Laskaratos, F-M;
Rombouts, K;
Caplin, M;
Toumpanakis, C;
Thirlwell, C;
Mandair, D;
(2017)
Neuroendocrine tumors and fibrosis: An unsolved mystery?
Cancer
, 123
(24)
pp. 4770-4790.
10.1002/cncr.31079.
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Abstract
Neuroendocrine tumors are a heterogeneous group of slow-growing neoplasms arising mainly from the enterochromaffin cells of thedigestive and respiratory tract. Although they are relatively rare, their incidence is rising. It has long been observed that they oftenare associated with the development of fibrosis, both local and distant. Fibrotic complications, such as carcinoid heart disease andmesenteric desmoplasia, may lead to considerable morbidity or even affect prognosis. The elucidation of the pathophysiology offibrosis would be of critical importance for the development of targeted therapeutic strategies. In this article, the authors review theavailable evidence regarding the biological basis of fibrosis in neuroendocrine tumors. They explore the role of the tumor microenvi-ronment and the interplay between tumor cells and fibroblasts as a key factor in fibrogenesis and tumor development/progression.They also review the role of serotonin, growth factors, and other peptides in the development of carcinoid-related fibrotic reactions.
| Type: | Article |
|---|---|
| Title: | Neuroendocrine tumors and fibrosis: An unsolved mystery? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/cncr.31079 |
| Publisher version: | http://doi.org/10.1002/cncr.31079 |
| Language: | English |
| Additional information: | © 2017 American Cancer Society. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Oncology, carcinoid heart disease, carcinoid tumor, fibrosis, mesenteric desmoplasia, neuroendocrine tumor, CARCINOID HEART-DISEASE, TRANSFORMING-GROWTH-FACTOR, SEROTONIN 5-HT2B RECEPTORS, VALVE INTERSTITIAL-CELLS, IN-VIVO MODEL, FACTOR-BETA, TGF-BETA, EXTRACELLULAR-MATRIX, DOPAMINE AGONISTS, DIGESTIVE-SYSTEM |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10043023 |
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