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Number of items: 40.
Article
Al-Olabi, L;
Polubothu, S;
Dowsett, K;
Andrews, KA;
Stadnik, P;
Joseph, AP;
Knox, R;
... Kinsler, VA; + view all
(2018)
Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy.
The Journal of Clinical Investigation
, 128
(4)
pp. 1496-1508.
10.1172/JCI98589.
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Ashford, P;
Hernandez, A;
Greco, TM;
Buch, A;
Sodeik, B;
Cristea, IM;
Grünewald, K;
... Topf, M; + view all
(2016)
HVint: A Strategy for Identifying Novel Protein-Protein Interactions in Herpes Simplex Virus Type 1.
Molecular & Cellular Proteomics
, 15
(9)
pp. 2939-2953.
10.1074/mcp.M116.058552.
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Atherton, J;
Jiang, K;
Stangier, MM;
Luo, Y;
Hua, S;
Houben, K;
van Hooff, JJE;
... Akhmanova, A; + view all
(2017)
A structural model for microtubule minus-end recognition and protection by CAMSAP proteins.
Nature Structural & Molecular Biology
, 24
(11)
pp. 931-943.
10.1038/nsmb.3483.
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Atherton, J;
Yu, I-M;
Cook, A;
Muretta, JM;
Joseph, A;
Major, J;
Sourigues, Y;
... Moores, CA; + view all
(2017)
The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry.
eLIFE
, 6
, Article e27793. 10.7554/eLife.27793.
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Beton, JG;
Moorehead, R;
Helfmann, L;
Gray, R;
Hoogenboom, BW;
Praveen Joseph, A;
Topf, M;
(2021)
TopoStats - a program for automated tracing of biomolecules from AFM images.
Methods
, 193
pp. 68-79.
10.1016/j.ymeth.2021.01.008.
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Bullock, JMA;
Schwab, J;
Thalassinos, K;
Topf, M;
(2016)
The Importance of Non-accessible Crosslinks and Solvent Accessible Surface Distance in Modeling Proteins with Restraints From Crosslinking Mass Spectrometry.
Molecular & Cellular Proteomics
, 15
(7)
pp. 2491-2500.
10.1074/mcp.M116.058560.
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Bullock, JMA;
Sen, N;
Thalassinos, K;
Topf, M;
(2018)
Modeling Protein Complexes Using Restraints from Crosslinking Mass Spectrometry.
Structure
, 26
(7)
pp. 1015-1024.
10.1016/j.str.2018.04.016.
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Bullock, JMA;
Thalassinos, K;
Topf, M;
(2018)
Jwalk and MNXL Web Server: Model Validation using Restraints from Crosslinking Mass Spectrometry.
Bioinformatics
, 34
(20)
pp. 3584-3585.
10.1093/bioinformatics/bty366.
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Carecchio, M;
Invernizzi, F;
Gonzàlez-Latapi, P;
Panteghini, C;
Zorzi, G;
Romito, L;
Leuzzi, V;
... Nardocci, N; + view all
(2019)
Frequency and phenotypic spectrum of KMT2B dystonia in childhood: A single-center cohort study.
Movement Disorders
10.1002/mds.27771.
(In press).
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Demetriou, C;
Chanudet, E;
GOSgene, .;
Joseph, A;
Topf, M;
Thomas, AC;
Bitner-Glindzicz, M;
... Moore, GE; + view all
(2019)
Exome sequencing identifies variants in FKBP4 that are associated with recurrent fetal loss in humans.
Human Molecular Genetics
, 28
(20)
pp. 3466-3474.
10.1093/hmg/ddz203.
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Deville, C;
Carroni, M;
Franke, KB;
Topf, M;
Bukau, B;
Mogk, A;
Saibil, HR;
(2017)
Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.
Science Advances
, 3
(8)
, Article e1701726. 10.1126/sciadv.1701726.
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Durán, AH;
Grünewald, K;
Topf, M;
(2019)
Conserved Central Intraviral Protein Interactome of the Herpesviridae Family.
mSystems
, 4
(5)
, Article e00295-19. 10.1128/mSystems.00295-19.
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Farabella, I;
Pham, T;
Henderson, NS;
Geibel, S;
Phan, G;
Thanassi, DG;
Delcour, AH;
... Topf, M; + view all
(2016)
Correction: Allosteric signalling in the outer membrane translocation domain of PapC usher.
eLife
, 5
, Article e21585. 10.7554/eLife.21585.
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Fedele, L;
Newcombe, J;
Topf, M;
Gibb, A;
Harvey, RJ;
Smart, TG;
(2018)
Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties.
Nature Communications
, 9
, Article 957. 10.1038/s41467-018-02927-4.
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Fumagalli, M;
Camus, SM;
Diekmann, Y;
Burke, A;
Camus, M;
Norman, P;
Joseph, A;
... Brodsky, F; + view all
(2019)
Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism.
eLife
, 2019
(8)
, Article e41517. 10.7554/eLife.41517.
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Ganser, LR;
Yan, Q;
James, VM;
Kozol, R;
Topf, M;
Harvey, RJ;
Dallman, JE;
(2013)
Distinct phenotypes in zebrafish models of human startle disease.
Neurobiol Dis
, 60
pp. 139-151.
10.1016/j.nbd.2013.09.002.
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Hernández Durán, A;
Greco, TM;
Vollmer, B;
Cristea, IM;
Grünewald, K;
Topf, M;
(2019)
Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships.
PLoS Biology
, 17
(6)
, Article e3000316. 10.1371/journal.pbio.3000316.
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Ignatiou, A;
Brasiles, S;
Fadel, MES;
Buerger, J;
Mielke, T;
Topf, M;
Tavares, P;
(2019)
Structural transitions during the scaffolding-driven assembly of a viral capsid.
Nature Communications
, 10
, Article 4840. 10.1038/s41467-019-12790-6.
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Joseph, AP;
Lagerstedt, I;
Patwardhan, A;
Topf, M;
Winn, M;
(2017)
Improved metrics for comparing structures of macromolecular assemblies determined by 3D electron-microscopy.
Journal of Structural Biology
, 199
(1)
pp. 12-26.
10.1016/j.jsb.2017.05.007.
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Joseph, AP;
Polles, G;
Alber, F;
Topf, M;
(2017)
Integrative modelling of cellular assemblies.
Current Opinion in Structural Biology
, 46
pp. 102-109.
10.1016/j.sbi.2017.07.001.
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Kalscheuer, VM;
James, VM;
Himelright, ML;
Long, P;
Oegema, R;
Jensen, C;
Bienek, M;
... Harvey, RJ; + view all
(2016)
Novel Missense Mutation A789V in IQSEC2 Underlies X-Linked Intellectual Disability in the MRX78 Family.
Frontiers in Molecular Neuroscience
, 8
, Article 85. 10.3389/fnmol.2015.00085.
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Lepore, R;
Kryshtafovych, A;
Alahuhta, M;
Veraszto, HA;
Bomble, YJ;
Bufton, JC;
Bullock, AN;
... Schwede, T; + view all
(2019)
Target highlights in CASP13: Experimental target structures through the eyes of their authors.
Proteins: Structure, Function, and Bioinformatics
, 87
(12)
pp. 1037-1057.
10.1002/prot.25805.
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Leung, C;
Dudkina, NV;
Lukoyanova, N;
Hodel, AW;
Farabella, I;
Pandurangan, AP;
Jahan, N;
... Hoogenboom, BW; + view all
(2014)
Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin.
Elife
, 3
, Article e04247. 10.7554/eLife.04247.
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Locke, J;
Joseph, AP;
Peña, A;
Möckel, MM;
Mayer, TU;
Topf, M;
Moores, CA;
(2017)
Structural basis of human kinesin-8 function and inhibition.
Proceedings of the National Academy of Sciences of the United States of America
, 114
(45)
E9539-E9548.
10.1073/pnas.1712169114.
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McTague, A;
Nair, U;
Malhotra, S;
Meyer, E;
Trump, N;
Gazina, EV;
Papandreou, A;
... Kurian, MA; + view all
(2018)
Clinical and molecular characterization of KCNT1-related severe early-onset epilepsy.
Neurology
, 90
(1)
e55-e66.
10.1212/WNL.0000000000004762.
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Menny, A;
Serna, M;
Boyd, CM;
Gardner, S;
Joseph, AP;
Morgan, BP;
Topf, M;
... Bubeck, D; + view all
(2018)
CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers.
Nature Communications
, 9
, Article 5316. 10.1038/s41467-018-07653-5.
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Meyer, E;
Carss, KJ;
Rankin, J;
Nichols, JM;
Grozeva, D;
Joseph, AP;
Mencacci, NE;
... Kurian, MA; + view all
(2017)
Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia.
Nature Genetics
, 49
(2)
pp. 223-237.
10.1038/ng.3740.
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Mortensen, M;
Iqbal, F;
Pandurangan, AP;
Hannan, S;
Huckvale, R;
Topf, M;
Baker, JR;
(2014)
Photo-antagonism of the GABAA receptor.
Nature Communications
, 5
, Article 4454. 10.1038/ncomms5454.
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Newcombe, J;
Chatzidaki, A;
Sheppard, TD;
Topf, M;
Millar, NS;
(2018)
Diversity of nicotinic acetylcholine receptor positive allosteric modulators revealed by mutagenesis and a revised structural model.
Molecular Pharmacology
, 93
(2)
pp. 128-140.
10.1124/mol.117.110551.
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Peña, A;
Sweeney, A;
Cook, AD;
Topf, M;
Moores, CA;
(2020)
Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy.
Structure
10.1016/j.str.2020.01.013.
(In press).
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Pereira, R;
Gendron, T;
Sanghera, C;
Greenwood, HE;
Newcombe, J;
McCormick, P;
Sander, K;
... Witney, TH; + view all
(2019)
Mapping Aldehyde Dehydrogenase 1A1 Activity using an [¹⁸F]Substrate-based Approach.
Chemistry & A European Journal
, 25
(9)
pp. 2345-2351.
10.1002/chem.201805473.
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Pilorge, M;
Fassier, C;
Le Corronc, H;
Potey, A;
Bai, J;
De Gois, S;
Delaby, E;
... Betancur, C; + view all
(2016)
Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism.
Molecular Psychiatry
, 21
(7)
pp. 936-945.
10.1038/mp.2015.139.
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Schaefer, N;
Berger, A;
van Brederode, J;
Zheng, F;
Zhang, Y;
Leacock, S;
Littau, L;
... Villmann, C; + view all
(2017)
Disruption of a structurally important extracellular element in the glycine receptor leads to decreased synaptic integration and signaling resulting in severe startle disease.
The Journal of Neuroscience
, 37
(33)
pp. 7948-7961.
10.1523/JNEUROSCI.0009-17.2017.
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Sinnott, M;
Malhotra, S;
Madhusudhan, MS;
Thalassinos, K;
Topf, M;
(2020)
Combining Information from Crosslinks and Monolinks in the Modeling of Protein Structures.
Structure
, 28
(9)
1061-1070.e3.
10.1016/j.str.2020.05.012.
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Smelt, CLC;
Sanders, VR;
Newcombe, J;
Burt, RP;
Sheppard, TD;
Topf, M;
Millar, NS;
(2018)
Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor.
Neuropharmacology
, 139
pp. 194-204.
10.1016/j.neuropharm.2018.07.009.
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Stödberg, T;
McTague, A;
Ruiz, AJ;
Hirata, H;
Zhen, J;
Long, P;
Farabella, I;
... Kurian, MA; + view all
(2015)
Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures.
Nature Communications
, 6
p. 8038.
10.1038/ncomms9038.
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Thalassinos, K;
Pandurangan, AP;
Xu, M;
Alber, F;
Topf, M;
(2013)
Conformational States of macromolecular assemblies explored by integrative structure calculation.
Structure
, 21
(9)
1500 - 1508.
10.1016/j.str.2013.08.006.
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Tweedy, JG;
Escriva, E;
Topf, M;
Gompels, UA;
(2018)
Analyses of Tissue Culture Adaptation of Human Herpesvirus-6A by Whole Genome Deep Sequencing Redefines the Reference Sequence and Identifies Virus Entry Complex Changes.
Viruses
, 10
(1)
, Article 16. 10.3390/v10010016.
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Vollmer, B;
Pražák, V;
Vasishtan, D;
Jefferys, EE;
Hernandez-Duran, A;
Vallbracht, M;
Klupp, BG;
... Grünewald, K; + view all
(2020)
The prefusion structure of herpes simplex virus glycoprotein B.
Science Advances
, 6
(39)
, Article eabc1726. 10.1126/sciadv.abc1726.
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Wright, ZVF;
McCarthy, S;
Dickman, R;
Reyes, FE;
Sanchez-Martinez, S;
Cryar, A;
Kilford, I;
... Tabor, AB; + view all
(2017)
The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Na(v)1.7.
Journal of the American Chemical Society
, 139
(37)
pp. 13063-13075.
10.1021/jacs.7b06506.
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