Lafont, E;
Hartwig, T;
Walczak, H;
(2018)
Paving TRAIL's Path with Ubiquitin.
Trends in Biochemical Sciences
, 43
(1)
pp. 44-60.
10.1016/j.tibs.2017.11.002.
Preview |
Text
Lafont TIBS_for_UCL_records.pdf - Accepted Version Download (7MB) | Preview |
Abstract
Despite its name, signalling induced by the tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is versatile. Besides eliciting cell death by both apoptosis and necroptosis, TRAIL can also induce migration, proliferation, and cytokine production in cancerous and non-cancerous cells. Unravelling the mechanisms regulating the intricate balance between these different outputs could therefore facilitate our understanding of the role of TRAIL in tissue homeostasis, immunity, and cancer. Ubiquitination and its reversal, deubiquitination, are crucial modulators of immune receptor signalling. This review discusses recent progress on the orchestration of TRAIL signalling outcomes by ubiquitination of various components of the signalling complexes, our understanding of the molecular switches that decide between cell death and gene activation, and what remains to be discovered.
| Type: | Article |
|---|---|
| Title: | Paving TRAIL's Path with Ubiquitin |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tibs.2017.11.002 |
| Publisher version: | https://doi.org/10.1016/j.tibs.2017.11.002 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, NF-KAPPA-B, APOPTOSIS-INDUCING LIGAND, AUGMENTS ANTITUMOR-ACTIVITY, RECEPTOR-SELECTIVE MUTANTS, FADD-DEPENDENT APOPTOSIS, MEDIATED GENE INDUCTION, NECROSIS-FACTOR-ALPHA, DEATH DOMAIN PROTEIN, INDUCED CELL-DEATH, SPATA2 LINKS CYLD |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10046768 |
Archive Staff Only
 |
View Item |
