Browse by UCL people
Group by: Type | Date
Number of items: 55.
Article
Al-Akkad, Walid;
Acedo, Pilar;
Vilia, Maria-Giovanna;
Frenguelli, Luca;
Ney, Alexander;
Rodriguez-Hernandez, Irene;
Labib, Peter L;
... Mazza, Giuseppe; + view all
(2022)
Tissue-Specific Human Extracellular Matrix Scaffolds Promote Pancreatic Tumour Progression and Chemotherapy Resistance.
Cells
, 11
(22)
, Article 3652. 10.3390/cells11223652.
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Alberts, R;
de Vries, EMG;
Goode, EC;
Jiang, X;
Sampaziotis, F;
Rombouts, K;
Böttcher, K;
... Weersma, RK; + view all
(2018)
Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.
Gut
, 67
(8)
pp. 1517-1524.
10.1136/gutjnl-2016-313598.
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Bárcena-Varela, M;
Caruso, S;
Llerena, S;
Álvarez-Sola, G;
Uriarte, I;
Latasa, MU;
Urtasun, R;
... Fernández-Barrena, MG; + view all
(2019)
Dual Targeting of Histone Methyltransferase G9a and DNA‐Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma.
Hepatology
, 69
(2)
pp. 587-603.
10.1002/hep.30168.
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Barcena-Varela, M;
Paish, H;
Alvarez, L;
Uriarte, I;
Latasa, MU;
Santamaria, E;
Recalde, M;
... Fernandez-Barrena, MG; + view all
(2020)
Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis.
Gut
10.1136/gutjnl-2019-320205.
(In press).
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Becares, N;
Gage, MC;
Voisin, M;
Shrestha, E;
Martin-Gutierrez, L;
Liang, N;
Louie, R;
... Pineda-Torra, I; + view all
(2019)
Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease.
Cell Reports
, 26
(4)
984-995.e6.
10.1016/j.celrep.2018.12.094.
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Böttcher, K;
Longato, L;
Marrone, G;
Mazza, G;
Ghemtio, L;
Hall, A;
Luong, TV;
... Rombouts, K; + view all
(2021)
AICAR and compound C negatively modulate HCC-induced primary human hepatic stellate cell activation in vitro.
American Journal of Physiology
, 320
(4)
G543-G556.
10.1152/ajpgi.00262.2020.
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Böttcher, K;
rombouts, K;
Saffioti, F;
Roccarina, D;
Rosselli, M;
Hall, A;
Luong, T;
... Pinzani, M; + view all
(2018)
MAIT cells are chronically activated in patients with autoimmune liver disease and promote pro-fibrogenic hepatic stellate cell activation.
Hepatology
, 68
(1)
pp. 172-186.
10.1002/hep.29782.
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Caon, E;
Martins, M;
Hodgetts, H;
Blanken, L;
Vilia, MG;
Levi, A;
Thanapirom, K;
... Rombouts, K; + view all
(2024)
Exploring the impact of the PNPLA3 I148M variant on primary human hepatic stellate cells using 3D extracellular matrix models.
Journal of Hepatology
10.1016/j.jhep.2024.01.032.
(In press).
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Carloni, V;
Lulli, M;
Madiai, S;
Mello, T;
Hall, A;
Luong, TV;
Pinzani, M;
... Galli, A; + view all
(2018)
CHK2 overexpression and mislocalisation within mitotic structures enhances chromosomal instability and hepatocellular carcinoma progression.
Gut
, 67
(2)
pp. 348-361.
10.1136/gutjnl-2016-313114.
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Claveria-Cabello, A;
Colyn, L;
Uriarte, I;
Latasa, MU;
Arechederra, M;
Herranz, JM;
Alvarez, L;
... Fernandez-Barrena, MG; + view all
(2020)
Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis.
Cancers
, 12
(12)
, Article 3748. 10.3390/cancers12123748.
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Cortes, E;
Lachowski, D;
Rice, A;
Thorpe, SD;
Robinson, B;
Yeldag, G;
Lee, DA;
... Del Río Hernández, AE; + view all
(2019)
Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor.
Oncogene
10.1038/s41388-018-0631-3.
(In press).
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Dat, NQ;
Thuy, LTT;
Hieu, VN;
Hai, H;
Hoang, DV;
Thi Thanh Hai, N;
Thuy, TTV;
... Kawada, N; + view all
(2021)
Hexa Histidine–Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species.
Hepatology
, 73
(6)
pp. 2527-2545.
10.1002/hep.31752.
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De Chiara, F;
Heebøll, S;
Marrone, G;
Hamilton-Dutoit, S;
Ferrandez, A;
Andreola, F;
Rombouts, K;
... Thomsen, KL; + view all
(2018)
Urea cycle dysregulation in non-alcoholic fatty liver disease.
Journal of Hepatology
, 69
(4)
pp. 905-915.
10.1016/j.jhep.2018.06.023.
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De Chiara, F;
Thomsen, KL;
Habtesion, A;
Jones, H;
Davies, N;
Gracia-Sancho, J;
Manicardi, N;
... Jalan, R; + view all
(2020)
Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease.
Hepatology
, 71
(3)
pp. 874-892.
10.1002/hep.30890.
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Gentilini, A;
Caligiuri, A;
Raggi, C;
Rombouts, K;
Pinzani, M;
Lori, G;
Correnti, M;
... Marra, F; + view all
(2019)
CXCR7 contributes to the aggressive phenotype of cholangiocarcinoma cells.
Biochimica et Biophysica Acta (BBA): Molecular Basis of Disease
, 1865
(9)
pp. 2246-2256.
10.1016/j.bbadis.2019.04.020.
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Giuffrida, P;
Curti, M;
Al-Akkad, W;
Biel, C;
Crowley, C;
Frenguelli, L;
Telese, A;
... Mazza, G; + view all
(2019)
Decellularized Human Gut as a Natural 3D Platform for Research in Intestinal Fibrosis.
Inflammatory Bowel Diseases
, 25
(11)
pp. 1740-1750.
10.1093/ibd/izz115.
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Heindryckx, F;
Binet, F;
Ponticos, M;
Rombouts, K;
Lau, J;
Kreuger, J;
Gerwins, P;
(2016)
Endoplasmic reticulum stress enhances fibrosis through IRE1α-mediated degradation of miR-150 and XBP-1 splicing.
EMBO Molecular Medicine
, 8
(7)
pp. 729-744.
10.15252/emmm.201505925.
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Hodgetts, Harry;
Martins, Maria Castanho;
Chen, Luohai;
Hall, Andrew R;
Luong, Tu Vinh;
Mandair, Dalvinder;
Caplin, Martyn;
(2025)
Telotristat ethyl affects tumour-fibroblast crosstalk in small intestinal neuroendocrine tumours.
Journal of Neuroendocrinology
, Article e70094. 10.1111/jne.70094.
(In press).
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Jalan, R;
De Chiara, F;
Balasubramaniyan, V;
Andreola, F;
Khetan, V;
Malago, M;
Pinzani, M;
... Rombouts, K; + view all
(2016)
Ammonia produces pathological changes in human hepatic stellate cells and is a target for therapy of portal hypertension.
Journal of Hepatology
, 64
(4)
pp. 823-833.
10.1016/j.jhep.2015.11.019.
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Kostrzewski, T;
Maraver, P;
Ouro-Gnao, L;
Levi, A;
Snow, S;
Miedzik, A;
Rombouts, K;
(2020)
A Microphysiological System for Studying Nonalcoholic Steatohepatitis.
Hepatology Communications
, 4
(1)
pp. 77-91.
10.1002/hep4.1450.
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Lachowski, D;
Cortes, E;
Rice, A;
Pinato, D;
Rombouts, K;
Del Rio Hernandez, A;
(2019)
Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis.
Scientific Reports
, 9
(1)
, Article 7299. 10.1038/s41598-019-43759-6.
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Lachowski, D;
Cortes, E;
Robinson, B;
Rice, A;
Rombouts, K;
Del Río Hernández, AE;
(2018)
FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis.
The FASEB Journal
, 32
(2)
pp. 1099-1107.
10.1096/fj.201700721R.
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Lachowski, D;
Cortes, E;
Robinson, BK;
Rombouts, K;
del Río Hernández, A;
(2016)
Assaying the rigidity guided migration of human tumour stromal myofibroblasts (TSMs) on polyacrylamide substrates mimicking the healthy and fibrotic tissue transition boundary.
Convergent Science Physical Oncology
, 2
(4)
, Article 044502. 10.1088/2057-1739/aa4e4c.
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Laskaratos, F-M;
Levi, A;
Schwach, G;
Pfragner, R;
Hall, A;
Xia, D;
von Stempel, C;
... Rombouts, K; + view all
(2021)
Transcriptomic Profiling of In Vitro Tumor-Stromal Cell Paracrine Crosstalk Identifies Involvement of the Integrin Signaling Pathway in the Pathogenesis of Mesenteric Fibrosis in Human Small Intestinal Neuroendocrine Neoplasms.
Frontiers in Oncology
, 11
, Article 629665. 10.3389/fonc.2021.629665.
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Laskaratos, F-M;
Mandair, D;
Hall, A;
Alexander, S;
von Stempel, C;
Bretherton, J;
Luong, T;
... Toumpanakis, C; + view all
(2019)
Clinicopathological correlations of mesenteric fibrosis and evaluation of a novel biomarker for fibrosis detection in small bowel neuroendocrine neoplasms.
Endocrine
, 67
, Article 527. 10.1007/s12020-019-02107-4.
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Laskaratos, F-M;
Rombouts, K;
Caplin, M;
Toumpanakis, C;
Thirlwell, C;
Mandair, D;
(2017)
Neuroendocrine tumors and fibrosis: An unsolved mystery?
Cancer
, 123
(24)
pp. 4770-4790.
10.1002/cncr.31079.
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Longato, L;
Andreola, F;
Davies, S;
Roberts, JL;
Fusai, G;
Pinzani, M;
Moore, K;
(2016)
Reactive gamma-ketoaldehydes as novel activators of hepatic stellate cells in vitro.
Free Radical Biology and Medicine
, 102
pp. 162-173.
10.1016/j.freeradbiomed.2016.11.036.
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Lulli, M;
Del Coco, L;
Mello, T;
Sukowati, C;
Madiai, S;
Gragnani, L;
Forte, P;
... Carloni, V; + view all
(2021)
DNA Damage Response Protein CHK2 Regulates Metabolism in Liver Cancer.
Cancer Research
, 81
(11)
pp. 2861-2873.
10.1158/0008-5472.CAN-20-3134.
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Marrone, G;
De Chiara, F;
Bottcher, K;
Levi, A;
Dhar, D;
Longato, L;
Mazza, G;
... Rombouts, K; + view all
(2018)
The adenosine monophosphate–activated protein kinase—vacuolar adenosine triphosphatase–pH axis: A key regulator of the profibrogenic phenotype of human hepatic stellate cells.
Hepatology
, 68
(3)
pp. 1140-1153.
10.1002/hep.30029.
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Martins, Maria Castanho;
Dixon, Emmanuel Dauda;
Lupo, Giulia;
Claudel, Thierry;
Trauner, Michael;
Rombouts, Krista;
(2025)
Role of PNPLA3 in Hepatic Stellate Cells and Hepatic
Cellular Crosstalk.
Liver International
, 45
(4)
, Article e16117. 10.1111/liv.16117.
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Mazza, G;
Al-Akkad, W;
Rombouts, K;
(2017)
Engineering in vitro models of hepatofibrogenesis.
Advanced Drug Delivery Reviews
, 121
pp. 147-157.
10.1016/j.addr.2017.05.018.
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Mazza, G;
Al-Akkad, W;
Rombouts, K;
Pinzani, M;
(2018)
Liver tissue engineering: From implantable tissue to whole organ engineering.
Hepatology Communications
, 2
(2)
pp. 131-141.
10.1002/hep4.1136.
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Mazza, G;
Al-Akkad, W;
Telese, A;
Longato, L;
Urbani, L;
Robinson, B;
Hall, A;
... Pinzani, M; + view all
(2017)
Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization.
Scientific Reports
, 7
, Article 5534. 10.1038/s41598-017-05134-1.
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Mazza, G;
Rombouts, K;
Rennie Hall, A;
Urbani, L;
Vinh Luong, T;
Al-Akkad, W;
Longato, L;
... Pinzani, M; + view all
(2015)
Decellularized human liver as a natural 3D-scaffold for liver bioengineering and transplantation.
Scientific Reports
, 5
, Article 13079. 10.1038/srep13079.
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Mazza, G;
Telese, A;
Al-Akkad, W;
Frenguelli, L;
Levi, A;
Marrali, M;
Longato, L;
... Rombouts, K; + view all
(2020)
Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition.
Cells
, 9
(1)
, Article 83. 10.3390/cells9010083.
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Muttillo, Edoardo M;
Felli, Eric;
Felli, Emanuele;
Muttillo, Edoardo M;
Urade, Takeshi;
Laracca, Giovanni G;
Giannelli, Valerio;
... Gracia-Sancho, Jordi; + view all
(2023)
Liver ischemia-reperfusion injury: From trigger loading to shot firing.
Liver Transplantation
, 29
(11)
pp. 1226-1233.
10.1097/LVT.0000000000000252.
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Okina, Y;
Sato-Matsubara, M;
Matsubara, T;
Daikoku, A;
Longato, L;
Rombouts, K;
Thanh Thuy, LT;
... Kawada, N; + view all
(2020)
TGF-β-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis.
Journal of Hepatology
10.1016/j.jhep.2020.03.051.
(In press).
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Pastore, M;
Caligiuri, A;
Raggi, C;
Navari, N;
Piombanti, B;
Di Maira, G;
Rovida, E;
... Marra, F; + view all
(2022)
Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators.
JHEP Reports
, 4
(4)
, Article 100444. 10.1016/j.jhepr.2022.100444.
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Pavlović, N;
Calitz, C;
Thanapirom, K;
Mazza, G;
Rombouts, K;
Gerwins, P;
Heindryckx, F;
(2020)
Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma.
eLife
, 9
, Article e55865. 10.7554/eLife.55865.
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Ratnayake, Gowri M;
Laskaratos, Faidon-Marios;
Mandair, Dalvinder;
Caplin, Martyn E;
Rombouts, Krista;
Toumpanakis, Christos;
(2022)
What Causes Desmoplastic Reaction in Small Intestinal Neuroendocrine Neoplasms?
Current Oncology Reports
, 24
pp. 1281-1286.
10.1007/s11912-022-01211-5.
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Rombouts, K;
Bemeur, C;
Rose, CF;
(2016)
Targeting the muscle for the treatment and prevention of hepatic encephalopathy.
Journal of Hepatology
, 65
(5)
pp. 876-878.
10.1016/j.jhep.2016.06.004.
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Sato-Matsubara, M;
Matsubara, T;
Daikoku, A;
Okina, Y;
Longato, L;
Rombouts, K;
Thuy, TTL;
... Kawada, N; + view all
(2017)
Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling.
Journal of Biological Chemistry
, 292
(46)
pp. 18961-18972.
10.1074/jbc.M117.793794.
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Simón Serrano, S;
Grönberg, A;
Longato, L;
Rombouts, K;
Kuo, J;
Gregory, M;
Moss, S;
... Massoumi, R; + view all
(2019)
Evaluation of NV556, a Novel Cyclophilin Inhibitor, as a Potential Antifibrotic Compound for Liver Fibrosis.
Cells
, 8
(11)
, Article 1409. 10.3390/cells8111409.
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Singh, Kasha P;
Pallett, Laura J;
Singh, Harsimran;
Chen, Antony;
Otano, Itziar;
Duriez, Marion;
Rombouts, Krista;
... Maini, Mala K; + view all
(2023)
Pro-fibrogenic role of alarmin HMGB1 in HIV-HBV co-infection.
AIDS
, 37
(3)
pp. 401-411.
10.1097/QAD.0000000000003435.
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Singh, HD;
Otano, I;
Rombouts, K;
Singh, KP;
Peppa, D;
Gill, US;
Bottcher, K;
... Maini, MK; + view all
(2017)
TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis.
Scientific Reports
, 7
, Article 5514. 10.1038/s41598-017-05845-5.
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Thanapirom, K;
Caon, E;
Papatheodoridi, M;
Frenguelli, L;
Al-akkad, W;
Zhenzhen, Z;
Vilia, MG;
... Rombouts, K; + view all
(2021)
Optimization and validation of a novel three-dimensional co-culture system in decellularized human liver scaffold for the study of liver fibrosis and cancer.
Cancers
, 13
(19)
, Article 4936. 10.3390/cancers13194936.
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Thomsen, KL;
De Chiara, F;
Rombouts, K;
Vilstrup, H;
Andreola, F;
Mookerjee, RP;
Jalan, R;
(2018)
Ammonia: A novel target for the treatment of Non-Alcoholic Steatohepatitis.
Medical Hypotheses
, 113
pp. 91-97.
10.1016/j.mehy.2018.02.010.
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van Dijk, F;
Hazelhoff, CM;
Post, E;
Prins, GGH;
Rombouts, K;
Poelstra, K;
Olinga, P;
(2020)
Design of a Gene Panel to Expose the Versatile Role of Hepatic Stellate Cells in Human Liver Fibrosis.
Pharmaceutics
, 12
(3)
p. 278.
10.3390/pharmaceutics12030278.
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Vespasiani-Gentilucci, U;
Rombouts, K;
(2014)
Boosting pigment epithelial-derived factor: a promising approach for the treatment of early portal hypertension.
Gut
10.1136/gutjnl-2014-307583.
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Zanieri, F;
Levi, A;
Montefusco, D;
Longato, L;
De Chiara, F;
Frenguelli, L;
Omenetti, S;
... Rombouts, K; + view all
(2020)
Exogenous Liposomal Ceramide-C6 Ameliorates Lipidomic Profile, Energy Homeostasis, and Anti-Oxidant Systems in NASH.
Cells
, 9
(5)
, Article 1237. 10.3390/cells9051237.
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Working / discussion paper
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Becares, N;
Gage, M;
Martin-Gutierrez, L;
Pourcet, B;
Louie, R;
Pello, O;
Luong, TV;
... Pineda Torra, I; + view all
(2017)
Changes In LXRα Phosphorylation Promote A Novel Diet-Induced Transcriptome That Alters The Transition From Fatty Liver To Steatohepatitis.
BioRxiv: Cold Spring Harbor, NY, USA.
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Thesis
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Al-Akkad Abu-Zeina, Walid;
(2020)
Decellularised Human Pancreata and Liver for the study of Pancreatic Ductal Adenocarcinoma: Development, Metastasis and Chemoresistance.
Doctoral thesis (Ph.D), UCL (University College London).
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Frenguelli, Luca;
(2020)
Development of Human Liver Extracellular Matrix Hydrogel for Three Dimensional Cell Culture and Cell Transplantation.
Doctoral thesis (Ph.D), UCL (University College London).
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Laskaratos, Faidon-Marios;
(2020)
Clinical outcomes and mechanisms of mesenteric fibrosis in small bowel neuroendocrine tumours.
Doctoral thesis (Ph.D), UCL (University College London).
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Mazza, G;
(2016)
The development of decellularised liver as a natural 3D scaffold for organ engineering and 3D disease modelling.
Doctoral thesis , UCL (University College London).
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