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Distinct pools of synaptic vesicles are released by different calcium channels

Dolphin, AC; (2023) Distinct pools of synaptic vesicles are released by different calcium channels. Cell Calcium , 112 , Article 102729. 10.1016/j.ceca.2023.102729. Green open access

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Abstract

Mueller et al. [1] uncover distinct roles for CaV1 and CaV2 channels in neurotransmitter release at the C. elegans neuromuscular junction. Although nanodomain coupling occurs via clustered CaV2 channels, evidence is also presented that release of a separate vesicular pool is mediated by more peripheral, dispersed CaV1 channels, requiring obligatory coupling with RYR to amplify the Ca2+ signal.

Type: Article
Title: Distinct pools of synaptic vesicles are released by different calcium channels
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ceca.2023.102729
Publisher version: https://doi.org/10.1016/j.ceca.2023.102729
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: C. elegans, Calcium channel, Endoplasmic reticulum, Ryanodine receptor, Synaptic machinery, Synaptic vesicle, Animals, Calcium Channels, Synaptic Vesicles, Caenorhabditis elegans, Synaptic Transmission, Calcium, Ryanodine Receptor Calcium Release Channel
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: https://discovery.ucl.ac.uk/id/eprint/10170111
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