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Solid-state protein formulations.

Angkawinitwong, U; Sharma, G; Khaw, PT; Brocchini, S; Williams, GR; (2015) Solid-state protein formulations. Therapeutic Delivery , 6 (1) 59 - 82. 10.4155/tde.14.98. Green open access

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Abstract

When formulated as liquid dosage forms, therapeutic proteins and peptides often show instability during handling as a result of chemical degradation. Solid formulations are frequently required to maintain protein stability during storage, transport and upon administration. Herein we highlight current strategies used to formulate pharmaceutical proteins in the solid form. An overview of the physical instabilities which can arise with proteins is first described. The key solidification techniques of crystallization, freeze-drying and particle forming technologies are then discussed. Examples of current commercial products that are formulated in the solid state are provided and include neutral protamine Hagedorn - insulin crystal suspensions, freeze-dried monoclonal antibodies and leuproride polylactide-co-glycolide microparticles. Finally, future perspectives in solid-state protein formulation are described.

Type: Article
Title: Solid-state protein formulations.
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.4155/tde.14.98
Publisher version: http://dx.doi.org/10.4155/tde.14.98
Language: English
Additional information: Copyright © 2015 Future Science Ltd
Keywords: Chemistry, Pharmaceutical, Crystallization, Freeze Drying, Protein Stability, Proteins
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/1460690
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