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Proteolytic regulation of calcium channels - avoiding controversy

Alberts, Bruce; Colbran, Roger J; Dolphin, Annette C; Pitt, Geoffrey S; Südhof, Thomas C; (2022) Proteolytic regulation of calcium channels - avoiding controversy. Faculty Opinions , 11 , Article 5. 10.12703/r-01-000006. Green open access

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Abstract

The publication of papers containing data obtained with suboptimal rigor in the experimental design and choice of key reagents, such as antibodies, can result in a lack of reproducibility and generate controversy that can both needlessly divert resources and, in some cases, damage public perception of the scientific enterprise. This exemplary paper by Buonarati et al. (2018)1 shows how a previously published, potentially important paper on calcium channel regulation falls short of the necessary mark, and aims to resolve the resulting controversy.

Type: Article
Title: Proteolytic regulation of calcium channels - avoiding controversy
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.12703/r-01-000006
Publisher version: https://doi.org/10.12703/r-01-000006
Language: English
Additional information: This is the published version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: C-terminal, Calcium, Calcium channels, Cav1.2
UCL classification: UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10147669
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