Browse by UCL people
Group by: Type | Date
Number of items: 64.
Article
Aalto, AL;
Mohan, AK;
Schwintzer, L;
Kupka, S;
Kietz, C;
Walczak, H;
Broemer, M;
(2018)
M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila.
Cell Death & Differentiation
10.1038/s41418-018-0164-x.
(In press).
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Annibaldi, A;
Walczak, H;
(2020)
Death Receptors and Their Ligands in Inflammatory Disease and Cancer.
Cold Spring Harbor Perspectives in Biology
10.1101/cshperspect.a036384.
(In press).
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Au, L;
Hatipoglu, E;
Robert de Massy, M;
Litchfield, K;
Beattie, G;
Rowan, A;
Schnidrig, D;
... TRACERx Renal Consortium; + view all
(2021)
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma.
Cancer Cell
, 39
pp. 1497-1518.
10.1016/j.ccell.2021.10.001.
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Boege, Y;
Malehmir, M;
Healy, ME;
Bettermann, K;
Lorentzen, A;
Vucur, M;
Ahuja, AK;
... Weber, A; + view all
(2017)
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Cancer Cell
, 32
(3)
pp. 342-359.
10.1016/j.ccell.2017.08.010.
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Bolik, J;
Krause, F;
Stevanovic, M;
Gandraß, M;
Thomsen, I;
Schacht, S-S;
Rieser, E;
... Schmidt-Arras, D; + view all
(2022)
Inhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis.
J Exp Med
, 219
(1)
, Article e20201039. 10.1084/jem.20201039.
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Chen, Yu-Guang;
Rieser, Eva;
Bhamra, Amandeep;
Surinova, Silvia;
Kreuzaler, Peter;
Ho, Meng-Hsing;
Tsai, Wen-Chiuan;
... Walczak, Henning; + view all
(2024)
LUBAC enables tumor-promoting LTβ receptor signaling by
activating canonical NF-κB.
Cell Death & Differentiation
, 31
(10)
pp. 1267-1284.
10.1038/s41418-024-01355-w.
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Di Benedetto, Carolina;
Khan, Taimoor;
Serrano-Saenz, Santiago;
Rodriguez-Lemus, Anthony;
Klomsiri, Chananat;
Beutel, Tim-Mathis;
Thach, Alysia;
... Betancur, Paola; + view all
(2023)
Enhancer Clusters Drive Type I Interferon-Induced TRAIL Overexpression in Cancer, and Its Intracellular Protein Accumulation Fails to Induce Apoptosis.
Cancers
, 15
(3)
, Article 967. 10.3390/cancers15030967.
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Dondelinger, Y;
Darding, M;
Bertrand, MJ;
Walczak, H;
(2016)
Poly-ubiquitination in TNFR1-mediated necroptosis.
Cellular Molecular Life Sciences
, 73
(11)
pp. 2165-2176.
10.1007/s00018-016-2191-4.
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Galleu, A;
Riffo-Vasquez, Y;
Trento, C;
Lomas, C;
Dolcetti, L;
Cheung, TS;
von Bonin, M;
... Dazzi, F; + view all
(2017)
Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation.
Science Translational Medicine
, 9
(416)
, Article eaam7828. 10.1126/scitranslmed.aam7828.
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Galluzzi, L;
Bravo-San Pedro, JM;
Vitale, I;
Aaronson, SA;
Abrams, JM;
Adam, D;
Alnemri, ES;
... Kroemer, G; + view all
(2015)
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.
Cell Death and Differentiation
, 22
(1)
pp. 58-73.
10.1038/cdd.2014.137.
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Galluzzi, L;
Vitale, I;
Aaronson, SA;
Abrams, JM;
Adam, D;
Agostinis, P;
Alnemri, ES;
... Kroemer, G; + view all
(2018)
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Cell Death & Differentiation
10.1038/s41418-017-0012-4.
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Galvez-Cancino, Felipe;
Navarrete, Mariela;
Beattie, Gordon;
Puccio, Simone;
Conde-Gallastegi, Enrique;
Foster, Kane;
Morris, Yasmin;
... Quezada, Sergio A; + view all
(2025)
Correction:
Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies.
[Corrigendum].
Immunity
, 58
(7)
pp. 1862-1864.
10.1016/j.immuni.2025.05.019.
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Giampazolias, E;
Zunino, B;
Dhayade, S;
Bock, F;
Cloix, C;
Cao, K;
Roca, A;
... Tait, SWG; + view all
(2017)
Mitochondrial permeabilization engages NF-kappa B-dependent anti-tumour activity under caspase deficiency.
Nature Cell Biology
, 19
(9)
pp. 1116-1129.
10.1038/ncb3596.
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Hartwig, T;
Montinaro, A;
von Karstedt, S;
Sevko, A;
Surinova, S;
Chakravarthy, A;
Taraborrelli, L;
... Walczak, H; + view all
(2017)
The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2.
Molecular Cell
, 65
(4)
pp. 730-742.
10.1016/j.molcel.2017.01.021.
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Hildebrandt, X;
Veli, Ö;
Hyoubi, A;
Zinngrebe, J;
Abdallah, AT;
Rodefeld, J;
Hoffmann, A;
... Peltzer, N; + view all
(2025)
Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome.
Science Advances
, 11
(38)
, Article eadw2539. 10.1126/sciadv.adw2539.
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Jain, R;
Zhao, K;
Sheridan, JM;
Heinlein, M;
Kupresanin, F;
Abeysekera, W;
Hall, C;
... Gray, DHD; + view all
(2021)
Dual roles for LUBAC signaling in thymic epithelial cell development and survival.
Cell Death & Differentiation
, 28
(10)
pp. 2946-2956.
10.1038/s41418-021-00850-8.
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Kolluri, KK;
Alifrangis, C;
Kumar, N;
Ishii, Y;
Price, S;
Michaut, M;
Williams, S;
... Janes, SM; + view all
(2018)
Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells.
eLIFE
, 7
, Article e30224. 10.7554/eLife.30224.
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Koschny, R;
Brost, S;
Hinz, U;
Sykora, J;
Batke, EM;
Singer, S;
Breuhahn, K;
... Ganten, TM; + view all
(2013)
Cytosolic and nuclear caspase-8 have opposite impact on survival after liver resection for hepatocellular carcinoma.
BMC Cancer
, 13
, Article 532. 10.1186/1471-2407-13-532.
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Krishna-Subramanian, S;
Singer, S;
Armaka, M;
Banales, JM;
Holzer, K;
Schirmacher, P;
Walczak, H;
... Kondylis, V; + view all
(2019)
RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury.
Cell Death & Differentiation
10.1038/s41418-019-0330-9.
(In press).
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Kupka, S;
De Miguel, D;
Draber, P;
Martino, L;
Surinova, S;
Rittinger, K;
Walczak, H;
(2016)
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
Cell Reports
, 16
(9)
pp. 2271-2280.
10.1016/j.celrep.2016.07.086.
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Lafont, E;
Draber, P;
Rieser, E;
Reichert, M;
Kupka, S;
de Miguel, D;
Draberova, H;
... Walczak, H; + view all
(2018)
TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation.
Nature Cell Biology
, 20
(12)
pp. 1389-1399.
10.1038/s41556-018-0229-6.
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Lafont, E;
Hartwig, T;
Walczak, H;
(2018)
Paving TRAIL's Path with Ubiquitin.
Trends in Biochemical Sciences
, 43
(1)
pp. 44-60.
10.1016/j.tibs.2017.11.002.
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Lafont, E;
Kantari-Mimoun, C;
Draber, P;
De Miguel, D;
Hartwig, T;
Reichert, M;
Kupka, S;
... Walczak, H; + view all
(2017)
The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death.
EMBO Journal
, 36
(6)
, Article e201695699. 10.15252/embj.201695699.
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Lagunas, Kristel Martinez;
Savcigil, Deniz Pinar;
Zrilic, Matea;
Fraile, Carlos Carvajal;
Craxton, Andrew;
Self, Emily;
Uranga-Murillo, Iratxe;
... Annibaldi, Alessandro; + view all
(2023)
Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair.
Science Advances
, 9
(30)
, Article eadg2829. 10.1126/sciadv.adg2829.
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Lemke, J;
von Karstedt, S;
Abd El Hay, M;
Conti, A;
Arce, F;
Montinaro, A;
Papenfuss, K;
... Walczak, H; + view all
(2014)
Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1.
Cell Death Differ
, 21
(3)
pp. 491-502.
10.1038/cdd.2013.179.
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Lemke, J;
von Karstedt, S;
Zinngrebe, J;
Walczak, H;
(2014)
Getting TRAIL back on track for cancer therapy.
Cell Death Differ
, 21
(9)
pp. 1350-1364.
10.1038/cdd.2014.81.
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Li, Xiang;
Huang, Chun-Hao;
Sánchez-Rivera, Francisco J;
Kennedy, Margaret C;
Tschaharganeh, Darjus F;
Morris, John P;
Montinaro, Antonella;
... Lowe, Scott W; + view all
(2022)
A preclinical platform for assessing antitumor effects and systemic toxicities of cancer drug targets.
Proceedings of the National Academy of Sciences
, 119
(17)
, Article e2110557119. 10.1073/pnas.2110557119.
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Litchfield, K;
Stanislaw, S;
Spain, L;
Gallegos, LL;
Rowan, A;
Schnidrig, D;
Rosenbaum, H;
... Turajlic, S; + view all
(2020)
Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue.
Cell Reports
, 31
(5)
p. 107550.
10.1016/j.celrep.2020.107550.
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Montinaro, A;
Areso Zubiaur, I;
Saggau, J;
Kretz, A-L;
Ferreira, RMM;
Hassan, O;
Kitzig, E;
... Walczak, H; + view all
(2021)
Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers.
Cell Death & Differentiation
10.1038/s41418-021-00869-x.
(In press).
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Montinaro, A;
Walczak, H;
(2018)
Sterile Inflammation Fuels Gastric Cancer.
Immunity
, 48
(3)
pp. 481-483.
10.1016/j.immuni.2018.03.011.
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Oda, Hirotsugu;
Manthiram, Kalpana;
Chavan, Pallavi Pimpale;
Rieser, Eva;
Veli, Oenay;
Kaya, Oeykue;
Rauch, Charles;
... Kastner, Daniel L; + view all
(2024)
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.
Nature Immunology
, 25
(5)
pp. 764-777.
10.1038/s41590-024-01817-w.
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Peltzer, N;
Darding, M;
Montinaro, A;
Draber, P;
Draberova, H;
Kupka, S;
Rieser, E;
... Walczak, H; + view all
(2018)
LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis.
Nature
, 557
(7703)
pp. 112-117.
10.1038/s41586-018-0064-8.
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Peltzer, N;
Darding, M;
Walczak, H;
(2016)
Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling.
Trends in Cell Biology
, 26
(6)
pp. 445-461.
10.1016/j.tcb.2016.01.006.
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Peltzer, N;
Rieser, E;
Taraborrelli, L;
Draber, P;
Darding, M;
Pemaute, B;
Shimizu, Y;
... Walczak, H; + view all
(2014)
HOIP Deficiency Causes Embryonic Lethality by Aberrant TNFR1-Mediated Endothelial Cell Death.
Cell Reports
, 9
(1)
pp. 153-165.
10.1016/j.celrep.2014.08.066.
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Peltzer, N;
Walczak, H;
(2019)
Cell Death and Inflammation - A Vital but Dangerous Liaison.
Trends in Immunology
, 40
(5)
pp. 387-402.
10.1016/j.it.2019.03.006.
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Peltzer, N;
Walczak, H;
(2019)
Endothelial Cell Killing by TAK1 Inhibition: A Novel Anti-angiogenic Strategy in Cancer Therapy.
Developmental Cell
, 48
(2)
pp. 127-128.
10.1016/j.devcel.2019.01.011.
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Pescatore, A;
Esposito, E;
Draber, P;
Walczak, H;
Ursini, MV;
(2016)
NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II.
Cell Death and Disease
, 7
(ARTN e23)
10.1038/cddis.2016.245.
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Petricevic, Branka;
Kabiljo, Julijan;
Zirnbauer, Rebecca;
Walczak, Henning;
Laengle, Johannes;
Bergmann, Michael;
(2022)
Neoadjuvant immunotherapy in gastrointestinal cancers - The new standard of care?
Seminars in Cancer Biology
, 86
(Pt 2)
pp. 834-850.
10.1016/j.semcancer.2022.05.015.
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Rizza, SA;
Challagundla, KB;
Natesampillai, S;
Bren, GD;
Sykora, J;
Walczak, H;
Badley, AD;
(2011)
TRAIL Dependent Fratricidal Killing of gp120 Primed Hepatocytes by HCV Core Expressing Hepatocytes.
PLoS ONE
, 6
(11)
, Article e27171. 10.1371/journal.pone.0027171.
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Ros, Uris;
Martinez-Osorio, Veronica;
Valiente, Pedro A;
Abdelwahab, Yasmin;
Gojkovic, Milos;
Shalaby, Raed;
Zanna, Silvia;
... Garcia-Saez, Ana J; + view all
(2025)
MLKL activity requires a splicing-regulated, druggable intramolecular interaction.
Molecular Cell
, 85
(8)
pp. 1589-1605.
10.1016/j.molcel.2025.03.015.
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Sakthivelu, Vignesh;
Schmitt, Anna;
Odenthal, Franka;
Ndoci, Kristiano;
Touet, Marian;
Shaib, Ali H;
Chihab, Abdulla;
... Beleggia, Filippo; + view all
(2025)
Functional synapses between neurons and small cell lung cancer.
Nature
10.1038/s41586-025-09434-9.
(In press).
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Schiffmann, LM;
de Groot, E;
Albert, MC;
Quaas, A;
dos Santos, D Pinto;
Babic, B;
Fuchs, HF;
... van Hillegersberg, R; + view all
(2023)
Laparoscopic ischemic conditioning of the stomach prior to esophagectomy induces gastric neo-angiogenesis.
European Journal of Surgical Oncology
, 49
(11)
, Article 107096. 10.1016/j.ejso.2023.107096.
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Serbanovic-Canic, J;
de Luca, A;
Warboys, C;
Ferreira, PF;
Luong, LA;
Hsiao, S;
Gauci, I;
... Evans, PC; + view all
(2017)
Zebrafish Model for Functional Screening of Flow-Responsive Genes.
Arteriosclerosis, Thrombosis and Vascular Biology
, 37
(1)
pp. 130-143.
10.1161/ATVBAHA.116.308502.
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Shimizu, Y;
Peltzer, N;
Sevko, A;
Lafont, E;
Sarr, A;
Draberova, H;
Walczak, H;
(2017)
The linear ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis.
Hepatology
, 65
(6)
pp. 1963-1978.
10.1002/hep.29074.
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Shimizu, Y;
Taraborrelli, L;
Walczak, H;
(2015)
Linear ubiquitination in immunity.
Immunol Rev
, 266
(1)
pp. 190-207.
10.1111/imr.12309.
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Singh, HD;
Otano, I;
Rombouts, K;
Singh, KP;
Peppa, D;
Gill, US;
Bottcher, K;
... Maini, MK; + view all
(2017)
TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis.
Scientific Reports
, 7
, Article 5514. 10.1038/s41598-017-05845-5.
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Spit, M;
Rieser, E;
Walczak, H;
(2019)
Linear ubiquitination at a glance.
Journal of Cell Science
, 132
(2)
, Article jcs208512. 10.1242/jcs.208512.
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Taraborrelli, L;
Peltzer, N;
Montinaro, A;
Kupka, S;
Rieser, E;
Hartwig, T;
Sarr, A;
... Walczak, H; + view all
(2018)
LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.
Nature Communications
, 9
(1)
, Article 3910. 10.1038/s41467-018-06155-8.
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Teh, CE;
Lalaoui, N;
Jain, R;
Policheni, AN;
Heinlein, M;
Alvarez-Diaz, S;
Sheridan, JM;
... Gray, DH; + view all
(2016)
Linear ubiquitin chain assembly complex coordinates late thymic T-cell differentiation and regulatory T-cell homeostasis.
Nat Commun
, 7
, Article 13353. 10.1038/ncomms13353.
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Theobald, Sebastian J;
Simonis, Alexander;
Mudler, Julie M;
Goebel, Ulrike;
Acton, Richard;
Kohlhas, Viktoria;
Albert, Marie-Christine;
... Rybniker, Jan; + view all
(2022)
Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS-CoV-2 mRNA vaccination.
EMBO Molecular Medicine
, 14
(8)
, Article e15888. 10.15252/emmm.202215888.
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Valdez Capuccino, L;
Kleitke, T;
Szokol, B;
Svajda, L;
Martin, F;
Bonechi, F;
Kreko, M;
... Peltzer, N; + view all
(2024)
CDK9 inhibition as an effective therapy for small cell
lung cancer.
Cell Death and Disease
, 15
, Article 345. 10.1038/s41419-024-06724-4.
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Veli, Ö;
Kaya, Ö;
Varanda, AB;
Hildebrandt, X;
Xiao, P;
Estornes, Y;
Poggenberg, M;
... Peltzer, N; + view all
(2024)
RIPK1 is dispensable for cell death regulation in β-cells during hyperglycemia.
Molecular Metabolism
, 87
, Article 101988. 10.1016/j.molmet.2024.101988.
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Voersmann, H;
Groeber, F;
Walles, H;
Busch, S;
Beissert, S;
Walczak, H;
Kulms, D;
(2013)
Development of a human three-dimensional organotypic skin-melanoma spheroid model for in vitro drug testing.
Cell Death and Disease
, 4
, Article e719. 10.1038/cddis.2013.249.
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von Karstedt, S;
Montinaro, A;
Walczak, H;
(2017)
Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy.
Nature Reviews Cancer
, 17
(6)
pp. 352-366.
10.1038/nrc.2017.28.
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von Karstedt, S;
Walczak, H;
(2020)
An unexpected turn of fortune: targeting TRAIL-Rs in KRAS-driven cancer.
Cell Death Discovery
, 6
, Article 14. 10.1038/s41420-020-0249-4.
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Walczak, H;
Iwai, K;
Dikic, I;
(2012)
Generation and physiological roles of linear ubiquitin chains.
BMC Biology
, 10
, Article 23. 10.1186/1741-7007-10-23.
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Willms, A;
Schupp, H;
Poelker, M;
Adawy, A;
Debus, JF;
Hartwig, T;
Krichel, T;
... Trauzold, A; + view all
(2021)
TRAIL-receptor 2-a novel negative regulator of p53.
Cell Death & Disease
, 12
(8)
, Article 757. 10.1038/s41419-021-04048-1.
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Zinngrebe, Julia;
Moepps, Barbara;
Monecke, Thomas;
Gierschik, Peter;
Schlichtig, Ferdinand;
Barth, Thomas FE;
Strauß, Gudrun;
... Debatin, Klaus-Michael; + view all
(2022)
Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS.
EMBO Molecular Medicine
, 14
(3)
, Article e14901. 10.15252/emmm.202114901.
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Zinngrebe, J;
Montinaro, A;
Peltzer, N;
Walczak, H;
(2014)
Ubiquitin in the immune system.
EMBO Rep
, 15
(1)
pp. 28-45.
10.1002/embr.201338025.
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Zinngrebe, J;
Rieser, E;
Taraborrelli, L;
Peltzer, N;
Hartwig, T;
Ren, H;
Kovacs, I;
... Walczak, H; + view all
(2016)
LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.
Journal of Experimental Medicine
, 213
(12)
pp. 2671-2689.
10.1084/jem.20160041.
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Zinngrebe, J;
Walczak, H;
(2017)
TLRs Go Linear – On the Ubiquitin Edge.
Trends in Molecular Medicine
, 23
(4)
pp. 296-309.
10.1016/j.molmed.2017.02.003.
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Book chapter
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Reichert, M;
Bhamra, A;
Kupka, S;
Walczak, H;
(2018)
Characterization of the TNFR1-SC Using “Modified Tandem Affinity Purification” in Conjunction with Liquid Chromatography–Mass Spectrometry (LC-MS).
In: Ting, AT, (ed.)
Programmed Necrosis. Methods and Protocols.
(pp. 161-169).
Springer Nature: New York (NY), USA.
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Thesis
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Reichert, Matthias;
(2017)
Regulation of TNFR1 signalling by LUBAC-dependent and -associated proteins.
Doctoral thesis , UCL (University College London).
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Shimizu, Y;
(2017)
Molecular and functional characterisation of linear ubiquitination in the liver.
Doctoral thesis , UCL (University College London).
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