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Neuroendocrine tumors and fibrosis: An unsolved mystery?

Laskaratos, F-M; Rombouts, K; Caplin, M; Toumpanakis, C; Thirlwell, C; Mandair, D; (2017) Neuroendocrine tumors and fibrosis: An unsolved mystery? Cancer , 123 (24) pp. 4770-4790. 10.1002/cncr.31079. Green open access

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Abstract

Neuroendocrine tumors are a heterogeneous group of slow-growing neoplasms arising mainly from the enterochromaffin cells of thedigestive and respiratory tract. Although they are relatively rare, their incidence is rising. It has long been observed that they oftenare associated with the development of fibrosis, both local and distant. Fibrotic complications, such as carcinoid heart disease andmesenteric desmoplasia, may lead to considerable morbidity or even affect prognosis. The elucidation of the pathophysiology offibrosis would be of critical importance for the development of targeted therapeutic strategies. In this article, the authors review theavailable evidence regarding the biological basis of fibrosis in neuroendocrine tumors. They explore the role of the tumor microenvi-ronment and the interplay between tumor cells and fibroblasts as a key factor in fibrogenesis and tumor development/progression.They also review the role of serotonin, growth factors, and other peptides in the development of carcinoid-related fibrotic reactions.

Type: Article
Title: Neuroendocrine tumors and fibrosis: An unsolved mystery?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/cncr.31079
Publisher version: http://doi.org/10.1002/cncr.31079
Language: English
Additional information: © 2017 American Cancer Society. This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, carcinoid heart disease, carcinoid tumor, fibrosis, mesenteric desmoplasia, neuroendocrine tumor, CARCINOID HEART-DISEASE, TRANSFORMING-GROWTH-FACTOR, SEROTONIN 5-HT2B RECEPTORS, VALVE INTERSTITIAL-CELLS, IN-VIVO MODEL, FACTOR-BETA, TGF-BETA, EXTRACELLULAR-MATRIX, DOPAMINE AGONISTS, DIGESTIVE-SYSTEM
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Internal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10043023
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