Materials
, 20
pp. 281-283.
10.1038/s41563-021-00944-1.
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Charras, G;
(2017)
Biological physics: Liquid crystals in living tissue.
Nature
, 544
(7649)
pp. 164-165.
10.1038/544164a.
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Charras, G;
Brieher, WM;
(2016)
Regulation and integrated functions of the actin cytoskeleton.
Molecular Biology of the Cell
, 27
(6)
, Article 881. 10.1091/mbc.E15-11-0766.
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Charras, G;
Yap, AS;
(2018)
Tensile Forces and Mechanotransduction at Cell-Cell Junctions.
Current Biology
, 28
(8)
R445-R457.
10.1016/j.cub.2018.02.003.
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Charras, G.T.;
Williams, B.A.;
Sims, S.M.;
Horton, M.A.;
(2004)
Estimating the sensitivity of mechanosensitive ion channels to membrane strain and tension.
Biophysical Journal
, 87
(4)
pp. 2870-2884.
10.1529/biophysj.104.040436.
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Charras, G.T.;
Williams, B.A.;
Sims, S.M.;
Horton, M.A.;
(2004)
Estimating the sensitivity of mechanosensitive ion channels to membrane strain and tension.
Biophysical Journal
, 87
(4)
pp. 2870-2884.
10.1529/biophysj.104.040436.
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Chugh, P;
Clark, AG;
Smith, MB;
Cassani, DAD;
Dierkes, K;
Ragab, A;
Roux, PP;
... Paluch, EK; + view all
(2017)
Actin cortex architecture regulates cell surface tension.
Nature Cell Biology
, 19
(6)
pp. 689-697.
10.1038/ncb3525.
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Crosas-Molist, E;
Graziani, V;
Maiques, O;
Pandya, P;
Monger, J;
Samain, R;
George, SL;
... Sanz-Moreno, V; + view all
(2023)
AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration.
Nature Communications
, 14
(1)
, Article 2740. 10.1038/s41467-023-38292-0.
(In press).
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Day, Nathan J;
Michalowska, Jasmine;
Kelkar, Manasi;
Vallardi, Giulia;
Charras, Guillaume;
Lowe, Alan R;
(2025)
Spatial and temporal signatures of cell competition revealed by K-function analysis.
Molecular Biology of the Cell
10.1091/mbc.E24-10-0481.
(In press).
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Duda, M;
Kirkland, NJ;
Khalilgharibi, N;
Tozluoglu, M;
Yuen, AC;
Carpi, N;
Bove, A;
... Mao, Y; + view all
(2019)
Polarization of Myosin II Refines Tissue Material Properties to Buffer Mechanical Stress.
Developmental Cell
, 48
(2)
245-260.e7.
10.1016/j.devcel.2018.12.020.
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Duque, Julia;
Bonfanti, Alessandra;
Fouchard, Jonathan;
Baldauf, Lucia;
Azenha, Sara R;
Ferber, Emma;
Harris, Andrew;
... Charras, Guillaume; + view all
(2024)
Rupture strength of living cell monolayers.
Nature Materials
, 23
(11)
pp. 1563-1574.
10.1038/s41563-024-02027-3.
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Esteki, MH;
Malandrino, A;
Alemrajabi, AA;
Sheridan, GK;
Charras, G;
Moeendarbary, E;
(2021)
Poroelastic osmoregulation of living cell volume.
iScience
, 24
(12)
, Article 103482. 10.1016/j.isci.2021.103482.
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Fouchard, J;
Wyatt, TPJ;
Proag, A;
Lisica, A;
Khalilgharibi, N;
Recho, P;
Suzanne, M;
... Charras, G; + view all
(2020)
Curling of epithelial monolayers reveals coupling between active bending and tissue tension.
Proceedings of the National Academy of Sciences of USA
, 117
(17)
pp. 9377-9383.
10.1073/pnas.1917838117.
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Fritzsche, M;
Erlenkämper, C;
Moeendarbary, E;
Charras, G;
Kruse, K;
(2016)
Actin kinetics shapes cortical network structure and mechanics.
Science Advances
, 2
(4)
, Article e1501337. 10.1126/sciadv.1501337.
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Fritzsche, M;
Li, D;
Colin-York, H;
Chang, VT;
Moeendarbary, E;
Felce, JH;
Sezgin, E;
... Eggeling, C; + view all
(2017)
Self-organizing actin patterns shape membrane architecture but not cell mechanics.
Nature Communications
, 8
, Article 14347. 10.1038/ncomms14347.
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Fritzsche, M;
Thorogate, R;
Charras, G;
(2014)
Quantitative analysis of ezrin turnover dynamics in the actin cortex.
Biophys J
, 106
(2)
343 - 353.
10.1016/j.bpj.2013.11.4499.
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Gradeci, D;
Bove, A;
Charras, G;
Lowe, AR;
Banerjee, S;
(2020)
Single-cell approaches to cell competition: high-throughput imaging, machine learning and simulations.
Seminars in Cancer Biology
, 63
pp. 60-68.
10.1016/j.semcancer.2019.05.007.
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Gradeci, D;
Bove, A;
Vallardi, G;
Lowe, AR;
Banerjee, S;
Charras, G;
(2021)
Cell-scale biophysical determinants of cell competition in epithelia.
eLife
, 10
10.7554/elife.61011.
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Harris, AR;
Daeden, A;
Charras, GT;
(2014)
Formation of adherens junctions leads to the emergence of a tissue-level tension in epithelial monolayers.
J Cell Sci
, 127
pp. 2507-2517.
10.1242/jcs.142349.
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Hirano, Sayuki;
Mii, Yusuke;
Charras, Guillaume;
Michiue, Tatsuo;
(2022)
Alignment of cell long axis by unidirectional tension acts cooperatively with Wnt signalling to establish PCP.
Development
, 149
(12)
, Article dev200515. 10.1242/dev.200515.
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Hollósi, A;
Pászty, K;
Kellermayer, M;
Charras, G;
Varga, A;
(2021)
BRAF Modulates Stretch-Induced Intercellular Gap Formation through Localized Actin Reorganization.
International Journal of Molecular Sciences
, 22
(16)
, Article 8989. 10.3390/ijms22168989.
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Hunter, GL;
Hadjivasiliou, Z;
Bonin, H;
He, L;
Perrimon, N;
Charras, G;
Baum, B;
(2016)
Coordinated control of Notch/Delta signalling and cell cycle progression drives lateral inhibition-mediated tissue patterning.
Development
, 143
(13)
pp. 2305-2310.
10.1242/dev.134213.
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Hunter, GL;
He, L;
Perrimon, N;
Charras, G;
Giniger, E;
Baum, B;
(2019)
A role for actomyosin contractility in Notch signaling.
BMC Biology
, 17
, Article 12. 10.1186/s12915-019-0625-9.
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Jayo, A;
Malboubi, M;
Antoku, S;
Chang, W;
Ortiz-Zapater, E;
Groen, C;
Pfisterer, K;
... Parsons, M; + view all
(2016)
Fascin Regulates Nuclear Movement and Deformation in Migrating Cells.
Developmental Cell
, 38
(4)
pp. 371-383.
10.1016/j.devcel.2016.07.021.
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Kalukula, Yohalie;
Luciano, Marine;
Simanov, Gleb;
Charras, Guillaume;
Brückner, David B;
Gabriele, Sylvain;
(2025)
The actin cortex acts as a mechanical memory of morphology in confined migrating cells.
Nature Physics
, 21
pp. 1451-1461.
10.1038/s41567-025-02980-z.
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Kelkar, Manasi;
Bohec, Pierre;
Smith, Matthew B;
Sreenivasan, Varun;
Lisica, Ana;
Valon, Léo;
Ferber, Emma;
... Charras, Guillaume; + view all
(2022)
Spindle reorientation in response to mechanical stress is an emergent property of the spindle positioning mechanisms.
Proceedings of the National Academy of Sciences
, 119
(26)
, Article e2121868119. 10.1073/pnas.2121868119.
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Kelkar, M;
Bohec, P;
Charras, G;
(2020)
Mechanics of the cellular actin cortex: From signalling to shape change.
Current Opinion in Cell Biology
, 66
pp. 69-78.
10.1016/j.ceb.2020.05.008.
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Khalilgharibi, N;
Fouchard, J;
Asadipour, N;
Barrientos, R;
Duda, M;
Bonfanti, A;
Yonis, A;
... Charras, G; + view all
(2019)
Stress relaxation in epithelial monolayers is controlled by the actomyosin cortex.
Nature Physics
, 15
pp. 839-847.
10.1038/s41567-019-0516-6.
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Khalilgharibi, N;
Fouchard, J;
Recho, P;
Charras, G;
Kabla, A;
(2016)
The dynamic mechanical properties of cellularised aggregates.
Current Opinion in Cell Biology
, 42
pp. 113-120.
10.1016/j.ceb.2016.06.003.
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Kuipers, D;
Mehonic, A;
Kajita, M;
Peter, L;
Fujita, Y;
Duke, T;
Charras, G;
(2014)
Epithelial repair is a two-stage process driven first by dying cells and then by their neighbours.
J Cell Sci
10.1242/jcs.138289.
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Kunda, P;
Rodrigues, NT;
Moeendarbary, E;
Liu, T;
Ivetic, A;
Charras, G;
Baum, B;
(2012)
PP1-mediated moesin dephosphorylation couples polar relaxation to mitotic exit.
Current Biology
, 22
(3)
231 - 236.
10.1016/j.cub.2011.12.016.
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Lam, MSY;
Lisica, A;
Ramkumar, N;
Hunter, G;
Mao, Y;
Charras, G;
Baum, B;
(2020)
Isotropic myosin-generated tissue tension is required for the dynamic orientation of the mitotic spindle.
Molecular Biology of the Cell
, 31
(13)
pp. 1370-1379.
10.1091/mbc.E19-09-0545.
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Lewalle, A;
Fritzsche, M;
Wilson, K;
Thorogate, R;
Duke, T;
Charras, G;
(2014)
A phenomenological density-scaling approach to lamellipodial actin dynamics.
Interface Focus
, 4
(6)
, Article 20140006. 10.1098/rsfs.2014.0006.
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Lisica, Ana;
Fouchard, Jonathan;
Kelkar, Manasi;
Wyatt, Tom PJ;
Duque, Julia;
Ndiaye, Anne-Betty;
Bonfanti, Alessandra;
... Charras, Guillaume T; + view all
(2022)
Tension at intercellular junctions is necessary for accurate orientation of cell division in the epithelium plane.
Proceedings of the National Academy of Sciences of the United States of America
, 119
(49)
, Article e2201600119. 10.1073/pnas.2201600119.
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Malboubi, M;
Jayo, A;
Parsons, M;
Charras, G;
(2018)
Microfluidic Devices for Examining the Physical Limits of Migration in Confined Environments.
Methods in Molecular Biology
, 1749
pp. 375-386.
10.1007/978-1-4939-7701-7_27.
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Malboubi, M;
Jayo, A;
Parsons, M;
Charras, G;
(2015)
An open access microfluidic device for the study of the physical limits of cancer cell deformation during migration in confined environments.
Microelectronic Engineering
, 144
pp. 42-45.
10.1016/j.mee.2015.02.022.
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Malinova, D;
Fritzsche, M;
Nowosad, CR;
Armer, H;
Munro, PM;
Blundell, MP;
Charras, G;
... Thrasher, AJ; + view all
(2016)
WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts.
Journal of Leukocyte Biology
, 99
(5)
pp. 699-710.
10.1189/jlb.2A0215-050RR.
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Mayor, R;
Barriga, E;
Franze, K;
Charras, G;
(2018)
Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo.
Nature
, 554
pp. 523-527.
10.1038/nature25742.
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Mohammed, D;
Charras, G;
Vercruysse, E;
Versaevel, M;
Lantoine, J;
Alaimo, L;
Bruyère, C;
... Gabriele, S; + view all
(2019)
Substrate area confinement is a key determinant of cell velocity in collective migration.
Nature Physics
, 15
pp. 858-866.
10.1038/s41567-019-0543-3.
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Papafilippou, Eleni;
Baldauf, Lucia;
Charras, Guillaume;
Kabla, Alexandre J;
Bonfanti, Alessandra;
(2025)
Interplay of damage and repair in the control of epithelial tissue integrity in response to cyclic loading.
Current Opinion in Cell Biology
, 94
, Article 102511. 10.1016/j.ceb.2025.102511.
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Prentice-Mott, HV;
Meroz, Y;
Carlson, A;
Levine, MA;
Davidson, MW;
Irimia, D;
Charras, GT;
... Shah, JV; + view all
(2016)
Directional memory arises from long-lived cytoskeletal asymmetries in polarized chemotactic cells.
Proceedings of the National Academy of Sciences
, 113
(5)
pp. 1267-1272.
10.1073/pnas.1513289113.
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Rahman, I;
Sánchez, AC;
Davies, J;
Rzeniewicz, K;
Abukscem, S;
Joachim, J;
Green, HLH;
... Ivetic, A; + view all
(2021)
L-selectin regulates human neutrophil transendothelial migration.
Journal of Cell Science
10.1242/jcs.250340.
(In press).
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Recho, P;
Fouchard, J;
Wyatt, T;
Khalilgharibi, N;
Charras, G;
Kabla, A;
(2020)
Tug-of-war between stretching and bending in living cell sheets.
Physical Review E
, 102
(1)
, Article 012401. 10.1103/PhysRevE.102.012401.
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Rheinlaender, J;
Dimitracopoulos, A;
Wallmeyer, B;
Kronenberg, NM;
Chalut, KJ;
Gather, MC;
Betz, T;
... Franze, K; + view all
(2020)
Cortical cell stiffness is independent of substrate mechanics.
Nature Materials
, 19
pp. 1019-1025.
10.1038/s41563-020-0684-x.
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Rhys, AD;
Monteiro, P;
Smith, C;
Vaghela, M;
Arnandis, T;
Kato, T;
Leitinger, B;
... Godinho, SA; + view all
(2017)
Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells.
Journal of Cell Biology
, 2017
, Article jcb.201704102. 10.1083/jcb.201704102.
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Roycroft, A;
Szabó, A;
Bahm, I;
Daly, L;
Charras, G;
Parsons, M;
Mayor, R;
(2018)
Redistribution of Adhesive Forces through Src/FAK Drives Contact Inhibition of Locomotion in Neural Crest.
Developmental Cell
, 45
(5)
565-579.e3.
10.1016/j.devcel.2018.05.003.
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Ruppel, Artur;
Wörthmüller, Dennis;
Misiak, Vladimir;
Kelkar, Manasi;
Wang, Irène;
Moreau, Philippe;
Méry, Adrien;
... Balland, Martial; + view all
(2023)
Force propagation between epithelial cells depends on active coupling and mechano-structural polarization.
Elife
, 12
, Article e83588. 10.7554/eLife.83588.
(In press).
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Serres, MP;
Samwer, M;
Truong Quang, BA;
Lavoie, G;
Perera, U;
Görlich, D;
Charras, G;
... Paluch, EK; + view all
(2020)
F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis.
Developmental Cell
10.1016/j.devcel.2019.12.011.
(In press).
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Shellard, A;
Weißenbruch, K;
Hampshire, PAE;
Stillman, NR;
Dix, CL;
Thorogate, R;
Imbert, A;
... Mayor, R; + view all
(2025)
Frictiotaxis underlies focal adhesion-independent durotaxis.
Nature Communications
, 16
, Article 3811. 10.1038/s41467-025-58912-1.
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Skoge, M;
Wong, E;
Hamza, B;
Bae, A;
Martel, J;
Kataria, R;
Keizer-Gunnink, I;
... Irimia, D; + view all
(2016)
A Worldwide Competition to Compare the Speed and Chemotactic Accuracy of Neutrophil-Like Cells.
PLoS ONE
, 11
(6)
, Article e0154491. 10.1371/journal.pone.0154491.
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Tajvidi Safa, B;
Rosenbohm, J;
Monemian Esfahani, A;
Minnick, G;
Ostadi Moghaddam, A;
Lavrik, NV;
Huang, C;
... Yang, R; + view all
(2025)
Sustained strain applied at high rates drives dynamic tensioning in epithelial cells.
Communications Biology
, 8
, Article 843. 10.1038/s42003-025-08210-9.
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Terry, SJ;
Elbediwy, A;
Zihni, C;
Harris, AR;
Bailly, M;
Charras, GT;
Balda, MS;
(2012)
Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion.
PLOS One
, 7
(11)
, Article e50188. 10.1371/journal.pone.0050188.
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Truong Quang, BA;
Peters, R;
Cassani, DAD;
Chugh, P;
Clark, AG;
Agnew, M;
Charras, G;
(2021)
Extent of myosin penetration within the actin cortex regulates cell surface mechanics.
Nature Communications
, 12
(1)
, Article 6511. 10.1038/s41467-021-26611-2.
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Ulicna, K;
Vallardi, G;
Charras, G;
Lowe, A;
(2021)
Automated Deep Lineage Tree Analysis Using a Bayesian Single Cell Tracking Approach.
Frontiers in Computer Science
, 3
, Article 734559. 10.3389/fcomp.2021.734559.
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Valon, L;
Marín-Llauradó, A;
Wyatt, T;
Charras, G;
Trepat, X;
(2017)
Optogenetic control of cellular forces and mechanotransduction.
Nature Communications
, 8
, Article 14396. 10.1038/ncomms14396.
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Wilson, K;
Lewalle, A;
Fritzsche, M;
Thorogate, R;
Duke, T;
Charras, G;
(2013)
Mechanisms of leading edge protrusion in interstitial migration.
Nat Commun
, 4
, Article 2896. 10.1038/ncomms3896.
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Wyatt, T;
Baum, B;
Charras, G;
(2016)
A question of time: tissue adaptation to mechanical forces.
Current Opinion on Cell Biology
, 38
pp. 68-73.
10.1016/j.ceb.2016.02.012.
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Wyatt, TPJ;
Fouchard, J;
Lisica, A;
Khalilgharibi, N;
Baum, B;
Recho, P;
Kabla, AJ;
(2020)
Actomyosin controls planarity and folding of epithelia in response to compression.
Nature Materials
, 19
pp. 109-117.
10.1038/s41563-019-0461-x.
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Proceedings paper
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Soelistyo, CJ;
Charras, G;
Lowe, AR;
(2023)
Virtual perturbations to assess explainability of deep-learning based cell fate predictors.
In:
Proceedings of the 2023 IEEE/CVF International Conference on Computer Vision Workshops (ICCVW).
(pp. pp. 3973-3982).
IEEE: Paris, France.
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Working / discussion paper
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Almada, P;
Pereira, P;
Culley, S;
Caillol, G;
Boroni-Rueda, F;
Dix, C;
Laine, R;
... Henriques, R; + view all
(2018)
Automating multimodal microscopy with NanoJ-Fluidics.
bioRxiv: Cold Spring Harbor Laboratory.
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Wyatt, T;
Fouchard, J;
Lisica, A;
Khalilgharibi, N;
Baum, B;
Recho, P;
Kabla, A;
(2018)
Actomyosin controls planarity and folding of epithelia in response to compression.
BioRxiv: Cold Spring Harbor, NY, USA.
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Thesis
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Wyatt, TPJ;
(2017)
Responses of epithelial monolayers to an imposed deformation.
Doctoral thesis , UCL (University College London).
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