Browse by UCL people
Group by: Type | Date
Number of items: 54.
Article
Aitken, J;
Ambrose, K;
Barrell, S;
Beale, R;
Bineva-Todd, G;
Biswas, D;
Byrne, R;
... Wu, M; + view all
(2020)
Scalable and robust SARS-CoV-2 testing in an academic center.
Nature Biotechnology
, 38
(8)
pp. 927-931.
10.1038/s41587-020-0588-y.
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Andrews, Rebecca;
Fu, Bin;
Toomey, Christina E;
Breiter, Jonathan C;
Lachica, Joanne;
Beckwith, Joseph S;
Tian, Ru;
... Lee, Steven F; + view all
(2025)
Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue.
Nature Biomedical Engineering
10.1038/s41551-025-01496-4.
(In press).
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Angelova, Plamena R;
Esteras, Noemi;
Evans, James;
Kostic, Marko;
Melki, Ronald;
Prehn, Jochen HM;
Gandhi, Sonia;
(2025)
α-synuclein fibrils per se but not α-synuclein seeded aggregation causes mitochondrial dysfunction and cell death in human neurons.
Redox Biology
, 86
, Article 103817. 10.1016/j.redox.2025.103817.
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Angelova, PR;
Barilani, M;
Lovejoy, C;
Dossena, M;
Viganò, M;
Seresini, A;
Piga, D;
... Lazzari, L; + view all
(2018)
Mitochondrial dysfunction in Parkinsonian mesenchymal stem cells impairs differentiation.
Redox Biology
, 14
pp. 474-484.
10.1016/j.redox.2017.10.016.
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Angelova, PR;
Choil, ML;
Berezhnov, A;
Horrocks, MH;
Hughes, CD;
De, S;
Rodrigues, M;
... Gandhi, S; + view all
(2020)
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation.
Cell Death & Differentiation
, 27
pp. 2781-2796.
10.1038/s41418-020-0542-z.
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Angelova, PR;
Horrocks, MH;
Klenerman, D;
Gandhi, S;
Abramov, AY;
Shchepinov, MS;
(2015)
Lipid peroxidation is essential for α-synuclein-induced cell death.
J Neurochem
, 133
(4)
582 - 589.
10.1111/jnc.13024.
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Angelova, PR;
Ludtmann, MH;
Horrocks, MH;
Negoda, A;
Cremades, N;
Klenerman, D;
Dobson, CM;
... Abramov, AY; + view all
(2016)
Ca2+ is a key factor in α-synuclein-induced neurotoxicity.
Journal of Cell Science
, 129
(9)
pp. 1792-1801.
10.1242/jcs.180737.
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Bhaskar, Haresh;
Gidden, Zoe;
Virdi, Gurvir;
Kleinjan, Dirk-Jan;
Rosser, Susan J;
Gandhi, Sonia;
Regan, Lynne;
(2025)
Super-resolution imaging of proteins inside live mammalian cells with mLIVE-PAINT.
Protein Science
, 34
(2)
, Article e70008. 10.1002/pro.70008.
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Celardo, I;
Martins, LM;
Gandhi, S;
(2014)
Unravelling mitochondrial pathways to Parkinson's disease.
British Journal of Pharmacology
, 171
(8)
pp. 1943-1957.
10.1111/bph.12433.
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Choi, Minee L;
Chappard, Alexandre;
Singh, Bhanu P;
Maclachlan, Catherine;
Rodrigues, Margarida;
Fedotova, Evgeniya I;
Berezhnov, Alexey V;
... Gandhi, Sonia; + view all
(2022)
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Nature Neuroscience
10.1038/s41593-022-01140-3.
(In press).
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Choi, ML;
Gandhi, S;
(2018)
Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases.
The FEBS Journal
, 285
(19)
pp. 3631-3644.
10.1111/febs.14587.
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D’Sa, Karishma;
Evans, James R;
Virdi, Gurvir S;
Vecchi, Giulia;
Adam, Alexander;
Bertolli, Ottavia;
Fleming, James;
... Gandhi, Sonia; + view all
(2023)
Prediction of mechanistic subtypes of Parkinson’s using patient-derived stem cell models.
Nature Machine Intelligence
10.1038/s42256-023-00702-9.
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Deas, E;
Cremades, N;
Angelova, PR;
Ludtmann, MHR;
Yao, Z;
Chen, S;
Horrocks, MH;
... Abramov, AY; + view all
(2016)
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.
Antioxidants & Redox Signaling
, 24
(7)
pp. 376-391.
10.1089/ars.2015.6343.
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Deas, E;
Plun-Favreau, H;
Gandhi, S;
Desmond, H;
Kjaer, S;
Loh, SHY;
Renton, AEM;
... Wood, NW; + view all
(2011)
PINK1 cleavage at position A103 by the mitochondrial protease PARL.
Human Molecular Genetics
, 20
(5)
pp. 867-879.
10.1093/hmg/ddq526.
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Devito, Liani G;
Zanjani, Zeinab Shadman;
Evans, James R;
Scardamaglia, Annarita;
Houlden, Henry;
Gandhi, Sonia;
Healy, Lyn;
(2023)
Generation of TWO G51D SNCA missense mutation iPSC lines (CRICKi011-A, CRICKi012-A) from two individuals at risk of Parkinson's disease.
Stem Cell Research
, 71
, Article 103134. 10.1016/j.scr.2023.103134.
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Dowgier, G;
Hobbs, A;
Greenwood, D;
Shawe-Taylor, M;
Stevenson-Leggett, P;
Bazire, J;
Penn, R;
... Wu, MY; + view all
(2025)
Accurate evaluation of live-virus microneutralisation for SARS-CoV-2 variant JN.1 in the assessment of vaccination and therapeutics.
Vaccine
, 54
, Article 126960. 10.1016/j.vaccine.2025.126960.
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Drews, A;
De, S;
Flagmeier, P;
Wirthensohn, DC;
Chen, W-H;
Whiten, DR;
Vincke, C;
... Klenerman, D; + view all
(2017)
Inhibiting the Ca2+ Influx Induced by Human CSF.
Cell Reports
, 21
(11)
pp. 3310-3316.
10.1016/j.celrep.2017.11.057.
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Flagmeier, P;
De, S;
Wirthensohn, DC;
Lee, SF;
Vincke, C;
Muyldermans, S;
Knowles, TPJ;
... Klenerman, D; + view all
(2017)
Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates.
Angewandte Chemie - International Edition
, 56
(27)
pp. 7750-7754.
10.1002/anie.201700966.
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Foltynie, Tom;
Gandhi, Sonia;
Gonzalez-Robles, Cristina;
Zeissler, Marie-Louise;
Mills, Georgia;
Barker, Roger;
Carpenter, James;
... EJS ACT-PD Consortium; + view all
(2023)
Towards a multi-arm multi-stage platform trial of disease modifying approaches in Parkinson's disease.
Brain
, Article awad063. 10.1093/brain/awad063.
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Gandhi, S;
Abramov, AY;
(2012)
Mechanism of Oxidative Stress in Neurodegeneration.
Oxidative Medicine and Cellular Longevity
, 2012
, Article 428010. 10.1155/2012/428010.
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Gandhi, S;
Plun-Favreau, H;
(2017)
Mutations and mechanism: how PINK1 may contribute to risk of sporadic Parkinson's disease.
Brain
, 140
(1)
pp. 2-5.
10.1093/brain/aww320.
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Gandhi, S;
Vaarmann, A;
Yao, Z;
Duchen, MR;
Wood, NW;
Abramov, AY;
(2012)
Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease.
PLoS One
, 7
(5)
, Article e37564. 10.1371/journal.pone.0037564.
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Girges, C;
Vijiaratnam, N;
Athauda, D;
Auld, G;
Gandhi, S;
Foltynie, T;
(2021)
The Future of Incretin-Based Approaches for Neurodegenerative Diseases in Older Adults: Which to Choose? A Review of their Potential Efficacy and Suitability.
Drugs & Aging
, 38
pp. 355-373.
10.1007/s40266-021-00853-7.
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Gonzalez-Robles, Cristina;
Athauda, Dilan;
Barber, Thomas R;
Barker, Roger A;
Dexter, David T;
Duty, Susan;
Ellis-Doyle, Romy;
... EJS ACT-PD Consortium; + view all
(2025)
Treatment Selection and Prioritization for the EJS ACT-PD MAMS Trial Platform.
Movement Disorders
, 40
(7)
pp. 1307-1317.
10.1002/mds.30190.
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Hall, CE;
Yao, Z;
Choi, M;
Tyzack, GE;
Serio, A;
Luisier, R;
Harley, J;
... Patani, R; + view all
(2017)
Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS.
Cell Reports
, 19
(9)
pp. 1739-1749.
10.1016/j.celrep.2017.05.024.
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Horrocks, MH;
Lee, SF;
Gandhi, S;
Magdalinou, NK;
Chen, SW;
Devine, MJ;
Tosatto, L;
... Klenerman, D; + view all
(2016)
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.
ACS Chemical Neuroscience
, 7
(3)
pp. 399-406.
10.1021/acschemneuro.5b00324.
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Houlihan, CF;
Vora, N;
Byrne, T;
Lewer, D;
Kelly, G;
Heaney, J;
Gandhi, S;
... SAFER Investigators; + view all
(2020)
Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers.
The Lancet
, 396
(10246)
e6-e7.
10.1016/S0140-6736(20)31484-7.
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Hughes, CD;
Choi, ML;
Ryten, M;
Hopkins, L;
Drews, A;
Botía, JA;
Iljina, M;
... Klenerman, D; + view all
(2019)
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.
Acta Neuropathologica
, 137
(1)
pp. 103-120.
10.1007/s00401-018-1907-y.
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Iljina, M;
Hong, L;
Horrocks, MH;
Ludtmann, MH;
Choi, ML;
Hughes, CD;
Ruggeri, FS;
... Klenerman, D; + view all
(2017)
Nanobodies raised against monomeric alpha-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
BMC Biology
, 15
, Article 57. 10.1186/s12915-017-0390-6.
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Iljina, M;
Tosatto, L;
Choi, ML;
Sang, JC;
Ye, Y;
Hughes, CD;
Bryant, CE;
... Klenerman, D; + view all
(2016)
Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein.
Scientific Reports
, 6
, Article 33928. 10.1038/srep33928.
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Little, D;
Luft, C;
Mosaku, O;
Lorvellec, M;
Yao, Z;
Paillusson, S;
Kriston-Vizi, J;
... Gissen, P; + view all
(2018)
A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA.
Scientific Reports
, 8
, Article 9033. 10.1038/s41598-018-27058-0.
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Ludtmann, M;
Angelova, P;
Ninkina, N;
Gandhi, S;
Buchman, V;
Abramov, A;
(2016)
Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase.
The Journal of Neuroscience
, 36
(41)
pp. 10510-10521.
10.1523/JNEUROSCI.1659-16.2016.
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Ludtmann, MHR;
Angelova, PR;
Horrocks, MH;
Choi, ML;
Rodrigues, M;
Baev, AY;
Berezhnov, AV;
... Gandhi, S; + view all
(2018)
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
Nature Communications
, 9
, Article 2293. 10.1038/s41467-018-04422-2.
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Ludtmann, MHR;
Arber, C;
Bartolome, F;
de Vicente, M;
Preza, E;
Carro, E;
Houlden, H;
... Abramov, AY; + view all
(2017)
Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons.
Journal of Biological Chemistry
, 292
(21)
pp. 8907-8917.
10.1074/jbc.M116.762898.
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Ludtmann, MHR;
Kostic, M;
Horne, A;
Gandhi, S;
Sekler, I;
Abramov, AY;
(2019)
LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation.
Cell Death & Disease
, 10
(4)
, Article 265. 10.1038/s41419-019-1469-5.
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McColgan, P;
Viegas, S;
Gandhi, S;
Bull, K;
Tudor, R;
Sheikh, F;
Pinney, J;
... Reilly, MM; + view all
(2015)
Oculoleptomeningeal Amyloidosis associated with transthyretin Leu12Pro in an African patient.
J Neurol
, 262
(1)
228 - 234.
10.1007/s00415-014-7594-2.
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Mead, S;
Gandhi, S;
Beck, J;
Caine, D;
Gallujipali, D;
Carswell, C;
Hyare, H;
... Collinge, J; + view all
(2013)
A Novel Prion Disease Presenting with Diarrhea and Autonomic Neuropathy.
New England Journal of Medicine
, 369
(20)
1904- 1914.
10.1056/NEJMoa1214747.
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Mears, HV;
Young, GR;
Sanderson, T;
Harvey, R;
Barrett-Rodger, J;
Penn, R;
Cowton, V;
... Bauer, DLV; + view all
(2025)
Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion.
PLoS Biology
, 23
(1)
, Article e3002982. 10.1371/journal.pbio.3002982.
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Neo, Ray Jen;
Mehta, Arpan R;
Weston, Mikail;
Magrinelli, Francesca;
Quattrone, Andrea;
Gandhi, Sonia;
Joyce, Eileen M;
(2024)
Neuropsychiatric Presentation of Anti-DPPX Progressive Encephalomyelitis with Rigidity and Myoclonus.
Movement Disorders Clinical Practice
, 11
(1)
pp. 97-100.
10.1002/mdc3.13928.
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Poole, OV;
Everett, CM;
Gandhi, S;
Marino, S;
Bugiardini, E;
Woodward, C;
Lam, A;
... Pitceathly, RDS; + view all
(2019)
Adult-onset Leigh syndrome linked to the novel stop codon mutation m.6579G>A in MT-CO1.
Mitochondrion
, 47
pp. 294-297.
10.1016/j.mito.2019.02.004.
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Reeve, AK;
Ludtmann, MH;
Angelova, PR;
Simcox, EM;
Horrocks, MH;
Klenerman, D;
Gandhi, S;
... Abramov, AY; + view all
(2015)
Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons.
Cell Death & Disease
, 6
(7)
, Article e1820. 10.1038/cddis.2015.166.
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Rodrigues, M;
Bhattacharjee, P;
Brinkmalm, A;
Do, DT;
Pearson, CM;
De, S;
Ponjavic, A;
... Klenerman, D; + view all
(2022)
Structure-specific amyloid precipitation in biofluids.
Nature Chemistry
, 14
pp. 1045-1053.
10.1038/s41557-022-00976-3.
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Saleeb, Rebecca S;
Leighton, Craig;
Lee, Ji-Eun;
O'Shaughnessy, Judi;
Jeacock, Kiani;
Chappard, Alexandre;
Cumberland, Robyn;
... Horrocks, Mathew H; + view all
(2023)
Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates.
Science Advances
, 9
(46)
, Article eadi7359. 10.1126/sciadv.adi7359.
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Shawe-Taylor, Marianne;
Greenwood, David;
Hobbs, Agnieszka;
Dowgier, Giulia;
Penn, Rebecca;
Sanderson, Theo;
Stevenson-Leggett, Phoebe;
... Wall, Emma C; + view all
(2024)
Divergent performance of vaccines in the UK autumn 2023 COVID-19 booster campaign.
The Lancet
, 403
(10432)
pp. 1133-1136.
10.1016/S0140-6736(24)00316-7.
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Toomey, Christina E;
Heywood, Wendy E;
Evans, James R;
Lachica, Joanne;
Pressey, Sarah N;
Foti, Sandrine C;
Al Shahrani, Mesfer;
... Gandhi, Sonia; + view all
(2022)
Mitochondrial dysfunction is a key pathological driver of early stage Parkinson's.
Acta Neuropathologica Communications
, 10
(1)
, Article 134. 10.1186/s40478-022-01424-6.
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Vaarmann, A;
Kovac, S;
Holmström, KM;
Gandhi, S;
Abramov, AY;
(2013)
Dopamine protects neurons against glutamate-induced excitotoxicity.
Cell Death Dis
, 4
, Article e455. 10.1038/cddis.2012.194.
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Varela, JA;
Rodrigues, M;
De, S;
Flagmeier, P;
Gandhi, S;
Dobson, CM;
Klenerman, D;
(2018)
Optical Structural Analysis of Individual alpha-Synuclein Oligomers.
Angewandte Chemie - International Edition
, 57
(18)
pp. 4886-4890.
10.1002/anie.201710779.
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Vokurka, P;
Barron, A;
Sumaria, S;
Stockford, L;
Jarman, P;
Bhatia, K;
Farmer, S;
... Foltynie, T; + view all
(2020)
Opicapone Efficacy and Tolerability in Parkinson's Disease Patients Reporting Insufficient Benefit/Failure of Entacapone.
Movement Disorders Clinical Practice
10.1002/mdc3.13094.
(In press).
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Whiten, DR;
Zuo, Y;
Calo, L;
Choi, M-L;
De, S;
Flagmeier, P;
Wirthensohn, DC;
... Horrocks, MH; + view all
(2018)
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.
ChemBioChem
, 19
(19)
pp. 2033-2038.
10.1002/cbic.201800209.
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Wood-Kaczmar, A;
Gandhi, S;
Yao, Z;
Abramov, ASY;
Miljan, EA;
Keen, G;
Stanyer, L;
... Wood, NW; + view all
(2008)
PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons.
PLOS ONE
, 3
(6)
, Article e2455. 10.1371/journal.pone.0002455.
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Wu, Mary Y;
Carr, Edward J;
Harvey, Ruth;
Mears, Harriet V;
Kjaer, Svend;
Townsley, Hermaleigh;
Hobbs, Agnieszka;
... Bauer, David LV; + view all
(2022)
WHO's Therapeutics and COVID-19 Living Guideline on mAbs needs to be reassessed.
The Lancet
, 400
(10369)
pp. 2193-2196.
10.1016/s0140-6736(22)01938-9.
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Wu, MY;
Shepherd, STC;
Fendler, A;
Carr, EJ;
Au, L;
Harvey, R;
Dowgier, G;
... Turajlic, S; + view all
(2023)
Sotrovimab restores neutralization against current Omicron subvariants in patients with blood cancer.
Cancer Cell
, 41
(5)
pp. 821-823.
10.1016/j.ccell.2023.04.005.
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Yao, Z;
Gandhi, S;
Burchell, VS;
Plun-Favreau, H;
Wood, NW;
Abramov, AY;
(2011)
Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease.
Journal of Cell Science
, 124
(24)
pp. 4194-4202.
10.1242/jcs.088260.
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Thesis
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R'Bibo, Léa Emma Sophie;
(2020)
Investigating the Role of GTP Cyclohydrolase I Mutations and the Tetrahydrobiopterin Pathway in Parkinson’s Disease.
Doctoral thesis (Ph.D), UCL (University College London).
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