Browse by UCL Departments and Centres
Group by: Author | Type
Number of items: 41.
B
Balusu, Sriram;
De Strooper, Bart;
(2024)
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disease.
Acta Neuropathologica
, 147
(1)
, Article 96. 10.1007/s00401-024-02747-5.
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C
Clarke-Williams, Charlie J;
Lopes-dos-Santos, Vítor;
Lefèvre, Laura;
Brizee, Demi;
Causse, Adrien A;
Rothaermel, Roman;
Hartwich, Katja;
... Dupret, David; + view all
(2024)
Coordinating brain-distributed network activities in memory resistant to extinction.
Cell
, 187
(2)
409-427.e19.
10.1016/j.cell.2023.12.018.
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Crowley, Gerard;
Attwell, David;
Phatnani, Hemali;
Sontheimer, Harald;
Hong, Soyon;
(2024)
Glia in Neurodegenerative Disease.
Cold Spring Harbor perspectives in biology
a041375.
10.1101/cshperspect.a041375.
(In press).
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D
de Boni, Laura;
Wallis, Amber;
Hays Watson, Aurelia;
Ruiz-Riquelme, Alejandro;
Leyland, Louise-Ann;
Bourinaris, Thomas;
Hannaway, Naomi;
... Bartels, Tim; + view all
(2024)
Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson's patients.
EMBO Molecular Medicine
10.1038/s44321-024-00083-5.
(In press).
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De Strooper, Bart;
Haass, Christian;
Hardy, John;
Zetterberg, Henrik;
(2024)
Divisions over the regulation of lecanemab.
The Lancet
10.1016/S0140-6736(24)02513-3.
(In press).
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De Strooper, Bart;
Karran, Eric;
(2024)
New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases.
The EMBO Journal
10.1038/s44318-024-00057-w.
(In press).
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Duggan, Michael R;
Gomez, Gabriela T;
Joynes, Cassandra M;
Bilgel, Murat;
Chen, Jingsha;
Fattorelli, Nicola;
Hohman, Timothy J;
... Walker, Keenan A; + view all
(2024)
Proteome-wide analysis identifies plasma immune regulators of amyloid-beta progression.
Brain, Behavior, and Immunity
, 120
pp. 604-619.
10.1016/j.bbi.2024.07.002.
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E
Erkert, Lena;
Gamez-Belmonte, Reyes;
Kabisch, Melanie;
Schödel, Lena;
Patankar, Jay V;
Gonzalez-Acera, Miguel;
Mahapatro, Mousumi;
... Becker, Christoph; + view all
(2024)
Alzheimer's disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis.
Gut
10.1136/gutjnl-2023-331622.
(In press).
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F
Farrell, Clíona;
(2024)
Exploring Alzheimer's disease and Down syndrome neuro-immune pathways using preclinical models and human post-mortem brain tissue.
Doctoral thesis (Ph.D), UCL (University College London).
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G
Germeys, Christine;
Vandoorne, Tijs;
Davie, Kristofer;
Poovathingal, Suresh;
Heeren, Kara;
Vermeire, Wendy;
Nami, FatemehArefeh;
... Van Den Bosch, Ludo; + view all
(2024)
Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response.
Cell Reports
, 43
(9)
, Article 114719. 10.1016/j.celrep.2024.114719.
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Giamogante, Flavia;
Barazzuol, Lucia;
Maiorca, Francesca;
Poggio, Elena;
Esposito, Alessandra;
Masato, Anna;
Napolitano, Gennaro;
... Brini, Marisa; + view all
(2024)
A SPLICS reporter reveals
-synuclein regulation of lysosome-mitochondria contacts which affects TFEB nuclear translocation.
Nature Communications
, 15
, Article 1516. 10.1038/s41467-024-46007-2.
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H
Hays Watson, Aurelia;
(2024)
The impact of lipid droplets on α-synuclein protein folding and aggregation propensities in Parkinson’s disease.
Doctoral thesis (Ph.D), UCL (University College London).
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I
Ibanez, Kristina;
Jadhav, Bharati;
Zanovello, Matteo;
Gagliardi, Delia;
Clarkson, Christopher;
Facchini, Stefano;
Garg, Paras;
... Tucci, Arianna; + view all
(2024)
Increased frequency of repeat expansion mutations across different populations.
Nature Medicine
10.1038/s41591-024-03190-5.
(In press).
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K
Kloske, CM;
Mahinrad, S;
Barnum, CJ;
Batista, AF;
Bradshaw, EM;
Butts, B;
Carrillo, MC;
... Wilcock, DM; + view all
(2024)
Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference.
Alzheimer's & Dementia
10.1002/alz.14291.
(In press).
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Koper, MJ;
Moonen, S;
Ronisz, A;
Ospitalieri, S;
Callaerts-Vegh, Z;
T'Syen, D;
Rabe, S;
... Thal, DR; + view all
(2024)
Inhibition of an Alzheimer’s disease–associated form of necroptosis rescues neuronal death in mouse models.
Science Translational Medicine
, 16
(771)
, Article eadf5128. 10.1126/scitranslmed.adf5128.
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L
Lam, Isabel;
Ndayisaba, Alain;
Lewis, Amanda J;
Fu, YuHong;
Sagredo, Giselle T;
Kuzkina, Anastasia;
Zaccagnini, Ludovica;
... Khurana, Vikram; + view all
(2024)
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions.
Neuron
10.1016/j.neuron.2024.06.002.
(In press).
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Lloyd, AF;
Martinez-Muriana, A;
Davis, E;
Daniels, MJD;
Hou, P;
Mancuso, R;
Brenes, AJ;
... Howden, AJM; + view all
(2024)
Deep proteomic analysis of microglia reveals fundamental biological differences between model systems.
Cell Reports
, 43
(11)
, Article 114908. 10.1016/j.celrep.2024.114908.
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M
Mallach, A;
Zielonka, M;
van Lieshout, V;
An, Y;
Khoo, JH;
Vanheusden, M;
Chen, WT;
... De Strooper, B; + view all
(2024)
Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer's disease mouse model, as revealed by spatial transcriptomics.
Cell Reports
, 43
(6)
, Article 114216. 10.1016/j.celrep.2024.114216.
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Mancuso, R;
Fattorelli, N;
Martinez-Muriana, A;
Davis, E;
Wolfs, L;
Van Den Daele, J;
Geric, I;
... De Strooper, B; + view all
(2024)
Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology.
Nature Neuroscience
10.1038/s41593-024-01600-y.
(In press).
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Masato, Anna;
Andolfo, Annapaola;
Favetta, Giulia;
Bellini, Edoardo Niccolo;
Cogo, Susanna;
Dalla Valle, Luisa;
Boassa, Daniela;
... Bubacco, Luigi; + view all
(2024)
Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis.
Cell Death & Disease
, 15
, Article 424. 10.1038/s41419-024-06763-x.
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Masato, Anna;
Bubacco, Luigi;
(2024)
The αSynuclein half-life conundrum.
Neurobiology of Disease
, 196
, Article 106524. 10.1016/j.nbd.2024.106524.
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Masato, Anna;
Panzi, Chiara;
Butnaru, Ioana;
Restani, Laura;
Mazzo, Francesca;
Sher, Emanuele;
Bose, Suchira;
(2024)
Synaptic Release of Pathological Tau Is Calcium- and SNAP25-Dependent, and Blocked by BoNT-A Activity.
Toxicon
, 237
(Supp 1)
, Article 107450. 10.1016/j.toxicon.2024.107450.
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Milioto, Carmelo;
Carcolé, Mireia;
Giblin, Ashling;
Coneys, Rachel;
Attrebi, Olivia;
Ahmed, Mhoriam;
Harris, Samuel S;
... Isaacs, Adrian M; + view all
(2024)
PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons.
Nature Neuroscience
10.1038/s41593-024-01589-4.
(In press).
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Mumford, Paige Soleil;
(2024)
Preclinical modelling of altered
neuroinflammation and interferon hyper-sensitivity in Alzheimer’s disease-Down syndrome.
Doctoral thesis (Ph.D), UCL (University College London).
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N
Nazish, Iqra;
Mamais, Adamantios;
Mallach, Anna;
Bettencourt, Conceisao;
Kaganovich, Alice;
Warner, Thomas;
Hardy, John;
... Bandopadhyay, Rina; + view all
(2024)
Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2.
Cells
, 13
(1)
, Article 53. 10.3390/cells13010053.
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O
Obensa Bertroli, Clara;
(2024)
Glucocerebrosidase dysfunction results in increased membrane binding and aggregation propensity of α-synuclein in Parkinson's disease.
Doctoral thesis (Ph.D), UCL (University College London).
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P
Pappolla, Miguel A;
Refolo, Lorenzo;
Sambamurti, Kumar;
Zambon, Daniel;
Duff, Karen;
(2024)
Hypercholesterolemia and Alzheimer’s Disease: Unraveling the Connection and Assessing the Efficacy of Lipid-Lowering Therapies.
Journal of Alzheimer's Disease
, 101
(s1)
S371-S393.
10.3233/JAD-240388.
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Preman, Pranav;
Moechars, Daan;
Fertan, Emre;
Wolfs, Leen;
Serneels, Lutgarde;
Shah, Disha;
Lamote, Jochen;
... De Strooper, Bart; + view all
(2024)
APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia.
EMBO Molecular Medicine
10.1038/s44321-024-00162-7.
(In press).
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Prosser, Lloyd;
(2024)
Investigating Imaging Biomarkers in Normal Ageing and Cognitive Impairment.
Doctoral thesis (Ph.D), UCL (University College London).
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R
Rajani, Rikesh M;
Ellingford, Robert;
Hellmuth, Mariam;
Harris, Samuel S;
Taso, Orjona S;
Graykowski, David;
Lam, Francesca Kar Wey;
... Busche, Marc Aurel; + view all
(2024)
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
PLoS Biology
, 22
(7)
, Article ARTN e3002727. 10.1371/journal.pbio.3002727.
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S
Schmidt, Andree;
Hrupka, Brian;
van Bebber, Frauke;
Sunil Kumar, Sanjay;
Feng, Xiao;
Tschirner, Sarah K;
Aßfalg, Marlene;
... Lichtenthaler, Stefan F; + view all
(2024)
The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling.
The Journal of Clinical Investigation
, Article e170550. 10.1172/JCI170550.
(In press).
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Scott-Solache, James;
(2024)
TREM2 signaling regulates microglial homeostatic
functions.
Doctoral thesis (Ph.D), UCL (University College London.
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Serneels, L;
Bammens, L;
Zwijsen, A;
Tolia, A;
Chávez-Gutiérrez, L;
De Strooper, B;
(2024)
Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex.
Journal of Biological Chemistry
, 300
(1)
, Article 105533. 10.1016/j.jbc.2023.105533.
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Simmonds, Emily;
Leonenko, Ganna;
Yaman, Umran;
Bellou, Eftychia;
Myers, Amanda;
Morgan, Kevin;
Brookes, Keeley;
... Escott-Price, Valentina; + view all
(2024)
Chromosome X-wide association study in case control studies of pathologically confirmed Alzheimer's disease in a European population.
Translational Psychiatry
, 14
, Article 358. 10.1038/s41398-024-03058-9.
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Sokolova, Dimitra;
Ghansah, Shari Addington;
Puletti, Francesca;
Georgiades, Tatiana;
De Schepper, Sebastiaan;
Zheng, Yongjing;
Crowley, Gerard;
... Hong, Soyon; + view all
(2024)
Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer's disease mouse models.
BioRXiv: Cold Spring Harbor, NY, USA.
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T
Taddei, Raquel N;
(2024)
Understanding the role of glia and oligomeric tau in the
early synapse loss of Alzheimer disease dementia.
Doctoral thesis (Ph.D), UCL (University College London).
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Thal, Dietmar Rudolf;
De Strooper, Bart;
(2024)
Regulated cell death in neurodegeneration: pathways and therapeutic horizons.
Acta Neuropathologica
, 148
, Article 47. 10.1007/s00401-024-02808-9.
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V
Vandermeulen, Lina;
Geric, Ivana;
Fumagalli, Laura;
Kreir, Mohamed;
Lu, Ashley;
Nonneman, Annelies;
Premereur, Jessie;
... Mancuso, Renzo; + view all
(2024)
Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer's disease.
, Article 37. 10.1186/s13024-024-00725-9.
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W
Watamura, Naoto;
Foiani, Martha S;
Bez, Sumi;
Bourdenx, Mathieu;
Santambrogio, Alessia;
Frodsham, Claire;
Camporesi, Elena;
... Saido, Takaomi C; + view all
(2024)
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds.
Nature Neuroscience
, 28
pp. 293-307.
10.1038/s41593-024-01829-7.
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Z
Zelek, Wioleta M;
Bevan, Ryan J;
Nimmo, Jacqui;
Dewilde, Maarten;
De Strooper, Bart;
Morgan, B Paul;
(2024)
Brain-penetrant complement inhibition mitigates neurodegeneration in an Alzheimer's disease mouse model.
Brain
10.1093/brain/awae278.
(In press).
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Zilio, Gianluca;
Masato, Anna;
Sandre, Michelle;
Caregnato, Alberto;
Moret, Francesca;
Maciola, Agnieszka Katarzyna;
Antonini, Angelo;
... Bubacco, Luigi; + view all
(2024)
SARS-CoV-2-Mimicking Pseudoviral Particles Accelerate α-Synuclein Aggregation In Vitro.
ACS Chemical Neuroscience
, 15
(2)
pp. 215-221.
10.1021/acschemneuro.3c00468.
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