Browse by UCL people
Group by: Type | Date
Number of items: 36.
Article
Behjati, S;
Tarpey, PS;
Sheldon, H;
Martincorena, I;
Van Loo, P;
Gundem, G;
Wedge, DC;
... Campbell, PJ; + view all
(2014)
Recurrent PTPRB and PLCG1 mutations in angiosarcoma.
Nature Genetics
, 46
(4)
376 - 379.
10.1038/ng.2921.
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Broncel, M;
Serwa, RA;
Bunney, TD;
Katan, M;
Tate, EW;
(2016)
Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach.
Molecular & Cellular Proteomics
, 15
(2)
pp. 715-725.
10.1074/mcp.O115.054429.
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Bull, Daniel;
Matte, Julie C;
Navarron, Carmen M;
McIntyre, Rebecca;
Whiting, Paul;
Katan, Matilda;
Ducotterd, Fiona;
(2024)
The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function – Insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
, 1870
(2)
, Article 166978. 10.1016/j.bbadis.2023.166978.
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Bunney, Tom D;
Kampyli, Charis;
Gregory, Ashley;
Katan, Matilda;
(2024)
Characterisation of molecular mechanisms for PLCγ2 disease-linked variants.
Advances in Biological Regulation
, 94
, Article 101053. 10.1016/j.jbior.2024.101053.
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Bunney, Tom D;
Katan, Matilda;
(2023)
Targeting G-CSF to treat autoinflammation.
Nature Immunology
, 24
pp. 736-737.
10.1038/s41590-023-01474-5.
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Bunney, Tom D;
Nyvall, Hunter G;
Macrae, Calum;
Lalović, Damjan;
Gregory, Ashley;
Le Huray, Kyle IP;
Harvey, Nikita;
... Katan, Matilda; + view all
(2025)
Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors.
Biochemical Journal
10.1042/BCJ20253358.
(In press).
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Bunney, TD;
Cole, AR;
Broncel, M;
Esposito, D;
Tate, EW;
Katan, M;
(2014)
Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions.
Structure
, 22
(12)
1831 - 1843.
10.1016/j.str.2014.10.007.
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Bunney, TD;
Inglis, AJ;
Sanfelice, D;
Farrell, B;
Kerr, CJ;
Thompson, GS;
Masson, GR;
... Katan, M; + view all
(2018)
Disease variants of FGFR3 reveal molecular basis for the recognition and new roles for Cdc37 in Hsp90 chaperone system.
Structure
, 26
(3)
446-458.e8.
10.1016/j.str.2018.01.016.
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Bunney, TD;
Wan, S;
Thiyagarajan, N;
Sutto, L;
Williams, SV;
Ashford, P;
Koss, H;
... Katan, M; + view all
(2015)
The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study.
EBioMedicine
, 2
(3)
194 - 204.
10.1016/j.ebiom.2015.02.009.
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Chan, JJ;
Flatters, D;
Rodrigues-Lima, F;
Yan, J;
Thalassinos, K;
Katan, M;
(2013)
Comparative analysis of interactions of RASSF1-10.
Advances in Biological Regulation
, 53
(2)
190 - 201.
10.1016/j.jbior.2012.12.001.
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Correia, T;
Lockwood, N;
Kumar, S;
Yin, J;
Ramel, MC;
Andrews, N;
Katan, M;
... Arridge, S; + view all
(2015)
Accelerated Optical Projection Tomography Applied to In Vivo Imaging of Zebrafish.
PLoS One
, 10
(8)
, Article e0136213. 10.1371/journal.pone.0136213.
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Elmentaite, R;
Kumasaka, N;
Roberts, K;
Fleming, A;
Dann, E;
King, HW;
Kleshchevnikov, V;
... Teichmann, SA; + view all
(2021)
Cells of the human intestinal tract mapped across space and time.
Nature
, 597
(7875)
pp. 250-255.
10.1038/s41586-021-03852-1.
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Gong, Grace Q;
Bilanges, Benoit;
Allsop, Ben;
Masson, Glenn R;
Roberton, Victoria;
Askwith, Trevor;
Oxenford, Sally;
... Vanhaesebroeck, Bart; + view all
(2023)
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Nature
, 618
pp. 159-168.
10.1038/s41586-023-05972-2.
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Katan, M;
Cockcroft, S;
(2020)
Phospholipase C families: Common themes and versatility in physiology and pathology.
Progress in Lipid Research
, 80
, Article 101065. 10.1016/j.plipres.2020.101065.
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Katan, M;
Cockcroft, S;
(2020)
Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane.
Essays in Biochemistry
, Article EBC20200041. 10.1042/EBC20200041.
(In press).
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Katan, M;
Perdios, P;
Lowe, AR;
Saladino, G;
Bunney, DT;
Thiyagarajan, N;
Alexandrov, Y;
... Tate, EW; + view all
(2017)
Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.
Scientific Reports
, 7
, Article 39841. 10.1038/srep39841.
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Koss, H;
Bunney, TD;
Behjati, S;
Katan, M;
(2014)
Dysfunction of phospholipase Cγ in immune disorders and cancer.
Trends in Biochemical Sciences
, 39
(12)
pp. 603-611.
10.1016/j.tibs.2014.09.004.
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Koss, H;
Bunney, TD;
Esposito, D;
Martins, M;
Katan, M;
Driscoll, PC;
(2018)
Dynamic Allostery in PLC gamma 1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR.
Biophysical Journal
, 115
(1)
pp. 31-45.
10.1016/j.bpj.2018.05.031.
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Kumar, S;
Lockwood, N;
Ramel, MC;
Correia, T;
Ellis, M;
Alexandrov, Y;
Andrews, N;
... French, P; + view all
(2016)
Quantitative in vivo optical tomography of cancer progression & vasculature development in adult zebrafish.
Oncotarget
, 7
(28)
pp. 43939-43948.
10.18632/oncotarget.9756.
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Le Huray, Kyle IP;
Bunney, Tom D;
Pinotsis, Nikos;
Kalli, Antreas C;
Katan, Matilda;
(2022)
Characterization of the membrane interactions of phospholipase Cγ reveals key features of the active enzyme.
Science Advances
, 8
(25)
, Article eabp9688. 10.1126/sciadv.abp9688.
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Lima, NC;
Atkinson, E;
Bunney, TD;
Katan, M;
Huang, PH;
(2020)
Targeting the Src Pathway Enhances the Efficacy of Selective FGFR Inhibitors in Urothelial Cancers with FGFR3 Alterations.
International Journal of Molecular Sciences
, 21
(9)
, Article 3214. 10.3390/ijms21093214.
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Liu, Y;
Bunney, TD;
Khosa, S;
Macé, K;
Beckenbauer, K;
Askwith, T;
Maslen, S;
... Katan, M; + view all
(2020)
Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes.
EBioMedicine
, 51
, Article 102607. 10.1016/j.ebiom.2019.102607.
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Lombardi, B;
Ashford, P;
Moya-Garcia, AA;
Rust, A;
Crawford, M;
Williams, SV;
Knowles, MA;
... Godovac-Zimmermann, J; + view all
(2017)
Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis.
Oncotarget
, 8
(61)
pp. 102898-102911.
10.18632/oncotarget.22048.
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Lombardi, B;
Rendell, N;
Edwards, M;
Katan, M;
Zimmermann, JG;
(2015)
Evaluation of phosphopeptide enrichment strategies for quantitative TMT analysis of complex network dynamics in cancer-associated cell signalling.
EuPA Open Proteom
, 6
pp. 10-15.
10.1016/j.euprot.2015.01.002.
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Magno, L;
Lessard, CB;
Martins, M;
Lang, V;
Cruz, P;
Asi, Y;
Katan, M;
... Whiting, PJ; + view all
(2019)
Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.
Alzheimer's Research & Therapy
, 11
, Article 16. 10.1186/s13195-019-0469-0.
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Margineanu, A;
Chan, JJ;
Kelly, DJ;
Warren, SC;
Flatters, D;
Kumar, S;
Katan, M;
... French, PM; + view all
(2016)
Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM).
Scientific Reports
, 6
, Article 28186. 10.1038/srep28186.
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Martin-Nalda, A;
Fortuny, C;
Rey, L;
Bunney, TD;
Alsina, L;
Esteve-Sole, A;
Bull, D;
... Arostegui, J; + view all
(2020)
Severe Autoinflammatory Manifestations and Antibody Deficiency Due to Novel Hypermorphic PLCG2 Mutations.
Journal of Clinical Immunology
10.1007/s10875-020-00794-7.
(In press).
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Martins, M;
McCarthy, A;
Baxendale, R;
Guichard, S;
Magno, L;
Kessaris, N;
El-Bahrawy, M;
... Katan, M; + view all
(2014)
Tumor suppressor role of phospholipase C epsilon in Ras-triggered cancers.
Proceedings of the National Academy of Sciences
, 111
(11)
4239 - 4244.
10.1073/pnas.1311500111.
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Neves, JF;
Doffinger, R;
Barcena-Morales, G;
Martins, C;
Papapietro, O;
Plagnol, V;
Curtis, J;
... Nejentsev, S; + view all
(2018)
Novel PLCG2 Mutation in a Patient With APLAID and Cutis Laxa.
Frontiers in Immunology
, 9
, Article 2863. 10.3389/fimmu.2018.02863.
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Patani, H;
Bunney, TD;
Thiyagarajan, N;
Norman, RA;
Ogg, D;
Breed, J;
Ashford, P;
... Katan, M; + view all
(2016)
Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use.
Oncotarget
, 7
(17)
pp. 24252-24268.
10.18632/oncotarget.8132.
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Patel, VM;
Flanagan, CE;
Martins, M;
Jones, CL;
Butler, RM;
Woollard, WJ;
Bakr, FS;
... Mitchell, TJ; + view all
(2020)
Frequent and Persistent PLCG1 Mutations in Sezary Cells Directly Enhance PLC gamma 1 Activity and Stimulate NF kappa B, AP-1, and NFAT Signaling.
Journal of Investigative Dermatology
, 140
(2)
pp. 380-389.
10.1016/j.jid.2019.07.693.
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Perdios, L;
Bunney, TD;
Warren, SC;
Dunsby, C;
French, PM;
Tate, EW;
Katan, M;
(2016)
Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1.
Advances in Biological Regulation
, 60
pp. 6-13.
10.1016/j.jbior.2015.09.002.
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Prawiro, Christy;
Bunney, Tom D;
Kampyli, Charis;
Yaguchi, Hiroko;
Katan, Matilda;
Bangham, Charles RM;
(2023)
A frequent PLCγ1 mutation in adult T-cell leukemia/lymphoma determines functional properties of the malignant cells.
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
, 1869
(2)
, Article 166601. 10.1016/j.bbadis.2022.166601.
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Sanfelice, D;
Koss, H;
Bunney, TD;
Thompson, GS;
Farrell, B;
Katan, M;
Breeze, AL;
(2018)
NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074.
Biomolecular NMR Assignments
10.1007/s12104-018-9814-7.
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Warren, SC;
Margineanu, A;
Alibhai, D;
Kelly, DJ;
Talbot, C;
Alexandrov, Y;
Munro, I;
... French, PM; + view all
(2013)
Rapid global fitting of large fluorescence lifetime imaging microscopy datasets.
PLoS One
, 8
(8)
, Article e70687. 10.1371/journal.pone.0070687.
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Thesis
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Lockwood, NJ;
(2016)
The Global Imaging of Physiological and Pathophysiological Angiogenesis in live zebrafish using Optical Projection Tomography.
Doctoral thesis , UCL (University College London).
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