Browse by UCL people
Group by: Type | Date
Number of items: 51.
2025
Henry, Albert;
Mo, Xiaodong;
Finan, Chris;
Chaffin, Mark D;
Speed, Doug;
Issa, Hanane;
Denaxas, Spiros;
... HERMES Consortium; + view all
(2025)
Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.
Nature Genetics
10.1038/s41588-024-02064-3.
(In press).
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Mcintosh, Andrew M;
Lewis, Cathryn M;
(2025)
Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.
Cell
, 188
(3)
640-652.e9.
10.1016/j.cell.2024.12.002.
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2024
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Dunca, Diana;
Chopade, Sandesh;
Gordillo-Maranon, Maria;
Hingorani, Aroon D;
Kuchenbaecker, Karoline;
Finan, Chris;
Schmidt, Amand F;
(2024)
Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study.
Nature Communications
, 15
(1)
, Article 5302. 10.1038/s41467-024-49109-z.
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Meng, Xiangrui;
Navoly, Georgina;
Giannakopoulou, Olga;
Levey, Daniel F;
Koller, Dora;
Pathak, Gita A;
Koen, Nastassja;
... Kuchenbaecker, Karoline; + view all
(2024)
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference.
Nature Genetics
10.1038/s41588-023-01596-4.
(In press).
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2023
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Austin-Zimmerman, Isabelle;
Levey, Daniel F;
Giannakopoulou, Olga;
Deak, Joseph D;
Galimberti, Marco;
Adhikari, Keyrun;
Zhou, Hang;
... Gelernter, Joel; + view all
(2023)
Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration.
Nature Communications
, 14
, Article 6059. 10.1038/s41467-023-41249-y.
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Martins Custodio, Helena;
Clayton, Lisa M;
Bellampalli, Ravishankara;
Pagni, Susanna;
Silvennoinen, Katri;
Caswell, Richard;
Genomics England Research Consortium;
... Sisodiya, Sanjay M; + view all
(2023)
Widespread genomic influences on phenotype in Dravet syndrome, a 'monogenic' condition.
Brain
, Article awad111. 10.1093/brain/awad111.
(In press).
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Mueller, Stefanie H;
Lai, Alvina G;
Valkovskaya, Maria;
Michailidou, Kyriaki;
Bolla, Manjeet K;
Wang, Qin;
Dennis, Joe;
... Kuchenbaecker, Karoline B; + view all
(2023)
Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry.
Genome Medicine
, 15
, Article 7. 10.1186/s13073-022-01152-5.
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O'Loughlin, Jessica;
Casanova, Francesco;
Fairhurst-Hunter, Zammy;
Hughes, Amanda;
Bowden, Jack;
Watkins, Edward R;
Freathy, Rachel M;
... Tyrrell, Jessica; + view all
(2023)
Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality.
BMC Medicine
, 21
(1)
, Article 37. 10.1186/s12916-023-02735-8.
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Shoham, Natalie;
Dunca, Diana;
Cooper, Claudia;
Hayes, Joseph F;
McQuillin, Andrew;
Bass, Nick;
Lewis, Gemma;
(2023)
Investigating the association between schizophrenia and distance visual acuity: Mendelian randomisation study.
BJPsych Open
, 9
(2)
, Article e33. 10.1192/bjo.2023.6.
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Wang, Baihan;
Irizar, Haritz;
Thygesen, Johan H;
Zartaloudi, Eirini;
Austin-Zimmerman, Isabelle;
Bhat, Anjali;
Harju-Seppänen, Jasmine;
... Bramon, Elvira; + view all
(2023)
Psychosis Endophenotypes: A Gene-Set-Specific Polygenic Risk Score Analysis.
Schizophrenia Bulletin
, Article sbad088. 10.1093/schbul/sbad088.
(In press).
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2022
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Borde, Julika;
Laitman, Yael;
Bluemcke, Britta;
Niederacher, Dieter;
Weber-Lassalle, Konstantin;
Sutter, Christian;
Rump, Andreas;
... Ernst, Corinna; + view all
(2022)
Polygenic risk scores indicate extreme ages at onset of breast cancer in female BRCA1/2 pathogenic variant carriers.
BMC Cancer
, 22
(1)
, Article 706. 10.1186/s12885-022-09780-1.
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Fatumo, S;
Chikowore, T;
Choudhury, A;
Ayub, M;
Martin, AR;
Kuchenbaecker, K;
(2022)
A roadmap to increase diversity in genomic studies.
Nature Medicine
, 28
(2)
pp. 243-250.
10.1038/s41591-021-01672-4.
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Fatumo, Segun;
Chikowore, Tinashe;
Kuchenbaecker, Karoline;
(2022)
Editorial: Genetics of Complex Traits and Diseases From Under-Represented Populations.
Frontiers in Genetics
, 12
, Article 817683. 10.3389/fgene.2021.817683.
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Hodgson, Sam;
Huang, Qin Qin;
Sallah, Neneh;
Genes & Health Research Team, .;
Griffiths, Chris J;
Newman, William G;
Trembath, Richard C;
... Finer, Sarah; + view all
(2022)
Integrating polygenic risk scores in the prediction of type 2 diabetes risk and subtypes in British Pakistanis and Bangladeshis: A population-based cohort study.
PLoS Med
, 19
(5)
, Article e1003981. 10.1371/journal.pmed.1003981.
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Huang, Qin Qin;
Sallah, Neneh;
Dunca, Diana;
Trivedi, Bhavi;
Hunt, Karen A;
Hodgson, Sam;
Lambert, Samuel A;
... Kuchenbaecker, Karoline; + view all
(2022)
Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals.
Nature Communications
, 13
, Article 4664. 10.1038/s41467-022-32095-5.
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Javidnia, Sara;
Cranwell, Stephen;
Mueller, Stefanie H;
Selman, Colin;
Tullet, Jennifer MA;
Kuchenbaecker, Karoline;
Alic, Nazif;
(2022)
Mendelian randomization analyses implicate biogenesis of translation machinery in human aging.
Genome Research
, 32
(2)
pp. 258-265.
10.1101/gr.275636.121.
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Kuchenbaecker, Karoline;
(2022)
Missing heritability found for height.
Nature
, 610
(7933)
pp. 631-632.
10.1038/d41586-022-03029-4.
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Kuchenbaecker, Karoline;
Gilly, Arthur;
Suveges, Daniel;
Southam, Lorraine;
Giannakopoulou, Olga;
Kilian, Britt;
Tsafantakis, Emmanouil;
... Zeggini, Eleftheria; + view all
(2022)
Insights into the genetic architecture of haematological traits from deep phenotyping and whole-genome sequencing for two Mediterranean isolated populations.
Scientific Reports
, 12
(1)
, Article 1131. 10.1038/s41598-021-04436-9.
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Mukadam, Naaheed;
Giannakopoulou, Olga;
Bass, Nick;
Kuchenbaecker, Karoline;
McQuillin, Andrew;
(2022)
Genetic risk scores and dementia risk across different ethnic groups in UK Biobank.
PLoS One
, 17
(12)
, Article e0277378. 10.1371/journal.pone.0277378.
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2021
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Bhat, A;
Irizar, H;
Thygesen, JH;
Kuchenbaecker, K;
Pain, O;
Adams, RA;
Zartaloudi, E;
... Bramon, E; + view all
(2021)
Transcriptome-wide association study reveals two genes that influence mismatch negativity.
Cell Reports
, 34
(11)
, Article 108868. 10.1016/j.celrep.2021.108868.
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Borde, J;
Ernst, C;
Wappenschmidt, B;
Niederacher, D;
Weber-Lasalle, K;
Schmidt, G;
Hauke, J;
... Hahnen, E; + view all
(2021)
Performance of Breast Cancer Polygenic Risk Scores in 760 Female CHEK2 Germline Mutation Carriers.
JNCI: Journal of the National Cancer Institute
, 113
(7)
pp. 893-899.
10.1093/jnci/djaa203.
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Farmaki, A-E;
Garfield, V;
Eastwood, SV;
Farmer, RE;
Mathur, R;
Giannakopoulou, O;
Patalay, P;
... Chaturvedi, N; + view all
(2021)
Type 2 diabetes risks and determinants in second-generation migrants and mixed ethnicity people of South Asian and African Caribbean descent in the UK.
Diabetologia
10.1007/s00125-021-05580-7.
(In press).
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Giannakopoulou, O;
Lin, K;
Meng, X;
Su, M-H;
Kuo, P-H;
Peterson, RE;
Awasthi, S;
... 23andMe Research Team, China Kadoorie Biobank Collaborative Grou; + view all
(2021)
The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.
JAMA Psychiatry
10.1001/jamapsychiatry.2021.2099.
(In press).
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Lumbers, RT;
Shah, S;
Lin, H;
Czuba, T;
Henry, A;
Swerdlow, D;
Malarstig, A;
... Smith, JG; + view all
(2021)
The genomics of heart failure: design and rationale of the HERMES consortium.
ESC Heart Failure
10.1002/ehf2.13517.
(In press).
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2020
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Shah, S;
Henry, A;
Roselli, C;
Lin, H;
Sveinbjörnsson, G;
Fatemifar, G;
Hedman, ÅK;
... Lumbers, RT; + view all
(2020)
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure.
Nature Communications
, 11
, Article 163. 10.1038/s41467-019-13690-5.
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Thygesen, JH;
Presman, A;
Harju-Seppanen, J;
Irizar, H;
Jones, R;
Kuchenbaecker, K;
Lin, K;
... Bramon, E; + view all
(2020)
Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study.
Molecular Psychiatry
10.1038/s41380-020-0820-7.
(In press).
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2019
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Giannakopoulou, O;
Dunn, E;
Lewis, C;
Kuchenbaecker, K;
(2019)
Genetic Associations With Depression in Ancestrally Diverse Populations.
Presented at: 27th World Congress of Psychiatric Genetics (WCPG), Los Angeles, CA, USA.
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Jiang, X;
Finucane, HK;
Schumacher, FR;
Schmit, SL;
Tyrer, JP;
Han, Y;
Michailidou, K;
... Lindström, S; + view all
(2019)
Shared heritability and functional enrichment across six solid cancers.
Nature Communications
, 10
(1)
, Article 431. 10.1038/s41467-018-08054-4.
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Kuchenbaecker, K;
Telkar, N;
Reiker, T;
Walters, RG;
Lin, K;
Eriksson, A;
Gurdasani, D;
... Understanding Society Scientific Group; + view all
(2019)
The transferability of lipid loci across African, Asian and European cohorts.
Nature Communications
, 10
, Article 4330. 10.1038/s41467-019-12026-7.
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Peterson, RE;
Kuchenbaecker, K;
Walters, RK;
Chen, C-Y;
Popejoy, AB;
Periyasamy, S;
Lam, M;
... Duncan, LE; + view all
(2019)
Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations.
Cell
, 179
(3)
pp. 589-603.
10.1016/j.cell.2019.08.051.
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Stanley, K;
Whitfield, T;
Kuchenbaecker, K;
Sanders, O;
Stevens, T;
Walker, Z;
(2019)
Rate of Cognitive Decline in Alzheimer's Disease Stratified by Age.
Journal of Alzheimer's Disease
, 69
(4)
pp. 1153-1160.
10.3233/JAD-181047.
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2018
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Gilly, A;
Southam, L;
Suveges, D;
Kuchenbaecker, K;
Moore, R;
Melloni, GEM;
Hatzikotoulas, K;
... Zeggini, E; + view all
(2018)
Very low depth whole genome sequencing in complex trait association studies.
Bioinformatics
10.1093/bioinformatics/bty1032.
(In press).
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Gilly, A;
Suveges, D;
Kuchenbaecker, K;
Pollard, M;
Southam, L;
Hatzikotoulas, K;
Farmaki, A-E;
... Zeggini, E; + view all
(2018)
Author Correction: Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits.
Nature Communications
, 9
, Article 5460. 10.1038/s41467-018-07730-9.
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Gilly, A;
Suveges, D;
Kuchenbaecker, K;
Pollard, M;
Southam, L;
Hatzikotoulas, K;
Farmaki, A-E;
... Zeggini, E; + view all
(2018)
Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits.
Nature Communications
, 9
(1)
, Article 4674. 10.1038/s41467-018-07070-8.
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Mamakou, V;
Hackinger, S;
Zengini, E;
Tsompanaki, E;
Marouli, E;
Serafetinidis, I;
Prins, B;
... Zeggini, E; + view all
(2018)
Combination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: The GOMAP study.
BMC Psychiatry
, 18
, Article 249. 10.1186/s12888-018-1826-4.
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2017
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Amos, CI;
Dennis, J;
Wang, Z;
Byun, J;
Schumacher, FR;
Gayther, SA;
Casey, G;
... Easton, DF; + view all
(2017)
The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers.
Cancer Epidemiology, Biomarkers and Prevention
, 26
(1)
pp. 126-135.
10.1158/1055-9965.EPI-16-0106.
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Kuchenbaecker, KB;
Hopper, JL;
Barnes, DR;
Phillips, K-A;
Mooij, TM;
Roos-Blom, M-J;
Jervis, S;
... Olsson, H; + view all
(2017)
Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers.
JAMA
, 317
(23)
pp. 2402-2416.
10.1001/jama.2017.7112.
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Kuchenbaecker, KB;
McGuffog, L;
Barrowdale, D;
Lee, A;
Soucy, P;
Dennis, J;
Domchek, SM;
... Antoniou, AC; + view all
(2017)
Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers.
JNCI: Journal of the National Cancer Institute
, 109
(7)
, Article djw302. 10.1093/jnci/djw302.
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Lecarpentier, J;
Silvestri, V;
Kuchenbaecker, KB;
Barrowdale, D;
Dennis, J;
McGuffog, L;
Soucy, P;
... Ottini, L; + view all
(2017)
Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores.
Journal of Clinical Oncology
, 35
(20)
pp. 2240-2250.
10.1200/JCO.2016.69.4935.
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Milne, RL;
Kuchenbaecker, KB;
Michailidou, K;
Beesley, J;
Kar, S;
Lindström, S;
Hui, S;
... Simard, J; + view all
(2017)
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.
Nature Genetics
, 49
pp. 1767-1778.
10.1038/ng.3785.
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Phelan, CM;
Kuchenbaecker, KB;
Tyrer, JP;
Kar, SP;
Lawrenson, K;
Winham, SJ;
Dennis, J;
... Pharoah, PDP; + view all
(2017)
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
Nature Genetics
, 49
(5)
pp. 680-691.
10.1038/ng.3826.
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Prins, BP;
Kuchenbaecker, KB;
Bao, Y;
Smart, M;
Zabaneh, D;
Fatemifar, G;
Luan, J;
... Zeggini, E; + view all
(2017)
Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations.
Scientific Reports
, 7
, Article 11008. 10.1038/s41598-017-10812-1.
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2016
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Couch, FJ;
Kuchenbaecker, KB;
Michailidou, K;
Mendoza-Fandino, GA;
Nord, S;
Lilyquist, J;
Olswold, C;
... Antoniou, AC; + view all
(2016)
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.
Nature Communications
, 7
, Article 11375. 10.1038/ncomms11375.
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Swerdlow, DI;
Kuchenbaecker, KB;
Shah, S;
Sofat, R;
Holmes, MV;
White, J;
Mindell, JS;
... Hingorani, AD; + view all
(2016)
Selecting instruments for Mendelian randomization in the wake of genome-wide association studies.
International Journal of Epidemiology
, 45
(5)
pp. 1600-1616.
10.1093/ije/dyw088.
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Vigorito, E;
Kuchenbaecker, KB;
Beesley, J;
Adlard, J;
Agnarsson, BA;
Andrulis, IL;
Arun, BK;
... Antoniou, AC; + view all
(2016)
Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
PLoS One
, 11
(7)
, Article e0158801. 10.1371/journal.pone.0158801.
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Zeng, C;
Guo, X;
Long, J;
Kuchenbaecker, KB;
Droit, A;
Michailidou, K;
Ghoussaini, M;
... Zheng, W; + view all
(2016)
Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus.
Breast Cancer Research
, 18
, Article 64. 10.1186/s13058-016-0718-0.
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2015
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Ovarian Cancer Association Consortium, Breast Cancer Association;
Hollestelle, A;
van der Baan, FH;
Berchuck, A;
Johnatty, SE;
Aben, KK;
Agnarsson, BA;
... Goode, EL; + view all
(2015)
No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.
Gynecologic Oncology
, 141
(2)
pp. 386-401.
10.1016/j.ygyno.2015.04.034.
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2014
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Holmes, MV;
Dale, CE;
Zuccolo, L;
Silverwood, RJ;
Guo, Y;
Ye, Z;
Prieto-Merino, D;
... InterAct Consortium; + view all
(2014)
Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.
BMJ
, 349
, Article g4164. 10.1136/bmj.g4164.
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Swerdlow, DI;
Preiss, D;
Kuchenbaecker, KB;
Holmes, MV;
Engmann, JE;
Shah, T;
Sofat, R;
... Sattar, N; + view all
(2014)
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials.
Lancet
, 385
(9965)
pp. 351-361.
10.1016/S0140-6736(14)61183-1.
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2013
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Couch, FJ;
Wang, X;
McGuffog, L;
Lee, A;
Olswold, C;
Kuchenbaecker, KB;
Soucy, P;
... CIMBA; + view all
(2013)
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
PLoS Genet
, 9
(3)
, Article e1003212. 10.1371/journal.pgen.1003212.
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2012
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Casas, JP;
Hingorani, AD;
(2012)
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Lancet
, 379
(9822)
1214 - 1224.
10.1016/S0140-6736(12)60110-X.
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