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Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling

Peltzer, N; Darding, M; Walczak, H; (2016) Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling. Trends in Cell Biology , 26 (6) pp. 445-461. 10.1016/j.tcb.2016.01.006. Green open access

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Abstract

The kinase RIPK1 is an essential signaling node in various innate immune signaling pathways being most extensively studied in the TNFR1 signaling pathway. TNF signaling can result in different biological outcomes including gene activation and cell death induction in the form of apoptosis or necroptosis. RIPK1 is believed to be crucial for regulating the balance between these opposing outcomes. It is therefore not surprising that RIPK1 is highly regulated, most notably by phosphorylation, ubiquitination, and their respective reversals. In this review, we discuss the biological functions of RIPK1 within the context of TNFR1 signaling. Finally, we discuss recent advances in the knowledge on three ubiquitin E3 ligases that exert regulatory functions on RIPK1 signaling: cIAP1, cIAP2, and LUBAC.

Type: Article
Title: Holding RIPK1 on the Ubiquitin Leash in TNFR1 Signaling
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tcb.2016.01.006
Publisher version: http://dx.doi.org/10.1016/j.tcb.2016.01.006
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Cell Biology, NF-KAPPA-B, CAUSES EMBRYONIC LETHALITY, SEVERE LIVER DEGENERATION, APOPTOSIS PROTEIN CIAP2, CHAIN ASSEMBLY COMPLEX, SHARPIN-DEFICIENT MICE, CELL-DEATH, LINEAR UBIQUITIN, IN-VIVO, C-FLIP
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
URI: https://discovery.ucl.ac.uk/id/eprint/10049340
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