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Number of items: 59.
Article
Al-Shohani, A;
Awwad, S;
Khaw, PT;
Brocchini, SJ;
(2017)
The preparation of HEMA-MPC films for ocular drug delivery.
British Journal of Pharmacy
, 2
(1)
, Article 5. 10.5920/bjpharm.2017.05.
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Angkawinitwong, U;
Awwad, S;
Khaw, PT;
Brocchini, S;
Williams, GR;
(2017)
Electrospun formulations of bevacizumab for sustained release in the eye.
Acta Biomaterialia
, 64
pp. 126-136.
10.1016/j.actbio.2017.10.015.
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Angkawinitwong, U;
Courtenay, AJ;
Rodgers, A;
Larraneta, E;
McCarthy, HO;
Brocchini, S;
Donnelly, RF;
(2020)
A novel transdermal protein delivery strategy via electrohydrodynamic coating of PLGA microparticles onto microneedles.
ACS Applied Materials & Interfaces
, 12
(11)
pp. 12478-12488.
10.1021/acsami.9b22425.
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Angkawinitwong, U;
Sharma, G;
Khaw, PT;
Brocchini, S;
Williams, GR;
(2015)
Solid-state protein formulations.
Therapeutic Delivery
, 6
(1)
59 - 82.
10.4155/tde.14.98.
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Awwad, S;
Abubakre, A;
Angkawinitwong, U;
Khaw, PT;
Brocchini, S;
(2019)
In situ antibody-loaded hydrogel for intravitreal delivery.
European Journal of Pharmaceutical Sciences
, 137
, Article 104993. 10.1016/j.ejps.2019.104993.
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Awwad, S;
Al-Shohani, A;
Khaw, PT;
Brocchini, S;
(2018)
Comparative Study of In Situ Loaded Antibody and PEG‐Fab NIPAAM Gels.
Macromolecular Bioscience
, 18
(2)
, Article 1700255. 10.1002/mabi.201700255.
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Awwad, S;
Day, RM;
Khaw, PT;
Brocchini, S;
Fadda, H;
(2017)
Sustained release ophthalmic dexamethasone: In vitro in vivo correlations derived from the PK-Eye.
International Journal of Pharmaceutics
, 522
(1-2)
pp. 119-127.
10.1016/j.ijpharm.2017.02.047.
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Awwad, S;
Henein, C;
Ibeanu, N;
Khaw, PT;
Brocchini, S;
(2020)
Preclinical challenges for developing long acting intravitreal medicines.
European Journal of Pharmaceutics and Biopharmaceutics
, 153
pp. 130-149.
10.1016/j.ejpb.2020.05.005.
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Awwad, S;
Lockwood, A;
Brocchini, S;
Khaw, PT;
(2015)
The PK-Eye: A Novel In Vitro Ocular Flow Model for Use in Preclinical Drug Development.
Journal of Pharmaceutical Sciences
, 104
(10)
pp. 3330-3342.
10.1002/jps.24480.
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Awwad, S;
Mohamed Ahmed, AHA;
Sharma, G;
Heng, JS;
Khaw, PT;
Brocchini, SJ;
(2017)
Principles of Pharmacology in the Eye.
British Journal of Pharmacology
, 174
(23)
pp. 4205-4223.
10.1111/bph.14024.
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Barata, TS;
Teo, I;
Brocchini, S;
Zloh, M;
Shaunak, S;
(2011)
Partially glycosylated dendrimers block MD-2 and prevent TLR4-MD-2-LPS complex mediated cytokine responses.
PLoS Computational Biology
, 7
(6)
, Article e1002095. 10.1371/journal.pcbi.1002095.
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Barata, TS;
Zhang, C;
Dalby, PA;
Brocchini, S;
Zloh, M;
(2016)
Identification of Protein-Excipient Interaction Hotspots Using Computational Approaches.
International Journal of Molecular Sciences
, 17(6)
(853)
10.3390/ijms17060853.
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Baskakova, A;
Awwad, S;
Jiménez, JQ;
Gill, H;
Novikov, O;
Khaw, PT;
Brocchini, S;
... Williams, GR; + view all
(2016)
Electrospun formulations of acyclovir, ciprofloxacin and cyanocobalamin for ocular drug delivery.
International Journal of Pharmaceutics
, 502
(1-2)
pp. 208-218.
10.1016/j.ijpharm.2016.02.015.
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Bouremel, Y;
Eames, I;
Madaan, S;
Brocchini, S;
Khaw, PT;
(2018)
Compression of pressurised elastic pockets.
International Journal of Non-Linear Mechanics
, 107
pp. 10-15.
10.1016/j.ijnonlinmec.2018.09.010.
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Bouremel, Y;
Lee, RMH;
Eames, I;
Brocchini, S;
Khaw, PT;
(2019)
Novel approaches to model effects of subconjunctival blebs on flow pressure to improve clinical grading systems after glaucoma drainage surgery.
PLoS One
, 14
(10)
, Article e0221715. 10.1371/journal.pone.0221715.
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Collins, M;
Awwad, S;
Ibeanu, N;
Khaw, PT;
Guiliano, D;
Brocchini, S;
Khalili, H;
(2021)
Dual-acting therapeutic proteins for intraocular use.
Drug Discovery Today
, 26
(1)
pp. 44-55.
10.1016/j.drudis.2020.10.025.
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Conniot, J;
Silva, JM;
Fernandes, JG;
Silva, LC;
Gaspar, R;
Brocchini, S;
Florindo, HF;
(2014)
Cancer immunotherapy: nanodelivery approaches for immune cell targeting and tracking.
Frontiers in Chemistry
, 2
p. 105.
10.3389/fchem.2014.00105.
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Dziemidowicz, K;
Brocchini, S;
Williams, GR;
(2021)
A simple route to functionalising electrospun polymer scaffolds with surface biomolecules.
International Journal of Pharmaceutics
, 597
, Article 120231. 10.1016/j.ijpharm.2021.120231.
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Egbu, R;
Brocchini, S;
Khaw, PT;
Awwad, S;
(2017)
Antibody loaded collapsible hyaluronic acid hydrogels for intraocular delivery.
European Journal of Pharmaceutics and Biopharmaceutics
, 124
pp. 95-103.
10.1016/j.ejpb.2017.12.019.
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Egbu, R;
van der Walle, C;
Brocchini, S;
Williams, GR;
(2020)
Inhibiting the fibrillation of a GLP-1-like peptide.
International Journal of Pharmaceutics
, 574
, Article 118923. 10.1016/j.ijpharm.2019.118923.
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Fernando, O;
Tagalakis, AD;
Shiekh Hassan Awwad, S;
Brocchini, S;
Khaw, PT;
Hart, S;
Yu-Wai-Man, C;
(2018)
Development of targeted siRNA nanocomplexes to prevent fibrosis in experimental glaucoma filtration surgery.
Molecular Therapy
, 26
(12)
pp. 2812-2822.
10.1016/j.ymthe.2018.09.004.
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Ginn, C;
Choi, J-W;
Brocchini, S;
(2016)
Disulfide-bridging PEGylation during refolding for the more efficient production of modified proteins.
Biotechnology Journal
, 11
(8)
pp. 1088-1099.
10.1002/biot.201600035.
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Henein, C;
Awwad, S;
Ibeanu, N;
Vlatakis, S;
Brocchini, S;
Tee Khaw, P;
Bouremel, Y;
(2019)
Hydrodynamics of Intravitreal Injections into Liquid Vitreous Substitutes.
MDPI — Pharmaceutics
, 11
(8)
, Article 371. 10.3390/pharmaceutics11080371.
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Herrington-Symes, A;
Choi, J;
Brocchini, S;
(2017)
Interferon dimers: IFN-PEG-IFN.
Journal of Drug Targeting
, 25
(9-10)
pp. 881-890.
10.1080/1061186X.2017.1363214.
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Ibeanu, N;
Egbu, R;
Onyekuru, L;
Javaheri, H;
Khaw, PT;
Williams, GR;
Brocchini, S;
(2020)
Injectables and Depots to Prolong Drug Action of Proteins and Peptides.
Pharmaceutics
, 12
(10)
, Article 999. 10.3390/pharmaceutics12100999.
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Khalili, H;
Brocchini, S;
Khaw, PT;
Filippov, SK;
(2018)
Comparative thermodynamic analysis in solution of a next generation antibody mimetic to VEGF.
RSC Advances
, 8
(62)
pp. 35787-35793.
10.1039/C8RA07059H.
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Khalili, H;
Khaw, PT;
Brocchini, S;
(2016)
Fc-fusion mimetics.
Biomaterials Science
, 4
(6)
pp. 943-947.
10.1039/c6bm00077k.
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Khalili, H;
Lee, RW;
Khaw, PT;
Brocchini, S;
Dick, AD;
Copland, DA;
(2016)
An anti-TNF-α antibody mimetic to treat ocular inflammation.
Scientific Reports
, 6
, Article 36905. 10.1038/srep36905.
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Khaw, PT;
Bouremel, Y;
Brocchini, S;
Henein, C;
(2020)
The control of conjunctival fibrosis as a paradigm for the prevention of ocular fibrosis-related blindness. "Fibrosis has many friends".
Eye
, 34
pp. 2163-2174.
10.1038/s41433-020-1031-9.
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Khaw, PT;
Bouremel, Y;
Lee, R;
Eames, I;
brocchini, S;
(2016)
A new method to assess the effect of conjunctiva tissue on Intra-Ocular Pressure immediately after drainage surgery.
Investigative Ophthalmology & Visual Science
, 57
(12)
, Article 6459.
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Khaw, PT;
Sharma, G;
Bailly, M;
Brocchini, S;
(2016)
Macrophages Promote Conjunctival Fibroblast Contraction And Nullify The Effect Of Anti-Scarring Agents.
Investigative Ophthalmology & Visual Science
, 57
(12)
, Article 5618.
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Lee, R;
Alband, M;
Penny, M;
Hilton, S;
Brocchini, S;
Khaw, PT;
(2016)
Cell adhesion and protein adsorption studies of 3D printed photopolymers.
Investigative Ophthalmology & Visual Science
, 57
(12)
, Article 2923.
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Lee, RMH;
Bouremel, Y;
Eames, I;
Brocchini, S;
Khaw, PT;
(2020)
Author response: Ab interno versus ab externo surgical approach on outflow resistance of a subconjunctival drainage device.
Translational Vision Science and Technology
, 9
(3)
, Article 15. 10.1167/tvst.9.3.15.
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Lee, RMH;
Bouremel, Y;
Eames, I;
Brocchini, S;
Khaw, PT;
(2020)
Translating Minimally Invasive Glaucoma Surgery Devices.
Clinical and Translational Science
, 13
(1)
pp. 14-25.
10.1111/cts.12660.
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Lee, RMH;
Bouremel, Y;
Eames, I;
Brocchini, S;
Khaw, PT;
(2019)
The Implications of an Ab Interno Versus Ab Externo Surgical Approach on Outflow Resistance of a Subconjunctival Drainage Device for Intraocular Pressure Control.
Translational Vision Science & Technology
, 8
(3)
, Article 58. 10.1167/tvst.8.3.58.
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Lee, RMH;
Bouremel, Y;
Eames, I;
Brocchini, S;
Khaw, PT;
(2019)
A Case Report of Complete Blockage of a Baerveldt Glaucoma Implant Following Insertion of a 3-0 Supramid Suture.
Journal of Glaucoma
, 28
(5)
e75-e76.
10.1097/IJG.0000000000001198.
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Lee, RMH;
Samsudin, A;
Bouremel, Y;
Brocchini, S;
Khaw, PT;
(2015)
Dimensional and Flow Properties of the EX-PRESS Glaucoma Drainage Device.
Investigative Ophthalmology & Visual Science
, 56
(13)
, Article 8026. 10.1167/iovs.15-18495.
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Martinho, N;
Florindo, H;
Silva, L;
Brocchini, S;
Zloh, M;
Silva Barata, T;
(2014)
Molecular Modeling to Study Dendrimers for Biomedical Applications.
Molecules
, 19
(12)
10.3390/molecules191220424.
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Martinho, N;
Silva, LC;
Florindo, HF;
Brocchini, S;
Barata, T;
Zloh, M;
(2017)
Practical computational toolkits for dendrimers and dendrons structure design.
Journal of Computer-Aided Molecular Design
, 31
(9)
pp. 817-827.
10.1007/s10822-017-0041-6.
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Martinho, N;
Silva, LC;
Florindo, HF;
Brocchini, S;
Zloh, M;
Barata, TS;
(2017)
Rational design of novel, fluorescent, tagged glutamic acid dendrimers with different terminal groups and in silico analysis of their properties.
International Journal of Nanomedicine
, 12
pp. 7053-7073.
10.2147/IJN.S135475.
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Mohamed-Ahmed, AHA;
Lockwood, A;
Fadda, H;
Madaan, S;
Khaw, PT;
Brocchini, S;
Karu, K;
(2018)
LC-MS analysis to determine the biodistribution of a polymer coated ilomastat ocular implant.
Journal of Pharmaceutical and Biomedical Analysis
, 157
pp. 100-106.
10.1016/j.jpba.2018.05.017.
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Mohamed-Ahmed, AHA;
Lockwood, A;
Li, H;
Bailly, M;
Khaw, PT;
Brocchini, S;
(2018)
Erratum in: “An Ilomastat-CD Eye Drop Formulation to Treat Ocular Scarring” by Abeer H. A. Mohamed-Ahmed, Alastair Lockwood, He Li, Maryse Bailly, Peng T. Khaw, and Steve Brocchini (Invest Ophthalmol Vis Sci. 2017;58:3425–3431).
Investigative Ophthalmology & Visual Science
, 59
(2)
p. 909.
10.1167/iovs.16-21377a.
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Mohamed-Ahmed, AHA;
Lockwood, A;
Li, H;
Bailly, M;
Khaw, PT;
Brocchini, S;
(2017)
An Ilomastat-CD Eye Drop Formulation to Treat Ocular Scarring.
Investigative Ophthalmology & Visual Science
, 58
(9)
pp. 3425-3431.
10.1167/iovs.16-21377.
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Moura, LIF;
Martinho, N;
Silva, LC;
Barata, TS;
Brocchini, S;
Florindo, HF;
Zloh, M;
(2017)
Poly-glutamic dendrimer-based conjugates for cancer vaccination – a computational design for targeted delivery of antigens.
Journal of Drug Targeting
, 25
(9-10)
pp. 873-880.
10.1080/1061186X.2017.1363213.
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Nardi, M;
Brocchini, S;
Somavarapu, S;
Procopio, A;
(2023)
Hydroxytyrosol oleate: A promising neuroprotective nanocarrier delivery system of oleuropein and derivatives.
International Journal of Pharmaceutics
, 631
, Article 122498. 10.1016/j.ijpharm.2022.122498.
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Onyekuru, LC;
Moreira, A;
Zhang, J;
Angkawinitwong, U;
Costa, PF;
Brocchini, S;
Williams, GR;
(2021)
An investigation of alkaline phosphatase enzymatic activity after electrospinning and electrospraying.
Journal of Drug Delivery Science and Technology
(102592)
p. 102592.
10.1016/j.jddst.2021.102592.
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Pandya, Akash;
Zhang, Cheng;
Barata, Teresa S;
Brocchini, Steve;
Howard, Mark J;
Zloh, Mire;
Dalby, Paul A;
(2024)
Molecular Dynamics Simulations Reveal How Competing Protein-Surface Interactions for Glycine, Citrate, and Water Modulate Stability in Antibody Fragment Formulations.
Molecular Pharmaceutics
10.1021/acs.molpharmaceut.4c00332.
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Peciak, K;
Laurine, E;
Tommasi, R;
Choi, J-W;
Brocchini, S;
(2019)
Site-selective protein conjugation at histidine.
Chemical Science
, 10
(2)
pp. 427-439.
10.1039/c8sc03355b.
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Picken, CAR;
Brocchini, S;
Burton, MJ;
Blundell-Hunter, G;
Kuguminkiriza, D;
Kaur, H;
Hoffman, JJ;
... Mohamed-Ahmed, AHA; + view all
(2023)
Local Ugandan Production of Stable 0.2% Chlorhexidine Eye Drops.
Translational Vision Science and Technology
, 12
(1)
, Article 27. 10.1167/tvst.12.1.27.
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Picken, C;
Laing, P;
Shen, L;
Clapp, LH;
Brocchini, S;
(2020)
Synthetic routes to treprostinil N-acyl methylsulfonamide.
Tetrahedron Letters
, 61
(5)
, Article 151428. 10.1016/j.tetlet.2019.151428.
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Pollitt, MJ;
Buckton, G;
Piper, R;
Brocchini, S;
(2015)
Measuring antibody coatings on gold nanoparticles by optical spectroscopy.
RSC Advances
, 5
(31)
pp. 24521-24527.
10.1039/c4ra15661g.
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Sainz, V;
Moura, LIF;
Peres, C;
Matos, AI;
Viana, AS;
Wagner, AM;
Vela Ramirez, JE;
... Florindo, HF; + view all
(2018)
α-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma.
Acta Biomaterialia
, 76
pp. 193-207.
10.1016/j.actbio.2018.06.029.
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Sainz, V;
Peres, C;
Ciman, T;
Rodrigues, C;
Viana, AS;
Afonso, CAM;
Barata, T;
... Lopes, JA; + view all
(2016)
Optimization of protein loaded PLGA nanoparticle manufacturing parameters following a quality-by-design approach.
RSC Advances
, 6
(106)
pp. 104502-104512.
10.1039/c6ra19092h.
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Xu, X;
Awwad, S;
Diaz-Gomez, L;
Alvarez-Lorenzo, C;
Brocchini, S;
Gaisford, S;
Goyanes, A;
(2021)
3D Printed Punctal Plugs for Controlled Ocular Drug Delivery.
Pharmaceutics
, 13
(9)
, Article 1421. 10.3390/pharmaceutics13091421.
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Conference item
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Awwad, S;
Al-Shohani, A;
Khaw, PT;
Brocchini, S;
(2016)
A Sustained Release Protein Formulation For Intraocular Use.
Presented at: 14th European Symposium on Controlled Drug Delivery, Amsterdam, Netherlands.
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Bouremel, Y;
Henein, C;
Lee, RMH;
Eames, I;
Brocchini, S;
Khaw, PT;
(2018)
A novel 3D printed eye flow resistance model for intraocular pressure after glaucoma surgery: R1, R2 and R3.
Presented at: Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, Hawaii.
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Henein, C;
Bouremel, Y;
Brocchini, S;
Khaw, P;
(2019)
Hydrodynamic effects of interfacial tension on microtubes.
Presented at: ARVO 2019, Vancouver B.C., Canada.
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Henein, C;
Bouremel, Y;
Brocchini, S;
Khaw, PT;
Lee, RMH;
(2018)
The impact of proteinaceous solutions on the outflow facility of micro-tubes.
Presented at: Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Honolulu, Hawaii.
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Lee, RMH;
Bouremel, Y;
Eames, I;
Brocchini, S;
Khaw, PT;
(2017)
The implications of an ab interno vs. ab externo surgical approach on intraocular pressure (IOP) control.
Presented at: Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Baltimore, MD, USA.
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