Tunnacliffe, E;
Chubb, JR;
(2020)
What Is a Transcriptional Burst?
Trends in Genetics
, 36
(4)
pp. 288-297.
10.1016/j.tig.2020.01.003.
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Abstract
The idea that gene activity can be discontinuous will not surprise many biologists – many genes are restricted in when and where they can be expressed. Yet during the past 15 years, a collection of observations compiled under the umbrella term ‘transcriptional bursting’ has received considerable interest. Direct visualization of the dynamics of discontinuous transcription has expanded our understanding of basic transcriptional mechanisms and their regulation and provides a real-time readout of gene activity during the life of a cell. In this review, we try to reconcile the different views of the transcriptional process emerging from studies of bursting, and how this work contextualizes the relative importance of different regulatory inputs to normal dynamic ranges of gene activity.
| Type: | Article |
|---|---|
| Title: | What Is a Transcriptional Burst? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tig.2020.01.003 |
| Publisher version: | https://doi.org/10.1016/j.tig.2020.01.003 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | transcriptional bursting, single-cell gene expression, stochastic gene expression, MS2, smFISH |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10091590 |
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