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Number of items: 34.
Article
Area-Gomez, E;
Larrea, D;
Pera, M;
Agrawal, RR;
Guilfoyle, DN;
Pirhaji, L;
Shannon, K;
... Nuriel, T; + view all
(2020)
APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice.
Scientific Reports
, 10
, Article 4277. 10.1038/s41598-020-61142-8.
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Blaudin de Thé, F-X;
Lassus, B;
Schaler, AW;
Fowler, SL;
Goulbourne, CN;
Jeggo, R;
Mannoury la Cour, C;
... Duff, KE; + view all
(2021)
P62 accumulates through neuroanatomical circuits in response to tauopathy propagation.
Acta Neuropathologica Communications
, 9
, Article 177. 10.1186/s40478-021-01280-w.
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Capano, LS;
Sato, C;
Ficulle, E;
Yu, A;
Horie, K;
Kwon, JS;
Burbach, KF;
... Yoo, AS; + view all
(2022)
Recapitulation of endogenous 4R tau expression and formation of insoluble tau in directly reprogrammed human neurons.
Cell Stem Cell
, 29
(6)
918-932.e8.
10.1016/j.stem.2022.04.018.
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Chen, S;
Acosta, D;
Li, L;
Liang, J;
Chang, Y;
Wang, C;
Fitzgerald, J;
... Fu, H; + view all
(2022)
Wolframin is a novel regulator of tau pathology and neurodegeneration.
Acta Neuropathologica
, 143
pp. 547-569.
10.1007/s00401-022-02417-4.
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Chen, S;
Chang, Y;
Li, L;
Acosta, D;
Li, Y;
Guo, Q;
Wang, C;
... Fu, H; + view all
(2022)
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease.
Acta Neuropathologica Communications
, 10
(1)
, Article 188. 10.1186/s40478-022-01494-6.
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Clelland, James D;
Read, Laura L;
Drouet, Valerie;
Kaon, Angela;
Kelly, Alexandra;
Duff, Karen E;
Nadrich, Robert H;
... Clelland, Catherine L; + view all
(2014)
Vitamin D insufficiency and schizophrenia risk: Evaluation of hyperprolinemia as a mediator of association.
Schizophrenia Research
, 156
(1)
pp. 15-22.
10.1016/j.schres.2014.03.017.
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Fa, M;
Puzzo, D;
Piacentini, R;
Staniszewski, A;
Zhang, H;
Baltrons, MA;
Li Puma, DD;
... Arancio, O; + view all
(2016)
Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory.
Scientific Reports
, 6
, Article 19393. 10.1038/srep19393.
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Fowler, Stephanie L;
Behr, Tiana S;
Turkes, Emir;
O'Brien, Darragh P;
Cauhy, Paula Maglio;
Rawlinson, Isadora;
Edmonds, Marisa;
... Ryskeldi-Falcon, Benjamin; + view all
(2025)
Tau filaments are tethered within brain extracellular vesicles in Alzheimer's disease.
Nature Neuroscience
, 28
(1)
pp. 40-48.
10.1038/s41593-024-01801-5.
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Fu, Hongjun;
Possenti, Andrea;
Freer, Rosie;
Nakano, Yoshikazu;
Hernandez Villegas, Nancy C;
Tang, Maoping;
Cauhy, Paula VM;
... Duff, Karen E; + view all
(2019)
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology.
Nature Neuroscience
, 22
pp. 47-56.
10.1038/s41593-018-0298-7.
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Fu, Hongjun;
Rodriguez, Gustavo A;
Herman, Mathieu;
Emrani, Sheina;
Nahmani, Eden;
Barrett, Geoffrey;
Figueroa, Helen Y;
... Duff, Karen E; + view all
(2017)
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease.
Neuron
, 93
(3)
533-541.e5.
10.1016/j.neuron.2016.12.023.
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Fu, H;
Hardy, J;
Duff, KE;
(2018)
Selective vulnerability in neurodegenerative diseases.
Nature Neuroscience
, 21
(10)
pp. 1350-1358.
10.1038/s41593-018-0221-2.
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Fung, CW;
Guo, J;
Fu, H;
Figueroa, HY;
Konofagou, EE;
Duff, KE;
(2020)
Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy.
Science Advances
, 6
(42)
, Article eabc8098. 10.1126/sciadv.abc8098.
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Jabbari, E;
Duff, KE;
(2021)
Tau-targeting antibody therapies: too late, wrong epitope or wrong target?
Nature Medicine
, 27
(8)
pp. 1341-1342.
10.1038/s41591-021-01465-9.
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Karakatsani, Maria Eleni;
Ji, Robin;
Murillo, Maria F;
Kugelman, Tara;
Kwon, Nancy;
Lao, Yeh-Hsing;
Liu, Keyu;
... Konofagou, Elisa E; + view all
(2023)
Focused ultrasound mitigates pathology and improves spatial memory in Alzheimer's mice and patients.
Theranostics
, 13
(12)
pp. 4102-4120.
10.7150/thno.79898.
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Khan, Usman A;
Liu, Li;
Provenzano, Frank A;
Berman, Diego E;
Profaci, Caterina P;
Sloan, Richard;
Mayeux, Richard;
... Small, Scott A; + view all
(2014)
Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease.
nature neuroscience
, 17
pp. 304-311.
10.1038/nn.3606.
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Kumar, JS Dileep;
Molotkov, Andrei;
Kim, Jongho;
Carberry, Patrick;
Idumonyi, Sidney;
Castrillon, John;
Duff, Karen;
... Mintz, Akiva; + view all
(2022)
Preclinical evaluation of a microtubule PET ligand [C-11]MPC-6827 in tau and amyotrophic lateral sclerosis animal models.
Pharmacological Reports
, 74
pp. 539-544.
10.1007/s43440-022-00359-y.
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Langworth-Green, C;
Patel, S;
Jaunmuktane, Z;
Jabbari, E;
Morris, H;
Thom, M;
Lees, A;
... Duff, K; + view all
(2023)
Chronic effects of inflammation on tauopathies.
The Lancet Neurology
, 22
(5)
pp. 430-442.
10.1016/S1474-4422(23)00038-8.
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Liu, Li;
Drouet, Valerie;
Wu, Jessica W;
Witter, Menno P;
Small, Scott A;
Clelland, Catherine;
Duff, Karen;
(2012)
Trans-Synaptic Spread of Tau Pathology In Vivo.
PLOS ONE
, 7
(2)
, Article e31302. 10.1371/journal.pone.0031302.
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Meisl, G;
Hidari, E;
Allinson, K;
Rittman, T;
DeVos, SL;
Sanchez, JS;
Xu, CK;
... Klenerman, D; + view all
(2021)
In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease.
Science Advances
, 7
(44)
, Article eabh1448. 10.1126/sciadv.abh1448.
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Miranda, AM;
Ashok, A;
Chan, RB;
Zhou, B;
Xu, Y;
McIntire, LB;
Area-Gomez, E;
... Nuriel, T; + view all
(2022)
Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice.
Translational psychiatry
, 12
(1)
, Article 129. 10.1038/s41398-022-01881-6.
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Morito, Takahiro;
Qi, Mohan;
Kamano, Naoko;
Sasaguri, Hiroki;
Bez, Sumi;
Foiani, Martha;
Duff, Karen;
... Watamura, Naoto; + view all
(2025)
Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community.
Cell Reports: Methods
, 5
(4)
, Article 101024. 10.1016/j.crmeth.2025.101024.
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Myeku, Natura;
Clelland, Catherine L;
Emrani, Sheina;
Kukushkin, Nikolay V;
Yu, Wai Haung;
Goldberg, Alfred L;
Duff, Karen E;
(2016)
Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.
nature medicine
, 22
pp. 46-53.
10.1038/nm.4011.
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Nuriel, T;
Angulo, SL;
Khan, U;
Ashok, A;
Chen, Q;
Figueroa, HY;
Emrani, S;
... Duff, KE; + view all
(2017)
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology.
Nature Communications
, 8
, Article 1464. 10.1038/s41467-017-01444-0.
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Pappolla, Miguel A;
Refolo, Lorenzo;
Sambamurti, Kumar;
Zambon, Daniel;
Duff, Karen;
(2024)
Hypercholesterolemia and Alzheimer’s Disease: Unraveling the Connection and Assessing the Efficacy of Lipid-Lowering Therapies.
Journal of Alzheimer's Disease
, 101
(s1)
S371-S393.
10.3233/JAD-240388.
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Rodriguez, GA;
Barrett, GM;
Duff, KE;
Hussaini, SA;
(2020)
Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus.
PLoS Biology
, 18
(8)
, Article e3000851. 10.1371/journal.pbio.3000851.
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Schaler, AW;
Runyan, AM;
Clelland, CL;
Sydney, EJ;
Fowler, SL;
Figueroa, HY;
Shioda, S;
... Myeku, N; + view all
(2021)
PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain.
Science Translational Medicine
, 13
(595)
, Article eaba7394. 10.1126/scitranslmed.aba7394.
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Song, S;
Ashok, A;
Williams, D;
Kaufman, M;
Duff, K;
Sproul, A;
(2021)
Efficient Derivation of Excitatory and Inhibitory Neurons from Human Pluripotent Stem Cells Stably Expressing Direct Reprogramming Factors.
Current Protocols
, 1
(6)
, Article e141. 10.1002/cpz1.141.
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Taddei, Raquel N;
Duff, Karen E;
(2025)
Synapse vulnerability and resilience across the clinical spectrum of dementias.
Nature Reviews Neurology
, 21
pp. 353-369.
10.1038/s41582-025-01094-7.
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Taddei, Raquel N;
Duff, Karen E;
(2025)
Synapse vulnerability and resilience underlying Alzheimer's disease.
eBioMedicine
, 112
, Article 105557. 10.1016/j.ebiom.2025.105557.
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Taddei, Raquel N;
Perbet, Romain;
Mate de Gerando, Anastasie;
Wiedmer, Anne E;
Sanchez-Mico, Maria;
Connors Stewart, Theresa;
Gaona, Angelica;
... Gómez-Isla, Teresa; + view all
(2023)
Tau Oligomer–Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease.
JAMA Neurology
10.1001/jamaneurol.2023.3530.
(In press).
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Walker, Lary C;
Diamond, Marc I;
Duff, Karen E;
Hyman, Bradley T;
(2013)
Mechanisms of Protein Seeding in Neurodegenerative Diseases.
JAMA Neurology
, 70
(3)
pp. 304-310.
10.1001/jamaneurol.2013.1453.
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Watamura, Naoto;
Foiani, Martha S;
Bez, Sumi;
Bourdenx, Mathieu;
Santambrogio, Alessia;
Frodsham, Claire;
Camporesi, Elena;
... Saido, Takaomi C; + view all
(2024)
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds.
Nature Neuroscience
, 28
pp. 293-307.
10.1038/s41593-024-01829-7.
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Wu, Jessica W;
Herman, Mathieu;
Liu, Li;
Simoes, Sabrina;
Acker, Christopher M;
Figueroa, Helen;
Steinberg, Joshua I;
... Duff, Karen E; + view all
(2013)
Small Misfolded Tau Species Are Internalized via Bulk
Endocytosis and Anterogradely and Retrogradely
Transported in Neurons.
Journal of Biological Chemistry (JBC)
, 288
(3)
pp. 1856-1870.
10.1074/jbc.M112.394528.
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Wu, JW;
Hussaini, SA;
Bastille, IM;
Rodriguez, GA;
Mrejeru, A;
Rilett, K;
Sanders, DW;
... Duff, KE; + view all
(2016)
Neuronal activity enhances tau propagation and tau pathology in vivo.
Nature Neuroscience
, 19
(8)
pp. 1085-1092.
10.1038/nn.4328.
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