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Number of items: 50.
Article
Alberts, Bruce;
Colbran, Roger J;
Dolphin, Annette C;
Pitt, Geoffrey S;
Südhof, Thomas C;
(2022)
Proteolytic regulation of calcium channels - avoiding controversy.
Faculty Opinions
, 11
, Article 5. 10.12703/r-01-000006.
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Alvarez-Laviada, A;
Kadurin, I;
Senatore, A;
Chiesa, R;
Dolphin, AC;
(2013)
The inhibition of functional expression of calcium channels by prion protein demonstrates competition with α2δ for GPI-anchoring pathways.
Biochem J
, 458
(2)
pp. 365-374.
10.1042/BJ20131405.
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Bauer, C;
Nieto-Rostro, M;
Rahman, W;
Tran-Van-Minh, A;
Ferron, L;
Douglas, L;
Kadurin, I;
... Dolphin, AC; + view all
(2009)
The Increased Trafficking of the Calcium Channel Subunit α₂δ-1 o Presynaptic Terminals in Neuropathic Pain Is Inhibited by the α₂δ Ligand Pregabalin.
Journal of Neuroscience
, 29
(13)
4076 - 4088.
10.1523/JNEUROSCI.0356-09.2009.
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Chemin, J;
Taiakina, V;
Monteil, A;
Piazza, M;
Guan, W;
Stephens, RF;
Kitmitto, A;
... Spafford, JD; + view all
(2017)
Calmodulin regulates Cav3 T-type channels at their gating brake.
Journal of Biological Chemistry
, 292
(49)
pp. 20010-20031.
10.1074/jbc.M117.807925.
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D'Arco, M;
Margas, W;
Cassidy, JS;
Dolphin, AC;
(2015)
The Upregulation of α2δ-1 Subunit Modulates Activity-Dependent Ca2+ Signals in Sensory Neurons.
J Neurosci
, 35
(15)
5891 - 5903.
10.1523/JNEUROSCI.3997-14.2015.
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Dahimene, Shehrazade;
Page, Karen M;
Nieto-Rostro, Manuela;
Pratt, Wendy S;
Dolphin, Annette C;
(2023)
The Interplay Between Splicing of Two Exon Combinations Differentially Affects Membrane Targeting and Function of Human CaV2.2.
Function
, 5
(1)
, Article zqad060. 10.1093/function/zqad060.
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Dahimene, Shehrazade;
von Elsner, Leonie;
Holling, Tess;
Mattas, Lauren S;
Pickard, Jess;
Lessel, Davor;
Pilch, Kjara S;
... Dolphin, Annette C; + view all
(2022)
Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy.
Brain
10.1093/brain/awac081.
(In press).
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Dahimene, S;
Page, KM;
Kadurin, I;
Ferron, L;
Ho, DY;
Powell, GT;
Pratt, WS;
... Dolphin, AC; + view all
(2018)
The α2δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α2δ-1.
Cell Reports
, 25
(6)
1610-1621.e5.
10.1016/j.celrep.2018.10.033.
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Dahimene, S;
Page, KM;
Nieto-Rostro, M;
Pratt, WS;
D'Arco, M;
Dolphin, AC;
(2016)
A Ca(V)2.1 N-terminal fragment relieves the dominant-negative inhibition by an Episodic ataxia 2 mutant.
Neurobiology of Disease
, 93
pp. 243-256.
10.1016/j.nbd.2016.05.020.
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Dolphin, AC;
(2023)
Distinct pools of synaptic vesicles are released by different calcium channels.
Cell Calcium
, 112
, Article 102729. 10.1016/j.ceca.2023.102729.
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Dolphin, A;
(2018)
Voltage-gated calcium channel α2δ subunits: an assessment of proposed novel roles.
F1000Research
, 2018
(7)
, Article 1830. 10.12688/f1000research.16104.1.
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Dolphin, AC;
(2021)
How postdoctoral research in Paul Greengard's laboratory shaped my scientific career, although I never did another phosphorylation assay.
Journal of Neuroscience
, 41
(10)
10.1523/JNEUROSCI.3002-20.2021.
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Dolphin, AC;
(2020)
Functions of Presynaptic Voltage-gated Calcium Channels.
Function
, 2
(1)
, Article zqaa027. 10.1093/function/zqaa027.
(In press).
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Dolphin, AC;
(2018)
Voltage-gated calcium channels: their discovery, function and importance as drug targets.
Brain and Neuroscience Advances
, 2
10.1177/2398212818794805.
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Dolphin, AC;
(2016)
Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology.
Journal of Physiology
, 594
(19)
pp. 5369-5390.
10.1113/JP272262.
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Dolphin, AC;
(2013)
The α2δ subunits of voltage-gated calcium channels.
Biochimica et Biophysica Acta (BBA) - Biomembranes
, 1828
(7)
1541 - 1549.
10.1016/j.bbamem.2012.11.019.
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Dolphin, AC;
Kadurin, I;
(2020)
Fight or flight: The culprit is lurking in the neighbourhood.
Cell Calcium
, 87
, Article 102180. 10.1016/j.ceca.2020.102180.
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Dolphin, AC;
Lee, A;
(2020)
Presynaptic calcium channels: specialized control of synaptic neurotransmitter release.
Nature Reviews Neuroscience
, 21
pp. 213-229.
10.1038/s41583-020-0278-2.
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Donato, R;
Page, KM;
Koch, D;
Nieto-Rostro, M;
Foucault, I;
Davies, A;
Wilkinson, T;
... Dolphin, AC; + view all
(2006)
The ducky^{2J} Mutation in Cacna2d2 Results in Reduced Spontaneous Purkinje Cell Activity and Altered Gene Expression.
The Journal of Neuroscience
, 26
(48)
pp. 12576-12586.
10.1523/JNEUROSCI.3080-06.2006.
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Dresviannikov, A.V.;
Page, K.M.;
Leroy, J.;
Pratt, W.S.;
Dolphin, A.C.;
(2009)
Determinants of the voltage dependence of G protein modulation within calcium channel β subunits.
Pflügers Archiv - European Journal of Physiology
, 457
(4)
pp. 743-756.
10.1007/s00424-008-0549-7.
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Ferron, L;
Kadurin, I;
Dolphin, AC;
(2018)
Proteolytic maturation of α2δ controls the probability of synaptic vesicular release.
eLife
, 7
, Article e37507. 10.7554/eLife.37507.
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Ferron, L;
Nieto-Rostro, M;
Cassidy, JS;
Dolphin, AC;
(2014)
Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density.
Nat Commun
, 5
, Article 3628. 10.1038/ncomms4628.
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Ferron, L;
Novazzi, CG;
Pilch, KS;
Moreno, C;
Ramgoolam, K;
Dolphin, AC;
(2020)
FMRP regulates presynaptic localization of neuronal voltage gated calcium channels.
Neurobiology of Disease
, Article 104779. 10.1016/j.nbd.2020.104779.
(In press).
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Gumerov, Vadim M;
Andrianova, Ekaterina P;
Matilla, Miguel A;
Page, Karen M;
Monteagudo-Cascales, Elizabet;
Dolphin, Annette C;
Krell, Tino;
(2022)
Amino acid sensor conserved from bacteria to humans.
Proceedings of the National Academy of Sciences of the United States of America
, 119
(10)
, Article e2110415119. 10.1073/pnas.2110415119.
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Harrison, PJ;
Tunbridge, EM;
Dolphin, AC;
Hall, J;
(2020)
Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal.
The British Journal of Psychiatry
, 216
(5)
pp. 250-253.
10.1192/bjp.2019.157.
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Kadurin, Ivan;
Dahimene, Shehrazade;
Page, Karen M;
Ellaway, Joseph IJ;
Chaggar, Kanchan;
Troeberg, Linda;
Nagase, Hideaki;
(2022)
ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α2δ Subunits, and Enables Calcium Current Enhancement.
Function
, 3
(3)
, Article zqac013. 10.1093/function/zqac013.
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Kadurin, I;
Ferron, L;
Rothwell, SW;
Meyer, JO;
Douglas, LR;
Bauer, CS;
Lana, B;
... Dolphin, AC; + view all
(2016)
Proteolytic maturation of alpha(2)delta represents a checkpoint for activation and neuronal trafficking of latent calcium channels.
ELIFE
, 5
(ARTN e21)
10.7554/eLife.21143.
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Kadurin, I;
Rothwell, SW;
Lana, B;
Nieto-Rostro, M;
Dolphin, AC;
(2017)
LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α2δ-1 subunit.
Scientific Reports
, 7
, Article 43802. 10.1038/srep43802.
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Kanellopoulos, AH;
Koenig, J;
Huang, H;
Pyrski, M;
Millet, Q;
Lolignier, S;
Morohashi, T;
... Zhao, J; + view all
(2018)
Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene targeted mice.
The EMBO Journal
, 37
(3)
pp. 427-445.
10.15252/embj.201796692.
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Kisiswa, L;
Erice, C;
Ferron, L;
Wyatt, S;
Osório, C;
Dolphin, AC;
Davies, AM;
(2017)
T-type Ca2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signalling.
Open Biology
, 7
, Article 160288. 10.1098/rsob.160288.
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Lana, B;
Page, KM;
Kadurin, I;
Ho, S;
Nieto-Rostro, M;
Dolphin, AC;
(2016)
Thrombospondin-4 reduces binding affinity of [(3)H]-gabapentin to calcium-channel α2δ-1-subunit but does not interact with α2δ-1 on the cell-surface when co-expressed.
Scientific Reports
, 6
, Article 24531. 10.1038/srep24531.
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Macabuag, N;
Dolphin, AC;
(2015)
Alternative Splicing in CaV2.2 Regulates Neuronal Trafficking via Adaptor Protein Complex-1 Adaptor Protein Motifs.
Journal of Neuroscience
, 35
(43)
pp. 14636-14652.
10.1523/JNEUROSCI.3034-15.2015.
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Margas, W;
Ferron, L;
Nieto-Rostro, M;
Schwartz, A;
Dolphin, AC;
(2016)
Effect of knockout of α2δ-1 on action potentials in mouse sensory neurons.
Philosophical Transactions of the Royal Society B
, 371
, Article 20150430. 10.1098/rstb.2015.0430.
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Meyer, JO;
Dahimene, S;
Page, KM;
Ferron, L;
Kadurin, I;
Ellaway, JIJ;
Zhao, P;
... Dolphin, AC; + view all
(2019)
Disruption of the Key Ca2+ Binding Site in the Selectivity Filter of Neuronal Voltage-Gated Calcium Channels Inhibits Channel Trafficking.
Cell Reports
, 29
(1)
22-33.e5.
10.1016/j.celrep.2019.08.079.
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Meyer, JO;
Dolphin, AC;
(2021)
Rab11-dependent recycling of calcium channels is mediated by auxiliary subunit α2δ-1 but not α2δ-3.
Scientific Reports
, 11
(1)
, Article 10256. 10.1038/s41598-021-89820-1.
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Moss, FJ;
Dolphin, AC;
Clare, JJ;
(2003)
Human neuronal stargazin-like proteins, gamma(2), gamma(3) and gamma(4); an investigation of their specific localization in human brain and their influence on Ca(V)2.1 voltage-dependent calcium channels expressed in Xenopus oocytes.
BMC NEUROSCI
, 4
, Article 23.
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Nieto-Rostro, Manuela;
Patel, Ryan;
Dickenson, Anthony H;
Dolphin, Annette C;
(2022)
Nerve injury increases native CaV2.2 trafficking in dorsal root ganglion mechanoreceptors.
Pain
10.1097/j.pain.0000000000002846.
(In press).
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Nieto-Rostro, M;
Ramgoolam, K;
Pratt, WS;
Kulik, A;
Dolphin, AC;
(2018)
Ablation of α_{2}δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo.
Proceedings of the National Academy of Sciences of the United States of America
, 115
(51)
E12043-E12052.
10.1073/pnas.1811212115.
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Nieto-Rostro, M;
Sandhu, G;
Bauer, CS;
Jiruska, P;
Jefferys, JG;
Dolphin, AC;
(2014)
Altered expression of the voltage-gated calcium channel subunit α2δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain.
Neuroscience
, 283
pp. 1224-137.
10.1016/j.neuroscience.2014.03.013.
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Page, Karen M;
Gumerov, Vadim M;
Dahimene, Shehrazade;
Zhulin, Igor B;
Dolphin, Annette C;
(2023)
The importance of cache domains in α2δ proteins and the basis for their gabapentinoid selectivity.
Channels
, 17
(1)
, Article 2167563. 10.1080/19336950.2023.2167563.
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Page, KM;
Heblich, F;
Davies, A;
Butcher, AJ;
Leroy, J;
Bertaso, F;
Pratt, WS;
(2004)
Dominant-negative calcium channel suppression by truncated constructs involves a kinase implicated in the unfolded protein response.
Journal of Neuroscience
, 24
(23)
5400 - 5409.
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Page, KM;
Rothwell, SW;
Dolphin, AC;
(2016)
The CaVβ Subunit Protects the I-II Loop of the Voltage-gated Calcium Channel CaV2.2 from Proteasomal Degradation but Not Oligoubiquitination.
Journal of Biological Chemistry
, 291
(39)
pp. 20402-20416.
10.1074/jbc.M116.737270.
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Page, KM;
Stephens, GJ;
Berrow, NS;
Dolphin, AC;
(1997)
The intracellular loop between domains I and II of the B type calcium channel confers aspects of G protein sensitivity to the E type calcium channel.
Journal of Neuroscience
, 17
1330 - 1338.
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Patel, R;
Bauer, CS;
Nieto-Rostro, M;
Margas, W;
Ferron, L;
Chaggar, K;
Crews, K;
... Dolphin, AC; + view all
(2013)
α2δ-1 Gene Deletion Affects Somatosensory Neuron Function and Delays Mechanical Hypersensitivity in Response to Peripheral Nerve Damage.
J Neurosci
, 33
(42)
16412 - 16426.
10.1523/JNEUROSCI.1026-13.2013.
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Pilch, Kjara S;
Ramgoolam, Krishma H;
Dolphin, Annette C;
(2022)
Involvement of CaV2.2 channels and α2δ-1 in homeostatic synaptic plasticity in cultured hippocampal neurons.
The Journal of Physiology
, 600
(24)
pp. 5333-5351.
10.1113/jp283600.
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Raghib, A;
Bertaso, F;
Davies, A;
Page, KM;
Meir, A;
Bogdanov, Y;
Dolphin, AC;
(2001)
Dominant-negative synthesis suppression of voltage-gated calcium channel Cav2.2 induced by truncated constructs.
Journal of Neuroscience
, 21
(21)
8495 - 8504.
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Rahman, W;
Bauer, CS;
Bannister, K;
Vonsy, JL;
Dolphin, AC;
Dickenson, AH;
(2009)
Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain.
Molecular Pain
, 5
, Article 45. 10.1186/1744-8069-5-45.
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Ramgoolam, Krishma H;
Dolphin, Annette C;
(2023)
Capsaicin-induced endocytosis of endogenous presynaptic Ca_{V}2.2 in DRG-spinal cord co-cultures inhibits presynaptic function.
Function
, 4
(1)
, Article zqac058. 10.1093/function/zqac058.
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Shi, Y;
Park, KS;
Kim, SH;
Yu, J;
Zhao, K;
Yu, L;
Oh, KW;
... Berggren, P-O; + view all
(2019)
IgGs from patients with amyotrophic lateral sclerosis and diabetes target CaVα2δ1 subunits impairing islet cell function and survival.
Proceedings of the National Academy of Sciences (PNAS)
10.1073/pnas.1911956116.
(In press).
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Conference item
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Topczewska, A;
Evans, T;
Pratt, W;
Burgess, N;
Dolphin, A;
Shah, M;
(2019)
T-Type Ca2+ Channels and Layer II Medial Entorhinal Cortical Stellate Cell Excitability.
Presented at: American Biophysics Society Annual Meeting 2019, Baltimore, MD, USA.
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