Browse by UCL people
Group by: Type | Date
Number of items: 23.
2019
Deville, C;
Franke, K;
Mogk, A;
Bukau, B;
Saibil, HR;
(2019)
Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor.
Cell Reports
, 27
(12)
3433-3446.e4.
10.1016/j.celrep.2019.05.075.
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Fitzpatrick, AW;
Saibil, HR;
(2019)
Cryo-EM of amyloid fibrils and cellular aggregates.
Current Opinion in Structural Biology
, 58
pp. 34-42.
10.1016/j.sbi.2019.05.003.
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Terry, C;
Harniman, RL;
Sells, J;
Wenborn, A;
Joiner, S;
Saibil, HR;
Miles, MJ;
... Wadsworth, JDF; + view all
(2019)
Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro.
Scientific Reports
, 9
, Article 376. 10.1038/s41598-018-36700-w.
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2018
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Brennan, AJ;
Law, RHP;
Conroy, PJ;
Noori, T;
Lukoyanova, N;
Saibil, H;
Yagita, H;
... Voskoboinik, I; + view all
(2018)
Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.
Cell Death & Differentiation
, 25
(8)
pp. 1517-1529.
10.1038/s41418-018-0057-z.
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Natesh, R;
Clare, DK;
Farr, GW;
Horwich, AL;
Saibil, HR;
(2018)
A two-domain folding intermediate of RuBisCO in complex with the GroEL chaperonin.
International Journal of Biological Macromolecules
, 118
(Part A)
pp. 671-675.
10.1016/j.ijbiomac.2018.06.120.
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Peskett, TR;
Rau, F;
O'Driscoll, J;
Patani, R;
Lowe, AR;
Saibil, HR;
(2018)
A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation.
Molecular Cell
, 70
(4)
588-601.e6.
10.1016/j.molcel.2018.04.007.
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Thomas, JA;
Tan, MSY;
Bisson, C;
Borg, A;
Umrekar, TR;
Hackett, F;
Hale, VL;
... Blackman, MJ; + view all
(2018)
A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells.
Nature Microbiology
, 3
(4)
pp. 447-455.
10.1038/s41564-018-0111-0.
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2017
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Clare, DK;
Siebert, CA;
Hecksel, C;
Hagen, C;
Mordhorst, V;
Grange, M;
Ashton, AW;
... Zhang, P; + view all
(2017)
Electron Bio-Imaging Centre (eBIC): the UK national research facility for biological electron microscopy.
Acta Crystallographica Section D - Structural Biology
, 73
pp. 488-495.
10.1107/S2059798317007756.
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Deville, C;
Carroni, M;
Franke, KB;
Topf, M;
Bukau, B;
Mogk, A;
Saibil, HR;
(2017)
Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.
Science Advances
, 3
(8)
, Article e1701726. 10.1126/sciadv.1701726.
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Leung, C;
Hodel, AW;
Brennan, AJ;
Lukoyanova, N;
Tran, S;
House, CM;
Kondos, SC;
... Hoogenboom, BW; + view all
(2017)
Real-time visualization of perforin nanopore assembly.
Nature Nanotechnology
, 12
pp. 467-473.
10.1038/nnano.2016.303.
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Patwardhan, A;
Brandt, R;
Butcher, SJ;
Collinson, L;
Gault, D;
Grunewald, K;
Hecksel, C;
... Kleywegt, GJ; + view all
(2017)
Cutting Edge: Building bridges between cellular and molecular structural biology.
eLife
, 6
, Article e25. 10.7554/eLife.25835.
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Saibil, HR;
(2017)
Blob-ology and biology of cryo-EM: an interview with Helen Saibil.
BMC Biology
, 15
, Article 77. 10.1186/s12915-017-0417-z.
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2016
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Hodel, AW;
Leung, C;
Dudkina, NV;
Saibil, HR;
Hoogenboom, BW;
(2016)
Atomic force microscopy of membrane pore formation by cholesterol dependent cytolysins.
Current Opinion in Structural Biology
, 39
pp. 8-15.
10.1016/j.sbi.2016.03.005.
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Terry, C;
Wenborn, A;
Gros, N;
Sells, J;
Joiner, S;
Hosszu, LL;
Tattum, MH;
... Wadsworth, JD; + view all
(2016)
Ex vivo mammalian prions are formed of paired double helical prion protein fibrils.
Open Biology
, 6
(5)
10.1098/rsob.160035.
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2015
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Dumoux, M;
Nans, A;
Saibil, HR;
Hayward, RD;
(2015)
Making connections: snapshots of chlamydial type III secretion systems in contact with host membranes.
Current Opinion in Microbiology
, 23
pp. 1-7.
10.1016/j.mib.2014.09.019.
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Nans, A;
Kudryashev, M;
Saibil, HR;
Hayward, RD;
(2015)
Structure of a bacterial type III secretion system in contact with a host membrane in situ.
Nature Communications
, 6
, Article 10114. 10.1038/ncomms10114.
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Wenborn, A;
Terry, C;
Gros, N;
Joiner, S;
D'Castro, L;
Panico, S;
Sells, J;
... Wadsworth, JD; + view all
(2015)
A novel and rapid method for obtaining high titre intact prion strains from mammalian brain.
Scientific Reports
, 5
, Article 10062. 10.1038/srep10062.
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2014
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Leung, C;
Dudkina, NV;
Lukoyanova, N;
Hodel, AW;
Farabella, I;
Pandurangan, AP;
Jahan, N;
... Hoogenboom, BW; + view all
(2014)
Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin.
Elife
, 3
, Article e04247. 10.7554/eLife.04247.
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Nans, A;
Saibil, HR;
Hayward, RD;
(2014)
Pathogen-host reorganization during Chlamydia invasion revealed by cryo-electron tomography.
Cellular Microbiology
, 16
(10)
pp. 1457-1472.
10.1111/cmi.12310.
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Trevitt, CR;
Hosszu, LL;
Batchelor, M;
Panico, S;
Terry, C;
Nicoll, AJ;
Risse, E;
... Clarke, AR; + view all
(2014)
N-terminal domain of prion protein directs its oligomeric association.
J Biol Chem
, 289
(37)
25497 - 25508.
10.1074/jbc.M114.566588.
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2013
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Nicoll, AJ;
Panico, S;
Freir, DB;
Wright, D;
Terry, C;
Risse, E;
Herron, CE;
... Collinge, J; + view all
(2013)
Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity.
Nature Communications
, 4
, Article 2416 . 10.1038/ncomms3416.
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2012
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Dumoux, M;
Clare, DK;
Saibil, HR;
Hayward, RD;
(2012)
Chlamydiae Assemble a Pathogen Synapse to Hijack the Host Endoplasmic Reticulum.
Traffic
, 13
(12)
pp. 1612-1627.
10.1111/tra.12002.
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2011
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Freir, DB;
Nicoll, AJ;
Klyubin, I;
Panico, S;
Mc Donald, JM;
Risse, E;
Asante, EA;
... Collinge, J; + view all
(2011)
Interaction between prion protein and toxic amyloid beta assemblies can be therapeutically targeted at multiple sites.
Nature Communications
, 2
, Article 336. 10.1038/ncomms1341.
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