Browse by UCL people
Group by: Type | Date
Number of items: 33.
2023
Kennedy, Alan;
Robinson, Maximillian A;
Hinze, Claudia;
Waters, Erin;
Williams, Cayman;
Halliday, Neil;
Dovedi, Simon;
(2023)
The CTLA-4 immune checkpoint protein regulates PD-L1:PD-1 interaction via transendocytosis of its ligand CD80.
The EMBO Journal
, Article e111556. 10.15252/embj.2022111556.
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Lax, Brianna M;
Palmeri, Joseph R;
Lutz, Emi A;
Sheen, Allison;
Stinson, Jordan A;
Duhamel, Lauren;
Santollani, Luciano;
... Wittrup, K Dane; + view all
(2023)
Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies.
Proceedings of the National Academy of Sciences of the United States of America (PNAS)
, 120
(31)
, Article e2300895120. 10.1073/pnas.2300895120.
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2022
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Fox, Thomas Andrew;
Houghton, Benjamin Christopher;
Petersone, Lina;
Waters, Erin;
Edner, Natalie Mona;
McKenna, Alex;
Preham, Olivier;
... Morris, Emma Catherine; + view all
(2022)
Therapeutic gene editing of T cells to correct CTLA-4 insufficiency.
Science Translational Medicine
, 14
(668)
, Article eabn5811. 10.1126/scitranslmed.abn5811.
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Kennedy, Alan;
Waters, Erin;
Rowshanravan, Behzad;
Hinze, Claudia;
Williams, Cayman;
Janman, Daniel;
Fox, Thomas A;
... Sansom, David M; + view all
(2022)
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation.
Nature Immunology
10.1038/s41590-022-01289-w.
(In press).
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Williams, Cayman;
Kennedy, Alan;
Robinson, Maximillian AA;
Lloyd, Christopher;
Dovedi, Simon JJ;
Sansom, David MM;
(2022)
Impact of CTLA-4 checkpoint antibodies on ligand binding and Transendocytosis.
Frontiers in Immunology
, 13
, Article 871802. 10.3389/fimmu.2022.871802.
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2021
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Janman, D;
Hinze, C;
Kennedy, A;
Halliday, N;
Waters, E;
Williams, C;
Rowshanravan, B;
... Sansom, DM; + view all
(2021)
Regulation of CTLA-4 recycling by LRBA and Rab11.
Immunology
10.1111/imm.13343.
(In press).
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2020
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Glinos, DA;
Soskic, B;
Williams, C;
Kennedy, A;
Jostins, L;
Sansom, DM;
Trynka, G;
(2020)
Genomic profiling of T-cell activation suggests increased sensitivity of memory T cells to CD28 costimulation.
Genes & Immunity
10.1038/s41435-020-00118-0.
(In press).
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Halliday, N;
Williams, C;
Kennedy, A;
Waters, E;
Pesenacker, AM;
Soskic, B;
Hinze, C;
... Sansom, DM; + view all
(2020)
CD86 Is a Selective CD28 Ligand Supporting FoxP3+ Regulatory T Cell Homeostasis in the Presence of High Levels of CTLA-4.
Frontiers in Immunology
, 11
, Article 600000. 10.3389/fimmu.2020.600000.
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Soskic, B;
Jeffery, LE;
Kennedy, A;
Gardner, DH;
Hou, TZ;
Halliday, N;
Williams, C;
... Sansom, DM; + view all
(2020)
CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis.
Frontiers Immunology
, 11
, Article 577655. 10.3389/fimmu.2020.577655.
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Thaventhiran, JED;
Lango Allen, H;
Burren, OS;
Rae, W;
Greene, D;
Staples, E;
Zhang, Z;
... Smith, KGC; + view all
(2020)
Whole-genome sequencing of a sporadic primary immunodeficiency cohort.
Nature
, 583
pp. 90-95.
10.1038/s41586-020-2265-1.
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2019
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Hou, TZ;
Qureshi, OS;
Sansom, DM;
(2019)
Measuring CTLA-4-Dependent Suppressive Function in Regulatory T Cells.
Immunological Tolerance. Methods in Molecular Biology
, 1899
pp. 87-101.
10.1007/978-1-4939-8938-6_7.
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Ovcinnikovs, V;
Ross, EM;
Petersone, L;
Edner, NM;
Heuts, F;
Ntavli, E;
Kogimtzis, A;
... Walker, LSK; + view all
(2019)
CTLA-4-mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells.
Science Immunology
, 4
(35)
, Article eaaw0902. 10.1126/sciimmunol.aaw0902.
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Sansom, DM;
Walker, LSK;
(2019)
Dimers Aren't Forever: CD80 Breaks up with PD-L1.
Immunity
, 51
(6)
pp. 972-974.
10.1016/j.immuni.2019.11.011.
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Serwas, NK;
Hoeger, B;
Ardy, RC;
Stulz, SV;
Sui, Z;
Memaran, N;
Meeths, M;
... Boztug, K; + view all
(2019)
Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis.
Nature Communications
, 10
, Article 3106. 10.1038/s41467-019-10812-x.
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2018
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Hou, TZ;
Olbrich, P;
Soto, JML;
Sanchez, B;
Moreno, PS;
Borte, S;
Stauss, HJ;
... Neth, O; + view all
(2018)
Study of an extended family with CTLA-4 deficiency suggests a CD28/CTLA-4 independent mechanism responsible for differences in disease manifestations and severity.
Clinical Immunology
, 188
pp. 94-102.
10.1016/j.clim.2018.01.001.
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Khailaie, S;
Rowshanravan, B;
Robert, PA;
Waters, E;
Halliday, N;
Herrera, JDB;
Walker, LSK;
... Meyer-Hermann, M; + view all
(2018)
Characterization of CTLA4 Trafficking and Implications for Its Function.
Biophysical Journal
, 115
(7)
pp. 1330-1343.
10.1016/j.bpj.2018.08.020.
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Rowshanravan, B;
Halliday, N;
Sansom, DM;
(2018)
CTLA-4: a moving target in immunotherapy.
Blood
, 131
(1)
pp. 58-67.
10.1182/blood-2017-06-741033.
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Schwab, C;
Gabrysch, A;
Olbrich, P;
Patiño, V;
Warnatz, K;
Wolff, D;
Hoshino, A;
... Grimbacher, B; + view all
(2018)
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4-insufficient subjects.
Journal of Allergy and Clinical Immunology
, 142
(6)
pp. 1932-1946.
10.1016/j.jaci.2018.02.055.
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2017
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Davies, G;
Cheung, M;
Gilmour, K;
Maimaris, J;
Curry, J;
Furmanski, A;
Sebire, N;
... Thrasher, A; + view all
(2017)
Thymus transplantation for complete DiGeorge syndrome: European experience.
Journal of Allergy and Clinical Immunology
10.1016/j.jaci.2017.03.020.
(In press).
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Douthwaite, J;
Moisan, J;
Privezentzev, C;
Soskic, B;
Sabbah, S;
Cohen, S;
Collinson, A;
... Jermutus, L; + view all
(2017)
A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding.
The Journal of Immunology
, 198
(1)
pp. 528-537.
10.4049/jimmunol.1600682.
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Hou, TZ;
Verma, N;
Wanders, J;
Kennedy, A;
Soskic, B;
Janman, D;
Halliday, N;
... Sansom, DM; + view all
(2017)
Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations.
Blood
, 129
pp. 1458-1468.
10.1182/blood-2016-10-745174.
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Jeffery, LE;
Henley, P;
Marium, N;
Filer, A;
Sansom, DM;
Hewison, M;
Raza, K;
(2017)
Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint.
Journal of Autoimmunity
10.1016/j.jaut.2017.10.001.
(In press).
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Liaskou, E;
Jeffery, L;
Chanouzas, D;
Soskic, B;
Seldin, MF;
Harper, L;
Sansom, D;
(2017)
Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals.
Sci Rep
, 7
, Article 7652. 10.1038/s41598-017-07967-2.
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Verma, N;
Burns, SO;
Walker, LS;
Sansom, DM;
(2017)
Immune deficiency and autoimmunity in patients with CTLA-4 mutations.
Clinical & Experimental Immunology
, 190
(1)
pp. 1-7.
10.1111/cei.12997.
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2016
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Navarini, AA;
Hruz, P;
Berger, CT;
Hou, TZ;
Schwab, C;
Gabrysch, A;
Higgins, R;
... Recher, M; + view all
(2016)
Vedolizumab as a successful treatment of CTLA-4-associated autoimmune enterocolitis.
Journal of Allergy and Clinical Immunology
10.1016/j.jaci.2016.08.042.
(In press).
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Slatter, MA;
Engelhardt, KR;
Burroughs, LM;
Arkwright, PD;
Nademi, Z;
Skoda-Smith, S;
Hagin, D;
... Torgerson, TR; + view all
(2016)
Hematopoietic stem cell transplantation for CTLA4 deficiency.
Journal of Allergy and Clinical Immunology
, 138
(2)
615-619.e1.
10.1016/j.jaci.2016.01.045.
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2015
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Gardner, DH;
Jeffery, LE;
Soskic, B;
Briggs, Z;
Hou, TZ;
Raza, K;
Sansom, DM;
(2015)
1,25(OH)2D3 Promotes the Efficacy of CD28 Costimulation Blockade by Abatacept.
Journal of Immunology
, 195
(6)
pp. 2657-2665.
10.4049/jimmunol.1500306.
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Hou, TZ;
Qureshi, OS;
Wang, CJ;
Baker, J;
Young, SP;
Walker, LSK;
Sansom, DM;
(2015)
A Transendocytosis Model of CTLA-4 Function Predicts Its Suppressive Behavior on Regulatory T Cells.
Journal of Immunology
, 194
(5)
pp. 2148-2159.
10.4049/jimmunol.1401876.
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Kenefeck, R;
Wang, CJ;
Kapadi, T;
Wardzinski, L;
Attridge, K;
Clough, LE;
Heuts, F;
... Walker, LS; + view all
(2015)
Follicular helper T cell signature in type 1 diabetes.
Journal of Clinical Investigation
, 125
(1)
292- 303.
10.1172/JCI76238.
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Walker, LS;
Sansom, DM;
(2015)
Confusing signals: recent progress in CTLA-4 biology.
Trends in Immunology
, 36
(2)
pp. 63-70.
10.1016/j.it.2014.12.001.
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Wang, CJ;
Heuts, F;
Ovcinnikovs, V;
Wardzinski, L;
Bowers, C;
Schmidt, EM;
Kogimtzis, A;
... Walker, LS; + view all
(2015)
CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement.
Proceedings of the National Academy of Sciences of the U S A
, 112
(2)
pp. 524-529.
10.1073/pnas.1414576112.
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2014
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Gardner, D;
Jeffery, LE;
Sansom, DM;
(2014)
Understanding the CD28/CTLA-4 (CD152) pathway and its implications for costimulatory blockade.
Am J Transplant
, 14
(9)
1985 - 1991.
10.1111/ajt.12834.
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2013
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Kaur, S;
Qureshi, OS;
Sansom, DM;
(2013)
Comparison of the intracellular trafficking itinerary of ctla-4 orthologues.
PLoS One
, 8
(4)
, Article e60903. 10.1371/journal.pone.0060903.
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